鄧慧華,男,1968年5月生,博士,東南大學生物科學與醫學工程學院教授,博士生導師。
基本介紹
- 中文名:鄧慧華
- 學位/學歷:博士
- 職業:教師
- 專業方向:頭髮新型生物標記的開發
- 任職院校:東南大學生物科學與醫學工程學院
人物經歷,研究方向,學術成果,
人物經歷
1998年於東南大學分子與生物分子電子學教育部重點實驗室(吳健雄實驗室)獲得工學博士學位。1999年1月至2000年3月在日本Tohuku University(東北大學)從事博士後研究工作。2000年12月至2006年3月在日本產業技術綜合研究所(AIST)進行納米功能合成技術在分子感測器研究中的套用。
研究方向
頭髮新型生物標記的開發、驗證和套用,兒童發展的社會生物機制,動作意圖理解
學術成果
主持或參與973、863、國家自然基金等國家級、省部級科研項目多項,以及NIH國際合作項目,獲2000 中國高校科學技術獎自然科學獎二等獎、2001年全國百篇優秀博士論文獎、2005 年日本納米技術國際博覽會技術創新獎、2008年教育部新世紀優秀人才支持計畫。自2012年以來,通過單胺類神經遞質,以及HPA軸、HPG軸和內源性大麻素系統的激素評估兒童青少年的社會情緒能力發展。開發頭髮新型生物標記的檢測技術,驗證這些新型生物標記的可靠性,探索其在青少年的抑鬱、焦慮等負性情緒、工作應激等慢性應激、創傷後應激障礙症狀,以及社會情緒能力的評估等方面的套用。拓展套用於兒童發展領域,嘗試探究社會情緒能力的神經生理基礎及其發展的生物社會機制。自2012年發表學術論文四十餘篇,其中SCI(SSCI)論文四十餘篇,CSSCI(CSCD)論文二十餘篇。
2012-2018年科研項目
1. 參與中國國家自然科學研究基金國際合作項目《愛滋病相關歧視與愛滋病臨床指標的關聯及影響機制研究》,2017-2020(進行中)
2.參與 美國國家健康研究院資助項目《愛滋病告知對患者臨床指標影響機制的佇列研究告知項目二期》, 2017-2019
3. 參與 江蘇省社科基金一般項目《工作倦怠的綜合評價及其預防措施:基於工作要求-資源模型視角》, 2015-2017
4. 主持 教育部人文社科基金十三五規劃項目《工作應激及其積累與頭髮皮質醇的關聯 》,2016-2018
5. 參與 科技部基礎項目973一級子課題《高級腦機互動中動作意圖與情感判讀》2015-2019
6. 主持 教育部人文社科基金十二五規劃項目《青少年抑鬱、焦慮與頭髮皮質醇的關聯研究 》, 2012-2014
7. 參與 哈佛大學-紐約大學-賓夕法尼亞大學-東南大學國際合作項目《南京都市青少年和南京都市寶貝項目》,2006-至今
2012-2018成果(*通訊作者)
生物標記檢測技術開發
1. Liuxi Chu, Yan Wu, Cailing Duan, Jin Yang, Haoran Yang, Ying Xie,Quan Zhang, Shan Qiao, Xiaoming Li, Zhiyong Shen, Huihua Deng, Simultaneous quantitation of zidovudine, efavirenz, lopinavir and ritonavir in human hair by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry, J Chromatography B, 2018,
2. Yan Wu, Jin Yang, Cailing Duan, Shenghuo Chen, Shan Qiao, Xiaoming Li, Huihua Deng*, Simultaneous determination of antiretroviral drugs in human hair by liquid chromatography-electrospray ionization-tandem mass spectrometry, J Chromatography B, 2018,
3. Quan Zhang, Zheng Chen, Shenghuo Chen, Tian Yu, Juxia Wang, Weiwen Wang, Huihua Deng*,Correlations of hair level with salivary level in cortisol and cortisone,Life Sciences, 2018,
4. Christopher Mwanza, Zheng Chen, Quan Zhang, Weiwen Wang, Huihua Deng*, Simultaneous HPLC-APCI-MS/MS quantification of endogenous cannabinoids and glucocorticoids in hair, J Chromatography B, 2016,
5. Tian Yu, Hang Xu, Weiwen Wang, Shifei Li, Zheng Chen, Huihua Deng*, Validation of hair corticosterone in mice and rats as an endogenous biomarker of chronic stress, J Chromatography B, 2015
6. Zheng Chen, Jifeng Li, Guanyi Xu, Jin Yang, Jing Zhang, Huihua Deng*,Simultaneous measurements of cortisol and cortisone in urine and hair for the assessment of 11-hydroxysteroid dehydrogenaseactivity among methadone maintenance treatment patients with LC-ESI-MS/MS, J. Chromatography B, 2014
7. Jing Zhang, Jifeng Li, Youyun Xu, Jin Yang, Zheng Chen,Huihua Deng*, Characteristics of novel hair-based biomarker for the activity assessment of 11β-hydroxysteroid dehydrogenase, Clinica Chimica Acta, 2013
Zheng Chen, Jifeng Li, Jing Zhang, Xue Xing, Wei Gao, Zuhong Lu, Huihua Deng*,8. Simultaneous determination of hair cortisol, cortisone and DHEAS with liquid chromatography–electrospray ionization-tandem mass spectrometry in negative mode,J. Chromatography B, 2013,
9. Wei Gao, Tobias Stalder, Paul Foley, Manfred Rauh, Huihua Deng, Clemens Kirschbaum, Quantitative analysis of steroid hormones in human hair using a column-switching LC-APCI-MS/MS assay, J. Chromatography B, 2013
10. Xue Xing, Zheng Chen, Jifeng Li, Jing Zhang, Huihua Deng*, Zuhong Lu,Study on dissolution mechanism of cortisol and cortisone from hair matrix with liquid chromatography-tandem mass spectrometry, Clinica Chimica Acta, 2013
11. Jifeng Li, Qiaozhen Xie, Wei Gao, Youyun Xu, Shuang Wang, Huihua Deng*, Zuhong Lu,Time course of cortisol loss in hair segments under immersion in hot water,Clinica Chimica Acta, 2012,
12.鄧慧華、皋偉、陸祖宏、謝巧珍,毛髮中氫化可的松的提取和檢測方法,
激素與應激行為
13. Youyun Xu, Jifeng Li, Qiaozhen Xie, Huihua Deng*, Hair cortisol levels and symptoms of anxiety and depression in Chinese adolescents: Comparison between incarcerated and community populations, PsyCH Journal,2018
14. Xingliang Qi*, Shuang Ji, Jing Zhang, Judith K. Sluiter, Huihua Deng, The impact of emotional labor on chronic stress accumulation among female teachers, International Archives of Occupational and Environmental Health, 2017,
15. Quan Zhang, Zheng Chen, Shenghuo Chen, Youyun Xu, Huihua Deng*, Intraindividual stability of cortisol and cortisone and the ratio of cortisol to cortisone in saliva, urine and hair, Steroids, 2017,
16. Jin Yang, Jifeng Li, Guanyi Xu, Jing Zhang, Zheng Chen, Huihua Deng*, Zuhong Lu, Elevated hair cortisollevelsamong heroin addicts in methadone maintenance treatment compared to controls, PLOS ONE, 2016,
17. Xingliang Qi, Yapeng Liu, Jing Zhang, Shuang Ji, Judith K. Sluiter, Renlai Zhou, Huihua Deng*, Relationship between work strain, subjective need for recovery and hair cortisol among kindergarten teachers,International Archives of Occupational and Environmental Health, 2015,
18. Weiwen Wang*, Huihua Deng, Li Wang, Chengqi Cao, Hang Xu, Jianxin Zhang,Hair cortisone level is associated with PTSD's dysphoric arousal symptoms in highly traumatized Chinese females, J Affective Disorder, 2015,
19. Li Wang, Chengqi Cao, Weiwen Wang*, Hang Xu, Jianxin Zhang, Huihua Deng, Xiangyang Zhang, Linking hair cortisol levels to phenotypic heterogeneity of posttraumatic stress symptoms in highly traumatized Chinese women, Biological Psychiatry, 2015,
20. Xingliang Qi, Jing Zhang, Yapeng Liu, Shuang Ji, Zheng Chen, Judith K. Sluiter, Huihua Deng*, Relationship between effort-reward imbalance and hair cortisol among kindergarten teachers,Journal of Psychosomatic Research, 2014,
21. Wei Gao, Ping Zhong, Qiaozhen Xie, Haiyang Wang, Jing Jin, Huihua Deng*, Zuhong Lu, Temporal features of elevated hair cortisol among earthquake survivors, Psychophysiology, 2014
22. 張權,陳崝,王瑋文,鄧慧華*,創傷後應激障礙患者的HPA軸功能變化的時間序列特徵,心理科學進展,2016,
23. 張權,鄧慧華*,頭髮皮質醇濃度測定在應激相關疾病研究中的套用,中國心理衛生雜誌,2017,
兒童發展的生物社會機制
24. Yapeng Liu, Xinyin Chen, Siman Zhao, Niobe Way, Hirokazu Yoshikawa, Guangzhen Zhang, Zongbao Liang, Minghao Zhang, Xiaoyan Ke, Zuhong Lu, Huihua Deng*, Interactions between MAOA Gene Polymorphism and Maternal Parenting in Predicting Externalizing and Internalizing Behavioral Problems and Social Competence among Chinese Children: Evidence to Genetic Vulnerability or Differential Susceptibility Model? Infants Child Development, 2017,
25. Yapeng Liu, Guangzhen Zhang, Minghao Zhang, Zongbao Liang, Zuhong Lu and Huihua Deng*, Contributions of 5-HTTLPR Polymorphism to Child Internalizing Problems across Toddlerhood to Childhood in Han Chinese,Journal of Nanoscience and Nanotechnology, 2016
26. M Zhang*, X Chen, H Deng, LuZ, During infancy, orienting and gaze aversion serve as major self-regulatory mechanisms and play an important role in the development of deliberate self-regulation, Infant Behavior & Development, 2014,
27. Niobe Way*, Sumie Okazaki, Jing Zhao, Joanna J. Kim, Xinyin Chen, Hirokazu Yoshikawa, Yueming Jia and Huihua Deng, Social and Emotional Parenting: Mothering in a Changing Chinese Society, Asian American Journal of Psychology2013,
28. Taveeshi Gupta, Niobe Way*, Rebecca K. McGill, Diane Hughes, Carlos Santos, Yueming Jia, Hirokazu Yoshikawa, Xinyin Chen, Huihua Deng, Gender-typed behaviors in friendships and well-being: a cross-cultural study of Chinese and American boys, Journal of Research on Adolescence, 2013,
29. Tony Tan*, Linda A Camras, Huihua Deng,Minghao Zhang, Zuhong Lu. Parenting Styles and Preschool-age Adopted Chinese Girls' Behavioral Adjustment, Early Childhood Research Quarterly (ECRQ), 2012,
30. Minghao Zhang, Xinyin Chen*, Niobe Way, Hirokazu Yoshikawa, Huihua Deng, Xiaoyan Ke, Weiwei Yu, Ping Chen, Chuan He, Xia Chi, Zuhong Lu*, The Association between Infants’ Self-Regulatory Behavior and MAOA Gene Polymorphism, Developmental Science, 2011,
31. 方燕玉,齊星亮,季爽,顧菲菲,鄧慧華*,新三元付出-回報失衡模型框架下護士的付出、回報和過度投入與工作倦怠的關係,心理科學,2018,
32. 劉亞鵬, 鄧慧華*,張光珍,梁宗保, 陸祖宏, 父母養育壓力對兒童問題行為的影響:養育方式的中介作用,心理發展與教育,2015
33. 張印平,劉亞鵬,朱穎,張光珍,梁宗保,鄧慧華*,陸祖宏,親子依戀與父母養育方式的關係,套用心理學, 2015,
34. 楊瑾, 李季峰, 許關怡, 鄧慧華*,陸祖宏, 美沙酮維持治療者感覺尋求、自我感知壓力與心理健康的關係, 現代預防醫學, 2015,
35. 楊瑾,李季峰,許關怡,鄧慧華*,陸祖宏, 南京市社區美沙酮維持治療者人際關係敏感水平及影響因素分析, 中華預防醫學雜誌, 2015,
36. 朱穎,劉亞鵬,張光珍,張印平,梁宗保,葉明,鄧慧華*,兒童早期氣質對學步期父母養育方式的影響,心理發展與教育,2014
37. 許有雲,周霄,劉亞鵬, 鄧慧華*, 學校氛圍對青少年抑鬱的影響:自我控制的中介作用, 中國臨床心理學雜誌,2014 ,
38. 齊星亮,劉亞鵬,季爽,鄭然,張彥,鄧慧華*,中文版恢復需要量表信效度的初步研究,中國臨床心理學雜誌,2014 ,
39. 劉亞鵬, 汪志鵬, 張明浩, 陳平, 張光珍, 梁宗保, 鄧慧華*, 陸祖宏, MAOA-uVNTR多態性與學步期兒童外顯問題行為的關係, 中國臨床心理學雜誌,2014 ,
40. 張光珍,梁宗保*,鄧慧華, 陸祖宏, 學校氛圍與青少年早期學校適應:一項三年的追蹤研究, 心理發展與教育,2014,
41.鄧慧華陳慧 鐘萍 梁宗保 張光珍,青少年早期自尊與抑鬱的交叉滯後分析:檢驗易感模型和創傷模型,心理發展與教育,2013,
42. 梁宗保 張光珍 鄧慧華宋 媛 鄭文明, 學前兒童努力控制的發展軌跡與父母養育的關係:一項多水平分析, 心理學報,2013,
43.鄧慧華陳慧 鐘萍 唐鑫 梁宗保,青少年早期抑鬱的自尊緩解假設的追蹤研究,心理發展與教育,2013,
44. 陳慧 鄧慧華* 梁宗保 鐘萍 張光珍 陸祖宏,青少年早期的抑鬱與生活事件的交叉滯後分析,中國臨床心理學雜誌,2012,
45. 於珩 張明浩 陳欣銀 鄧慧華陸祖宏*,嬰兒氣質的實驗室觀察與母親報告的一致性及其影響因素研究,心理發展與教育,2011