基本介紹
- 中文名稱：鄧大君
- 教學職稱：教授
- 執業地點：北京大學腫瘤醫院
擅長領域,教育經歷,工作經歷,社會兼職,主要學術成就,發表論文,
擅長領域
腫瘤病因學和表觀遺傳學研究；
p16基因甲基化可預測上皮異型增生癌變並揭示其作用機制。
教育經歷
1986年中國協和醫科大學研究生畢業。
工作經歷
2001年美國維吉尼亞大學高級訪問學者。
社會兼職
中國抗癌協會病因專業委員會主任委員
主要學術成就
承擔國家自然科學基金、973、863等項目，在《Genome Biology》、《EBioMedicine》、《Nucl Acids Res》、《PNAS》、《Clin Cancer Res》等刊物上發表論文，獲7項國內/國際發明專利授權。
發表論文
1. CH Cui, Y Gan, LK Gu, J Wilson, ZL Liu, BZ Zhang*, DJ Deng*. P16-specific methylation by engineered zinc finger methyltransferase inactivates gene transcription and promotes cancer metastasis. Genome Biology, 2015, 16:252
2. HW Liu#, XW Liu#, GY Dong#, Y Liu, J Zhou, Y Gao, XY Liu, LK Gu, Z Sun*, DJ Deng*. P16 Methylation as an Early Predictor for Cancer Development from Oral Epithelial Dysplasia: A Double-Blind Multicentre Prospective Study. EBioMedicine, 2015, 2(5): 432-437
3. Z Liu#, J Zhang#, Y Gao#, L Pei, J Zhou, LK Gu, L Zhang, B Zhu, N Hattori, J Ji, Y Yuasa, WH Kim, T Ushijima, H Shi*, DJ Deng *. Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis. Clinical Cancer Research, 2014, 20(17):4598-4612
4. LZ Qin, XB Liu, Q Sun, Z Fan, D Xia, G Ding, HL Ong, D Adams, WA Gahl, C Zheng, S Qi, L Jin, C Zhang, LK Gu, J He, DJ Deng*, IS Ambudkar*, SL Wang*. Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(33):13434-9
5. J Cao, J Zhou, Y Gao, LK Gu, HX Meng, HW Liu*, DJ Deng*. Methylation of p16 CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study. Clinical Cancer Research 15: 5178-83, 2009
6. Y Sun, DJ Deng*, WC You, H Bai, L Zhang, J Zhou, L Shen, JL Ma, YQ Xie, JY Li*. Methylation of p16 CpG islands associated with malignant transformation of gastric dysplasia in a population-based study. Clinical Cancer Research 10: 5087-93, 2004
7. DJ Deng*, GR Deng, MF Smith, J Zhou, HJ Xin, SM Powell, YY LU. Simultaneous detection of CpG methylation and single nucleotide polymorphism by denaturing high performance liquid chromatography. Nucleic Acids Research 30: 13E, 2002
