錢兆生

錢兆生，男，博士，浙江師範大學副教授，碩士生導師。

基本介紹

• 中文名：錢兆生
• 職業：教師
• 畢業院校：南京大學化學化工學院
• 學位/學歷：博士
• 專業方向：化學
• 任職院校：浙江師範大學

研究方向

納米材料的光致發光性能及其感測套用研究和基於小分子有機化合物的分子開關的設計與合成

1. 新型發光納米材料的合成和性質研究，包括碳量子點、金銀銅納米簇及無機量子點等；
   基於新型納米螢光材料，設計與構建可逆的發光納米開關，用於磷酸酶、糖苷酶等水解酶活性定量檢測方法的建立。
   
2. 基於有機小分子化合物的分子開關的設計、合成及分析檢測套用，著重研究基於聚集誘導發光體系的磷光分子開關的設計與構建，並將其用於酪氨酸酶、硝基還原酶等氧化還原酶活性定量檢測方法的建立， 探索小分子光學探針在細胞和生物體內實時螢光示蹤功能。
   

個人經歷

2009.6月南京大學化學化工學院化學專業獲理學博士學位。

2009.8 -—至今 在浙江師範大學分析化學學科開展分析化學教學工作和相關科研工作。

2013-2014年由國家公派到美國華盛頓大學做訪問研究一年。

學術成果

承擔項目

主持一項國家自然科學基金面上項目和浙江省傑出青年基金；

主持完成國家自然科學基金青年基金和一項浙江省自然科學基金；

參與兩項國家自然科學基金面上項目和一項浙江省自然科學基金、

主持完成一項橫向項目

(1)功能化碳量子點螢光納米開關的設計、構建及在生物酶檢測中的套用 國家自然科學基金面上項目 2017-2020 主持

(2)聚集誘導磷光金屬納米簇的設計合成及基於時間門控發光技術的生物感測和成像套用 浙江省傑出青年基金 2018-2021 主持

(3)鋁形態水交換反應在碳基納米管作用下的動力學研究 國家自然科學基金青年科學基金 2011 -2013 主持

(4)採用密度泛函理論研究鈣在多聚鋁團簇形成中的作用 高露潔公司橫向項目2012 -2013 主持

(5)基於碳納米管和碳量子點的納米靶向藥物輸送體系的構建及生物學評價浙江省自然科學基金2013-2016 主持

(6)多層薄膜型拉曼器件的設計、構建及遠程調控國家自然科學基金面上項目 2012 – 2016 參與

(7)石墨烯-介孔氧化物對有機化合物的吸附、催化及分析檢測國家自然科學基金面上項目 2013 – 2017 參與

(8)碳量子點/氧化石墨烯螢光檢測平台的構建及其對生物標記物DNA分子的檢測 浙江省自然科學基金2013-2016 參與

(9)基於光誘導電子轉移機制的可控納米探針的構建及套用浙江省自然科學基金

學術論文

其論文已在JACS、ChemComm、Anal. Chem.、Biosens. Bioelectron.、Chem. Eur. J.、Nanoscale、J. Mater. Chem.、SNB、ACS Applied Mater. Interface等國際著名學術期刊上發表六十餘篇論文; 高被引論文有3篇，總引用次數超過1300次，被邀為JACS、Anal. Chem.、Biosens. Bioelectron.、SNB、Nanoscale、ACA、Talanta、Carbon等刊物的審稿人

(68) Hui Feng, Zhaosheng Qian*. Functional Carbon Quantum Dots: A Versatile Platform for Chemosensing and Biosensing.Chem. Rec., 2018, DOI: 10.10002/tcr/201700055. (Invited Review)(67) Guilin Chen, Hui Feng, Xiaogan Jiang, Jing Xu, Saifei Pan, Zhaosheng Qian*. Redox-controlled fluorescent nanoswitch based on reversible disulfide and its application in butyrylcholinesterase activity assay.Anal.Chem., 2018, 90, 1643-1651.(66) Jing Xu, Fengqi Zhou, Luxi Chen, Guilin Chen, Saifei Pan, Zhaosheng Qian, Hui Feng.* Thiol-triggered disaggregation-induced emission controlled by competitive coordination for acetylcholinesterase monitoring and inhibitor screening. Sens. Actuat. B-Chem, 2018, 255, 22-28.(65) Meizhi Zhao, Hui Feng, Xiaoxiao Zhang, Hang Ao, Zhaosheng Qian*. Bonding-Induced Emission of Silyl-Protected Copper Nanoclusters for Luminescence Turn-on Detection of Trace Water in Organic Solvents.Analyst, 2017, 142, 4613-4617. (Cover Paper)(64) Hang Ao, Hui Feng, Mengting Zhao, Meizhi Zhao, Jianrong Chen, Zhaosheng Qian.* Redox-triggered bonding-induced emission of thiol-functionalized gold nanoclusters for luminescence turn-on detection of molecular oxygen. ACS Sens., 2017, 2, 1692-1699.(63) Meizhi Zhao, Zhaosheng Qian(Coauthors), Mengting Zhong, Zhentian Chen, Hang Ao, Hui Feng.* Fabrication of stable and luminescent copper nanocluster-based AIE particles and their application in β-galactosidase activity assay. ACS Appl. Mater. Interfaces, 2017, 9, 32887-32895.(62) Meizhi Zhao, Hui Feng, Jiaonan Han, Hang Ao, Zhaosheng Qian*. Multi-stimuli responsive copper nanoclusters with bright red luminescence for quantifying acid phosphatase via redox-controlled luminescence switch. Anal Chim. Acta, 2017, 984, 202-210.(61) Yuanyuan Huang, Hui Feng, Weidong Liu, Shasha Zhang, Cong Tang, Jianrong Chen, Zhaosheng Qian,* Cation-driven luminescent self-assembled dots of copper nanoclusters with aggregation-induced emission for beta-galactosidase activity monitoring, J. Mater. Chem. B, 2017, 5, 5120-5127.(60) Cong Tang, Hui Feng, Yuanyuan Huang, Zhaosheng Qian*. Reversible Luminescent Nanoswitches Based on Aggregation-Induced Emission Enhancement of Silver nanoclusters for Luminescence Turn-on Assay of Inorganic Pyrophosphatase Activity. Anal. Chem. 2017, 89, 4994-5002. (59) Qian Sun, Siying Fang, Yafen Fang, Zhaosheng Qian, Hui Feng*. Fluorometric Detection of Cholestrol Based on beta-Cyclodextrin Functionalized Carbon Quantum Dots via Competitive Host-Guest Recognition.Talanta, 2017,167, 513-519.(58) Ao Hang, Hui Feng, Xiaolu Huang, Meizhi Zhao, Zhaosheng Qian*. A Reversible Fluorescence Nanoswitch Based on Dynamic Covalent B-O Bonds Using Functional Carbon Quantum Dots and Its Application for α-Glucosidase Activity Monitoring. J. Mater. Chem. C, 2017, 5, 2826-2832.(57) Cong Tang, Jin Zhou, Zhaosheng Qian(Co-first author), Yanyan Ma, Yuanyuan Huang, Hui Feng*. A Universal Fluorometric Assay Strategy for Glycosidases Based on Functional Carbon Quantum Dots: ß-Galactosidase Activity Detection in vitro and in Living Cells. J. Mater. Chem. B, 2017, 5, 1971-1979.(56) Cong Tang, Zhaosheng Qian(Co-first author), Yinjie Qian, Yuanyuan Huang, Meizhi Zhao, Hang Ao, Hui Feng*. A Fluorometric and Real-time Assay for α-Glucosidase Activity Through Supramolecular Self-assembly and Its Application for Inhibitor Screening. Sens. Actuat. B-Chem, 2017, 245, 282-289.(55) Hong Huang, Hua Li, Jiuju Feng, Hui Feng, Aijun Wang,* Zhaosheng Qian.* One-pot green synthesis of highly fluorescent glutathione-stabilized copper nanoclusters for Fe3+ sensing. Sens. Actuat. B Chem. 2017, 241, 292-297. 2015 – 2016(54) Aijun Wang, Hua Li, Hong Huang, Zhaosheng Qian, Jiuju Feng*. Fluorescent graphene-like carbon nitrides: synthesis, properties and applications, J. Mater. Chem. C, 2016, 4, 8146-8160.(53) Yuanyuan Huang, Hui Feng, Weidong Liu, Yingying Zhou, Cong Tang, Hang Ao, Meizhi Zhao, Guilin Chen, Jianrong Chen, Zhaosheng Qian*. Luminescent aggregated copper nanoclusters nanoswitch controlled by hydrophobic interaction for real-time monitoring of acid phosphatatse activity. Anal. Chem., 2016, 88, 11575-11583.(52) Fengqi Zhou, Hui Feng, Yafen Fang, Qian Sun, Zhaosheng Qian*. Phenylsulfonic acid functionalized carbon quantum dots based on biosensor for acetylcholinesterase activity monitoring and inhibitor screening. RSC Adv., 2016, 6, 105454-105460.(51) Yuanyuan Huang, Jin Zhou, Hui Feng, Jieyu Zheng, Hui-Min Ma, Weidong Liu, Cong Tang, Hang Ao, Meizhi Zhao, Zhaosheng Qian*. A dual-channel fluorescent chemosensor for discriminative detection of glutathione based on functionalized carbon quantum dots. Biosens. Bioelectron., 2016, 86, 748-755.(50) Hang Ao, Zhaosheng Qian (Co-first author), Yuyu Zhu, Meizhi Zhao, Cong Tang, Yuanyuan Huang, Hui Feng,* Aijun Wang. A fluorometric biosensor based on functional Au/Ag nanoclusters for real-time monitoring of tyrosinase activity. Biosens. Bioelectron., 2016, 83, 542-547.(49) Cong Tang, Zhaosheng Qian, Yuanyuan Huang, Jiamin Xu, Hang Ao, Meizhi Zhao, Jin Zhou, Jianrong Chen, Hui Feng.* A fluorometric assay for alkaline phosphatase activity based on beta-cyclodextrin-modified carbon quantum dots through host-guest recognition. Biosens. Bioelectron., 2016, 83, 274-280. (48) Yuanyuan Huang, Weidong Liu, Hui Feng, Yangting Ye, Cong Tang, Hang Ao, Meizhi Zhao, Guilin Chen, Jianrong Chen, Zhaosheng Qian.* Luminiescent nanoswitch based on organic-phase copper nanoclusters for sensitive detection of trace amount of water in organic solvents. Anal. Chem., 2016, 88, 7429-7434. http://www.x-mol.com/news/3512(47) Zhaosheng Qian, Lujing Chai, Cong Tang, Yuanyuan Huang, Jianrong Chen, Hui Feng.* A fluorometric assay for acetylcholinesterase activity and inhibitor screening with carbon quantum dots. Sens. Actuators B: Chemical, 2016, 222, 879-886. (46) Lujing Chai, Jin Zhou, Hui Feng, Cong Tang, Yuanyuan Huang, Zhaosheng Qian.* Functionalized carbon quantum dots with dopamine for tyrosinase activity monitoring and inhibitor screening: in vitro and intracellular investigation. ACS Appl. Mater. Interfaces, 2015, 7, 23564-23574. (45) Lujing Chai, Jin Zhou, Hui Feng, Jingjing Lin, Zhaosheng Qian.* A reversible fluorescence nanoswitch based carbon quantum dots nanoassembly for detection of pyrophosphate ion. Sens. Actuators B: Chemical, 2015, 220, 138-145. (44) Zhaosheng Qian, Lujing Chai, Qian Zhou, Yuanyuan Huang, Cong Tang, Jianrong Chen, Hui Feng.* Reversible fluorescent nanoswitch based on carbon quantum dots nanoassembly for real-time acid phosphatase activity monitoring. Anal. Chem., 2015, 87, 7332-7339. (43) Zhaosheng Qian, Lujing Chai, Cong Tang, Yuanyuan Huang, Jianrong Chen, Hui Feng.* Carbon quantum dots-based recyclable real-time fluorescence assay for alkaline phosphatase with adenosine triphosphate as substrate. Anal. Chem., 2015, 87, 2966-2973.(42) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Jianrong Chen, Hui Feng.* A fluorescent nanosensor based on graphene quantum dots-aptamer probe and graphene oxide for detection of lead(II) ion. Biosens. Bioelectron., 2015, 68, 225-230. (Highly cited paper)(41) Zhaosheng Qian, Lujing Chai, Yuanyuan Huang, Cong Tang, Jiajia Shen, Jianrong Chen, Hui Feng.* A real-time fluorescent assay for the detection of alkaline phosphatase activity based on carbon quantum dots. Biosens. Bioelectron., 2015, 68, 675-680. (40) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Jianrong Chen, Hui Feng.* Simultaneous detection of multiple DNA targets by integrating dual-color graphene quantum dots nanoprobes and carbon nanotubes. Chem. Eur. J., 2014, 20, 16065-16069.(39) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Jianrong Chen, Hui Feng.* Dual-colored graphene quantum dots-labeled nanoprobes/graphene oxide: functional carbon materials for respective and simultaneous detection of DNA and thrombin. Nanotechnology, 2014, 25, 415501. This paper was selected as IOPselect article by the journal. The Nanotechnology Lab Talk on this work is available at http://nanotechweb.org/cws/article/lab/58679.(38) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Jianrong Chen, Hui Feng.* DNA nanosensor based on biocompatible graphene quantum dots and carbon nanotubes. Biosens. Bioelectron., 2014, 60, 64-70. (37) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Jianrong Chen, Hui Feng.* Si-doped carbon quantum dots: a facile and general preparation strategy, bioimaging application, and multifunctional sensor. ACS Appl. Mater. & Interfaces, 2014, 6, 6797-6805. (Highly cited paper)(36) Zhaosheng Qian, Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Jianrong Chen, Hui Feng.* A universal fluorescence sensing strategy based on biocompatible graphene quantum dots and graphene oxide for detection of DNA. Nanoscale, 2014, 6, 5671-5674. (35) Xiaoyue Shan, Lujing Chai, Juanjuan Ma, Zhaosheng Qian, Jianrong Chen, Hui Feng.* B-doped carbon quantum dots as a sensitive fluorescence probe for hydrogen peroxide and glucose detection. Analyst, 2014, 139, 2322-2325. (34) Gangguo Zhu,* Wei Kong, Hui Feng, Zhaosheng Qian.* Synthesis of (Z)-1-thio- and (Z)-2-thio-alkenyl boronates via copper-catalyzed regiodivergent hydroboration of thioacetylenes: an experimental and theoretical study. J. Org. Chem., 2014, 79, 1786-1795.(33) Jin Zhou, Xiaoyue Shan, Juanjuan Ma, Yamin Gu, Zhaosheng Qian, Jianrong Chen, Hui Feng.* Facile synthesis of P-doped carbon quantum dots with highly efficient photoluminescence. RSC Adv., 2014, 4, 5465-5468. (32) Zhaosheng Qian,* Juanjuan Ma, Xiaoyue Shan, Hui Feng, Linxiang Shao, Jianrong Chen. Highly luminescent N-doped carbon quantum dots as an effective multifunctional fluorescence sensing platform. Chem. Eur. J., 2014, 29, 2254-2263. (Highly cited paper)(31) Zhaosheng Qian, Juanjuan Ma, Xiaoyue Shan, Linxiang Shao, Jin Zhou, Jianrong Chen, Hui Feng.* Surface functionalization of graphene quantum dots with small organic molecules from photoluminescence modulation to bioimaging applications: an experimental and theoretical investigation. RSC Adv., 2013, 3, 14571-14579. (30) Jin Zhou, Pei Lin, Juanjuan Ma, Xiaoyue Shan, Hui Feng,* Congcong Chen, Jianrong Chen, Zhaosheng Qian.* Facile synthesis of halogenated carbon quantum dots as an important intermediate for surface modification. RSC Adv., 2013, 3, 9625-9628. (29) Zhaosheng Qian, Jin Zhou, Juanjuan Ma, Xiaoyue Shan, Congcong Chen, Jianrong Chen, Hui Feng.* The visible photoluminescence mechanism of oxidized multi-walled carbon nanotubes: an experimental and theoretical investigation. J. Mater. Chem. C, 2013, 22, 22113-22119. (28)Zhaosheng Qian, Juanjuan Ma, Jin Zhou, Pei Lin, Congcong Chen, Jianrong Chen, Hui Feng.* Facile synthesis of halogenated multi-walled carbon nanotubes and their unusual photoluminescence. J. Mater. Chem., 2012, 22, 22113-22119. (27)Zhaosheng Qian*, Chen Wang, Gaohui Du, Jin Zhou, Congcong Chen, Juanjuan Ma, Jianrong Chen, Hui Feng. Multicolour fluorescent graphene oxide by cutting carbon nanotubes upon oxidation. CrystEngComm, 2012, 14, 4976-4979. (26) Jin Zhou, Chen Wang, Zhaosheng Qian*, Congcong Chen, Juanjuan Ma, Gaohui Du, Jianrong Chen, Hui Feng. Highly efficient fluorescent multi-walled carbon nanotubes functionalized with diamines and amides. J. Mater. Chem., 2012, 22, 11912-11914.(25) Zhaosheng Qian*, Congcong chen, Jianrong Chen, Lichun Kong, Chen Wang, Jin Zhou, Hui Feng. Unusual visible luminescence of aluminium polyoxocations in aqueous solution.Chem. Commun., 2011, 47, 12652-12654.(24) Zhaosheng Qian*, Jin Zhou, Jianrong Chen, Chen Wang, Congcong Chen, Hui Feng. Nanosized N-doped graphene oxide with visible fluorescence in water for metal ions sensing. J. Mater. Chem., 2011, 21, 17635-17637.(23) Jinjin Chen, Keming Fang, Yuqing Miao, Zhaosheng Qian, Jianrong Chen.* Study on adsorption of Co(II) and Ni(II) onto mesoporous Ti-containing MCM-48. J. Nanosci. Nanotech., 2011, 11, 6796-6803.(22) Zhaosheng Qian*, Chen Wang, Hui Feng, Congcong Chen, Jin Zhou, Jianrong Chen. Well dispersed single-walled carbon nanotubes with strong visible fluorescence in water for metal ions sensing. Chem. Commun., 2011, 47, 7167-7169.(21) Xiaoyan Jin, Wenjing Yang, Zhaosheng Qian, Yingjie Wang, Shuping Bi.* DFT study on the interaction between monomeric aluminium and chloride ion in aqueous solution. Dalton Trans., 2011, 40, 5052-5058.(20) Hui Feng, Zhaosheng Qian*, Chen Wang, Congcong Chen, Jianrong Chen. Tuning the energy barrier of water exchange reactions on Al(III) by interaction with the single-walled carbon nanotubes. Dalton Trans., 2011, 40, 4183-4189.(19) Hui Feng, Zhaosheng Qian*, Chen Wang, Congcong Chen, Jianrong Chen. Theoretical investigation of formation mechanism of bipyridyl molecule on Ni(111) surface: implication for synthesis of N-doped graphene from pyridine. Phys. Chem. Chem. Phys., 2011, 13, 6053-6058.(18) Xiaoyan Jin, Zhaosheng Qian, Bangmei Lu, Shuping Bi.* DFT study on the mechanism for the substitution of F- into Al(III) complexes in aqueous solution. Dalton Trans., 2011, 40, 567-572.(17) Xiaoyan Jin, Zhaosheng Qian, Bangmei Lu, Wenjing Yang, Shuping Bi.* Density Functional Theory Study on Aqueous Aluminum-Fluoride Complexes: Exploration of the Intrinsic Relationship between Water-Exchange Rate Constants and Structural Parameters for Monomer Aluminum Complexes. Environ. Sci. Technol., 2011, 45, 288-293.(16) Xiaoyan Jin, Zhaosheng Qian, Bangmei Lu, Shuping Bi.* DFT study on the mechanism for the subsitution of F- into Al complexes in aqueous solution. Dalton Trans., 2010, 40, 567-572.(15) Zhaosheng Qian,* Hui Feng, Chen Wang, Jianrong Chen. Theoretical investigation of the dissociative interchange (Id) mechanism for water exchange on magnesium(II) in aqueous solution. Inorg. Chem. Acta, 2010, 363, 3627-3631.(14) Wenjing Yang, Zhaosheng Qian, Bangmei Lu, Jing Zhang, Shuping Bi.* Density functional theory study and kinetic analysis of the formation mechanism of Al30O8(OH)56(H2O)2618+ (Al30) in aqueous solution. Geochim. Cosmochim. Acta, 2010, 74, 1220-1229.(13) Zhaosheng Qian, Hui Feng, Wenjing Yang, Xiaoyan Jin, Yingjie Wang, Shuping Bi.* Density functional studies of the structural characteristics, 27Al NMR chemical shifts and water-exchange reactions of Al30O8(OH)24(H2O)2618+ (Al30) in aqueous solution. Geochim. Cosmochim. Acta, 2010, 74, 1230-1237.(12) Zhaosheng Qian, Hui Feng, Zhenjiang Zhang, Wenjing Yang, Yingjie Wang, Shuping Bi.* Theoretical Exploration of water exchange mechanism of the polyoxocation GaO4Al12(OH)24(H2O)127+ in aqueous solution. Geochim. Cosmochim. Acta, 2009, 73, 1588-1596.(11) Zhaosheng Qian, Hui Feng, Zhejiang Zhang, Wenjing Yang, Jing Jin, Qiang Miao, Lina He, Shuping Bi.* Theoretical investigation on the dimerization of the deprontonated aquo ion of Al(III) in water. Dalton Trans., 2009, 521-529.(10) Zhaosheng Qian, Hui Feng, Wenjing Yang, Zhejiang Zhang, Yingjie Wang, Shuping Bi.* Theoretical investigation of dehydration of aquated Al(OH)2+ species in aqueous solution. Dalton Trans., 2009, 1554-1558.(9) Zhaosheng Qian, Hui Feng, Lina He, Wenjing Yang, Shuping Bi.* Assessment of the accuracy of theoretical methods for calculating 27Al nuclear magnetic resonance shielding tensor of aquated aluminum species. J. Phys. Chem. A, 2009, 113, 5138-5143.(8) Zhaosheng Qian, Hui Feng, Wenjing Yang, Xiaoyan Jin, Shuping Bi.* Density functional study of the water exchange reaction of the polyoxocation GeO4Al12(OH)24(H2O)128+ (K-GeAl12) in aqueous solution. Dalton Trans., 2009, 8013-8017.(7) Zhaosheng Qian, Hui Feng, Xiaoyan jin, Wenjing Yang, Yingjie Wang, Shuping Bi.* Density functional investigation of the water exchange reaction on the gibbsite surface. Environ. Sci. Technol., 2009, 43, 9281-9286.(6) Wenjing Yang, Zhaosheng Qian, Qiang Miao, Yingjie Wang, Shuping Bi.* Density functional theory study of the aluminium(III) hydrolysis in aqueous solution. Phys. Chem. Chem. Phys., 2009, 11, 2396-2401.(5) Zhaosheng Qian, Hui Feng, Wenjing Yang, Shuping Bi.* Theoretical investigation of water exchange on the nanometer-sized polyoxocation AlO4Al12(OH)24(H2O)127+ (Keggin-Al13) in aqueous solution. J. Am. Chem. Soc., 2008, 130, 14402-14403.(4) Zhaosheng Qian, Hui Feng, Wenjing Yang, Qiang Miao, Lina He, Shuping Bi.* Supermolecule density functional calculations on the water exchange of aquated Al(III) species in aqueous solution. Chem. Commun., 2008, 3930-3932.(3) 錢兆生, 周傳健, 李根, 曹玲華.* 糖基修飾的胺基酸類化合物的合成. 有機化學, 2008, 28, 467-471.(2) 田添, 曹玲華,* 錢兆生. N-糖基-Nˊ-醯氨基硫脲及其環合產物的合成. 有機化學, 2007, 27, 744-748.(1) 錢兆生, 周傳健, 曹玲華.* 糖基異硫氰酸酯的合成及其套用. 化學進展

教學成果

目前指導研究生七名，已畢業研究生六名，指導研究生曾獲研究生國家獎學金、耿兒獎學金、學校科學創新一等獎和二等獎、浙江省優秀研究生學位論文培育基金、校級優秀研究生學位論文培育基金等。

榮譽獎項

博士論文曾獲2011年度全國優秀博士學位論文提名論文。