馬莉, 女，博士, 研究員,博士生導師，現任中國科學院昆明動物研究所洞穴魚類發育與進化學科組負責人。2008年在中國科學院昆明動物研究所獲博士學位；2010-2016年間分別在美國馬里蘭大學、美國芝加哥大學-伍茲霍爾海洋生物學實驗室和美國辛辛那提大學從事博士後研究，跟隨進化發育生物學家William R. Jeffery教授以墨西哥脂鯉為研究對象，對視覺及色素退化等機制進行了深入研究；2016年9月至2020年8月在美國馬里蘭大學生物系任教職專家。在墨西哥脂鯉視覺退化、色素髮育、母源性調控和器官不對稱等領域做出了多項原創性成果：1，鑑定了首個導致墨西哥脂鯉盲魚種群視覺退化的基因胱硫醚β-合酶（cbsa）, 並提出盲魚眼部血液系統出現缺陷進而誘導視覺退化的全新機制，統一了當前學術界關於到底是晶狀體凋亡退化還是視網膜凋亡退化導致盲魚視覺缺失的爭議；2，首次在墨西哥脂鯉中利用基因組編輯的方式成功敲除色素基因；3，首次揭示了在墨西哥脂鯉發育中存在母源性調控；4，首次在墨西哥脂鯉洞穴種群中發現心臟位置左右互換的現象, 開啟了洞穴生物一個全新的研究領域-即器官不對稱的研究。相關成果發表於Nature Communications、Nature Ecology & Evolution、Developmental Biology、EvoDevo、Journal of Experimental Zoology Part B、PloS One、Journal of Fish Biology等刊物；兩次受邀為《洞穴百科全書》撰寫《中國洞穴魚類》章節。
基本介紹
- 中文名：馬莉
- 外文名：Li Ma
- 國籍：中國
- 民族：漢族
- 畢業院校：中國科學院昆明動物研究所
- 職業：科學家
- 主要成就：《洞穴百科全書》中國洞穴魚類章節撰寫者
- 職稱：研究員
- 學位：博士
研究方向,人物經歷,學術成果,發表論文,會議摘要,
研究方向
主要研究方向為洞穴魚類的進化發育生物學。通過對近緣物種和不同進化地位的代表類群發育調控機制的比較研究, 分析物種演化過程中重要類群特定表型產生的分子發育生物學機制。
洞穴魚類發育與進化研究組將以中國洞穴魚類和墨西哥脂鯉為研究模型，系統性研究洞穴魚類表型多樣性，建立室內洞穴魚類飼養及繁育系統，全面開發中國洞穴魚類的研究潛能，以洞穴魚類為研究模型探索遺傳學機制 （如母源性調控等）、發育機制（如視覺系統和色素系統退行性發育等）、適應性進化機制（如何適應洞穴黑暗和食物匱乏的環境等），並以洞穴魚類為研究模型開展人類相關疾病（如視覺疾病，白化病，同型半胱氨酸尿症，器官發育不對稱等）分子機理的探索。
人物經歷
1998.9-2002.5， 西北師範大學生物系獲學士學位
2002.9-2005.5, 蘭州大學生命科學學院獲碩士學位
2005.9-2008.6, 中國科學院昆明動物研究所獲博士學位
2008.7-2010.1， 中國科學院昆明動物研究所，任助理研究員
2010.2-2014.1， 美國馬里蘭大學生物系, 博士後助理研究員
2014.2-2015.5， 美國芝加哥大學海洋生物學實驗室, 研究科學家
2015.6-2016.5， 美國辛辛那提大學生物系, 博士後
2016.9-2020.7， 美國馬里蘭大學生物系, 首席教職專家
2020.8 - 至今， 中國科學院昆明動物研究所，任研究員，博士生導師
學術成果
馬莉博士主要利用洞穴魚類墨西哥脂鯉為模型研究洞穴魚視覺系統降解及色素退化的分子機制。相關成果發表於Nature Communications、Nature Ecology & Evolution、Developmental Biology、EvoDevo、Journal of Experimental Zoology Part B、PloS One、Journal of Fish Biology等刊物；兩次受邀為世界洞穴領域最權威的書籍《洞穴百科全書》撰寫《中國洞穴魚類》章節，讓世界對中國科學家在洞穴魚類研究領域的成果有更深入的了解。迄今已發表專著五章節、論文20餘篇、多次在相關領域國際會議上做報告。
發表論文
1.Li Ma,Aniket V.Gore, Daniel Castranova, Janet Shi, Mandy Ng, Kelly T. Tomins, Cornelia Maria Van, Brant M. Weinstein, William R. Jeffery. (2020) The hypomorphic cystathionine beta-synthase gene controls eye loss by disrupting optic vasculature in blind cavefish. Nature Communications,11(1):2772
2.Li Ma, Ruby Dessiatoun, Janet Shi, William R. Jeffery (2020) Incremental temperature changes for maximal breeding and spawning in Astyanax mexicanus. Journal of Visualized Experiments e61708, doi:10.3791/61708
3.Li Ma, Mandy Ng, Corine Maria Van, Masato Yoshizawa, William R. Jeffery. (2019) Dual roles of the Retinal Pigment Epithelium and Lens in cavefish eye degeneration. Journal of Experimental Zoology PartB: Molecular and Developmental Evolution DOI:10.1002/jez.b.229231.
4. Li Ma, Ya-hui Zhao, Junxing Yang. Cavefish of China, (2019) ENCYCLOPEDIA OF CAVES, Third Edition. ELSEVIER, Academic Press
5. Pengcheng Ma, Ning-Ning Song, Yongxin Li, Qiong Zhang, Lei Zhang, Longlong Zhang, Qinghua Kong, Li Ma, Xiangcai Yang, Biyu Ren, Chaocui Li, Xudong Zhao, Yan Li, Ying Xu, Xiang Gao, Yu-Qiang Ding, Bingyu Mao. (2019) Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning. Cell Reports 28 (2): 541-553
6.Li Ma, Allen G. Strickler, Amy Parkhurst, Masato Yoshizawa, and William R. Jeffery. (2018) Maternal Genetic effects in Astyanax Cavefish development.Developmental Biology,441(2):209-220
7. Aniket V.Gore, Kelly T.Tomins, James Iben, Li Ma, Deniel Castranova, Andrew Davis, Amy Parkhurst, Sara Soueidan, William R. Jeffery and Brant M. Weinstein (2018) An epigenetic mechanism for cavefish eye degeneration. Nature Ecology & Evolutiondoi:10.1038/s41559-018-0569-4
8. B.A. Stahl, C.R. Sears, L. Ma, M. Perkins, J.B. Gross (2018) “Pmela and Tyrp1b contribute to melanophore variation in Mexican cavefish.” Evolutionary Biology. Volume 21. P. Pontarotti and M.-H. Rome, editors. Springer-Verlag, Heidelberg.
9. Helena Bilandžija, Lindsey Abraham, Li Ma, Kenneth Renner, William R. Jeffery. (2018) Behavioral changes controlled by catecholaminergic systems explain recurrent loss of pigmentation in cavefish. Proceedings of the Royal Society B,285(1878):20180243
10. Tao Liu, Huaiqing Deng, Li Ma, Ning Xiao & Jiang Zhou (2018) Sinocyclocheilus zhenfengensis, a new cyprinid species (Pisces: Teleostei) from Guizhou Province, Southwest China.J Appl Ichthyol.34:945-953
11. Xiaoliang Liu, Yingjie Xia, Jixin Tanga, Li Ma, Chaocui Lia, Pengcheng Ma, Bingyu Mao (2017) Dual roles of Akirin2 during Xenopus neural development. Journal of Biological Chemistry DOI: 10.1074 / jbc.M117.7771109.
12. Joshua B. Gross, James Weagley, Bethany A. Stahl, Li Ma, Luis Espinasa, Suzanne McGaugh (2017) A local duplication of the Melanocortin receptor 1 locus in Astyanax mexicanus. Genome Jul 24. doi: 10.1139/gen-2017-0049.
13.Li Ma, (2016) The eye development of Astyanax cavefish. Cave Research 2016, 2:1
14. Kowalko, J. E., Li, Ma, & Jeffery, W. R. (2016). Genome editing in Astyanax mexicanus using transcription activator-like effector nucleases (talens).Journal of Visualized Experiments (112).
15. Li Ma and William Jeffery. (2015) Eye development (vertebrate) McGraw-Hill Encyclopedia Yearbook of Science & Technology. Mc-Graw Hill Education (invited) DOI: 10.13140/RG.2.1.1079.6004
16. Li Ma, Jeffery J. Essner, William R. Jeffery, Johanna E. Kowalko. (2015) Genome editing using TALENS in blind Mexican cavefish, Astyanax mexicanus. PLoS One 2015 Mar 16;10(3):e0119370.
doi: 10.1371/journal.pone.0119370. eCollection.
17.Li Ma. (2015) Think about caves globally. Cave Research 2015, 1:1
18. William R. Jeffery, Li Ma, Amy Parkhurst, Helena Bilandžija. (2014) Pigment cell regression and albinism in Astyanax cavefish. The Biology of Mexican Cavefish. Elsevier Press
19.Li Ma, Amy Parkhurst, William R. Jeffery. (2014) The role of a lens survival pathway including sox2 and alphaA-crystallin in the evolution of cavefish eye degeneration. EvoDevo, 5:28
20. Suzanne E. McGaugh, Joshua B. Gross, Bronwen Aken, Maryline Blin, Richard Borowsky, Domitille Chalopin, Hélène Hinaux, William Jeffery, Alex Keene, Li Ma, Pat Minx1, Daniel Murphy, Kelly E. O’Quin, Sylvie Rétaux, Nicolas Rohner, Steve M. J. Searle, Bethany Stahl, Cliff Tabin, Jean-Nicolas Volff, Masato Yoshizawa, Wes C. Warren1. (2014) The cavefish genome reveals candidate genes for eye loss. Nature Communications, 5:5307. doi:10.1038/ncomms6307.
21. Xiao-Fu Pan, Xiao-Ai Wang, Li Ma, Zai-Yun Li, Xiao-Yong Chen and Jun-Xing Yang. (2014) Artificial Fertilization and Embryonic Development of Sinocyclocheilus grahami (Regan) from Dianchi Lake, China. J Biodivers Biopros Dev, 1: 1-6
22. *Helena Bilandžija, *Li Ma, Amy Parkhurst, and William R. Jeffery. (2013) A potential benefit of albinism in Astyanax cavefish: downregulation of theoca2 gene increase tyrosine and catecholamine levels as an alternative to melanin synthesis. PLoS One. 8 (11): e80823. (* indicate the first two authors contributed equally to this work)
23. Peng-cheng Ma, Yin-jie Xia, Li Ma, Shu-hua Zhao*,Bing-yu Mao*. (2013) Xenopus Nkx6.1 and Nkx6.2 are required for mid-hindbrain boundary development. Dev Genes Evol. 223:253-259
24. Li Ma and Ya-hui Zhao. Cavefish of China, (2012) ENCYCLOPEDIA OF CAVES, Second Edition. ELSEVIER, Academic Press, C: 107-125
25.Li Ma, Qing-hua Kong, Shu-hua Zhao, Yun-hu Wei, Bing-yu Mao. (2009) Post-transcriptional control through 3’UTR of Xenopus Sox2 gene (in Chinese). Zoological Research 30 (6): 633-638
26.Li Ma, Xiao-fu Pan, Yun-hu Wei, Zai-yun Li, Chao-cui Li, Jun-xing Yang, Bing-yu Mao. (2008) Developmental stages and eye development of the cyprinoid fish Anabarilius grahami in Fuxian Lake of Southwest China. Journal of Fish Biology 73: 1946-1959
27.Li Ma, Shu-hua Zhao, Qing-hua Kong, Bing-yu Mao. (2007) Temporal and spatial expression patterns of Sox1 gene in Xenopus laevis embryo Zoological Research28(4):403-405
會議摘要
1. Li Ma and William R. Jeffery, Global Analysis of Maternal Transcripts in Astyanax Cavefish Eggs. Sixth Astyanax International Meeting, Cine Teatro Rosalio Solano, Queretaro, March 17-20, 2019
2. William R. Jeffery and Li Ma, Evolution of Left-Right Axis Astymmetry in Astyanax Cavefish. Sixth Astyanax International Meeting, Cine Teatro Rosalio Solano, Queretaro, March 17-20, 2019
3. Li Ma, Daniel Castranova, Brant M. Weinstein, Aniket Gore, and William R. Jeffery, Molecular Mechanism of Eye Loss in the Cavefish Astyanax. The Society for Integrative & Comparative Biology Annual Meeting, San Francisco, CA, USA, January 3-7, 2018
4.Li Ma and William R. Jeffery, Paralogous Cystathionine ß Synthase Genes in Astyanax mexicanus : Functional Diversification and Evolution of Cavefish Eye Degeneration. Fifth Astyanax International Meeting, Cine Teatro Rosalio Solano, Queretaro, Mexico March 12-15, 2017
5. William Jeffery, Li Ma, Kelly Tomins, Brant M Weinstein and Aniket Gore, Analysis of the Eye QTL Gene cbsa Reveals the Role of Cranial Vasculature in Regression of the Cavefish Visual System. Fifth Astyanax International Meeting, Cine Teatro Rosalio Solano, Queretaro, Mexico March 12-15, 2017
6.Li Ma, Stahl Bethany, Adams Hannah, and Joshua B. Gross, Molecular analysis of melanophore lineage genes in cavefish depigmentation. 23rd International Conference on Subterranean Biology, Fayetteville, Arkansas, USA, June13-17, 2016
7.Li Ma and William R. Jeffery, Molecular analysis of an A.mexicanus Eye QTL reveals a potential role of Cystathionine beta-synthase A in cavefish eye degeneration, Fourth Astyanax International Meeting, Cine Teatro Rosalio Solano, Queretaro, Mexico October 26-28, 2015
8.Li Ma, Brian Carlson, Bethany Stahl, Hannah Adams, Amanda K.Powers and Joshua B. Gross, Candidate genes analysis for pigment development in Astyanax cavefish, Fourth Astyanax International Meeting, Cine Teatro Rosalio Solano, Queretaro, Mexico October 26-28, 2015
9. Bethany Stahl, Li Ma, Joshua B. Gross, High-resolution genomic mapping reveals genes contributing to complex melanophore variation in Astyanax mexicanus cavefish, the Fourth Astyanax International Meeting, Cine Teatro Rosalio Solano, Queretaro, Mexico October 26-28, 2015
10. Johanna Kowalko, Li Ma, William Jeffery, Jeff Essner, Utilizing genome editing to explore the genetic basis of evolution in the cavefish Astyanax mexicanus, the Society for Developmental Biology 73rd Annual Meeting, University of Washington, Seattle, WA, USA July 17, 2014
11.Li Ma and William R. Jeffery, Role of aA-crystallin in Astyanax cavefish eye degeneration, Third Astyanax International Meeting, Ciudad Valles, Mexico, March 19, 2013
12.Li Ma and William R. Jeffery, The function ofaA-crystallin in lens degeneration in Astyanax mexicanus cavefish, the Second Astyanax International Meeting Ciudad Valles, Mexico March 15, 2011
