陳雨(上海矽酸鹽研究所研究員):教育經歷,工作經歷,研究方向,主要成就,個人作品,

教育經歷

2007 - 2012，中國科學院上海矽酸鹽研究所，高性能陶瓷和超微結構國家重點實驗室，博士，

2003 - 2007，南京工業大學，材料科學院與工程學院，學士

工作經歷

2016–至今，中國科學院上海矽酸鹽研究所，高性能陶瓷和超微結構國家重點實驗室，特聘研究員

2014–2016，中國科學院上海矽酸鹽研究所，高性能陶瓷和超微結構國家重點實驗室，副研究員（所百人計畫）

2012–2014，中國科學院上海矽酸鹽研究所，高性能陶瓷和超微結構國家重點實驗室，助理研究員

研究方向

主要研究工作圍繞生物醫用微納功能材料的可控制備、生物學效應及其在生物醫學特別是腫瘤診斷與治療中的套用，發展了多種新型的製備方法獲得了具有臨床套用前景的無機非金屬生物材料體系。

主要成就

截至2016年，共發表學術論文90餘篇，其中以第一作者(24篇)或通訊作者（14篇）在Chem. Soc. Rev., Acc. Chem. Res., J. Am. Chem. Soc. (2篇), Angew. Chem. Int. Ed., Adv. Mater.（10篇）, Adv. Funct. Mater.（3篇）, ACS Nano（3篇）, Nano Today, NPG Asia Mater., Small, Biomaterials（4篇）等重要學術期刊上發表論文38篇，第一/通訊作者論文中影響因子（IF）大於10的論文22篇，大於20論文2篇（IF分別為30.425和24.348）。論文被引用3900餘次，H-index為31。11篇論文被Chem. Soc. Rev., Adv. Mater.（7篇）, Adv. Funct. Mater等期刊選為封面或內插畫文章發表，10篇論文入ESI高引用論文（Highly Cited Paper）。博士論文入選Springer Theses叢書以專著和英文全球發行（ISSN 2190-5053）。

個人作品

【1】出版專著和章節

Yu Chen,《Design, Synthesis, Multifunctionalization and Biomedical Applications of Multifunctional Mesoporous Silica-Based Drug Delivery Nanosystems》, Springer Press, ISBN 978-3-662-48622-1. (Springer Theses)

Yu Chen, Ming Ma, Hangrong Chen and Jianlin Shi,Multifunctional Hollow Mesoporous Silica Nanoparticles for MR/US Imaging-Guided Tumor Therapy,《Advances in Nanotheranostics》, Volume 7, pp. 189-222, Springer Press,

Qianjun He,Yu Chenand Jianlin Shi, Chapter 10: Biomedical applications and biological effects of mesoporous silica nanoparticles,《Chemistry of Nanoporous Materials》(pp. 324-355). China: Science Press.

【2】代表性第一/通訊作者學術論文

2016年

Luodan Yu,Yu Chen,* Meiying Wu, Xiaojun Cai, Heliang Yao, Linlin Zhang, Hangrong Chen* and Jianlin Shi,* “Manganese Extraction” Strategy Enables Tumor-Sensitive Biodegradability and Theranostics of Nanoparticles,Journal of the American Chemical Society, 2016, 138(31), 9881-9894.

Yu Chen* and Jianlin Shi*, Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic-Inorganic Hybridization into Framework,Advanced Materials, 2016, 28, 3235-3272.

Xiaoqin Qian, Yuanyi Zheng* andYu Chen,* Micro/nanoparticle-augmented sonodynamic therapy: breaking the depth shallow of photoactivation,Advanced Materials, 2016, DOI: 10.1002/adma.201602012.

Meiying Wu, Qingshuo, Meng,Yu Chen,* Lingxia Zhang, Mengli Li, Xiaojun Cai, Yaping Li,* Pengcheng Yu, Linlin Zhang and Jianlin Shi,* Large Pore-Sized Hollow Mesoporous Organosilica for Redox-Responsive Gene Delivery and Synergistic Cancer Chemotherapy,Advanced Materials, 2016, 28, 1963-1969.

Yu Chen,* Lianzhou Wang and Jianlin Shi, Two-dimensional Nano-carbonaceous Materials-enabled Efficient Photothermal Cancer Therapy,Nano Today, 2016, 11(3), 292-308.

Yang Zhou,Yu Chen,* Yuanyi Zheng,* et al,Magnetic Nanoparticle-Promoted Droplet Vaporization for In Vivo Stimuli-Responsive Cancer Theranostics,NPG Asia Materials, 2016, In press.

Minfeng Huo,Yu Chen* and Jianlin Shi,* Triggered-release drug delivery nanosystems for cancer therapy by intravenous injection: where are we now?,Expert Opinion on Drug Delivery, 2016, 13(9), 1195-1198.

Jinshun Xu,Yu Chen,* Liming Deng, Jianxin Liu, Yang Cao, Pan Li, Haitao Ran, Yuanyi Zheng* and Zhigang Wang,*Microwave-Activated Nanodroplet Vaporization for Highly Efficient Tumor Ablation with Real-time Monitoring Performance,Biomaterials, 2016, DOI:10.1016/j.biomaterials.2016.08.034.

Kai Zhu, Meiying Wu, H. Lai, C. Guo, Jun Li, Yulin Wang,Yu Chen,* Chunsheng Wang,* Jianlin Shi,* Nanoparticle-enhanced generation of gene-transfected mesenchymal stem cells for in vivo cardiac repair,Biomaterials, 2016, 74, 188-199.

Yufeng You, Zhigang Wang, Haitao Ran, Yuanyi Zheng, Dong Wang, Jinshun Xu, Zhibiao Wang,Yu Chen* and Pan Li,*Nanoparticle-enhanced synergistic HIFU ablation and transarterial chemoembolization for efficient cancer therapy,Nanoscale, 2016, 8, 4324-4339.

2015年

Yu Chen, Chaoliang Tan, Hua Zhang* and Lianzhou Wang,* Two-dimensional graphene analogues for biomedical applications,Chemical Society Reviews, 2015,44, 2681-2701.

Shige Wang,Yu Chen,* X. Li, W. Gao, L. Zhang, J. Liu, Y. Zheng, Hangrong Chen,* Jianlin Shi, Injectable 2D MoS2‐Integrated Drug Delivering Implant for Highly Efficient NIR‐Triggered Synergistic Tumor Hyperthermia,Advanced Materials, 2015, 27, 7117-7122.

Meiying Wu, Qingshuo Meng,Yu Chen,* Yanyan Du, Lingxia Zhang, Yaping Li,* Linlin Zhang, Jianlin Shi,*Large-Pore Ultrasmall Mesoporous Organosilica Nanoparticles: Micelle/Precursor Co-templating Assembly and Nuclear-Targeted Gene Delivery,Advanced Materials, 2015, 27, 215-222.

Yu Chen, Hangrong Chen* and Jianlin Shi,*Nanobiotechnology Promotes Noninvasive High-Intensity Focused Ultrasound Cancer Surgery,Advanced Healthcare Materials, 2015, 4, 158-165.

Yu Chen* and Jianlin Shi,* Mesoporous Carbon Biomaterials,SCIENCE CHINA Materials, 2015, 58, 241-257.

Shengjian Zhang, Xiaoqin Qian, Linlin Zhang, Weijun Peng,*Yu Chen,* Composition–property relationships in multifunctional hollow mesoporous carbon nanosystems for PH-responsive magnetic resonance imaging and on-demand drug release,Nanoscale, 2015, 7, 7632-7643.

2014年

Yu Chen, Hangrong Chen and Jianlin Shi, Construction of Homogenous/Heterogeneous Hollow Mesoporous Silica Nanostructures by Silica-Etching Chemistry: Principles, Synthesis and Applications,Accounts of Chemical Research, 2014, 47, 125-137.

Yu Chen, Qingshuo Meng, Meiying, Wu, Shige Wang, Pengfei Xu, Hangrong Chen, Yaping Li, Lingxia Zhang, Lianzhou Wang and Jianlin Shi,Hollow Mesoporous Organosilica Nanoparticles: A Generic Intelligent Framework-Hybridization Approach for Biomedicine,Journal of the American Chemical Society, 2014, 136, 16326-16334.

Yu Chen, Pengfei Xu, Meiying Wu, Qingshuo Meng, Hangrong Chen, Zhu Shu, Jin Wang, Lingxia Zhang, Yaping Li and Jianlin Shi, Colloidal RBCs-Shaped, Hydrophilic and Hollow Mesoporous Carbon Nanocapsules for Highly Efficient Biomedical Engineering,Advanced Materials, 2014, 26, 4294-4301.

Yu Chen, Ling Jiang, Ronghui Wang, Ming Lu, Qunxia Zhang, Yang Zhou, Zhigang Wang, Guangming Lu, Ping Liang, Haitao Ran, Hangrong Chen and Yuanyi Zheng,Injectable Smart Phase-Transformation Implants for Highly Efficient In Vivo Magnetic-Hyperthermia Regression of Tumors,Advanced Materials, 2014, 26, 7468-7473.

Yu Chen, Delai Ye, Meiying Wu, Hangrong Chen, Linlin Zhang, Jianlin Shi and Lianzhou Wang,Break-up of Two-Dimensional MnO2Nanosheets Promotes Ultrasensitive pH-Triggered Theranostics of Cancer,Advanced Materials, 2014, 26, 7019-7026.

Yu Chen, Pengfei Xu, Zhu Shu, Meiying Wu, Lianzhou Wang, Shengjian Zhang, Yuanyi Zheng, Hangrong Chen, Jin Wang, Yaping Li and Jianlin Shi, Multifunctional Graphene Oxide-Based Triple Stimuli-Responsive Nanotheranostics,Advanced Functional Materials, 2014, 24(28), 4386-4396.

Yu Chen, Hangrong Chen and Jianlin Shi, Drug Delivery/Imaging Multifunctionality of Mesoporous Silica-Based Composite Nanostructures,Expert Opinion on Drug Delivery, 2014, 11(6), 917-930.

Yu Chen,Hangrong Chen and Jianlin Shi, Inorganic Nanoparticles-Based Drug Co-Delivery Nanosystems to Overcome the Multidrug Resistance of Cancer Cells,Molecular Pharmaceutics, 2014, 11, 2495-2510.

2013年

Yu Chen, Hangrong Chen and Jianlin Shi, In Vivo Bio-Safety Evaluations and Diagnostic/Therapeutic Applications of Chemically Designed Mesoporous Silica Nanoparticles,Advanced Materials, 2013, 25, 3144-3176.

Yu Chen, Pengfei Xu, Hangrong Chen, Yongsheng Li, Wenbo Bu, Zhu Shu, Yaping Li, Jiamin Zhang, Lingxia Zhang, Limin Pan, Xiangzhi Cui, Zile Hua, Jin Wang, Linlin Zhang and Jianlin Shi, Colloidal HPMOs NPs: Silica-Etching Chemistry Tailoring, Topological Transformation and Nano-Biomedical Applications,Advanced Materials, 2013, 2013, 25, 3100-3105.

Yu Chen,Hangrong Chen and Jianlin Shi, Engineering of Hollow Mesoporous Nanoparticles for Biomedical Applications,Advanced Porous Materials, 2013, 1, 36-62.

2013年之前

Yu Chen, Hangrong Chen, Yang Sun, Yuanyi Zheng, Deping Zeng, Faqi Li, Shengjian Zhang, Xia Wang, Kun Zhang, Ming Ma, Qianjun He, Linlin Zhang and Jianlin Shi, Multifunctional Mesoporous Composite Nanocapsules for Highly Efficient MRI-Guided High Intensity Focused Ultrasound Cancer Surgery,Angewandte Chemie International Edition, 2011, 50(52), 12505-12509.

Yu Chen, Yu Gao, Hangrong Chen, Deping Zeng, Yaping Li, Yuanyi Zheng, Faqi Li, Xia Wang, Feng Chen, Qianjun He, Linlin Zhang and Jianlin Shi, Engineering “Inorganic Nanoemulsion/Nanoliposome” by Fluoride-Silica Chemistry for Efficient Delivery/Co-delivery of Hydrophobic Agents,Advanced Functional Materials, 2012, 22(8), 1586-1597.

Yu Chen, Hangrong Chen, Shengjian Zhang, Feng Chen, Lingxia Zhang, Jiamin Zhang, Min Zhu, Huixia Wu, Jingwei Feng and Jianlin Shi, Multifunctional Mesoporous Nanoellipsoids for Biological Bimodal Imaging and Magnetically Targeted Delivery of Anticancer Drugs,Advanced Functional Materials, 2011, 21(2), 270-278.

Yu Chen, Hangrong Chen, Limin Guo, Qianjun He, Feng Chen, Jian Zhou, Jingwei Feng and Jianlin Shi, Hollow/Rattle-type Mesoporous Nanostructures by a Structural Difference-Based Selective Etching Strategy,ACS Nano, 2010, 4(1), 529-539.

Yu Chen, Hangrong Chen, Deping Zeng, Yunbo Tian, Feng Chen, Jingwei Feng and Jianlin Shi, Core/Shell Structured Hollow Mesoporous Nanocapsules: A Potential Platform for Simultaneous Cell Imaging and Anticancer Drug Delivery,ACS Nano, 2010, 4(10), 6001-6013.

Yu Gao,Yu Chen,Xiufeng Ji,Xinyu He, Jianlin Shi and Yaping Li, Controlled Intracellular Release of Doxorubicin in Multidrug Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles,ACS Nano, 2011, 5(12), 9788-9798. (Co-first author)

Yu Chen, Hangrong Chen, Shengjian Zhang, Feng Chen, Shikuan Sun, Qianjun He, Ming Ma, Xia Wang, Huixia Wu, Lingxia Zhang and Jianlin Shi, Structure-Property Relationships in Manganese oxide - Mesoporous Silica Nanoparticles Used for T1-Weighted MRI and Simultaneous Anticancer Drug Delivery,Biomaterials, 2012, 33(7), 2388-2398.

Yu Chen, Qi Yin, Xiufeng Ji, Shengjian Zhang, Hangrong Chen, Yuanyi Zheng, Yang Sun, Haiyun Qu, Zheng Wang, Yaping Li, Xia Wang, Kun Zhang, Linlin Zhang and Jianlin Shi, Manganese Oxide-Based Multifunctionalized Mesoporous Silica Nanoparticles for pH-Responsive MRI, Ultrasonography and Circumvent of MDR in Cancer Cells,Biomaterials, 2012, 33(29), 7126-7137.

Yu Chen, Chen Chu, Yuchuan Zhou, Hangrong Chen, Feng Chen, Qianjun He, Yonglian Zhang, Linlin Zhang and Jianlin Shi, Reversible Pore-Structure Evolution in Hollow Silica Nanocapsules: Large Pores for siRNA Delivery and Nanoparticle Collecting,Small, 2011, 7(20), 2935-2944.

Yu Chen, Hangrong Chen, Ming Ma, Feng Chen, Limin Guo, Lingxia Zhang and Jianlin Shi, Double Mesoporous Silica Shelled Spherical/Ellipsoidal Nanostructures: Synthesis and Hydrophilic/Hydrophobic Anticancer Drug Delivery,Journal of Materials Chemistry, 2011, 21(14), 5290-5298.

Yu Chen, Hangrong Chen, Limin Guo and Jianlin Shi, Magnetic Hollow Mesoporous Silica Nanospheres: Facile Fabrication and Ultrafast Immobilization of Enzymes,Journal of Nanoscience and Nanotechnology, 2011, 11(12), 10844-10848.