陸瑤(中國科學院大連化學物理研究所研究員、博士生導師，國家高層次人才特殊支持計畫青年拔尖人才)

陸瑤(中國科學院大連化學物理研究所研究員、博士生導師，國家高層次人才特殊支持計畫青年拔尖人才)

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陸瑤，中國科學院大連化學物理研究所研究員、博士生導師。

長期從事微流控晶片、單細胞分析技術發展及其套用研究（微流控晶片、單細胞分析均是科技部《“十三五”生物技術創新專項規劃》重點部署的顛覆性技術），相關工作以第一、通訊作者發表於PNAS (3), National Science Review, Science Signaling, Advanced Science (2 ), Biofabrication, Analytical Chemistry (6 )等著名期刊，單篇最高他引490 余次；發展的噴蠟列印製造紙基質微流控晶片技術成為紙晶片最主要製備技術，大大推動相關領域發展；發展的單細胞分泌蛋白分析技術已被商業化，並被世界各地100 多家製藥公司和醫療中心廣泛使用，幫助腫瘤免疫治療、細胞治療藥物開發和臨床測試，被美國The Scientist 雜誌評為2017 年度十大醫療技術發明首位；主持國家自然科學基金（3 項）等科研項目10 餘項；共同主編中文（器官晶片，2019，科學出版社）、英文（Biosensors for Single-Cell Analysis, 2021, Elsevier 出版社）專著各一部；授權發明專利8 項（包括美國專利兩件）。

基本介紹

工作經歷,研究方向,所獲榮譽,教育背景,發表著作,發表論文,

工作經歷

2015年10月—至今 中國科學院大連化學物理研究所
2014年10月—2015年9月 耶魯大學生物醫學工程系Associate Research Scientist
2010年10月—2014年9月 耶魯大學生物醫學工程系Postdoctoral Associate

研究方向

1. 高通量單細胞多維、動態、互作分泌分析技術發展及其生物醫學套用；
2. 微流控數字液滴中央處理器；
3. 面向中藥現代化、細胞治療的（單）細胞分析；
4. 基於微流控晶片的高通量、快速、高靈敏分析。

所獲榮譽

1. 國家高層次人才特殊支持計畫青年拔尖人才
2. 中國科學院青年創新促進會優秀會員
3. 國際分析科學大會青年報告獎（2017 年，中國化學會）
4. 中國科學院特聘研究崗位
5. 中國科學院大連化學物理研究所“張大煜青年學者”
6. 遼寧省百千萬人才工程
7. 大連市青年科技之星

教育背景

2003-09--2010-07 中科院大連化物所 碩博連讀
1999-09--2003-07 安徽大學 學士

發表著作

1.Chen Jian, Yao Lu. BIOSENSORS FOR SINGLE-CELL ANALYSIS. United Kingdom :Academic Press, 2021.
1. 林炳承，羅勇，劉婷姣，陸瑤，器官晶片[M]. 北京，科學出版社，2019：1-352.

發表論文

2022
1. Fengjiao Zhu, Yahui Ji, Jiu Deng, Linmei Li, Xue Bai, Xianming Liu, Bingcheng Lin, Yao Lu*. Microfluidics-based technologies for the analysis of extracellular vesicles at the single-cell level and single-vesicle level. Chinese chemical letters, 2022, 33(6), 2893-2900.
2021
1. Tahereh Khajvand, Peifeng Huang, Linmei Li, Mingxia Zhang, Fengjiao Zhu, Xing Xu, Mengjiao Huang, Chaoyong Yang, Yao Lu* and Zhi Zhu*. Interfacing Droplet Microfluidics with Antibody Barcodes for Multiplexed Single-Cell Protein Secretion Profiling. Lab on a chip, 2021,21(24):4823-4830.
2. Fengjiao Zhu, Yahui Ji, Linmei Li, Xue Bai, Xianming Liu, Yong Luo, Tingjiao Liu, Bingcheng Lin, Yao Lu*. High-throughput single-cell extracellular vesicle secretion analysis on the desktop scanner without cell counting. Analytical chemistry, 2021, 93(39): 13152–13160.
3. Linmei Li, Weiwei Shi, Meimei Liu, Xue Bai, Yanting Sun, Xue Zhu, Haoran Su, Yahui Ji, Fengjiao Zhu, Xianming Liu, Yong Luo, Tingjiao Liu, Bingcheng Lin, Yao Lu*. Single-cell Secretion Analysis in the Engineered Tumor Microenvironment Reveals Differential Modulation of Macrophage Immune Responses. Analytical Chemistry, 2021, 93(9):4198-4207.
4. Shiqiang Yan, Shuting Wang, Zhujing Hao, Meimei Liu, Chunyue Miao, Md Fazle Alam, Ruihan Bai, Linmei Li, Yong Luo, Tingjiao Liu, Bingcheng Lin, Weijia Zhang*, Yao Lu*. Rapid prototyping of PDMS microdevices via mu PLAT on nonplanar surfaces with flexible hollow-out mask. Biofabrication, 2021, 13(3):035003.
5. Yaru Xing*, Yu Liu, Rifei Chen, Yuyan Li, Chengzhi Zhang, Youwei Jiang, Yao Lu, Bingcheng Lin, Peizhong Chen, Ruijun Tian, Xianming Liu* and Xing Cheng*. A Robust and Scalable Active-Matrix Driven Digital Microfluidic Platform Based on Printed-Circuit Board Technology Dagger. Lab on a chip, 2021, 21(10):1886-1896.
2020
1. Meimei Liu, Meihua Jin, Linmei Li, Yahui Ji, Fengjiao Zhu, Yong Luo, Tingjiao Liu, Bingcheng Lin, Yao Lu* PDMS Microwell Stencil Based Multiplexed Single‐Cell Secretion Analysis. Proteomics, 2020, 1900231.
2019
1. Yahui Ji, Dongyuan Qi, Linmei Li, Haoran Su, Xiaojie Li, Yong Luo, Bo Sun, Fuyin Zhang, Bingcheng Lin, Tingjiao Liu*, Yao Lu* Multiplexed Profiling of Single-cell Extracellular Vesicles Secretion. PNAS, 2019, 116 (13) 5979-5984.
2. Zhuo Chen#, Yao Lu#*, Kerou Zhang, Yang Xiao, Jun Lu, Rong Fan* Multiplexed, sequential secretion analysis of the same single cells reveals distinct effector response dynamics dependent on the initial basal state. Advanced Science, 2019, 6, 1801361 (Highlighted as Inside Cover).
3. Jun Ma#, Shiqiang Yan#, Chunyue Miao, Linmei Li, Weiwei Shi, Xianming Liu, Yong Luo, Tingjiao Liu, Bingcheng Lin, Wenming Wu,*, Yao Lu* Paper Microfluidics for Cell Analysis. Advanced Healthcare Materials, 2019, 8, 1801084.
2018
1. Ruihan Bai, Linmei Li, Meimei Liu, Shiqiang Yan, Chunyue Miao, Ruijun Li, Yong Luo, Tingjiao Liu, Bingcheng Lin, Yibing Ji*, and Yao Lu* Paper Based 3D Scaffold for Multiplexed Single Cell Secretomic Analysis. Analytical Chemistry, 2018, 90 (9), pp 5825–5832.
2. Linmei Li, Shiqiang Yan, Bingcheng Lin, Qihui Shi*, Yao Lu*. Single-Cell Proteomics for Cancer Immunotherapy, Advances in Cancer Research, 2018.
3. Yueyang Qu, Fan An, Yong Luo*, Yao Lu, Tingjiao Liu, Weijie Zhao, Bingcheng Lin. A nephron model for study of drug-induced acute kidney injury and assessment of drug-induced nephrotoxicity. Biomaterials, 2018, 155, 41-53.
2017
1. Yao Lu, Liu Yang, Wei Wei*, Qihui Shi* Microchip-Based Single-Cell Functional Proteomics for BiomedicalApplications. Lab on a Chip, 2017, Mar 29;17(7):1250-1263.
2. Shimeng Fang, Hongzhu Tian, Xiancheng Li, Dong Jin, Xiaojie Li, Jing Kong, Chun Yang, Xuesong Yang, Yao Lu, Yong Luo, Bingcheng Lin, Weidong Niu*, Tingjiao Liu* Clinical application of a microfluidic chip for immunocapture and quantification of circulating exosomes to assist breast cancer diagnosis and molecular classification. PLoS One. 2017 Apr 3;12(4):e0175050. doi: 10.1371/journal.pone.0175050. eCollection 2017.
3. 高志剛, 鄭婷婷, 鄧九, 李曉瑞, 曲玥陽, 陸瑤, 劉婷嬌, 羅勇*, 趙偉傑, 林炳承 ,基於便攜拉曼光譜儀和雙層紙晶片的頭髮皮質醇超高靈敏檢測, 化學學報(Acta Chim. Sinica), 2017, 75, 355-359
2016
1.Kun Zou, Zhigang Gao, Quanfeng Deng, Yong Luo, Lijuan Zou, Yao Lu, Weijie Zhao and Bingcheng Lin Picomolar detection of carcinoembryonic antigen in whole blood using microfluidics and surface-enhanced Raman spectroscopy. Electrophoresis, 2016, 37(5-6):786-9.
Before 2016
  1. Qiong Xue†, Yao Lu†, Markus R. Eisele, Endah S. Sulistijo, Nafeesa Khan, Rong Fan*, and Kathryn Miller-Jensen* Analysis of single cell secretion reveals a role for paracrine signaling in coordinating macrophage response to TLR4 stimulation. Science Signaling, 2015, 8(381), ra59.
  2. Yao Lu†, Qiong Xue†, Markus Eisele, Endah Sulistijo, Kara Brower, Lin Han, El-ad David Amir, Dana Pe’er, Kathryn Miller-Jensen* & Rong Fan* Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands. PNAS, 2015, 112 (7), E607-E615.
  3. Yao Lu†, Jonathan J. Chen†, Luye Mu, Qiong Xue, Yu Wu, Pei-Hsun Wu, Jie Li, Alexander O. Vortmeyer, Kathryn Miller-Jensen, Denis Wirtz, and Rong Fan* High-Throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity. Analytical Chemistry 2013, 85 (4), 2548–2556
  4. Yao Lu, Bingcheng Lin*, Jianhua Qin*. Patterned Paper as a Low-cost, Flexible Substrate for Rapid Prototyping PDMS Microdevices via “liquid molding” . Analytical Chemistry 2011, 83 (5), 1830–1835
  5. Yao Lu, Weiwei Shi, Jianhua Qin*, Bingcheng Lin*. Fabrication And Characterization of Paper Based Microfluidics Prepared in Nitrocellulose Membrane By Wax Printing. Analytical Chemistry 2010, 82, 329–335
  6. Yao Lu, Weiwei Shi, Lei Jiang, Jianhua Qin*, Bingcheng Lin*. Rapid prototyping of paper-based microfluidics with wax for low-cost, portable bioassay . Electrophoresis 2009, 30, 1497–1500
  7. Yao Lu, Weiwei Shi, Jianhua Qin*, Bingcheng Lin*. Low cost, portable detection of gold nanoparticle-labeled microfluidic immunoassay with camera cell phone. Electrophoresis 2009, 30, 579–582 (selected by editor as Fast Track)
  8. Lei Jiang, Yao Lu, Zhongpeng Dai, Minhao Xie, Bingcheng Lin*. Mini-electrochemical Detector for Microchip Electrophoresis. Lab Chip 2005, 5(9), 930-934
  9. Lei Jiang, Xuening Jiang, Yao Lu, Zhongpeng Dai, Minhao Xie, Jianhua Qin*, Bingcheng Lin*. Development of a universal serial bus-powered mini-high-voltage power supply for microchip electrophoresis. Electrophoresis 2007, 28(8), 1259–1264.
  10. Weiwei Shi, Hui Wen, Yao Lu, Yang Shi, Bingcheng Lin*，Jianhua Qin* Droplet Microfluidics for Characterizing the Neurotoxin-induced Responses in Individual Caenorhabditis elegans. Lab Chip, 2010, 10, 2855 – 2863
  11. Wu Y, Lu Y, Chen WQ, Fu JP & Fan R*. In silico experimentation of glioma microenvironment development and anti-tumor therapy. PLoS Computational Biology, 8(2), 1002355 (2012).
  12. Lee SK*, Kim GS, Wu Y, Kim DJ, Lu Y, Kwak M, Han L, Hyung JH, Seol JK, Sander C, Gonzalez A, Li J, Fan R*. Nanowire Substrate-Based Laser Scanning Cytometry for Quantitation of Circulating Tumor Cells. Nano Letters, 12(6), 2697-2704(2012)
  13. Minsuk Kwak, Luye Mu, Yao Lu, Jonathan Chen, Yu Wu, Kara Brower and Rong Fan*. Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction. Frontiers in Oncology, 2013; 3: 10
  14. Meltem Elitas†, Kara Brower†, Yao Lu, Jonathan J. Chen and Rong Fan* A Microchip Platform for Interrogating Tumor-Immune Cell Communication at the Single-Cell Level. Lab on a Chip 14 (18), 3582-3588
  15. Mao, Lin†; Shen, Li†; Chen, Jiahui; Wu, Yu; Kwak, Minsuk; Lu, Yao; Xue, Qiong; Pei, Jia; Zhang, Lei; Yuan, Guangyin; Fan, Rong; Ge, Junbo; Ding, Wen-Jiang Enhanced bioactivity of Mg-Nd-Zn-Zr alloy achieved with nanoscale MgF2 surface for vascular stent application ACS applied materials & interfaces, 7 (9), 5320–5330.

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