基本介紹
- 中文名：陳曉嵐
- 畢業院校：鄭州大學
- 學位/學歷：博士
- 職稱：鄭州大學化學系教授
個人簡介,主要經歷,研究方向,研究領域,成果概述,科研項目,教學項目,獲獎情況,近期文章,出版專著,
個人簡介
陳曉嵐，博士，二級教授，鄭州大學特聘教授（學科骨幹），博士/碩士研究生導師，河南省高等學校教學名師；河南省高層次人才；河南省優秀創新型科技團隊主持人；英國Reading大學留學、美國南加州大學高級訪問學者；河南省化學會常務理事。主要從事有機合成方法學、有機磷化學、藥物化學及化學生物學等方面研究。主持完成國家自然科學基金項目多項，主持河南省傑出青年基金、河南省科技創新人才計畫、鄭州市科技領軍人才等項目；主持兩項國家級教學項目：國家雙語教學示範課程（2010質量工程：有機化學）和來華留學英語授課品牌課程（2013有機化學）。教學累計工作量超過7000，培養碩士研究生60餘人、博士研究生7人、博士後7人；以第一作者或通訊作者在“J. Am. Chem. Soc.”, “Green Chem.”, “Anal. Chem.”, “Chem. Commun.”, “Org. Lett.”, “Adv. Synth. Catal.”, “J. Org. Chem.”, “Bioconjugate Chem.”, “Ultrason Sonochem”等期刊發表科研論文130餘篇，其中SCI收錄論文110餘篇，總被他引次數達千餘次，其中JCR一區論文50餘篇，2019年發表ESI前百分之一高被引論文4篇，ESI前千分之一熱點論文3篇。
主要經歷
1983.9-1987.6，在鄭州大學化學系學習，獲得理學學士學位；1996.1-1997.1，在英國READING大學留學，主要從事天然產物化學研究；2001.9-2004.6，在鄭州大學化學系攻讀博士學位；2000-2005，鄭州大學化學系副教授；2005年至今，鄭州大學化學系教授；2006.8-2007.2，作為高級訪問學者，在美國南加州大學化學藥學系進行合作科研。
研究方向
化學生物與有機化學
研究領域
化學生物學、有機磷化學和天然藥物化學。近幾年來，系統開展了化學生物學、天然藥物化學、有機磷化學等方面的研究，在藥物結構改造和小分子與大分子相互作用方面開展了出色的工作, 合成了系列磷醯化黃酮化合物，並用螢光與ESI質譜法研究比較了黃酮及其磷醯化產物與蛋白的相互作用，並對改造的有機磷小分子化合物活性進行了研究，探討了磷醯化黃酮抗腫瘤作用及其機理。與美國南加州大學藥學化學系進行合作開展雙膦螢光標記物的合成和作用機理的研究。
成果概述
相關的研究成果已發表在“Bioconjugate Chem.”, “Anal. Chem.”,“Bioorg. Med. Chem.”, “Phosphorus, Sulfur Silicon Relat. Elem.”“J. Chin. Chem. Soc.”等國內外知名雜誌上，“Anal. Chem.”上相關內容被“Chem. Rev.”, “Nat. Prod. Rep.”, “J. Am. Soc. Mass Spectr.”等引用，其中Chem. Rev. 用專門的段落對此項有意義的工作給予介紹。已經發表國內外論文40餘篇，其中SCI 20餘篇。
科研項目
1、腫瘤靶位蛋白與磷醯化黃酮的弱相互作用研究，國家自然科學基金項目主持
2、磷醯化黃酮與蛋白弱相互作用和作用位點研究，省傑出青年基金項目項目主持
3、自由基加成串聯反應構建聚集誘導發光效應新型芳香氮雜稠環，國家自然科學基金（No. 22071222）
4、基於Click反應三氮唑橋連雙膦酸類化合物的設計、合成研究，國家自然科學基金（No. 21072178）
5、新型抗骨質疏鬆雙膦酸藥物設計、合成及工藝最佳化，河南省科技創新人才計畫（114200510023）
6、新型三氮唑雙膦酸衍生物的合成與活性研究，鄭州市科技領軍人才（112PLJRC359）
7、博士學科點專項科研基金(20124101110003)：基於Click反應1,2，3-三氮唑橋連新型雙膦酸類化合物的設計、合成研究，高等學校
8、河南省優秀創新型科技團隊主持：功能磷化合物設計合成及推廣套用 （編號：16008）
教學項目
1. 有機化學雙語教學，2010年國家雙語教學示範課程。
2. 2013來華留學英語授課品牌課程（有機化學）。
3. 2020河南省高等學校精品線上開放課程。
獲獎情況
1、聚維酮碘泡騰片的研製與開發，2000年河南省科技進步二等獎；
2、富馬酸福莫特羅原料藥的合成方法研究，2000年通過科學技術廳鑑定；
3、聚維酮碘泡騰片消毒殺菌劑的研製，2001年通過科學技術廳鑑定；
4、聯苯類化合物的合成方法、反應機理、相關化合物合成，2006年河南省科學技術進步獎一等獎。
近期文章
1.Chen Xiaolan, Yuan Jinwei, Zhang Shouren, Qu Lingbo, Zhao Yufen. Synthesis of the novel phosphoramidate derivatives of chrysin [J]. Phosphorus Sulfur Silicon Relat. Elem. 2009, (In print)
2. Yuan Jinwei, Chen Xiaolan, Qu Lingbo, Zhang Shouren, Lu Jiansha, Zhao Yufen. A Covenient Synthesis of Novel Phosphoramide Mustard Analogues of 2-arylquinolone. [J]. Phosphorus Sulfur and Silicon Relat. Elem. 2009, (in print)
3. Jin-Wei Yuan, Xiao-Lan Chen, Ling-Bo Qu, Zhi-Bo Qu, Ya-Dong Zhou, Yu-Fen Zhao. Synthesis of a Novel Type of Phosphoramidate Derivatives of 2-Arylquinolone [J]. J. Chin. Chem. Soc. 2009, 56(1): 51-58.
4. YUAN Jin-Wei, CHEN Xiao-Lan, QU Ling-Bo, ZHU Yu, HUANG Xiao-Ying, ZHAO Yu-Fen. Synthesis and Crystal Structure of 5, 7-dimethoxy-2-phenylquinoline-4-yl Phenyloxy (N-L-alanine ethyl ester) Phosphoramidate [J]. Chin. J. Struct. Chem. 2009, 28(4): 498-502.
5．Kashemirov B A, Bala J L F, Chen X L, Ebetino F H, Xia Z, Russell R G G, Coxon F P, Roelofs A J , Rogers M J, McKenna C E. Fluorescently Labeled Risedronate and Related Analogues: “ Magic Linker” Synthesis. Bioconjugate Chem., 2008, 19, 2308-2310.
6. Chen Xiaolan, Qu Lingbo, Li Wenfeng, Yuan Jinwei, Zhao Yufen. Synthesis of phosphoryl amino acids chrysin esters [J]. Phosphorus, Sulfur and Silicon Relat. Elem. 2008, 183, 603-609.
7. Qu Lingbo, Shi Xiaona, Chen Xiaolan, Fan Libo. Synthesis of Solanesyl Phosphonate [J]. Phosphorus, Sulfur and Silicon Relat. Elem. 2008, 183, 631-635.
8. Zhang Liuji, Qu Lingbo, Zhang Baojun, Chen Xiaolan and Zhao Yufen. A Convenient Method for the Synthesis of Cyclophosphamide Analogues [J]. Phosphorus, Sulfur and Silicon Relat. Elem. 2008, 183, 799-803.
9. Qu Lingbo, Wang Ling, Chen Xiaolan, Yuan Jinwei, Yang Ran, Li Ping. Study on the interaction of bovine serum albumin with puerarin and its derivatives [J]. Acta Chinica Sinica, 2007, 65, 2417-2422.
10. Chen Xiao-lan, Qu Ling-bo, Yuan Jin-wei, Zhao Yu-fen. Synthesis of a novel type of phosphates of puerarin [J]. J. Chin. Chem. Soc. 2007, 54, 583-585.
11. Chen Xiao-lan, Shi Xiaona, Qu Lingbo, Yuan Jinwei, Lu Jiansha, Zhao Yufen. Synthesis of novel phosphorylated daidzein derivatives and ESI investigation on their non-covalent complexes with lysozyme [J]. Chin. J. Chem. 2007, 25, 1008-1013.
12. Qu Lingbo, Chen Xiaolan, Yang Ran, Wang Ling, Zeng Huajin. Investigation of the interaction between isoflavonoids and bovine serum albumin by fluorescence spectroscopy [J]. Chin. J. Chem. 2007, 25, 1151-1155.
13. Yang Ran, Chen Xiaolan, Li Ping, Qu Lingbo. Interaction between lysozyme and three flavones by fluorescence spectroscopy [J]. Chem. J. of Chin. Univer. 2006, 27, 1673-1676.
14. Guo Yuhua, Chen Xiaolan, Zhang Ting, Qu Lingbo, Zhao Yufen, Yu Youzhu. Study on the non-covalent interaction of 7-hydroxy flavone and its phosphate with DNA by fluorescence method [J]. Spectrosc. Spect. Anal. 2006, 26, 475-479.
15. Yuan Jinwei, Chen Xiaolan, Qu Lingbo, Liang Ruiling, Tang Mingsheng, Zhao Yufen. A Novel Conformation Investigation on Newly Synthesized Compound of Diethyl Puerarin-7-yl Phosphate [J]. Chin. J.Struct. Chem. 2006, 25, 78-84.
16. Chen Xiaolan, Qu Lingbo, Guo Lei, Lu Jiansha, Liu Yan, Wu Jianli, Zhao Yufen Study on the reaction of salicylic acid with dialkyl phosphite by NMR and electrospray ionization mass spectrometry [J]. Chin. J. Chem. 2005, 23, 733-739.
17. Chen Xiaolan, Qu Lingbo, Zhao Yufen.Studies on the Reaction of Salicylic Acid with Dialkyl phosphite by Electrospray Ionization Mass Spectrometry [J]. Chin. J. Chem. 2005, 23, 733-739.
18. Chen Xiaolan, Qu Lingbo, Liu Hongxia, Zhao Yufen. Study on the Nature of Phosphorylated Chrysin-Protein Interactions Involved in Noncovalent Complex Formation by Electrospray Ionization Mass Spectroscopy [J]. Anal. Chem. 2004, 76, 211-217.
19. Chen Xiaolan, Qu Lingbo, Liu Hongxia, Zhao Yufen. Direct observation of non-covalent complexes formed through phosphorylated-flavonoid protein interaction by electrospray ionization mass spectroscopy [J]. Supramol. Chem. 2004, 16, 67-75.
20. Zhang Ting, Chen Xiao-lan, Qu Ling-bo, Wu Jian-li, Cui Ran, Zhao Yu-fen. Chrysin and its phosphate ester inh Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells ibit cell proliferation and induce apoptosis in Hela cells [J]. Bioorg. Med. Chem. 2004, 12, 6097-6105.
21. ChenXiaolan, Yu Youzhu, Qu Lingbo, Zhao Yufen.Synthesis of Novel Phosphoric Ester Flavone And Isoflavone By Atheron-Todd Reaction [J]. Synthetic Commun. 2004, 34, 493-499.
22. ChenXiaolan, Qu Lingbo,Lu Jiansha, Zhao Yufen.Ortho effects in bis-phosphoric esters of the dihydroxy- and aminohydroxybenzenes observed by ESI-MS/MS [J]. Mass Spectrom. Soc. Japan, 2004, 52, 63-67.
23. Yan Liu,Xiao-Lan Chen,*Xiao-Yun Li, Shan-Shan Zhu, Shi-Jun Li, Yan Song, Ling-Bo Qu, and Bing Yu*, 4CzIPN-tBu Catalyzed Proton-Coupled Electron Transfer for Photosynthesis of Phosphorylated N-Heteroaromatics.J. Am. Chem. Soc.,2021, 143(2), 964-972.
24. Kai Sun, Qi-Yan Lv*Xiao-Lan Chen,* Ling-Bo Qu, Bing Yu*, Recent Advances of Visible-Light-Mediated Organic Transformations in Water.Green Chem.,2021, 23(1), 232-248.
25. Hu-Lin Zhu,#Fan-Lin Zeng,#Xiao-Lan Chen,* Kai Sun, Hao-Cong Li, Xiao-Ya Yuan, Ling-Bo Qu, Bing Yu*, Acyl Radicals from α-Keto Acids: Metal-Free Visible-Light-Promoted Acylation of Heterocycles,Org. Lett.,2021, DOI: 10.1021/acs.orglett.1c00655
26. Fan-Lin Zeng,Xiao-Lan Chen,* Kai Sun,* Hu-Lin Zhu, Xiao-Ya Yuan, Yan Liu, Ling-Bo Qu, Yu-Fen Zhao, and Bing Yu*, Visible-Light-Induced Metal-Free Cascade Cyclization of N-arylpropiolamides to 3-Phosphorylated, Trifluoromethylated and Thiocyanated azaspiro[4.5]trienones.Org. Chem. Front.,2021, 8, 760-766
27. Ya-Feng Si,#Kai Sun,#Xiao-Lan Chen,* Xiao-Yang Fu, Yan Liu, Fan-Lin Zeng, Tao Shi, Ling-Bo Qu, Bing Yu*, Arylaminomethyl radical-initiated cascade annulation reaction of quinoxalin-2(1H)-ones catalyzed by recyclable photocatalyst perovskite.Org. Lett.,2020, 22(17), 6960-6965
28. Ya-Feng Si,Xiao-Lan Chen,* Xiao-Yang Fu, Kai Sun, Xiaojie Song, Ling-Bo Qu, and Bing Yu*, Divergent g-C3N4-catalyzed reactions of quinoxalin-2(1H)-ones with N-aryl glycines under visible light: Solvent-controlled hydroaminomethylation and annulation.ACS Sustainable Chem. Eng.,2020, 8(29), 10740-10746.
29. Xiao-Yun Li#, Yan Liu#,Xiao-Lan Chen,* Xin-Yuan Lu, Xing-Xing Liang, Shan-Shan Zhu, Chuan-Wan Wei, Ling-Bo Qu, and Bing Yu*, 6π-Electrocyclization in Water: Microwave-Assisted Synthesis of Polyheterocyclic-Fused Quinoline-2-Thiones.Green Chem.,2020, 22(14), 4445-4449.
30. Mehwish Hussain Muhammad,Xiao-Lan Chen,* Yan Liu, Tao Shi, Yuyu Peng, Lingbo Qu, and Bing Yu*, Recyclable Cu@C3N4-catalyzed hydroxylation of aryl boronic acids in water under visible-light: Synthesis of phenols under ambient condition and room temperature.ACS Sustainable Chem. Eng.,2020, 8, 7, 2682-2687.
31. Xiao-Ceng Liu,Xiao-Lan Chen,* Yan Liu, Kai Sun, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Visible-Light-Induced Metal-Free Synthesis of 2‑Phosphorylated Thioflavones in Water.ChemSusChem,2020, 13(2), 298-303.
32. Fan Gao, Kai Sun,*Xiao-Lan Chen,* Tao Shi, Xiao-Yun Li, Ling-Bo Qu, Yu-Fen Zhao, Bing Yu*，Visible-light-induced Phosphorylation of Imidazo-fused Heterocycles under Metal-free Conditions.J. Org. Chem.,2020, 85(22), 14744-14752.
33. Tao Shi,#Kai Sun,#Xiao-Lan Chen,* Zhao-Xin Zhang, Xian-Qiang Huang, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Recyclable Perovskite as Heterogeneous Photocatalyst for Aminomethylation of Imidazo-fused Heterocycles.Adv. Synth. Catal.,2020, 362(11), 2143-2149.
34. Shuai-Qi He,Xiao-Lan Chen,* Fan-Lin Zeng, Pei-Pei Lu, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Visible-Light-Promoted Oxidative Decarboxylation of Arylacetic Acid in Air: Metal-Free Synthesis of Aldehydes and Ketones at Room Temperature.Chin. Chem. Lett.,2020, 31(7), 1863-1867.
35. Yan Liu,#Shi-Jun Li,#Xiao-Lan Chen,* Lu-Lu Fan, Xiao-Yun Li, Shan-Shan Zhu, Ling-Bo Qu, and Bing Yu*, Mn(III)-Mediated Regioselective 6-endo-trig Radical Cyclization of o-Vinyl Arylisocyanides to Access 2-Functionalized Quinolines.Adv. Synth. Catal.,2020, 362(3), 688-694.
36. Kai Sun,Xiao-Lan Chen,* Yin-Li Zhang, Kai Li*, Xian-Qiang Huang, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Metal-free Sulfonyl Radical-initiated Cascade Cyclization to Access Sulfonated Indolo[1,2-a]quinolines.Chem. Commun.,2019, 55,12615-12618.
37. Yan Liu,Xiao-Lan Chen,* Kai Sun, Xiao-Yun Li, Fan-Lin Zeng, Xiao-Ceng Liu, Ling-Bo Qu, Yufen Zhao and Bing Yu*, Visible-Light Induced Radical Perfluoroalkylation/Cyclization Strategy to Access 2-Perfluoroalkylbenzothiazoles/benzoselenazoles by EDA Complex.Org. Lett.,2019, 21(11), 4019-4024.
38. Fan-Lin Zeng,Xiao-Lan Chen,* Shuai-Qi He, Kai Sun, Yan Liu, Rui Fu, Ling-Bo Qu, Yu-Fen Zhao, and Bing Yu*, Copper-Catalyzed One-Pot Three-Component Thioamination of 1,4-Naphthoquinone.Org. Chem. Front.,2019, 6, 1476-1480.
39. Junchao Wang,#Kai Sun,#Xiaolan Chen,* Tong Chen, Yan Liu, Lingbo Qu, Yufen Zhao, and Bing Yu*, An External-catalyst-free Trifluoromethylation/cyclization Strategy to Access Trifluoromethylated-Dihydroisoquinolinones/Indolines with Togni Reagent II.Org. Lett.,2019, 21, 1863-1867.
40. Kai Sun, Shi-Jun Li,Xiao-Lan Chen,* Yan Liu, Xian-Qiang Huang, Dong-Hui Wei*, Ling-Bo Qu, Yu-Fen Zhao, and Bing Yu*, Silver-Catalyzed Decarboxylative Radical Cascade Cyclization toward Benzimidazo[2,1-a]isoquinolin-6(5H)-ones.Chem. Commun.,2019, 55(19), 2861-2864.
41. Chunfeng Jing,Xiaolan Chen,* Kai Sun, Yongkang Yang, Tong Chen, Yan Liu, Lingbo Qu, Yufen Zhao, and Bing Yu*, Copper-Catalyzed C4-H Regioselective Phosphorylation/Trifluoromethylation of Free 1-Naphthylamines.Org. Lett.,2019, 21(2), 486-489.
42. Fan-Lin Zeng,#Kai Sun,#Xiao-Lan Chen,* Xiao-Ya Yuan, Shuai-Qi He, Yan Liu, Yu-Yu Peng, Ling-Bo Qu, Qi-Yan Lv, and Bing Yu*, Metal-Free Visible-Light Promoted Radical Cyclization to Access Perfluoroalkyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones and Indolo[2,1-a]isoquinolin-6(5H)-ones.Adv. Synth. Catal.,2019, 361, 5176-5181
43. Kai Sun#, Ya-Feng Si#,Xiao-Lan Chen,* Qi-Yan Lv, Nan Jiang, Shan-Shan Wang, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Silver-Catalyzed Radical Cascade Cyclization of Unactivated Alkenes towards Cyclopenta[c]quinolines.Adv. Synth. Catal.,2019, 361, 4483-4488
44. Xiao-Ceng Liu#, Kai Sun#,Xiao-Lan Chen,* Wen-Fei Wang, Yan Liu, Qian-Li Li, Yu-Yu Peng, Ling-Bo Qu and Bing Yu*, Visible-Light-Promoted Transition-Metal-Free Approach toward Phosphoryl-Substituted Dihydroisoquinolones via Cascade Phosphorylation/Cyclization of N-Allylbenzamides.Adv. Synth. Catal.,2019, 361, 3712-3717
45. Yin-Li Zhang,#Kai Sun,#Qi-Yan Lv,Xiao-Lan Chen,* Ling-Bo Qu, and Bing Yu*, Recent Applications of Radical Cascade Reaction in the Synthesis of Functionalized 1-Indenones.Chin. Chem. Lett.,2019, 30(7), 1361-1368.
46. Hao Hu,Xiaolan Chen*, Kai Sun, Junchao Wang, Yan Liu, Hui Liu, Bing Yu*, Yuanqiang Sun, Lingbo Qu, and Yufen Zhao.Silver-Catalyzed Radical Cascade Cyclization toward 1,5-/1,3-Dicarbonyl Heterocycles: An Atom-/Step-Economical Strategy Leading to Chromenopyridines and Isoxazole-/Pyrazole-Containing Chroman-4-Ones.Org. Lett.,2018, 20, 6157-6160.
47. Hao Hu,Xiaolan Chen*, Kai Sun, Junchao Wang, Yan Liu, Hui Liu, Bing Yu*, Yuanqiang Sun, Lingbo Qu, and Yufen Zhao, Silver-catalyzed decarboxylative cascade radical cyclization of tert-carboxylic acids and o-(allyloxy)arylaldehydes towards chroman-4-one derivatives.Org. Chem. Front.,2018, 5(20), 2925-2929.
48. Rui Li,Xiaolan Chen*, Shengkai Wei, Kai Sun, Lulu Fan, Yan Liu, Lingbo Qu, Yufen Zhao, and Bing Yu*. A visible-light-promoted metal-free strategy towards arylphosphonates: organic-dye-catalyzed phosphorylation of arylhydrazines with trialkylphosphites.Adv. Synth. Catal.2018, 360, 4807-4813.
49. Kai Sun,Xiaolan Chen*, Shi-Jun Li, Dong-Hui Wei, Xiao-Ceng Liu, Yin-Li Zhang, Yan Liu, Lu-Lu Fan, Ling-Bo Qu, Bing Yu*, Kai Li, Yuan-Qiang Sun, and Yu-Fen Zhao. Copper-Catalyzed Radical Cascade Cyclization to Access 3-Sulfonated Indenones with AIE Phenomenon.J. Org. Chem.,2018, 83, 14419-14430
50. Yan Liu,Xiao-Lan Chen*, Fan-Lin Zeng, Kai Sun, Chen Qu, Lu-Lu Fan, Zi-Long An, Rui Li, Chun-Feng Jing, Sheng-Kai Wei, Ling-Bo Qu, Bing Yu*, Yuan-Qiang Sun, and Yu-Fen Zhao, Phosphorus Radical-initiated Cascade Reaction to Access 2-Phosphoryl Substituted Quinoxalines,J. Org. Chem.,2018, 83, 11727-11735
51. Yang, Yongkang; Qu, Chen;Chen, Xiaolan; Sun, Kai; Qu, Lingbo; Bi, Wenzhu; Hu, Hao; Li, Rui; Jing, Chunfeng; Wei, Donghui; Wei, Shengkai; Sun, Yuanqiang; Liu, Hui; Zhao, Yufen, A Multiheteroatom [3,3]-Sigmatropic Rearrangement: Disproportionative Entries into 2-(N-Heteroaryl)methyl Phosphates and α-Keto Phosphates.Org. Lett.2017,19(21), 5864-5867.Highlighted by SynFacts (Synfacts 2019; 15(03): 0280)
52. Bi, Wen-Zhu; Sun, Kai; Qu, Chen; Chen, Xiao-Lan; Qu, Ling-Bo; Zhu, Shao-Hua; Li, Xu; Wu, Hai-Tao; Duan, Li-Kun; Zhao, Yu-Fen, A direct metal-free C2-H functionalization of quinoline N-oxides: a highly selective amination and alkylation strategy towards 2-substituted quinolines.Org. Chem. Front.,2017,4(8), 1595-1600.
53. Gang Li, Chunqi Jia, Qingliang Chen, Kai Sun, Feng Zhao, Hankui Wu, Zhiyong Wang, Yunhe Lv, Xiaolan Chen, Copper(I)-Catalyzed Dehydrogenative Amidation of Arenes Using Air as the Oxidant.Adv. Synth. Catal.2015, 357 (6), 1311-1315.
54. Chen, Xin; Li, Xu;Chen, Xiao-Lan; Qu, Ling-Bo; Chen, Jian-Yu; Sun, Kai; Liu, Zhi-Dong; Bi, Wen-Zhu; Xia, Ying-Ya; Wu, Hai-Tao; Zhao, Yu-Fen, A one-pot strategy to synthesize beta-ketophosphonates: silver/copper catalyzed direct oxyphosphorylation of alkynes with H-phosphonates and oxygen in the air.Chem. Commun.2015,51(18), 3846-3849
55. Zhao, Wei-Ming;Chen, Xiao-Lan;Yuan, Jin-Wei; Qu, Ling-Bo; Duan, Li-Kun; Zhao, Yu-Fen, Silver catalyzed decarboxylative direct C2-alkylation of benzothiazoles with carboxylic acids.Chem. Commun.2014,50(16), 2018-2020
56. Xiaolan, Chen; Li, Xu; Qu, Zhibo; Ke, Diandian; Qu, Lingbo; Duan, Likun; Mai, Wenpeng; Yuan, Jinwei; Chen, Jianyu; Zhao, Yufen, H-Phosphonate-Mediated Amination of Quinoline N-Oxides with Tertiary Amines: A Mild and Metal-Free Synthesis of 2-Dialkylaminoquinolines.Adv. Synth. Catal.2014,356(9), 1979-1985
57. Chen, Xiao-Lan; Li, Xu; Qu, Ling-Bo; Tang, Yu-Chun; Mai, Wen-Peng; Wei, Dong-Hui; Bi, Wen-Zhu; Duan, Li-Kun; Sun, Kai; Chen, Jian-Yu; Ke, Dian-Dian; Zhao, Yu-Fen, Peroxides as “Switches” of Dialkyl H-Phosphonate: Two Mild and Metal-Free Methods for Preparation of 2-Acylbenzothiazoles and Dialkyl Benzothiazol-2-ylphosphonates.J. Org. Chem.2014,79(17), 8407-8416
58. Chen, Xiao-Lan, Qu, Ling Bo, Zhang, Ting,Liu, Hong-Xia, Yu Fei, Yu, youzhu, Liao, Xincheng and Zhao, Yu-Fen. The nature of phosphorylated chrysin-protein interactions involved in noncovalent complex formation by electrospray ionization mass spectroscopy. Anal. Chem. 2004, 76 (1), 211-217.
出版專著
1. 醫用基礎化學（中文版）（主編），“十三五國家重點圖書出版規劃項目”“一帶一路背景下國際化臨床醫學叢書”，鄭州大學出版社，2021年
2. 醫用有機化學（英文版）（主編）， “十三五國家重點圖書出版規劃項目”“一帶一路背景下國際化臨床醫學叢書”，鄭州大學出版社，2021年
3. 有機化學學習指導（副主編）， 鄭州大學出版社，2008年
4. 有機化學實驗，中國醫藥科技出版社， 2015年
5. 有機化學學習指導，中國醫藥科技出版社，2015年
6. 生物有機質譜，鄭州大學出版社，2005年
7. 磷與生活，鄭州大學出版社，2005年
