鄒向宏,男,博士,首都師範大學教授。學術研究協會會員, 從事細胞調亡和癌症以及分子藥物學研究。
基本介紹
- 中文名:鄒向宏
- 職稱:首都師範大學教授
- 學歷:博士研究生
- 性別:男
人物簡介,工作經歷,資助項目,主要貢獻,研究方向,
人物簡介
男,博士,首都師範大學教授。
工作經歷
1991 華中農業大學微生物棵說翻專業 獲理學碩士學位
1995-1997 中國農業大學 承擔碩謎講棗員士、博士生“分子系統學和微生物進化”全部課程,“細菌遺傳學”部分內容:分子細菌與植物的相互關係
1998-1999 阿拉巴馬大學,口腔醫學院淚連匙嚷(Birmingham, USA)博士後, 從事口腔微生物和口腔生物學研究
2000-2001 依利諾伊大學醫學院(Chicago, USA)助理樂阿艱研究員(Research associate),從事細胞調亡和癌症研究
2001-2002 依利諾伊大學醫學院(Chicago, USA)講師(Instructor), 從事細胞調亡和癌症研究
2003-現在催估 依利諾伊大學醫學院(Chicago, USA)助理研究教授(Assistant Research Professor/Assistant Professor), 從事細胞調亡和癌症以及分子藥物學研究
2005-現在 首都師範大學生命科學學院, 特聘教授, 從事細胞調亡和癌症以及分子藥物學研究
學術研究協會會員
American Association for Cancer Research
American Society for Microbiology
資助項目
2002-2005 Role of CDC25A in transformation and breast cancer development. (No. BC010557)美國國防部 .(CDMRP/Breast Cancer Research Program).
共主持人(Co-Investigator)
2002-2007 Role of G1-Cdks in immortalization and oncogenesis. (No.CA100204) 美國衛生部(NIH/R01), 共主持人(Co-Investigator)
2006-2008 Cdk4在Ink4a/Arf/p53失活相關的乳腺癌抹舟詢中的作用(30571006)
國家自然科學基金, 主持人
2005-2010 Role of Cdks in B cell lymphoma (R01 CA113579)
美國衛生部(NIH/R01), 主持人
主要貢獻
(部分)
Zou X, F Li and H Chen (1997). Characteristics of different plasmids in Rhizobium huakuii strains. Current Microbiology, 35: 215-220.
Zou X, Feng X, Chen W and Li F (1998). Biological behavior of plasmid in Rhizobium sp.strain S25 from Tephrosia candida. Plasmid, 40:158-163.·Caufield P, Y Li and Zou X (1999). Evidence for clonality among African-derived strains of S. mutans. J. Dent. Res. 78, 290.
Zou X, P Caufield, Y Li and F Qi .(2001). Complete nucleotide sequence and characterization ofpUA140, a cryptic plasmid from Streptococcus mutans. Plasmid, 46:77-85
Zou X, Tsutsui T, Ray D, Blomquist JF, Ichijo H, Ucker DS and Kiyokawa H. (2001). The cell cycle-regulatory CDC25A phosphatase inhibits Apoptosis Signal-regulating Kinase 1 . Mol. Cell. Biol. 21:4818-4828.
Zou X, Ray D, Aziyu A, Christov-Tzelkov K, Boiko A, Gudkov A, Kiyokawa H.(2002). Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence. Genes Dev. 16: 2923- 2934.
Jirawatnotai S, Aziyu A, Osmundson E, Moons DS, Zou X, Kineman R, Kiyokawa H.(2004). Cdk4 is indispensable specifically for postnatal proliferation of somato/lactotrophsof the murine pituitary. JBC 279(49):51100-51106.
Ray D, Terao Y,Donzelli M,Ghosh AK,Tsutsui T, Zou X, Varga J, Draetta GF, Kiyokawa H. (2005). The Smad3-mediated signaling of TGF-beta facilitates proteasome-dependent degradation of Cdc25A. Mol. Cell. Biol. 25(8): 3338-3347.
Li Y , Caufield P, Qi F and Zou X. IS1216 and IS199, two functional insertion sequences (IS) in Streptococcus mutans isolated from human dental caries. (submitted).
Aziyu A, Hirai H, Kiyokawa H, Christov-Tzelkov K, Zou X. Cdk4 is required for developmental and oncogenic proliferation of p53-deficient cells. (submitted)
Sandoval R, Xue J, Tian X, Barrett K, Pilkinton M, Ucker DS, Raychaudhuri P, Kineman RD, Luque RM, Baida G, Zou X et al(2006). A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes. Exp Cell Res. 1;312(13):2465-75.
研究方向
Zou X etc. (2005). Induction of Cellular Senescence by Cdk4 Disruption:
A Prospective Tool for Tumor Suppression and Regression. (International Patent, ID
No: CW06/NPU)
擅長微生物發酵,曾獨立設計與創建兩個小型微生物發酵工廠
主要貢獻
(部分)
Zou X, F Li and H Chen (1997). Characteristics of different plasmids in Rhizobium huakuii strains. Current Microbiology, 35: 215-220.
Zou X, Feng X, Chen W and Li F (1998). Biological behavior of plasmid in Rhizobium sp.strain S25 from Tephrosia candida. Plasmid, 40:158-163.·Caufield P, Y Li and Zou X (1999). Evidence for clonality among African-derived strains of S. mutans. J. Dent. Res. 78, 290.
Zou X, P Caufield, Y Li and F Qi .(2001). Complete nucleotide sequence and characterization ofpUA140, a cryptic plasmid from Streptococcus mutans. Plasmid, 46:77-85
Zou X, Tsutsui T, Ray D, Blomquist JF, Ichijo H, Ucker DS and Kiyokawa H. (2001). The cell cycle-regulatory CDC25A phosphatase inhibits Apoptosis Signal-regulating Kinase 1 . Mol. Cell. Biol. 21:4818-4828.
Zou X, Ray D, Aziyu A, Christov-Tzelkov K, Boiko A, Gudkov A, Kiyokawa H.(2002). Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence. Genes Dev. 16: 2923- 2934.
Jirawatnotai S, Aziyu A, Osmundson E, Moons DS, Zou X, Kineman R, Kiyokawa H.(2004). Cdk4 is indispensable specifically for postnatal proliferation of somato/lactotrophsof the murine pituitary. JBC 279(49):51100-51106.
Ray D, Terao Y,Donzelli M,Ghosh AK,Tsutsui T, Zou X, Varga J, Draetta GF, Kiyokawa H. (2005). The Smad3-mediated signaling of TGF-beta facilitates proteasome-dependent degradation of Cdc25A. Mol. Cell. Biol. 25(8): 3338-3347.
Li Y , Caufield P, Qi F and Zou X. IS1216 and IS199, two functional insertion sequences (IS) in Streptococcus mutans isolated from human dental caries. (submitted).
Aziyu A, Hirai H, Kiyokawa H, Christov-Tzelkov K, Zou X. Cdk4 is required for developmental and oncogenic proliferation of p53-deficient cells. (submitted)
Sandoval R, Xue J, Tian X, Barrett K, Pilkinton M, Ucker DS, Raychaudhuri P, Kineman RD, Luque RM, Baida G, Zou X et al(2006). A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes. Exp Cell Res. 1;312(13):2465-75.
研究方向
Zou X etc. (2005). Induction of Cellular Senescence by Cdk4 Disruption:
A Prospective Tool for Tumor Suppression and Regression. (International Patent, ID
No: CW06/NPU)
擅長微生物發酵,曾獨立設計與創建兩個小型微生物發酵工廠