魏聞，男，博士，重慶大學生命科學學院碩士生導師、副研究員。主要研究方向為進化生物學和生物信息學。
基本介紹
- 中文名：魏聞
- 畢業院校：電子科技大學
- 學位/學歷：博士
- 專業方向：進化生物學和生物信息學
- 職務：重慶大學生命科學學院碩士生導師
人物經歷,研究方向,主講課程,學術成果,
人物經歷
2017/09至今，重慶大學，副研究員
2016/01-2017/08，重慶大學，講師
2014/07–2015/12，天津醫科大學，講師
2008/09–2014/06，電子科技大學，博士
2016/01-2017/08，重慶大學，講師
2014/07–2015/12，天津醫科大學，講師
2008/09–2014/06，電子科技大學，博士
研究方向
主要研究方向為進化生物學和生物信息學
I. 基於大腸桿菌的實驗室進化研究進化機制。採用實驗室進化方法，以大腸桿菌這種模式生物研究生物的進化過程，目前主要關注（1）基因突變和基因丟失對適應度的影響（2）生物網路進化的分子機制及驅動力。
II. 理論進化基因組研究。基於進化理論，比較基因組學及系統生物學方法等，通過挖掘公有資料庫數據研究（1）新基因的起源和進化（2）適應性進化（3）協同進化（4）蛋白質進化率差異成因等相關遺傳學和進化生物學問題。
II. 理論進化基因組研究。基於進化理論，比較基因組學及系統生物學方法等，通過挖掘公有資料庫數據研究（1）新基因的起源和進化（2）適應性進化（3）協同進化（4）蛋白質進化率差異成因等相關遺傳學和進化生物學問題。
主講課程
本科生《生物統計學》，研究生《生物信息學》
學術成果
*通訊作者
10. Du MZ, Zhang CJ, Wang H, Liu S, Wei W*, Guo FB*(2018) The GC content as a main factor shaping the amino acid usage during bacterial evolution process. Front Microbiol. 9:2948.
9. Wei W, Xiong L, Ye YN, Du MZ, Gao YZ, Zhang KY, Jin YT, Yang Z, Wong PC, Lau SKP, Kan B, Zhu J, Woo PCY*, Guo FB* (2018) Mutation landscape of base substitutions, duplications, and deletions in the representative current cholera pandemic strain. Genome Biol Evol. 10(8):2072-2085.
8. Du MZ, Liu S, Zeng Z, Alemayehu LA, Wei W*, Guo FB*(2018) Amino acid compositions contribute to the proteins' evolution under the influence of their abundances and genomic GC content. Sci Rep. 8(1):7382.
7. Li YM, Zhuang H, Zhang X, Li Y, Liu Y, Yi X, Qin G, Wei W*, Chen R* (2018) Multiomics integration reveals the landscape of prometastasis metabolism in hepatocellular carcinoma. Mol Cell Proteomics.17(4): 607-618. (Cover Story)
6. Wei W, Gao F, Du MZ , Hua HL, Wang J, Guo FB* (2017) Zisland Explorer: detect genomic islands by combining homogeneity and heterogeneity properties. Brief Bioinform. 18 (3) :357-366. (Impact Factor: 9.617)
5. Wei W, Jin YT, Du MZ, Wang J, Rao N, Guo FB* (2016) Genomic complexity places less restrictions on the evolution of young coexpression networks than protein - protein interactions. Genome Biol Evol. 8(8):2624-31.
4. Wei W, Ning LW, Ye YN, Li SJ, Zhou HQ, Huang J, Guo FB* (2014) SMAL: A resource of spontaneous mutation accumulation lines. Mol Biol Evol. 31(5): 1302-1308. (Impact Factor: 10.353)
3. Wei W, Ye YN, Luo S, Deng YY, Lin D, Guo FB* (2014) IFIM: a database of integrated fitness information for microbial genes. Database. 2014: bau052.
2. Wei W, Zhang T, Lin D, Yang ZJ, Guo FB*. (2013) Transcriptional abundance is not the single force driving the evolution of bacterial proteins. BMC Evol Biol. 13: 162.
1. Wei W, Ning LW, Ye YN, Guo FB*. (2013) Geptop: a gene essentiality prediction tool for sequenced bacterial genomes based on orthology and phylogeny. PLoS One. 8(8): e72343.
10. Du MZ, Zhang CJ, Wang H, Liu S, Wei W*, Guo FB*(2018) The GC content as a main factor shaping the amino acid usage during bacterial evolution process. Front Microbiol. 9:2948.
9. Wei W, Xiong L, Ye YN, Du MZ, Gao YZ, Zhang KY, Jin YT, Yang Z, Wong PC, Lau SKP, Kan B, Zhu J, Woo PCY*, Guo FB* (2018) Mutation landscape of base substitutions, duplications, and deletions in the representative current cholera pandemic strain. Genome Biol Evol. 10(8):2072-2085.
8. Du MZ, Liu S, Zeng Z, Alemayehu LA, Wei W*, Guo FB*(2018) Amino acid compositions contribute to the proteins' evolution under the influence of their abundances and genomic GC content. Sci Rep. 8(1):7382.
7. Li YM, Zhuang H, Zhang X, Li Y, Liu Y, Yi X, Qin G, Wei W*, Chen R* (2018) Multiomics integration reveals the landscape of prometastasis metabolism in hepatocellular carcinoma. Mol Cell Proteomics.17(4): 607-618. (Cover Story)
6. Wei W, Gao F, Du MZ , Hua HL, Wang J, Guo FB* (2017) Zisland Explorer: detect genomic islands by combining homogeneity and heterogeneity properties. Brief Bioinform. 18 (3) :357-366. (Impact Factor: 9.617)
5. Wei W, Jin YT, Du MZ, Wang J, Rao N, Guo FB* (2016) Genomic complexity places less restrictions on the evolution of young coexpression networks than protein - protein interactions. Genome Biol Evol. 8(8):2624-31.
4. Wei W, Ning LW, Ye YN, Li SJ, Zhou HQ, Huang J, Guo FB* (2014) SMAL: A resource of spontaneous mutation accumulation lines. Mol Biol Evol. 31(5): 1302-1308. (Impact Factor: 10.353)
3. Wei W, Ye YN, Luo S, Deng YY, Lin D, Guo FB* (2014) IFIM: a database of integrated fitness information for microbial genes. Database. 2014: bau052.
2. Wei W, Zhang T, Lin D, Yang ZJ, Guo FB*. (2013) Transcriptional abundance is not the single force driving the evolution of bacterial proteins. BMC Evol Biol. 13: 162.
1. Wei W, Ning LW, Ye YN, Guo FB*. (2013) Geptop: a gene essentiality prediction tool for sequenced bacterial genomes based on orthology and phylogeny. PLoS One. 8(8): e72343.
