魏成喜

魏成喜，男，1982年12月生， 2005年畢業於延邊大學獲學士學位，2011年獲得醫學博士學位。2009年9月，就職於內蒙古民族大學附屬醫院神經外科研究所。2010年3月，師從延邊大學生理學教研室邱德來教授和金清華教授學習神經科學研究。

基本介紹

• 中文名：魏成喜
• 國籍：中國
• 出生日期：1982年12月
• 畢業院校：延邊大學
• 性別：男

[主要研究方向與興趣]

一直從事藥物化學科研工作，研究方向為：

1、寒組己循先導化合物的尋殃定棵找與結構最佳化。

2、布魯菌病相關研究。

3、保健品研究與開發。

主要參與的科研項目

1. 吡唑烷酮類化合物的合成及抗癲癇作用研究，國家自然科學基金課題，2005-2007。

2．喹喔啉酮衍寒項設生物的合成及抗癲癇作用研究．國家自然科學基金課疊挨只題，2008-2010。

3. 二苯甲基哌嗪類衍生物的合成和抗癲癇作用及作用機制研究。國家自然科學基金課題，2009-2011。

4. 抗癲癇新藥三唑喹酮的研製，教育部重點項目，2007-2009。

5. 三唑酮並喹啉類化合物的合成及抗癲癇作用研究，教盛辨育部留學回國啟動項目，2008-2010。

獲獎

1. 內蒙禁艱翻嫌古自治區“草原英才”

2. 內蒙古民族大學“科爾沁學者”微只習

主要發表論文

1. Wei CX, Guan LP, Jia JH, Chai KY, Quan ZS. Synthesis of 2-substituted-6-

(4H-1,2,4-triazol-4-yl)benzo[d]oxazoles as potential anticonvulsant agents. Arch Pharm Res.

2009; 32(1):23-31.

2. Wei CX, Li FN, Zhao LX, Zhao LM, Quan ZS. Synthesis of 2-substituted-7-

heptyloxy-4,5-dihydro[1,2,4]-triazolo[4,3-a]quinolin-1(2H)-ones with

anticonvulsant activity. Arch Pharm (Weinheim). 2007;340(9):491-5.

3. Wei CX, Zhang W, Quan ZS, Han RB, Jiang RS, Piao FY. Synthesis,

Anticonvulsant Evaluation of 2,3,4,5-Tetrahydro-7-alkoxy-1H-2-benzazepin- 1-ones.

Letters in Drug Design & Discovery, 2009,6, 548-553

4. Wei CX, Wu D, Sun ZG, Chai KY, Quan ZS. Synthesis of 6-(3-substituted-4H-

1,2,4-triazol-4-yl)-2-phenylbenzo[d]oxazoles as potential anticonvulsant agents.

Med Chem Res. 2009. Published online.

5. Wei CX, Xian-Qing Deng, Kyu-Yun Chai, Zhi-Gang Sun, and Zhe-Shan Quan.Synthesis and

Anticonvulsant Activity of 1-Formamide-triazolo[4,3-a]quinoline Derivatives. Arch Pharm Res. 2010; 33

(5): 655-62.

6. Wei CX, Guo Z, Li FN and Quan ZS. Synthesis and Anticonvulsant Activity Alkoxy-[1,2,4]triazolo[3,4-a]

phthalazin-3(2H)-ones. Asian Journal of Chemistry. Vol. 23, No. 1 (2011), inpress.

7. Sun XY, Wei CX, Deng XQ, Sun ZG, Quan ZS. Evaluation of the anticonvulsant

activity of 6-(4-chlorophenyoxyl)-tetrazolo[5,1-a]phthalazine in various experimental

seizure models in mice. Pharmacol Rep. 2010, 62, 273-277.

8. Sun XY, Wei CX, Deng XQ, Sun ZG, Quan ZS. Synthesis and primary

anticonvulsant activity evaluation of 6-alkyoxyl-tetrazolo[5,1-a]phthalazine

derivatives. Arzneimittel Forschung / Drug Research. 2010; 60(6): 289-92.

9. Deng XQ, Wei CX, Li FN, Sun ZG, Quan ZS. Design and synthesis of 10-alkoxy-5,

6-dihydro-triazolo[4,3-d]benzo[f][1,4]oxazepine derivatives with anticonvulsant

activity. Eur J Med Chem. 2010 (45), 3080-3086.

10. Hu C, Sun ZG, Wei CX, Quan ZS, Synthesis and Anticonvulsant Activity of Some

Cinnamylpiperazine Derivatives. Letters in Drug Design & Discovery, 2010; 7(9):

661-4.

11. Deng XQ, Wei CX, Song MX, Chai KY, Sun ZG, and Quan ZS.Synthesis and

Studies on Anticonvulsant and Antidepressant Activities of 5-Alkoxy- tetrazolo[1,5-

a] quinolines. Bull. Korean Chem. Soc. 2010, 31(2): 447-452

12. Deng XQ, Wei CX, Song MX, Quan ZS. Synthesis and antidepressant-like action

of 9-alkoxy-7H-furo[3,2-g]chromen-7-ones in mice. Arzneimittelforschung. [In press]

13. Wang HJ, Wei CX, Deng XQ, Li FL, Quan ZS. Synthesis and evaluation on

anticonvulsant and antidepressant activities of 5-Alkoxy-tetrazolo[1,5-a]

quinazolines. Arch Pharm (Weinheim).2009; 342(11): 671-5.

14. Guo LJ, Wei CX, Jia JH, Zhao LM, Quan ZS. Design and synthesis of

5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity. Eur

J Med Chem. 2009; 44(3):954-8.

15. Guan LP, Wei CX, Deng XQ, Sui X, Piao HR, Quan ZS. Synthesis and

anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives. Eur J Med

Chem. 2009; 44(9): 3654-7.

16. Sun XY, Wei CX, Chai KY, Piao HR, Quan ZS. Synthesis and anti-inflammatory

activity evaluation of novel 7-alkoxy-1-amino-4,5-dihydro[1,2,4]triazole[4,3-a]

quinolines. Arch Pharm (Weinheim). 2008; 341(5):288-93.

17. Zhang LQ, Guan LP, Wei CX, Deng XQ, Quan ZS. Synthesis and anticonvulsant

activity of some 7-alkoxy-2H-1,4-benzothiazin-3(4H)-ones and 7-alkoxy-4H- [1,2,4]

triazolo[4,3-d]benzo[b][1,4]thiazines. Chem Pharm Bull (Tokyo). 2010; 58(3): 326-

31.

18. Sun XY, Hu C, Deng XQ, Wei CX, Sun ZG, Quan ZS.Synthesis and anti-

inflammatory activity evaluation of some novel 6-alkoxy(phenoxy)-[1,2,4] triazolo

[3,4-a]phthalazine-3-amine derivatives. Eur J Med Chem. 2010; 45(11): 4807-12.

19. Sun XY, Zhang L, Wei CX, Piao HR, Quan ZS. Characterization of the

anticonvulsant activity of doxepin in various experimental seizure models in mice.

Pharmacol Rep. 2009; 61(2): 245-51.

20. Zhang L, Guan LP, Sun XY, Wei CX, Chai KY, Quan ZS. Synthesis and

anticonvulsant activity of 6-alkoxy-[1,2,4]triazolo[3,4-a]phthalazines. Chem Biol

Drug Des. 2009; 73(3): 313-9.

21. Sun XY, Zhang L, Wei CX, Piao HR, Quan ZS. Design, synthesis of 8-alkoxy- 5,6-

dihydro-[1,2,4]triazino[4,3-a]quinolin-1-ones with anticonvulsant activity. Eur J Med

Chem. 2009; 44(3):1265-70.

22. Sun XY, Guan LP, Zhang L, Wei CX, Piao HR, Quan ZS. Design, Synthesis and

Anticonvulsant Activity Evaluation of 7-Substituted-4H-[1,2,4]triazino[3,4-a]

phthalazin-4-one Derivatives. J. Braz. Chem. Soc. 2009, 20(5), 826-831.

Med Chem Res. 2009. Published online.

5. Wei CX, Xian-Qing Deng, Kyu-Yun Chai, Zhi-Gang Sun, and Zhe-Shan Quan.Synthesis and

Anticonvulsant Activity of 1-Formamide-triazolo[4,3-a]quinoline Derivatives. Arch Pharm Res. 2010; 33

(5): 655-62.

6. Wei CX, Guo Z, Li FN and Quan ZS. Synthesis and Anticonvulsant Activity Alkoxy-[1,2,4]triazolo[3,4-a]

phthalazin-3(2H)-ones. Asian Journal of Chemistry. Vol. 23, No. 1 (2011), inpress.

7. Sun XY, Wei CX, Deng XQ, Sun ZG, Quan ZS. Evaluation of the anticonvulsant

activity of 6-(4-chlorophenyoxyl)-tetrazolo[5,1-a]phthalazine in various experimental

seizure models in mice. Pharmacol Rep. 2010, 62, 273-277.

8. Sun XY, Wei CX, Deng XQ, Sun ZG, Quan ZS. Synthesis and primary

anticonvulsant activity evaluation of 6-alkyoxyl-tetrazolo[5,1-a]phthalazine

derivatives. Arzneimittel Forschung / Drug Research. 2010; 60(6): 289-92.

9. Deng XQ, Wei CX, Li FN, Sun ZG, Quan ZS. Design and synthesis of 10-alkoxy-5,

6-dihydro-triazolo[4,3-d]benzo[f][1,4]oxazepine derivatives with anticonvulsant

activity. Eur J Med Chem. 2010 (45), 3080-3086.

10. Hu C, Sun ZG, Wei CX, Quan ZS, Synthesis and Anticonvulsant Activity of Some

Cinnamylpiperazine Derivatives. Letters in Drug Design & Discovery, 2010; 7(9):

661-4.

11. Deng XQ, Wei CX, Song MX, Chai KY, Sun ZG, and Quan ZS.Synthesis and

Studies on Anticonvulsant and Antidepressant Activities of 5-Alkoxy- tetrazolo[1,5-

a] quinolines. Bull. Korean Chem. Soc. 2010, 31(2): 447-452

12. Deng XQ, Wei CX, Song MX, Quan ZS. Synthesis and antidepressant-like action

of 9-alkoxy-7H-furo[3,2-g]chromen-7-ones in mice. Arzneimittelforschung. [In press]

13. Wang HJ, Wei CX, Deng XQ, Li FL, Quan ZS. Synthesis and evaluation on

anticonvulsant and antidepressant activities of 5-Alkoxy-tetrazolo[1,5-a]

quinazolines. Arch Pharm (Weinheim).2009; 342(11): 671-5.

14. Guo LJ, Wei CX, Jia JH, Zhao LM, Quan ZS. Design and synthesis of

5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity. Eur

J Med Chem. 2009; 44(3):954-8.

15. Guan LP, Wei CX, Deng XQ, Sui X, Piao HR, Quan ZS. Synthesis and

anticonvulsant activity of N-(2-hydroxyethyl) cinnamamide derivatives. Eur J Med

Chem. 2009; 44(9): 3654-7.

16. Sun XY, Wei CX, Chai KY, Piao HR, Quan ZS. Synthesis and anti-inflammatory

activity evaluation of novel 7-alkoxy-1-amino-4,5-dihydro[1,2,4]triazole[4,3-a]

quinolines. Arch Pharm (Weinheim). 2008; 341(5):288-93.

17. Zhang LQ, Guan LP, Wei CX, Deng XQ, Quan ZS. Synthesis and anticonvulsant

activity of some 7-alkoxy-2H-1,4-benzothiazin-3(4H)-ones and 7-alkoxy-4H- [1,2,4]

triazolo[4,3-d]benzo[b][1,4]thiazines. Chem Pharm Bull (Tokyo). 2010; 58(3): 326-

31.

18. Sun XY, Hu C, Deng XQ, Wei CX, Sun ZG, Quan ZS.Synthesis and anti-

inflammatory activity evaluation of some novel 6-alkoxy(phenoxy)-[1,2,4] triazolo

[3,4-a]phthalazine-3-amine derivatives. Eur J Med Chem. 2010; 45(11): 4807-12.

19. Sun XY, Zhang L, Wei CX, Piao HR, Quan ZS. Characterization of the

anticonvulsant activity of doxepin in various experimental seizure models in mice.

Pharmacol Rep. 2009; 61(2): 245-51.

20. Zhang L, Guan LP, Sun XY, Wei CX, Chai KY, Quan ZS. Synthesis and

anticonvulsant activity of 6-alkoxy-[1,2,4]triazolo[3,4-a]phthalazines. Chem Biol

Drug Des. 2009; 73(3): 313-9.

21. Sun XY, Zhang L, Wei CX, Piao HR, Quan ZS. Design, synthesis of 8-alkoxy- 5,6-

dihydro-[1,2,4]triazino[4,3-a]quinolin-1-ones with anticonvulsant activity. Eur J Med

Chem. 2009; 44(3):1265-70.

22. Sun XY, Guan LP, Zhang L, Wei CX, Piao HR, Quan ZS. Design, Synthesis and

Anticonvulsant Activity Evaluation of 7-Substituted-4H-[1,2,4]triazino[3,4-a]

phthalazin-4-one Derivatives. J. Braz. Chem. Soc. 2009, 20(5), 826-831.