頡孝賢:教學課程,育人成果,科研項目,科研成果,社會服務,

頡孝賢，男，工學博士，前期是浙江工業大學生物工程學院副教授，碩士生導師，後入職上海交通大學醫學院附屬重點實驗室；研究方向為抑鬱症等疾病中的線粒體能量代謝機制、生物鐘與抑鬱症等疾病的患病機制，靶向藥物的研究開發。

基本介紹

中文名：頡孝賢
國籍：中國
學位/學歷：博士
職稱：浙江工業大學生物工程學院副教授

教學課程,育人成果,科研項目,科研成果,社會服務,

教學課程

核心課程《生理與分子免疫學》建設獲得立項，同年被評為研究生雙語示範性課程，並連續多年獲得優課優酬教學獎勵。並發表教改論文1篇。

育人成果

在學生的競賽指導上，指導本科學生獲得全國生命科學創新創業大賽一、二、三等獎各1項，浙江省第十一屆挑戰杯銅獎1項，浙江省“網際網路+”大學生創新創業大賽銅獎1項。同時帶領研究生進行多元化的科研探索，近幾年培養的3名研究生獲得省級優秀研究生稱號，轉博研究生2名，校極優秀研究生3名，並有1名學生獲得國家獎學金。指導的本科生直接保送至華東理工大學讀研，讀研學生共5名，並指導本科生髮表SCI論文4篇。

指導學生競賽列表

2018至2020年全國大學生生命科學創新創業大賽一等、二等及三等獎/指導教師（唯一指導教師）

2018年浙江省第十一屆挑戰杯銅獎（並列）

2018第四屆浙江省“網際網路+”大學生創新創業大賽銅獎（並列）

科研項目

1.人才引進科研啟動基金（G3817101205），2015.01-2015.12，主持；

2. Per3基因對小鼠細胞ATP含量及晝夜節律變化的調節機制（LY20C110002），浙江省自然科學基金面上項目，2020.1-2022.12，在研，主持；

3．生物鐘基因Per3調控小鼠衰老的機制研究（31701028），國家自然科學基金項目， 2018.1-2020.12，已結題，主持；

4．國家重點研發計畫子課題（2017YFD0200503），2017.7-2020.12，在研，骨幹參與；

5. 特定蛋白表達的動物細胞系的構建（KYY-HX-20220114），2022.1-2025.1，企業橫向項目，在研，主持;

6．國家自然科學基金面上基金項目（21777146），2018.1-2021.12，在研，參與；

7．國家自然科學基金青年基金項目（51603186），2017.1-2019.12，結題，參與。

科研成果

一作或通訊代表作部分SCI論文（近5年，23篇）COVER Story亮點文章2篇

(1) Xiaoxian Xie, Jiafeng Zhou, Luting Hu, Ruonan Shu, Mengya Zhang, Lei Sun, Fengchun Wu, Zezhi Li*, Zhengwei Fu*. Oral exposure to a hexafluoropropylene oxide trimer acid (HFPO-TA) disrupts mitochondrial function and biogenesis in mice, J Hazard Mater ,430:128376, 2022. IF: 14.224, 中科院1區.

(2) Xiaoxian Xie, Rongnan Shu, Chunan Yu, Jiafeng Zhou, Qingfeng Xiao, Qichen Shen, Ze Xiong, Zezhi Li*, Zhengwei Fu*. Mammalian AKT, the emerging roles on mitochondrial function in diseases, Aging Dis (Review), 13(1):157-174, 2022. IF: 10, Q1

(3) Xiaoxian Xie, Jiafeng Zhou, Luting Hu, Ruonan Shu, Mengya Zhang, Ze Xiong, Zezhi Li, Fengchun Wu, Zhengwei Fu*. Exposure to hexafluoropropylene oxide dimer acid (HFPO-DA) disturbs the gut barrier function and gut microbiota in mice, Environ Pollut, 290, 117934, 2021. IF: 10，中科院1區

(4) Jiafeng Zhou, Ruonan Shu, Chunan Yu, Ze Xiong, Qingfeng Xiao, Zezhi Li*, Xiaoxian Xie*( corresponding), Zhengwei Fu*. Exposure to low concentration of trifluoromethanesulfonic acid induces the disorders of liver lipid metabolism and gut microbiota in mice, Chemosphere, 258, 127255, 2020. IF: 8.943, Q1

(5) Xiaoxian Xie et al,. Crocin-I ameliorates the disruption of lipid metabolism and dysbiosis of the gut microbiota induced by chronic corticosterone in mice, Food funct, 10, 6779-6791, 2019. IF: 6.317 中科院1區

(6) Xiaoxian Xie, Yangyang Chen, Qi Wang, Qichen Shen, Lingyan Ma, Liangfeng Huang, Tao Wu, Zhengwei Fu*. Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress, Life Sci, 188: 96-100, 2017. IF: 6.78, Q1

(7) Xiaoxian Xie*, Liangliang Wang, Binggong Zhao, Yangyang Chen, Jiaqi Li: SIRT3 mediates decrease of oxidative damage and prevention of ageing in porcine fetal fibroblasts, Life Sci 177:41-48, 2017. IF: 6.78, Q1

(8) Qingfeng Xiao, Ruonan Shu, Yingpeng Tong, Chenlu Wu, Chunan Yu, Ze Xiong1, Jiafeng Zhou, Zezhi Li*, Xiaoxian Xie*( corresponding), Zhengwei Fu*. Crocin-I alleviates the depression-like behaviors via modulating “microbiota-gut-brain” axis in mice exposed to chronic restraint stress, J Affect Disord, 276, 476-486, 2020. IF: 6.533, Q1

(9) Xiaoxian Xie, Chunan Yu, Jiafeng Zhou, Qingfeng Xiao, Qichen Shen, Zezhi Li*, Zhengwei Fu*. Nicotinamide mononucleotide ameliorates the depression-like behaviors and is associated with attenuating the disruption of mitochondrial bioenergetics in depressed mice, J Affect Disord, 263: 166-174, 2020. IF: 6.533, Q1

(10) Xiaoxian Xie, Qichen Shen, Lingyan Ma, Yangyang Chen, Binggong Zhao, Zhengwei Fu*. Chronic corticosterone-induced depression mediates premature aging in rats, J Affect Disord, 229:254-261, 2018. IF: 6.533, Q1

(11) Xiaoxian Xie, Qichen Shen, Chunan Yu, Qingfeng Xiao, Jiafeng Zhou, Xiong Ze, Zezhi Li*, Zhengwei Fu*. Depression-like behaviors are accompanied by disrupted mitochondrial energy metabolism in chronic corticosterone-induced mice, J Steroid Biochem Mol Biol, 200: 105607, 2020. Q1

(12)Xiaoxian Xie, Yangyang Chen, Lingyan Ma, Qichen Shen, Liangfeng Huang, Binggong Zhao, Tao Wu, Zhengwei Fu*: Major depressive disorder mediates accelerated aging in rats subjected to chronic mild stress, Behav Brain Res 329:96-103, 2017.

(13)Qingfeng Xiao, Ze Xiong, Chunan Yu, Jiafeng Zhou, Qichen Shen, Liangliang Wang, Xiaoxian Xie*( corresponding), Zhengwei Fu*. Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in mice, Physiol Behav, 212: 112699, 2019.

(14) Xiaoxian Xie, Qichen Shen, Lisha Cao, Yangyang Chen, Lingyan Ma, Qingfeng Xiao, Chunan Yu, Zhengwei Fu*. Depression caused by long-term stress regulates premature aging and is possibly associated with disruption of circadian rhythms in mice, Physiol Behav, 199(1): 100-110, 2019.

(15)Lingyan Ma, Qichen Shen, Song Yang, Xiaoxian Xie*( corresponding), Qingfeng Xiao, Chuanan Yu, Lisha Cao, Zhengwei Fu*. Effect of chronic corticosterone-induced depression on circadian rhythms and age-related phenotypes in mice, Acta Biochimica et Biophysica Sinica, 50(12):1236-1246, 2018.

(16) Ze Xiong, Yuyao Zeng, Jiafeng Zhou, Ruonan Shu, Xiaoxian Xie*(corresponding), Zhengwei Fu*. Exposure to dibutyl phthalateimpairs lipid metabolism and causes inflammation via disturbing microbiota-related gut-liver axis, Acta Biochimica et Biophysica Sinica, 0:1-12, 2020.

(17) Xiaoxian Xie, Binggong Zhao, Liangfeng Huang, Qichen Shen, Lingyan Ma, Yangyang Chen, Tao Wu, Zhengwei Fu*. Effects of altered photoperiod on circadian clock and lipid metabolism in rats, Chronobiol Int, 10: 1-11, 2017.

(18) Qichen Shen, Junli Wu, Yuehan Ni,Xiaoxian Xie*( corresponding), Chunan Yu, Qingfeng Xiao, Jiafeng Zhou, Xia Wang, Zhengwei Fu*. Exposure to jet lag aggravates depression-like behaviours and age-related phenotypes in rats subjected to chronic corticosterone, Acta Biochimica et Biophysica Sinica, 51(8):834-844, 2019 (COVER Story).

(19) Qingfeng Xiao, Ze Xiong, Xiaoxian Xie* (corresponding), Chunan Yu, Qichen Shen, Jiafeng Zhou, Zhengwei Fu*. Increased oxidative damage contributes to mitochondrial dysfunction in muscle of chronic mild stress-induced depressed rats probably via SIRT3 pathway, Biol Bull, 46(6):615-625, 2019.

(20) Xiaoxian Xie, Anqi Guo, Tao Wu, Qinglian Hu, Liangfeng Huang, Cencen Yao, Binggong Zhao, Wanjing Zhang, Bingbing Chi, Ping Lu, Zhenzhen Zhao, Zhengwei Fu*: Preventive effect of L-Carnitine on the disorder of lipid metabolism and circadian clock of mice subjected to chronic jet-lag, Physiol Res, 66: 801-810, 2017.

社會服務

受邀請參加國際會議8次，並在國際會議上做全英文學術報告

擔任Aging Cell、Food Funct等10餘種雜誌的邀約審稿人

浙江省基金委項目評審專家

頡孝賢