顏丙春

顏丙春，男，漢族，1983年2月生，吉林雙遼人，醫學博士，教授，碩士生導師。本科畢業於延邊大學中醫學專業，博士畢於韓國翰林大學解剖神經生物學專業，於韓國國立江原大學血管研究中心從事博士後研究2年。

主要研究方向缺血性卒中的防治，中藥功效物質基礎及神經藥理等。

基本介紹

• 中文名：顏丙春
• 國籍：中國
• 出生日期：1983年2月

人物經歷

本科畢業於延邊大學中醫學專業，博士畢於韓國翰林大學解剖神經生物學專業，於韓國國立江原大學血管研究中心從事博士後研究2年。

主持項目

1.國家自然科學基金面上項目：基於ACE2-CAV1互作雙核心分子網路正反饋血管內皮細胞穩態探討益氣活血祛瘀法治療氣虛血瘀型缺血性卒中的作用機制，82274392。

2.國家留學基金委創新型人才國際合作培養項目：中醫藥+健康老齡化綜合型醫學人才培養項目，CXXM2110100036。

3.國家自然科學基金青年項目：IGF-R/PI-3K/Akt信號通路對幼及成年缺血性腦卒中模型所致神經損傷的作用機制比較，81401005。

4.中國博士後科學基金特別資助項目：ERK1/2通路對BBB-TJ的調節在幼年缺血性卒中的作用, 2014M561720。

5.江蘇省自然科學基金：RhoA/ROCK信號通路對BBB-TJ連線蛋白的調節在幼年缺血性腦卒中的作用，BK20140494

6.江蘇省高校自然科學研究面上項目：PI-3K-Akt信號通路對幼年缺血性腦卒中的作用，14KJB310027

7.江蘇省高校自然科學研究重大項目：MiR144/451對卒中後神經幹細胞分化的作用，16KJA310006。

8.江蘇省博士後科學基金（神經營養因子激活PI-3K/Akt信號通路對幼年缺血性腦卒中的作用機制），1401155C。

近年代表性著作

1．Wang J, Xia Z, Sheng P, Shen M, Ding L,Liu D*,Bing Chun Yan﹡.Enhanced autophagy interacting proteins negatively correlated with the activation of apoptosis-related caspase family proteins after focal ischemic stroke of young rats. BMC Neurosci. 2022 Sep 28;23(1):55.

2．Zhao L, Ding LD,Xia ZH, Sheng P, Shen MM, Cai ZM,Bing Chun Yan﹡. A Network-Based Approach to Investigate the Neuroprotective Effects and Mechanisms of Action of Huangqi-Chuanxiong and Sanleng-Ezhu Herb Pairs in the Treatment of Cerebral Ischemic Stroke. Front Pharmacol. 2022 Mar 23;13:844186.

3．Wang J, Xia Z, Sheng P, Rui Y, Cao J, Zhang J, Gao M, Wang L,Yu D﹡,Bing Chun Yan*. Targeting MicroRNA-144/451-AKT-GSK3βAxis Affects the Proliferation and Differentiation of Radial Glial Cells in the Mouse Hippocampal Dentate Gyrus. ACS Chem Neurosci. 2022 Apr 6;13(7):897-909.

4．Wang F, Xia Z,Sheng P, Ren Y, Liu J, Ding L,Bing Chun Yan﹡. Targeting the Erk1/2 and autophagy signaling easily improved the neurobalst differentiation and cognitive function after young transient forebrain ischemia compared to old gerbils. Cell Death Discov. 2022 Feb 26;8(1):87.

5．Jiajia Liu,FuxingWang,PengSheng,ZihaoXia,YunyaoJiang,Bing Chun Yan﹡.A network-based method for mechanistic investigation and neuroprotective effect on treatment of tanshinoneⅠagainst ischemic stroke in mouse.J Ethnopharmacol. 2021 May 23;272:113923.

6．Bing Chun Yan,Jianwen Cao, Jiajia Liu, Yunhao Gu, Zhuobin Xu, Dandan Li, Lizeng Gao Dietary FeONanozymes Prevent the Injury of Neurons and Blood-Brain Barrier Integrity from Cerebral Ischemic Stroke.ACS Biomater Sci Eng. 2021 Jan 11;7(1):299-310

7．Jie Zhang, Yanggang Rui, Manman Gao , Li Wang ,Bing Chun Yan﹡.Expression of Long Non-coding RNA RGD1566344 in the Brain Cortex of Male Mice After Focal Cerebral Ischemia-Reperfusion and the Neuroprotective Effect of a Non-coding RNA RGD1566344 Inhibitor. Cell Mol Neurobiol.2020 May 18.doi:10.1007/s10571-020-00877-4.

8．Jianwen Cao, Cheng Tang,Manman Gao, Yanggang Rui, Jie Zhang, Li Wang, Yang Wang, Bo Xu,Bing Chun Yan﹡.Hyperoside alleviates epilepsy-induced neuronal damage by enhancing antioxidant levels and reducing autophagy.J Ethnopharmacol. 2020 Apr 18;257:112884.

9．Zhang Hong Xiao, Li Wang,Ping Gan, Jing He,Bing Chun Yan﹡, Li Dong Ding﹡.Dynamic Changes in miR-126 Expression in the Hippocampus and Penumbra Following Experimental Transient Global and Focal Cerebral Ischemia-Reperfusion. Neurochem Res. 2020 May;45(5):1107-1119.

10．Jie Zhang, Yunyao Jiang,Nan Liu, Ting Shen, Hyo Won Jung,Jianxun Liu,Bing Chun Yan﹡.A Network-Based Method for Mechanistic Investigation and Neuroprotective Effect on Post-treatment of Senkyunolid-H Against Cerebral Ischemic Stroke in Mouse. Front Neurol. 2019 Dec 19;10:1299.

11．Bing Chun Yan﹡, Jie Wang,Yanggang Rui, Jianwen Cao, Pei Xu, Dan Jiang, Xiaolu Zhu, Moo-Ho Won, Ping Bo, Peiqing Su. Neuroprotective Effects of Gabapentin Against Cerebral Ischemia Reperfusion-Induced Neuronal Autophagic Injury via Regulation of the PI3K/Akt/mTOR Signaling Pathways. J Neuropathol Exp Neurol. 2019 Feb 1;78(2):157-171.

12．Bing Chun Yan﹡,Pei Xu,Manman Gao, Jie Wang, Dan Jiang, Xiaolu Zhu, Moo-Ho Won, Pei Qing Su. Changes in the Blood-Brain Barrier Function Are Associated With Hippocampal Neuron Death in a Kainic Acid Mouse Model of Epilepsy. Front Neurol. 2018 Sep 12;9:775.

13．Bing Chun Yan﹡, Dan Jiang,Jie Wang, Yuanyuan Zhang, Xiaolu Zhu, Pei Xu, Xing Yu, Moo-Ho Won, Pei Qing Su. Both Decreased Akt Expression and mTOR Phosphorylation Are Related to Decreased Neuronal Differentiation in the Hippocampal Alveus of Aged Mice. Aging Clin Exp Res. 2018 Jul;30(7):737-743.

14．Zi-Gang Zhang,Xin Wang, Jin-Hai Zai, Cai-Hua Sun,Bing Chun Yan﹡.Icariin Improves Cognitive Impairment After Traumatic Brain Injury by Enhancing Hippocampal Acetylation. Chin J Integr Med. 2018 May;24(5):366-371.

15．Bing Chun Yan﹡, Jie Wang,Jianwen Cao, Moo-Ho Won. Less Hippocampal Neuronal Death in Young Gerbils Following Transient Global Cerebral Ischemia Is Associated With Long-term Maintenance of Insulin-like Growth Factor 1 and Its Receptors in the Hippocampal CA1 Region. Mol Med Rep. 2018 Feb;17(2):3055-3061.

16．Bing Chun Yan﹡, Hui Shen,Yuanyuan Zhang, Xiaolu Zhu, Jie Wang, Pei Xu, Dan Jiang, Xing Yu. The Antiepileptic Drug Levetiracetam Promotes Neuroblast Differentiation and Expression of Superoxide Dismutase in the Mouse Hippocampal Dentate Gyrus via PI3K/Akt Signalling. Neurosci Lett. 2018 Jan 1;662:84-90.

17．Hui Shen, Jie Wang,Dan Jiang, Pei Xu, Xiaolu Zhu, Yuanyuan Zhang, Xing Yu, Moo-Ho Won,Pei Qing Su,Bing Chun Yan﹡.Topiramate Improves Neuroblast Differentiation of Hippocampal Dentate Gyrus in the D-Galactose-Induced Aging Mice via Its Antioxidant Effects.Cell Mol Neurobiol. 2017 Jul;37(5):869-877.

社會任職

1.中國高等教育學會醫學教育專委會理事

2.中國中西醫結合學會教育工作委員會青年委員

3.江蘇省卒中學會基礎與轉化專委會委員

4.揚州市卒中專委會委員。