鄭啟凡

鄭啟凡，女，博士，廈門大學醫學院助理教授，碩士生導師。

基本介紹

  • 中文名：鄭啟凡
  • 畢業院校：哈爾濱醫科大學
  • 學位/學歷：博士
  • 職業：教師
  • 專業方向：醫學免疫學、腫瘤免疫
  • 任職院校：廈門大學醫學院
個人經歷,學習經歷,工作經歷,研究方向,學術成果,代表成果,科研課題,論文,

個人經歷

學習經歷

2005～2013 哈爾濱醫科大學基礎醫學八年制 醫學博士

工作經歷

2014～2015 廈門大學醫學院 科研實習；
2015～2017 廈門大學生物學博士後流動站 博士後；
2017～至今 廈門大學醫學院 助理教授。

研究方向

主要開展腫瘤及免疫細胞分化的表觀遺傳學研究，聚焦腫瘤發生髮展的組蛋白修飾以及腫瘤免疫中的表觀遺傳學修飾分子機制。近幾年的研究證實了表觀調控因子menin通過印跡非依賴途徑促進肝細胞肝癌IGF2基因的表達，進而導致肝細胞肝癌惡性進展的表觀遺傳學分子機制；闡明了TrxG與PcG家族成員在單核細胞向巨噬細胞的分化及功能活化中的重要生物學功能及其表觀遺傳學機制等。部分研究成果發表在BBA-Gene Regulatory Mechanisms, FEBS J等SCI雜誌。

學術成果

代表成果

  1. Zheng QF, Xu B*, Wang HM, Ding LH, Liu JY, Zhu LY, Qiu H, Zhang L, Ni GY, Ye J, Gao SB and Jin GH*. Epigenetic alterations contribute to promoter activity of imprinting gene IGF2. BBA -Gene Regulatory Mechanisms. 2018,1861(2):117-124；
  2. Zheng QF, Wang HM, Wang ZF, Liu JY, Zhang Q, Zhang L, Lu YH, You H and Jin GH*. Reprogramming of histone methylation controls the differentiation of monocytes into macrophages. The FEBS Journal. 2017,284(9):1309-1323;
  3. Zheng QF, Han L, Dong YC, Tian J, Huang W, Liu ZY, Jia XZ, Jiang T, Zhang JN, Li X*, Kang CS*, Ren H*. JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2 /STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma. Neuro-Oncology. 2014,16(9):1229-1243;
  4. Gao SB, Zheng QF, Xu B, Pan CB, Li KL, Zhao Y, Zheng QL, Lin X, Xue LX and Jin GH*. EZH2 represses target genes through H3K27-dependent and H3K27-independent mechanisms in hepatocellular carcinoma. Molecular Cancer Research. 2014, 12: 1388-1397;
  5. Gao SB, Xu B, Ding LH, Zheng QL, Zhang L, Zheng QF, Li SH, Feng ZJ, Wei J, Yin ZY, Hua X, Jin GH*. The functional and mechanistic relatedness of the EZH2 and menin in hepatocellular carcinoma. Journal of Hepatology. 2014, 61(4): 832-839;
  6. Hu MH, Zheng QF, Jia XZ, Li Y, Dong YC, Wang CY, Lin QY, Zhang FY, Zhao RB, Xu HW, Zhou JH, Yuan HP, Zhang WH, Ren H*. Neuroprotection effect of interleukin (IL)-17 secreted by reactive astrocytes is emerged from a high-level IL-17-containing environment during acute neuroinflammation. Clin Exp Immunol. 2014, 175(2): 268-284;
  7. Li X*, Wang Q, Zheng Y, Lv S, Ning S, Sun J, Huang T, Zheng Q, Ren H, Xu J, Wang X, Li Y*. Prioritizing human cancer microRNAs based on genes' functional consistency between microRNA and cancer. Nucleic Acids Research. 2011, 39(22):e153.

科研課題

  1. 國家自然科學基金青年科學基金項目，81502444，肝癌中印記基因IGF2轉錄激活的H3K4組蛋白甲基化修飾機制，2016/01-2018/12，在研，主持；
  2. 中國博士後科學基金面上資助（一等），2015M580563，肝癌中組蛋白修飾調控IGF2轉錄激活的表觀遺傳學機制，2015/11-2017/03，已結題，主持。

論文

  1. Zheng QF, Xu B*, Wang HM, Ding LH, Liu JY, Zhu LY, Qiu H, Zhang L, Ni GY, Ye J, Gao SB and Jin GH*. Epigenetic alterations contribute to promoter activity of imprinting gene IGF2. BBA -Gene Regulatory Mechanisms. 2018,1861(2)
  2. Zheng QF, Wang HM, Wang ZF, Liu JY, Zhang Q, Zhang L, Lu YH, You H and Jin GH*. Reprogramming of histone methylation controls the differentiation of monocytes into macrophages. The FEBS Journal. 2017,284(9)
  3. Zheng QF, Han L, Dong YC, Tian J, Huang W, Liu ZY, Jia XZ, Jiang T, Zhang JN, Li X*, Kang CS*, Ren H*. JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2 /STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma. Neuro-Oncology. 2014,16(9):1229-1243 DOI
  4. Gao SB, Zheng QF, Xu B, Pan CB, Li KL, Zhao Y, Zheng QL, Lin X, Xue LX and Jin GH*. EZH2 represses target genes through H3K27-dependent and H3K27-independent mechanisms in hepatocellular carcinoma. Molecular Cancer Research. 2014, 12
  5. Gao SB, Xu B, Ding LH, Zheng QL, Zhang L, Zheng QF, Li SH, Feng ZJ, Wei J, Yin ZY, Hua X, Jin GH*. The functional and mechanistic relatedness of the EZH2 and menin in hepatocellular carcinoma. Journal of Hepatology. 2014, 61(4)
  6. Hu MH, Zheng QF, Jia XZ, Li Y, Dong YC, Wang CY, Lin QY, Zhang FY, Zhao RB, Xu HW, Zhou JH, Yuan HP, Zhang WH, Ren H*. Neuroprotection effect of interleukin (IL)-17 secreted by reactive astrocytes is emerged from a high-level IL-17-containing environment during acute neuroinflammation. Clin Exp Immunol. 2014, 175(2)
  7. Li X*, Wang Q, Zheng Y, Lv S, Ning S, Sun J, Huang T, Zheng Q, Ren H, Xu J, Wang X, Li Y*. Prioritizing human cancer microRNAs based on genes' functional consistency between microRNA and cancer. Nucleic Acids Research. 2011, 39(22)

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