陽大海，男，華東理工大學生物工程學院，講師，上海市浦江學者, 晨光計畫入選者，中國科協“2016-2018”年度青年人才托舉工程入選者。
個人經歷：
2010年09月-2015年06月，華東理工大學生物工程學院，工學博士
2013年08月-2015年05月，美國密西根大學，聯合培養博士
研究方向：細菌性感染介導的宿主先天免疫分子機制
1. 主要從事海洋病原細菌殺魚愛德華氏菌毒力因子鑑定及其介導的魚類宿主免疫應答分子機制研究。主持國家自然科學基金青年基金項目“細菌類硫氧還蛋白調控MAPK信號通路及魚類抗感染機制的研究”(31602187)，參加國家“863”海洋技術領域重點項目“遲鈍愛德華氏菌活疫苗的套用研究和產業化開發”(2013AA093101)、國家自然科學基金重點項目“遲鈍愛德華氏菌T3SS效應蛋白的系統鑑定及其與魚類宿主互作機制研究”(31430090) 。
2. 以斑馬魚幼魚為模型，研究炎症小體（inflammasome）激活在細菌性感染過程發揮的分子功能，並進行相關抗感染藥物的篩選。主持2016上海市浦江人才計畫（D）類項目（2016PJD020）和2016上海市晨光計畫項目，入選中國科協2016-2018年度“青年人才托舉工程”項目。
學術兼職：
中國免疫學會高級會員。
擔任Journal of Fisheries & Livestock Production, Journal of Aquaculture Research & Development和Mycobacterial Diseases等SCI雜誌審稿人。
主要發表文章：
1. Chen H.,Yang D., Han F., Tan J., Wang Q., Zhang Y., Liu Q.*, Bacterial T6SS effector EvpP prevents NLRP3 inflammasome activation by inhibiting Ca-dependent JNK pathway,Cell Host & Microbe2017, 21: 47-58.
2. He Y., Zeng M.Y.,Yang D., Motro B., Núñez G.*. Nek7 is an essential mediator of NLRP3 activation downstream of potassium efflux.Nature2016, 530(7590):354-7.
Editor’s choice inScience Signaling, Nek7 activates NLRP3, Sci. Signal, 2016, 9 (416): ec39.
3. Hou M, Chen R.,Yang D., Núñez G., Wang Z., Wang Q., Zhang Y., Liu Q.*, Identification and functional characterization of EseH, a new effector of the type III secretion system ofEdwardsiella piscicida,Cellular Microbiology2016, doi: 10.1111/cmi.12638.
4. Zhang L., Ni C., Xu W., Dai T.,Yang D., Wang Q. Zhang Y., Liu Q.*, Intra-macrophage infection reinforces the virulence ofEdwardsiella tarda,Journal of Bacteriology2016, 198 (10): 1534-1542.
5. Fang S., Zhang L., Lou Y.,Yang D., Wang Q., Zhang Y., Liu Q.*, Intracellular translocation and localization ofEdwardsiella tardatype III secretion system effector EseG in host cells,Microbial Pathogenesis2016, 97: 166-171.
6.Yang D., He Y., Muñoz-Planillo R., Liu Q.*, Núñez G.*. Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock.Immunity2015, 43: 923-932.
Previewed by:Aude de Gassart and Fabio Martinon*. Pyroptosis: Caspase-11 unlocks the gates of death. Immunity 2015, 43: 835-837.
7.Yang D., Liu Q.*, Ni C., Li S., Wu H., Wang Q., Xiao J., Zhang Y.. Gene expression profiling in live attenuatedEdwardsiella tardavaccine immunized and challenged zebrafish: Insights into the basic mechanisms of protection seen in immunized fish,Developmental and Comparative Immunology2013, 40: 132-141.
8.Yang D., Liu Q.*, Yang M, Wu H., Wang Q., Xiao J., Zhang Y.*. RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish,BMC genomics2012, 13: 319.
Highly accessed articlein BMC genomics (online 30 days).
