基本介紹
- 中文名:韓永龍
- 國籍:中國
- 畢業院校:上海中醫藥大學
- 學位/學歷:博士
- 職業:教師
- 專業方向:藥理學
- 職務:常務副主任
- 任職院校:上海海洋大學食品學院
- 職稱:主任藥師
個人經歷,教育經歷,工作經歷,研究方向,學術成果,專利著作,論文發表,榮譽獎項,
個人經歷
現任中國醫藥教育協會臨床用藥評價專業委員會常務理事、上海市醫院協會臨床藥事管理專業委員會青年委員和上海市浦東新區醫學會藥學專委會副主任委員等7個學術任職;《中國醫院藥學雜誌》和《中國臨床藥理學與治療學》審稿專家、《醫藥導報》編委。
教育經歷
2007/09 – 2010/07,上海中醫藥大學,穆拉德中藥現代化研究中心,中藥學專業,醫學博士;
2002/09 – 2007/06,黑龍江中醫藥大學,中醫藥研究院,藥劑學專業,醫學碩士;
1993/09 – 1997/06,中國藥科大學,藥學院,化學製藥專業,工學士。
工作經歷
2015/01–至今,上海市第六人民醫院東院,藥劑科,主任藥師;
2012/10–2014/12,上海市第六人民醫院東院,藥劑科,副主任藥師;
2012/04–2012/10,上海市第六人民醫院/上海交通大學附屬第六人民醫院,藥劑科,副主任藥師;
2008/12–2012/04,大慶油田總醫院,藥劑科,副主任藥師;
2002/06–2008/12,大慶油田總醫院,藥劑科,主管藥師;
1997/07–2002/06,大慶油田總醫院,藥劑科,藥師。
研究方向
藥理學
長期從事醫院藥學的臨床實踐、教學和科研工作,特別是在藥物代謝與藥物動力學、臨床藥學和醫院製劑等方面有較深的造詣。
學術成果
已發表和合作發表SCI和國內期刊收錄的學術論文80多篇,其中SCI收錄的學術論文24篇;副主編專著2部,參編2部,其中1部為全國中醫藥行業高等教育“十三五”創新教材。主持或參與了國家級、省部級和廳局級等科研課題10多項,目前在研國家自然科學基金面上項目等3項課題。
專利著作
[2] 《中國動物藥用研究與臨床套用》:副主編,黑龍江人民出版社,2006年7月出版。
[3] 《常見疾病的臨床診斷與治療》:副主編,黑龍江科學技術出版社,2011年2月出版。
[4] 全國中醫藥行業高等教育“十三五”創新教材《中醫藥學概論》(第二版):編者,中國中醫藥出版社,2019年1月出版。
論文發表
[1] Shi MZ#, Xing TY#, Chen JJ, Jiang B, Xiao X, Yang J, Zhu J, Guo C, Hu JD﹡, Han YL﹡. Effect of Xiao-Ai-Ping injection on paclitaxel pharmacokinetics in rats by LC–MS/MS method. J Pharm Biomed Anal.
[2] Zhang JX, Qi MJ, Shi MZ, Chen JJ, Zhang XQ, Yang J, Zhang KZ, Han YL﹡, Guo C﹡. Effects of Danhong injection, a traditional Chinese medicine, on nine cytochrome P450 isoforms in vitro. Biomed Chromatogr.
[3] Yang QJ, Zhao JR, Hao J, Li B, Huo Y, Han YL, Wan LL, Li J, Huang J, Lu J, Yang GJ, Guo C. Serum and urine metabolomics study reveals a distinct diagnostic model for cancer cachexia. J Cachexia Sarcopenia Muscle.
[4] Chen JJ, Zhang JX, Zhang XQ, Qi MJ, Shi MZ, Yang J, Zhang KZ, Guo C, Han YL. Effects of diosmetin on nine cytochrome P450 isoforms, UGTs and three drug transporters in vitro. Toxicol Appl Pharmacol
[5] Sun XP, Wan LL, Yang QJ, Huo Y, Han YL, Guo C. Scutellarin protects against doxorubicin-induced acute cardiotoxicity and regulates its accumulation in the heart. Arch Pharm Res
[6] Quan-Jun Y, Jian-Ping Z, Jian-Hua Z, Yong-Long H, Bo X, Jing-Xian Z, Bona D, Yuan Z, Cheng G. Distinct Metabolic Profile of Inhaled Budesonide and Salbutamol in Asthmatic Children during Acute Exacerbation. Basic Clin Pharmacol Toxicol.
[7] Quan-Jun Y, Yan H, Yong-Long H, Li-Li W, Jie L, Jin-Lu H, Jin L, Peng-Guo C, Run G, Cheng G. Selumetinib attenuate skeletal muscle wasting in murine cachexia model through ERK inhibition and AKT activation. Mol Cancer Ther
[8] QuanJun Y, GenJin Y, LiLi W, YongLong H, Yan H, Jie L, JinLu H, Jin L, Run G, Cheng G. Protective Effects of Dexrazoxane against Doxorubicin-Induced Cardiotoxicity: A Metabolomic Study. PLoS One
[9] Yong-Long Han, Jun-Ming Chen, Jiao Yang, Cheng Guo. Drug-drug interaction potential of 1,5-dicaffeylquinic acid, a new herbal drug for the treatment of hepatitis B and human immunodeficiency virus infection, based on the inhibition of cytochrome P450s in human and rat liver microsomes. Int J Clin Exp Med
[10] Zhou ZY, Wan LL, Yang QJ, Han YL, Li D, Lu J, Guo C. Nilotinib reverses ABCB1/P-glycoprotein-mediated multidrug resistance but increases cardiotoxicity of doxorubicin in a MDR xenograft model. Toxicol Lett
[11] Lu J, Wan L, Zhong Y, Yu Q, Han Y, Chen P, Wang B, Li W, Miao Y, Guo C. Stereoselective metabolism of donepezil and steady-state plasma concentrations of S-donepezil based on CYP2D6 polymorphisms in the therapeutic responses of Han Chinese patients with Alzheimer's disease. J Pharmacol Sci
[12] Zhang XH, Yu HL, Wang FJ, Han YL, Yang WL. Pim-2 Modulates Aerobic Glycolysis and Energy Production during the Development of Colorectal Tumors. Int J Med Sci.
[13] Yang Quan-Jun, Bian Jun, Wan Li-Li, Han Yong-Long, Li Bin, Yu Qi, Li Yan, Guo Cheng, Yang Gen-Jin. NMR-based metabolomics reveals distinct pathways mediated by curcumin in cachexia mice bearing CT26 tumor. RSC Adv.
[14] Chen J, Han Y, Xu C, Xiao T, Wang B. Effect of type 2 diabetes mellitus on the risk for hepatocellular carcinoma in chronic liver diseases: a meta-analysis of cohort studies. Eur J Cancer Prev.
[15] Liu LY, Han YL, Zhu JH, Yu Q, Yang QJ, Lu J, Guo C. A sensitive and high-throughput LC-MS/MS method for inhibition assay of seven major cytochrome P450s in human liver microsomes using an in vitro cocktail of probe substrates. Biomed Chromatogr.
[16] Li B, Wan L, Li Y, Yu Q, Chen P, Gan R, Yang Q, Han Y, Guo C. Baicalin, a component of Scutellaria baicalensis, alleviates anorexia and inhibits skeletal muscle atrophy in experimental cancer cachexia. Tumour Biol.
[17] Han YL, Li D, Yang QJ, Zhou ZY, Liu LY, Li B, Lu J, Guo C. In Vitro Inhibitory Effects of Scutellarin on Six Human/Rat Cytochrome P450 Enzymes and P-glycoprotein. Molecules
[18] Quanjun Y, Genjin Y, Lili W, Bin L, Jin L, Qi Y, Yan L, Yonglong H, Cheng G, Junping Z. Serum metabolic profiles reveal the effect of formoterol on cachexia in tumor-bearing mice. Mol Biosyst
[19] Zhou ZY, Wan LL, Yang QJ, Han YL, Li Y, Yu Q, Guo C, Li X. Evaluation of the pharmacokinetics and cardiotoxicity of doxorubicin in rat receiving nilotinib. Toxicol Appl Pharmacol.
[20] Zhou Z, Wan L, Han Y, Meng X, Yang Q, Li Y, Yu Q, Shen Z, Guo C. ABCB1-overexpressing MG63/DOX cell xenograft model: Maintain the MDR phenotype in vivo. Pharm Biol
[21] Han YL, Li D, Ren B, Jing GP, Meng XL, Zhou ZY, Yu Q, Li Y, Wan LL, Guo C. Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs. J Ethnopharmacol
[22] Han YL, Yu HL, Meng XL, Li D, Zhou ZY, Yu Q, Wang FJ, Zhang XY, Guo C. In Vitro Inhibition of Huanglian [Rhizoma coptidis (L.)] and its Six Active Alkaloids on Six Cytochrome P450 Isoforms in Human Liver Microsomes. Phytother Res
[23] Han YL, Yu HL, Meng XL, Li D, Zhou ZY, Yu Q, Wang FJ, Zhang XY, Guo C. Inhibitory effects of limonin on six human cytochrome P450 enzymes and P-glycoprotein in vitro. Toxicol In Vitro
[24] Li D, Han Y, Meng X, Sun X, Yu Q, Li Y, Wan L, Huo Y, Guo C. Effect of regular organic solvents on cytochrome P450-mediated metabolic activities in rat liver microsomes. Drug Metab Dispos
榮譽獎項
曾獲2014年度上海中西醫結合科學技術獎一等獎和2012年度上海醫學科技獎三等獎等7項獎勵。
[1] 郭澄、韓永龍、余奇、萬麗麗、李顏、霍炎、劉麗雅、李丹,基於細胞色素P450 酶系的常用中藥代謝性相互作用研究,上海市中西醫結合學會,上海中西醫結合科學技術獎,一等獎,2014
[2] 郭澄、韓永龍、余奇、萬麗麗、李顏,基於細胞色素P450 酶系的常用中藥代謝性相互作用研究,上海市衛生局,上海醫學科技獎,三等獎,2012
[3] 韓永龍、張學輝、楊姣、馬紀江、任彬、李麗輝、楊秀峰,清開靈注射液調控CYP450酶引發代謝性藥物相互作用的安全性評價研究,黑龍江省衛生廳,黑龍江省醫藥衛生科技進步獎,二等獎,2011