雷蓓蕾，女，1984年生，博士，西北農林科技大學副教授，碩士研究生導師。
基本介紹
- 中文名：雷蓓蕾
- 出生日期：1984年
- 畢業院校：蘭州大學
- 學位/學歷：博士
- 職業：教師
- 專業方向：植物
- 任職院校：西北農林科技大學
人物經歷,開設課程,研究方向,科研項目,發表論文,
人物經歷
2006年本科畢業於蘭州大學化學化工學院；2011年6月博士畢業於蘭州大學化學化工學院；2009年9月至2011年4月在美國肯塔基大學藥學院聯合培養。2011年7月進入西北農林科技大學生命科學學院工作。中國化學會會員。
開設課程
承擔本科生《生物信息學》、《生物信息學綜合實驗》，參與研究生《生物信息學研究進展》課程教學工作。
研究方向
植物激素類似物的計算機輔助分子設計；
化學小分子對植物生長及逆境回響的調控。
科研項目
國家自然科學基金青年基金，基於靶標BRI1的新型油菜素內酯受體激動劑的合理設計（21302153，2014-2016）；
中央高校基本科研業務費青年培育項目，基於藥效團的BRI1激動劑的虛擬篩選及活性評價（2015）；
發表論文
Lei, B. L., Heng, NJ, Dang, XX, Liu, J. Y., Yao, X. J and Zhang CL*. Structure based in silico identification of potentially non-steroidal brassinosteroids mimics. Molecular Biosystems, 2017. 13(7): p.1364-1369.
Lei, B. L.*, Liu, J. Y., and Yao, X. J. Unveiling the molecular mechanism of brassinosteroids: Insights from structure-based molecular modeling studies . Steroids, 2015. 104: p. 111-117.
Lei, B. L.*, Li, J. Z., and Yao, X. J., A Novel Strategy of Structural Similarity Based Consensus Modeling. Molecular Informatics, 2013. 32(7): p. 599-608.
Lei, B. L., Adel, H. and Zhan, C.-G.*, Structural features and binding free energies for non-covalent inhibitors interacting with immunoproteasome by molecular modeling and dynamics simulations. Theoretical Chemistry Accounts, 2012. 131(4): p. 1203-1213.
Wei, D. H., Lei, B. L., Tang M. S., and Zhan C.-G.*, Fundamental Reaction Pathway and Free Energy Profile for Inhibition of Proteasome by Epoxomicin , Journal of the American Chemical Society, 2012. 134(25): p. 10436-10450.
Lei, B. L., Hameed, Mdma, Hamza, A., Wehenkel, M., Muzyka, J. L., Yao, X. J., Kim, K. B., and Zhan, C. G.*, Molecular Basis of the Selectivity of the Immunoproteasome Catalytic Subunit LMP2-Specific Inhibitor Revealed by Molecular Modeling and Dynamics Simulations. Journal of Physical Chemistry B, 2010. 114(38): p. 12333-12339.
Lei, B. L., Ma, Y. M., Li, J. Z., Liu, H. X., Yao, X. J.*, and Gramatica, P., Prediction of the adsorption capability onto activated carbon of a large data set of chemicals by local lazy regression method. Atmospheric Environment, 2010. 44(25): p. 2954-2960.
Lei, B. L., Li, J. Z., Lu, J., Du, J., Liu, H. X., and Yao, X. J.*, Rational Prediction of the Herbicidal Activities of Novel Protoporphyrinogen Oxidase Inhibitors by Quantitative Structure-Activity Relationship Model Based on Docking-Guided Active Conformation. Journal of Agricultural and Food Chemistry, 2009. 57(20): p. 9593-9598.
Lei, B. L., Li, S. Y., Xi, L. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Novel approaches for retention time prediction of oligonucleotides in ion-pair reversed-phase high-performance liquid chromatography. Journal of Chromatography A, 2009. 1216(20): p. 4434-4439.
Lei, B. L., Xi, L. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Global, local and novel consensus quantitative structure-activity relationship studies of 4-(Phenylaminomethylene) isoquinoline-1, 3 (2H, 4H)-diones as potent inhibitors of the cyclin-dependent kinase 4. Analytica Chimica Acta, 2009. 644(1-2): p. 17-24.
Lei, B. L., Du, J., Li, S. Y., Liu, H. X., Ren, Y. Y., and Yao, X. J.*, Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of thiazolone derivatives as hepatitis C virus NS5B polymerase allosteric inhibitors. Journal of Computer-Aided Molecular Design, 2008. 22(10): p. 711-725.
Lei, B. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Accurate prediction of aquatic toxicity of aromatic compounds based on Genetic Algorithm and Least Squares Support Vector Machines. Qsar & Combinatorial Science, 2008. 27(7): p. 850-865.
