金毅，博士，雲南大學化學科學與工程學院副教授。
基本介紹
- 中文名：金毅
- 國籍：中國
- 畢業院校：中國科學院上海藥物研究所
- 學位/學歷：博士
- 專業方向：藥物化學
- 職務：雲南大學碩士生導師
人物經歷,教學課程,研究領域,學術成果,
人物經歷
2006獲中國科學院上海藥物研究所博士學位；
1998年獲蘭州大學化學系學士學位；
2016-2017，美國密西根大學安娜堡分校 藥學院 訪問學者；
2007-2008，中國科學院昆明植物所博士後研究
2006至今，雲南大學任教。
2006至今，雲南大學任教。
教學課程
主講生物製藥與生物技術、生藥學。
研究領域
藥物化學，有機合成化學，藥物設計學
學術成果
論文、專著
1. Xi, L.; Wu, D.; Zhu, H.; Zhang, C.; Jin, Y.*; Lin, J. Improved and Large-Scale Synthesis of N-methyl-D-aspartic Acid. Current Organic Synthesis 2015, 12, 197-201.
2. Zhang, J.; Wu, D.; Jiang, K.; Zhang, D.; Zheng, X.; Wan, C.; Zhu, H.; Xie, X.; Jin, Y.*; Lin, J. Preparation, spectroscopy and molecular modelling studies of the inclusion complex of cordycepin with cyclodextrins. Carbohydrate Research 2015, 406, 55-64.
3. Gao, R.; Jin, Y.; Yang, Q.; Sun, B.; Lin, J. Study of stability and drug-excipient compatibility of estradiol and pharmaceutical excipients. Journal Of Thermal Analysis And Calorimetry 2015, 120, 839-845.
4. Ye, Q.; Li, X.; Jin, Y.*; Yu, J.; Chang, Q.; Jiang, J.; Yan, C.; Li, J.; Liu, W. 1-(2,6-Difluorobenzoyl)-Crystal Structures and Catalytic activity of dirhodium(II) Complexes with Axial Picoline Ligandsenyl)urea. Inorganica Chimica Acta 2015, 4(8), 540-546
5. An, X.; Liu, H.; Xu, Z.; Jin, Y.; Peng, X.; Yao, Y.; Geng, M.; Long, Y. Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization. Bioorganic & Medicinal Chemistry Letters 2015, 25, 708-716.
6. Jiang, K.; Dai, X.; Li, K.; Wu, D.; Zhang, J.; Jin, Y.*; Lin, J. Synthesis and In-Vitro Cytotoxicity of (E)-N,2,3-Triarylacrylamide Derivativeances in the inhibitors of Janus Kinase. Medicinal Chemistry 2014, 4(8), 540-546
8. Zhang, J.; Li, K.; Cong, Y.; Pu, S.; Zhu, H.; Xie, X.; Jin, Y.* Lin, J. Preparation, characterisation and bioactivity evaluation of the inclusion complex formed between picoplatin and gamma-cyclodextrin. Carbohydrate Research 2014, 396, 54-61.
9. Zhi, Y.; Gao, L.; Jin, Y.; Tang, C.; Li, J.; Li, J.; Long, Y. 4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B. Bioorganic & Medicinal Chemistry 2014, 22, 3670-3683.
10. Xiao, C.; Li, K.; Huang, R.; He, G.; Zhang, J.; Zhu, L.; Yang, Q.; Jiang, K.; Jin, Y.* Lin, J. Investigation of inclusion complex of Epothilone A with cyclodextrins. Carbohydrate Polymers 2014, 102, 297-305.
11. Fan, J.; Yang, Q.; He, G.; Xie, X.; Zhu, H.; Jin, Y.*s as Analogs of Combretastatin A-4. Medicinal Chemistry 2015, 11.
7. Jiang, J.; Wang, X.; Zhang, Y.; Jin, Y.* Lin, J. AdvLin, J. Efficient and regioselective synthesis of bicyclic pyrrolidones or bicyclic pyridones by cyclocondensation of heterocyclic ketene aminals with nitro-phenylpropiolate. Rsc Advances 2014, 4, 28852-28855.
科研項目、成果和專利
1. Design, synthesis and biological activity evaluation of tumor inhibitors based on the structure of VEGFR-2 kinase protein (主持國家自然科學基金Nos:20902079)
2. Design, synthesis and antitumor activity of a new type of novel double ring and the tubulin polymerization inhibitor (主持國家自然科學基金Nos:21262043)
