韓守法，男，博士，畢業於Toledo大學，廈門大學化學生物學系教授。
基本介紹
- 中文名：韓守法
- 畢業院校：Toledo大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：化學生物學
- 任職院校：廈門大學化學生物學系
個人經歷,研究方向,學術成果,
個人經歷
北京大學化學系,獲學士學位(1996)
中國科學院北京化學研究所,獲得高分子化學與物理專業碩士學位（1999）
Toledo大學,獲得生物化學專業博士（2003）
The Scripps Research Institute博士後（2003-2006）
廈門大學化學生物學系教授，博導（2006-今）
研究方向
1.化學生物學，研究包括糖蛋白所含的唾液酸的功能,如IgG；
2.化學或酶催化法引入非天然唾液酸到蛋白上改善其生物活性；
3.酶催化法合成含有唾液酸的小分子或納米材料探針把小分子藥物或蛋白質運載到特定的細胞內。
學術成果
1. A self-referenced nanodosimeter for reaction based ratiometric detection of hypochlorous acid in living cells，Chemical Science, 2013, 460-467; Xuanjun Wu, Zhu Li, Yuhui Yang, Liu Yang, Jiahuai Han andShoufa Han*
2. Rhodamine-deoxylactam functionalized poly[styrene-alter-(maleic acid)] as lysosome activatable probes for intraoperative detection of tumors，Chemical Science, 2012, 2941-2948; Zhu Li, Yunlong Song, Yuhui Yang, Liu Yang, Jiahuai Han andShoufa Han*
3. Cytosolic delivey of proteins mediated by aldehyde-displaying silica nanoparticles with pH responsive characteristics,Journal of Materials Chemistry, 2012, 17121-17127; Xuanjun Wu, Shuqi Wu, Jiahuai Han andShoufa Han*
4. Fluorogenic detection of hydrogen sulfide via reductive unmasking of o-azidomethylbenzoyl-coumarin conjugate,Chemical Communication, 2012, 48, 10120-10122; Zhisheng Wu, Zhu Li, Liu Yang, Jiahuai Han andShoufa Han*
5. Covalent labeling of Mitochondria with a photostable fluorescent thiol-reactive rhodamine-based probe,Analytical Methods, 2012, 4, 1699-1703; Shuqi Wu, Yunlong Song, Zhu Li, Zhisheng Wu, Jiahuai Han andShoufa Han*
6. A rhodamine-deoxylactam based sensor for chromo-fluorogenic detection of nerve agent stimulant,Bioorganic and Medicinal Chemistry Letter, 2012, 6358-6361; Zhisheng Wu, Xuanjun Wu, Tingbin Wen andShoufa Han*
7. A highly sensitive fluorogenic chemodosimeter for rapid visual detection of phosgene,Chemical Communication, 2012, 48, 1895; Xuanjun Wu, Zhisheng Wu, Yuhui Yang andShoufa Han*
8. A selective fluorogenic sensor for visual detection of nitrite,Analytical Methods, 2012, 4, 2021-2026; Zhongwei Xue, Zhisheng Wu andShoufa Han*
9. Dual colored mesoporous silica nanoparticles with pH activatable rhodamine-lactam for sensing of lysosomal acidity,Chemical Communication, 2011, 47, 11276, Shuqi Wu, Zhu Li, Jiahuai han, andShoufa Han*
10. Imaging of intracellular acidic compartments with a sensitive rhodamine based fluorogenic pH sensor,Analyst, 2011, 136, 3698, Zhu Li, Shuqi Wu, J. Han andShoufa Han*
11. Chromogenic and fluorogenic detection of a nerve agent simulant with a rhodamine-deoxylactam based sensor,Chemical Communication, 2011, 47, 11468, Xuanjun Wu, Zhisheng Wu, andShoufa Han*
12. Chromo-fluorogenic detection of aldehydes with a rhodamine based sensor,Organic and Biomolecualr Chemistry, 2011, 9, 7652-7654, Zhu Li, Z. Xue, Jiahuai Han, andShoufa Han*
13. Visual and fluorogenic detection of nerve agent stimulant via Lossen rearrangement of Rhodamine-hydroxamate；Chemical Communication, 2010，46, 8413；Zhongwei Xue, Zhen Wang and Ting Bin Wen,Shoufa Han*
14. Multivalent mannose-displaying nanoparticles constructed from polystyrene-co-poly- (styrene-alt-maleic anhydride);Organic and Biomolecular Chemistry. 2009, 7, 2040, Su R, Li L, Chen X, Han J,Shoufa Han*
15. Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates,Bioorganic and Medicinal Chemistry Letter, 2009, 19, 1903；Fang W, Cai Y, Chen X, Su R, Chen T, Xia N, Li L, Yang Q, Jiahuai Han *,Shoufa Han*
16. Synthesis of 9-substituted sialic acids as probes for CD22-ligand interactions on B cells；Frontiers in Modern Carbohydrate Chemistry, 2006, 2-16;Shoufa Han, Brian E. Collins and James C. Paulson,
17. High-affinity ligand probes of CD22 overcome the threshold set by cis ligands to allow for binding, endocytosis, and killing of B cells；Journal of Immunology, 2006, 177: 2994-3003; Brian E. Collins, Ola Blixt, Shoufa Han, Bao Duong, Nicolai Bovin, and James C. Paulson,
18. Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking；Nature Chemical Biology, 2005, 1, 93-97；Shoufa Han, Brian E. Collins, Per Bengtson, and James C. Paulson*
19. A facile synthesis of a difluoromethylene analog of aspartyl phosphate for inhibition of L-aspartate dehydrogenase；Synlett, 2003, Vol6, 845-846；Shoufa Han, Roger A. Moore, and Ronald E. Viola*
20. Synthesis and evaluation of alternative substrates for arginase；Bioorganic Chemistry, 2002, vol30, 81-94；Shoufa Han, Roger A. Moore, and Ronald E. Viola*
21. A Spectrophotometric assay of arginase；Analytical Biochemistry, 2001, 295(1), 117-119,Shoufa Hanand Ronald E. Viola*
