關爽，男，博士，吉林大學食品科學與工程學院副教授，博士生導師。畢業於吉林大學，獲得藥理學博士學位，康奈爾大學訪問學者。主講《食品毒理學》、《食品免疫學》、《食品質量與安全》和《分子毒理學》（研究生課）。近年來主持或參加多項省部級科研課題及企業課題，以第一作者或通訊作者發表SCI論文約28篇。主要從事食品中有害物質毒性機理及安全評價研究、長白山特色資源綜合開發研究。
基本介紹
- 中文名：關爽
- 畢業院校：吉林大學
- 學位/學歷：博士
- 專業方向：食品毒理學
- 職務：博士生導師
教育經歷,工作經歷,學術任職,科研項目,發表論文,
教育經歷
1992-1996長春中醫學院 中藥系 學士
2007-2009吉林大學 軍需科技學院食品科學系 碩士
2009-2011吉林大學 畜牧獸醫學院基礎獸醫系 博士
工作經歷
2000-2009吉林亞泰藥業 新藥研發部 研究員
2012-2015吉林大學軍需科技學院食品質量與安全系 講師
2015-現在 吉林大學食品科學與工程學院 副教授
2013/03-2013/11美國康奈爾大學 農業與生命學院 食品系 訪問學者
2012-2016吉林大學 畜牧獸醫學院（動物科學學院）生物化學與分子生物學 博士後
學術任職
中國毒理學會會員、吉林省食品學會會員。
科研項目
1、主持國家自然科學國際合作項目子課題，抗沙門氏菌三型分泌系統天然化合物的篩選，2017-2021 149.75萬元；
2、主持十二五科技支撐項目子課題，林蛙骨補鈣製劑的研究及相關產品開發，2013-2017，80萬元；
3、主持國家教育部博士點基金項目（新教師類），3-氯-1，2-丙二醇抑制小鼠T淋巴細胞的毒性，2014-2017，4萬元；
4、主持博士後科學基金面上項目，苯並芘對小鼠T淋巴細胞的抑制作用，2013-2016，10萬元；
5、主持企業項目，林蛙多肽口服液技術開發（委託）項目，2013-2017，10萬；
6、參加吉林省科技廳重點項目，林蛙綜合深加工技術研究開發，2018-2020，80萬；
7、參加吉林省世行貸款項目，吉林省養殖魚類常見細菌性病害新藥篩選，2012-2014，25萬元；
8、參加吉林省科技廳重點項目，玉米汁中農藥殘留快速檢測及控制技術的研究，2012-2014，14萬元；
發表論文
[1]Cheng, BJ;Lu, J;Li, TJ;Meng, ZQ;Liu, MT;Guan Shuang(*).1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells. FOOD AND CHEMICAL TOXICOLOGY. 2018(122):143-150
[1] Lu J, Cheng B, Meng Z, Fang B, Li T, Sun M, Liu M,Guan Shuang(*). Alliin attenuates 1, 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway.Life Sci. 2018 Feb 15;195:19-24.
[2] Lu J, Cheng B, Fang B, Meng Z, Zheng Y, Tian X,Guan Shuang(*).Protective effects of allicin on 1,3-DCP-induced lipid metabolism disorder in HepG2 cells.Biomed Pharmacother. 2017 Dec;96:1411-1417.
[3] Lu J, Fang B, Zheng Y, Yu X, Huang G, Wang Z, Deng X,Guan Shuang(*).1,3-dichloro-2-propanol induced lipid accumulation in HepG2 cells through cAMP/protein kinase A and AMP-activated protein kinase pathways via Gi/o-coupled receptors.Environ Toxicol Pharmacol. 2017 Oct;55:118-126.
[4]Guan, Shuang; Zheng, Yiying; Yu, Xin; Lu, Jing. Ellagic acid protects against LPS-induced acute lung injury through inhibition of nuclear factor kappa B, proinflammatory cytokines and enhancement of interleukin-10. FOOD AND AGRICULTURAL IMMUNOLOGY,2017:28(6):1347-1361
[5]Guan, Shuang ;Yu, Xin; Fang, Baochen;Lu, JingThe toxicity of 3-monochloro-1,2-propanediol (+) to activated T cells in mice.AGRICULTURAL IMMUNOLOGY:28(4):612-624.
[6]Guan S, Huang Y, Feng Z, Xu L, Jin Y, Lu J. The toxic effects of benzo[a]pyrene on activated mouse T cells in vitro. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):117-123.
[7] Lu J, Wang Z, Ren M, Huang G, Fang B, Bu X, Liu Y,Guan Shuang(*).Antibacterial Effect of Gallic Acid against Aeromonas hydrophila and Aeromonas sobria Through Damaging Membrane Integrity.Curr Pharm Biotechnol. 2016;17(13):1153-1158.
[8] Jin Y, Wang Y, Zhao D, Ma S, Lu J,Guan Shuang(*).Pristimerin attenuates ovalbumin-induced allergic airway inflammation in mice.Immunopharmacol Immunotoxicol. 2016 Jun;38(3):221-7
[9] jing lu (#)，Ren Mengrou(#)，Fang Baochen，Huang Guoren，Zhang Shuang，Wang Yi，Deng Xuming(*)，Guan Shuang(*)，Nonalcoholic fatty liver disease induced by 13-week oral administration of 1,3-dichloro-2-propanol in C57BL/6J mice，Environ Toxicol Pharmacol，2015，39（3）：1115-1121
[10] jing lu (#)，Wang Zhenning，Ren Mengrou，Feng Guangxin，Ye Beining，Wang Yi，Fang Baochen，Deng Xuming，Guan Shuang(*)，A 4-week study of four 3-monochloropropane-1,2-diol diesters on lipid metabolism in C57BL/6J mice，Environ Toxicol Pharmacol，2015.9.01，40（2）：453-458
[11] Lu Jing，Huang, Guoren，Hu, Sizhuo，Wang, Zhenning，Guan, Shuang(*)，1,3-Dichloro-2-propanol induced hyperlipidemia in C57BL/6J mice via AMPK signaling pathway，Food and Chemical Toxicology，2014，64：403~409
[12] Jing Lu (#)，Guoren Huang(#)，Bocui Song，Zhenning Wang，Linli Xu，Shuonan Zhang，Shuang Guan(*)，The inhibition of 2,3-dichloro-1-Propanol on T cell in vitro and in vivo，International Immunopharmacology，2013，17（2）：321~328
[13] Jing Lu (#)，Guoren Huang，Zhenning Wang，Shuang Zhuang，Linli Xu，Bocui Song，Ying Xiong，Shuang Guan (*)，Tyrosol exhibits negative regulatory effects on LPS response and endotoxemia，Food and Chemical Toxicology，2013，62：172~178
[14] Bocui Song (#)，Shuang Guan(#)，Jing Lu (#)，Zhibao Chen，Guoren Huang，Gen Li，Ying Xiong，Shuang Zhang，Zhanpeng Yue(*)，Xuming Deng(*)，Suppressive effects of fisetin on mice T lymphocytes in vitro and in vivo，Journal of Surgical Research，2013.11.01，185（1）：399~409
[15] Ying Xiong(#)，Shuang Zhang(#)，Jing Lu (#)，Shicheng Sun，Bocui Song，Linli Xu，Zhenguo Yang(*)，Shuang Guan(*)，Investigation of effects of farrerol on suppression of murine T lymphocyte activation in vitro and in vivo，International Immunopharmacology，2013，16（2）：313~321
[16] Jing Lu (#)，Wenhui Qian(#)，Linli Xu，Guoren Huang，Wen Cong，Zhenning Wang，Xuming Deng，Dacheng Wang，Shuang Guan(*)，Phytochemical composition andtoxicity of an antioxidant extract from Pimpinella brachycarpa (Kom.) Nakai，Environmental Toxicology and Pharmacology，2012，34（2）：409~415
[17]Guan Shuang,Song Yu, Guo Weixiao, Chu Xiao, Zhang Xiaozhe, Wang Dacheng, Lu Jing, Deng Xuming. Immunosuppressive activity of tilmicosin on the immune responses in mice. Immunopharmacol Immunotoxicol, 33(2), 323-8, 2011.
[18]Shuang Guan,Yu Songa, Weixiao Guoa, Zhenguo Yang, Jing Lu,Xuming Deng. Immunosuppressive activity of Florfenicolon on the immune responses in mice. Immunological Investigations, 40(4), 356-66, 2011.
[19]Guan Shuang,Feng Haihua, Song Bocui, Guo Weixiao, Xiong Ying, Huang Guoren, Zhong Weiting, Huo Meixia, Chen Na,Lu, Jing, Deng Xuming. Salidroside attenuates LPS-induced pro-inflammatory cytokine responses and improves survival in murine endotoxemia. International immunopharmacology,11(12), 2194-2199, 2011.
[20]Shuang Guan,Lu Jing, Weixiao Guo, Xuming Deng. Adjuvant effects of salidroside from Rhodiola rosea L.on the immune responses to ovalbumin in mice. Immunopharmacology And Immunotoxicology, 33 (4), 738-743, 2011.
[21]Shuang Guan,Jing Lu, Wenhui Qian, Jingbo Liu, Xuming Deng. Florfenicol impairs the immune responses to vaccination against foot-and-mouth disease in mice. Immunopharmacology and immunotoxicology, 33 (4), 609-613, 2011.
[22]Guan S,Wang W, Lu J, Qian W, Huang G, Deng X, Wang X. Salidroside attenuates hydrogen peroxide-induced cell damage through a cAMP-dependent pathway. Molecules,16(4), 3371-9, 2011.
[23]Shuang Guan,Ying Xiong, Bocui Song, Yu Song , Dacheng Wang, Xiao Chu, Na Chen, Meixia Huo, Xuming Deng , Jing Lu. Protective Effects of salidroside from Rhodiola rosea on LPS-Induced Acute Lung Injury in Mice. Immunopharmacology and immunotoxicology, 34(4), 667-672, 2012.
[24]Lanan Wassy Soromou, Rongtao Li , Weixiao Guo , Weiting Zhong, Na Chen, Meixia Huo, Jing Lu,Shuang Guan*, Xuming Deng, Regulation of inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 murine macrophage by 7-O-methylnaringenin. Molecules. 2011.
[25]Shuang Guan,Jing Lu, Xue Shen, Wenhui Qian, Guoren Huang, Dacheng Wang, Xuming Deng, Guanghong Xie. Immunosuppressive activity of 8-gingerol on the immune responses in mice.Molecules,16(3), 2636-45, 2011.
[26]Guan Shuang,Lu Jing , Liu Jingbo, Guo Na, Shen Xue, Qian Wenhui, Deng Xuming. In vivo genotoxicity evaluation of crude extract from Ledum palustre and protective effects on cyclophosphamide-induced genotoxicity in mice. Lat. Am. J.Pharm, 30 (1), 112-118, 2010.
[27] Jing Lu, Wenhui Qian, Linli Xua, Guoren Huang, Wen Cong, Zhenning Wang, Xuming Deng, Dacheng Wang,Shuang Guan*. Phytochemical composition and toxicity of an antioxidant extract from Pimpinella brachycarpa (Kom.) Nakai. Environmental toxicology andpharmacology, 34, 409-415, 2012.
