陸昌瑞，1983年6月出生。美國科爾蓋特大學（Colgate University）全額獎學金分子生物學學士（2005），美國康奈爾大學（Cornell University）生命科學研究生院生物化學、生物物理學博士（2011），美國密西根大學（University of Michigan）醫學院博士後，2012年6月被東華大學評定為教授。同年12 月入選上海市2012 年度上海高校特聘教授（東方學者）計畫。
基本介紹
- 中文名：陸昌瑞
- 國籍：中國
- 民族：漢
- 畢業院校：美國科爾蓋特大學
研究方向,論文論著,
研究方向
核開關三維結構與機理 X-ray晶體結構、RNA調節因子發現、功能和機理。
論文論著
從事RNA的結構與功能、基因的表達與調控等研究:核開關和其他非編碼RNA 的結構、機理和功能；Packaging RNA (pRNA)的晶體結構與複合體的包裝機理；外切體複合物的晶體結構與機理；昆蟲胚胎耐凍性的分子機理,其成果發表於Nature SMB、PNAS、Journal of Molecular Biology等國際著名雜誌。
1、Ding F,Lu Changruiet al. Structure and assembly of the essential RNA ring component of a viral DNA packaging motor.PNAS.2011
2、Lu Changrui, Ding F, Ke A. Folding of the SAM-III/SMK box riboswitch is hypersensitive to sequences outside the SAM-binding core.Journal of Molecular Biology.2011
3、Lu Changrui,et al. SAM Recognition and Conformational Switching Mechanism in theBacillus subtilis yitJ SBox/SAM-I Riboswitch.Journal of Molecular Biology.2010
4、Lu Changrui, Ding F, Ke A. Crystal structure of theS. solfataricusarchaeal exosome reveals conformational flexibility in the RNA-binding ring.PLoS ONE.2010
5、Lu Changrui.et al. Crystal Structures of the SMK box (SAM-III) Riboswitch Reveal the SAM-dependent Translation Inhibition Mechanism.Nature SMB.2008
6、Pruitt NL,Changrui Lu.Seasonal changes in phospholipid class and class-specific fatty acid composition associated with the onset of freeze tolerance in third-instar larvae of Eurosta solidaginis.Physiological and biochemical zoology. 2008
7、Perreira M, Jiang JK, Klutz AM, Gao ZG, Shainberg A, Changrui Lu, Thomas CJ, Jacobson KA.“Reversine” and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.Journal of medicinal chemistry. 2005
8、Jeong LS, Lee HW, Jacobson KA, Kim HO, Shin DH, Lee JA, Gao ZG,Changrui Lu, Duong HT, Gunaga P, Lee SK, Jin DZ, Chun MW, Moon HR. Structure-activity relationships of 2-chloro-N6-substituted-4‘-thioadenosine-5’-uronamides as highly potent and selective agonists at the human A3 adenosine receptor.J Med Chem. 2006
9、Cosyn L, Gao ZG, Van Rompaey P,Changrui Lu, Jacobson KA, Van Calenbergh S. Synthesis of hypermodified adenosine derivatives as selective adenosine A3 receptor ligands.Bioorg Med Chem.2006
