郭曉奎

郭曉奎

郭曉奎，微生物學教授。1964年生， 1986年畢業於四川大學獲理學學士學位，1991年於哈爾濱醫科大學獲醫學碩士學位，2000年於日本獲博士學位。分別於1994年和1996年晉升為副教授和教授。現任上海交通大學基礎醫學院副院長；上海交通大學基礎醫學教學實驗中心主任、臨床微生物學教研室主任；上海交通大學醫學科學研究院分子微生物學研究室主任。 國家高等學校教學名師，全國優秀教師，全國“十一五”教育科研先進個人，國家精品課程和國家精品共享課程“醫學微生物學”負責人，上海市優秀教學團隊負責人，“十一五”和“十二五”國家本科和研究生規劃教材“病原生物學”主編。關於鉤端螺旋體和益生菌安全性的研究處於國際領先地位

基本介紹

  • 中文名：郭曉奎
  • 出生日期：1964年
  • 職業：教授
  • 畢業院校：四川大學
個人簡介,主要兼職,研究方向,個人榮譽,綜合獎勵,教學研究獎勵,科學研究獎勵,其他獎勵,個人作品,主要著作和教材,部分論文,

個人簡介

郭曉奎，微生物學教授、博士生導師。現任上海交通大學基礎醫學院副院長；上海交通大學醫學院基礎醫學教學實驗中心主任、病原生物學教研室/臨床微生物學教研室主任；上海交通大學醫學科學研究院分子微生物學課題組PI。 國家高等學校教學名師,全國優秀教師，全國“十一五”教育科研先進個人，國家精品課程“醫學微生物學”負責人，上海市優秀教學團隊負責人，“十一五”和“十二五”國家規劃教材“病原生物學”主編。關於鉤端螺旋體和益生菌安全性的研究處於國際領先地位

主要兼職

中華預防醫學會微生態學分會副主任委員；中國微生物學會普及與教育工作委員會副主任委員；上海市微生物學會副理事長；上海市食品微生物學專業委員會主任委員； 上海市預防醫學會微生態學專業委員會主任委員； 上海市食品學會乳酸菌專業委員會副主任委員； 上海市醫學病毒學專科學會副主任委員； 中國醫學微生物學和免疫學專業委員會委員； 中國人獸共患病病原專業委員會委員； 《中國人獸共患病學報》副主編； 《國際生物製品學雜誌》副主編；《中國微生態學雜誌》編委； 《微生物與感染雜誌》編委； 《上海交通大學學報》（醫學版）編委; 《醫學參考報》（微生物學與免疫學）編委

研究方向

耐藥細菌控制技術研究
鉤端螺旋體分子生物學研究。
人體微生態學與益生菌安全性研究

個人榮譽

綜合獎勵

2011年獲國家級教學名師稱號
2010年獲全國教育科研先進工作者
2010年上海交通大學校長獎
2009年獲全國優秀教師稱號
2009年獲上海市教學名師稱號
2009年被評為上海市優秀學科帶頭人
2008年被評為上海交通大學醫學院“優秀教師”
2007年獲教育部寶鋼教育基金會“優秀教師獎”
2005年獲上海第二醫科大學首屆“校長獎”
1996年獲教育部霍英東基金會“青年教師獎”
1996年獲黑龍江省“青年科技獎”
1995年獲哈爾濱醫科大學”優秀青年教師”

教學研究獎勵

2010年領導的“病原生物學”團隊被評為上海市優秀教學團隊
2010年獲全國“十一五”教育科研優秀成果特等獎
2009年主編的“病原生物學”獲上海交通大學優秀教材一等獎
2009年獲上海市教學成果三等獎
2008年獲上海交通大學教學成果特等獎
2008年主持的“病原生物學”被評為“雙語示範課程”
2007年領導的“病原生物學”團隊被評為上海交通大學優秀教學團隊
2005年主持的“醫學微生物學”課程被評為國家精品課程
2003年主講的“醫學微生物學”課程被評為上海市精品課程
1996年獲黑龍江省教學成果二等獎。

科學研究獎勵

鉤端螺旋體全基因組測序和部分功能的研究 2004年上海市科技進步獎二等獎。
肺炎克雷伯桿菌的分子生物學研究及在院內感染監控中的套用獲1999年黑龍江省醫藥衛生科學技術進步一等獎和1999年獲黑龍江省科學技術進步三等獎。
克隆識別技術研究及其套用獲1997年獲黑龍江省教育委員會科學技術進步一等獎和1997年獲黑龍江省科學技術進步三等獎。
住院患者肺炎桿菌感染的分子流行病學研究獲1997年黑龍江省教育委員會科學技術進步一等獎。
淋病的病原學鑑別診斷的研究獲1995年哈爾濱市科學技術進步三等獎。
柯薩奇病毒性心肌炎診斷的研究獲1994年黑龍江省醫藥衛生科學技術進步一等獎。
淋球菌基因探針的製備及哈市淋球分子流行病學研究獲1994年黑龍江省科學技術進步二等獎。
綠膿桿菌質粒圖譜血清型和耐藥譜的研究獲1993年黑龍江省科學技術進步三等獎。

其他獎勵

2010年所領導的“病原生物學教研室”獲全國教育科研先進集體
2009年所領導的“病原生物學教研室”獲“上海市教育系統先進集體”稱號
2009年所領導的“病原生物學教研室”獲“上海市文明班組”稱號
2008年所領導的“病原生物學教研室”獲“上海交通大學醫學院文明班組”稱號

個人作品

主要著作和教材

郭曉奎（主編）病原生物學-醫學微生物學 科學出版社 2012
郭曉奎（主編）病原生物學-醫學寄生蟲學 科學出版社 2012
郭曉奎（主審）醫學微生物學實驗教程 人民衛生出版社 2011
郭曉奎（主編）醫學微生物學實驗技術 人民衛生出版社 2010
郭曉奎(主編) 感染與優生優育 第二軍醫大學出版社 上海 2009
郭曉奎（主編）病原生物學教育教學 第二軍醫大學出版社 上海 2008
郭曉奎（主編）病原生物學綱要（英文版） 科學出版社 2008
郭曉奎（主編）病原生物學 科學出版社 2007
郭曉奎(主編) 細胞微生物學 第二軍醫大學出版社 上海 2004
郭曉奎(主編) 克隆識別 北京醫科大學和中國協和大學聯合出版社 北京1994

部分論文

  1. Zhang ZY, Sun ZQ, Wang ZL, Hu HR, Wen ZL, Song YZ, Zhao JW, Wang HH, Guo XK*, Zhang SL. Identification and pathogenicity analysis of a novel non-tuberculous mycobacterium clinical isolate with nine-antibiotic resistance.Clin Microbiol Infect.2013; 19(1):91-6.
  2. Zhang SM,Qiu J,Tian F,Guo XK,Zhang FQ,Huang QFCorrosion behavior of pure titanium in the presence of Actinomyces naeslundii.J Mater Sci Mater Med.2013 Feb 21. [Epub ahead of print]
  3. Zelin Cui, Yuhua Zhou, Hong Li, Yan Zhang, Shenjie Tang, Xiaokui Guo. Complex sputum microbial composition in patients with pulmonary tuberculosis. BMC microbiology. 2012, 12:276
  4. Zelin Cui, WenbinShen, Zheng Wang, Haotian Zhang, Rao Me, Yanchun Wang, LingbingZeng, Yongzhang Zhu, Jinhong Qin, Ping He, and Xiao-Kui Guo*. Complete Genome Sequence of Klebsiellapneumoniae phage JD001. Journal of Virology. 2012, 86(24):13843.
  5. Zelin Cui, Zhen Song, Yanchun Wang, LingbingZeng, WenbinShen, Zheng Wang, Qingtian Li, Ping He, Jinhong Qin, and Xiao-Kui Guo*. Complete Genome Sequence of wide host-range Staphylococcus aureus phage JD007. Journal of Virology. 2012, 86(24):13880.
  6. Zhou Y, Tao J, Yu H, Ni JJ, Zeng LB, Teng QH, Kim K, Zhao GP, Guo XK*, and Yao YF. Hcp-family proteins secreted via type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells. Infection and Immunity, 2012 , 80(3):1243-51
  7. Zhang ZY, Liu C, Zhu YZ, Wei YX, Tian F, Zhao GP, Guo XK*. Safety assessment of Lactobacillus plantarumJDM1 based on the complete genome. Int J Food Microbiol. 2012 Feb 1;153(1-2):166-70. Epub 2011 Nov 12.
  8. Wei YX, Zhang ZY, Liu C, Malakar PK, Guo XK*.Safety assessment of Bifidobacterium longum JDM301 based on complete genome sequences.World J Gastroenterol. 2012 Feb 7;18(5):479-88.
  9. Zhang MM, Zhao JW, Sun ZQ, Liu J, Guo XK, Liu WD, Zhang SL. Identification of RD5-encoded Mycobacterium tuberculosis proteins as B-cell antigens used for serodiagnosis of tuberculosis. Clin Dev Immunol. 2012; 2012:738043.
  10. Zhang Y, Lou XL, Yang HL, Guo XK, Zhang XY, He P, Jiang XC. Establishment of a leptospirosis model in guinea pigs using an epicutaneous inoculations route.BMC Infect Dis. 2012 Jan 25;12:20.
  11. Li QT, Huang JW, Guo HX, Guo XK, Zhu YZ, Dong K. Bactericidal activity against meticillin-resistant Staphylococcus aureus of a novel eukaryotic therapeutic recombinant antimicrobialpeptide.IntJ Antimicrob Agents, 2012, 39 (6):496-499.
  12. Peng N, Zhong Y, Zhang Q, Zheng M, Zhao W, Jiang H, Yang C, Guo X, Zhao G.Characterization of acetyl-CoA and propionyl-CoA carboxylases encoded by Leptospira interrogans serovar Lai: an initial biochemical study for leptospiral gluconeogenesis via anapleroticCO(2) assimilation. Acta Biochim Biophys Sin. 2012;44(8):692-702.
  13. Shi, Si-feng, Jia, Jing-fu, Guo, Xiao-kui, Zhao, Ya-ping, Liu, Bo-yu, Chen, De-sheng, Guo, Yong-yuan, Zhang, Xian-long. Toxicity of iron oxide nanoparticles against osteoblasts. JOURNAL OF NANOPARTICLE RESEARCH 2012; 14(9),1091,
  14. Zheng LL, Li YX, Ding J, Guo XK, Feng KY, Wang YJ, Hu LL, Cai YD, Hao P, Chou KC. A comparison of computational methods for identifying virulence factors. PLoS One. 2012; 7(8):e42517.
  15. Shi SF, Jia JF, Guo XK, Zhao YP, Chen DS, Guo YY, Cheng T, Zhang XL.Biocompatibility of chitosan-coated iron oxide nanoparticles with osteoblast cells.Int J Nanomedicine. 2012; 7:5593-602.
  16. Li QT, Zhu YZ, Dong K, Liu C, Zhou YH, Ni YX, Guo XK*. A novel sequence-based coa genotyping method to discriminate nosocomial ethicillin-resistant Staphylococcus aureus isolates. Ir J Med Sci. 2011, 180 (2): 463-8.
  17. Zhong Y, Chang X, Cao XJ, Zhang Y, Zheng H, Zhu Y, Cai C, Cui Z, Zhang Y, Li YY, Jiang XG, Zhao GP, Wang S, Li Y, Zeng R, Li X, Guo XK*. Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601. Cell Res. 2011, 21 (8): 1210-29.
  18. Zhao JW, Sun ZQ, Zhang CZ, Yang HG, Yu XL, Wen ZL, Gao YF, Guo XK, Qi YM, Zhang SL. Cloning, expression and immunological evaluation of a short fragment from Rv3391 of Mycobacterium tuberculosis . Ann Microbiol. 2011, 61 (2): 345-353
  19. Zhang ZY, Sun ZQ, Wang ZL, Wen ZL, Sun QW, Zhu ZQ, Song YZ, Zhao JW, Wang HH, Zhang SL, Guo XK*. Complete genome of a novel clinical isolated non-tuberculous mycobacterium strain JDM601.J Bacteriol. 2011, 193 (16): 4300-1.
  20. Zhang SM, Tian F, Huang QF, Zhao YF, Guo XK, Zhang FQ. Bacterial diversity of subgingival plaque in 6 healthy Chinese individuals.Exp Ther Med.2011; 2(5):1023-1029.
  21. Zhang Q, Zhang Y, Zhong Y, Ma J, Peng N, Cao X, Yang C, Zeng R, Guo X, Zhao G. Leptospira interrogans encodes an ROK family glucokinase involved in a cryptic glucose utilization pathway. Acta Biochim Biophys Sin . 2011, 43 (8): 618-29.
  22. Ning R, Zhang X, Guo X, Li Q. Staphylococcus aureus regulates secretion of interleukin-6 and monocyte chemoattractant protein-1 through activation of nuclear factor kappaB signaling pathway in human osteoblasts. Braz J Infect Dis. 2011, 15 (3): 189-94.
  23. Ning R, Zhang X, Guo X, Li Q. Attachment of Staphylococcus aureus is required for activation of nuclear factor kappa B in human osteoblasts. Acta Biochim Biophys Sin. 2010, 42(12): 883-92.
  24. Zhu YZ, Cai CS, Zhang W, Guo HX, Zhang JP, Ji YY, Ma GY,Wu JL, Li QT, Lu CP, Guo XK*. Immunoproteomic analysis of human serological antibodyresponses to vaccination with whole-cell pertussis vaccine (WCV). PLoS One. 2010; 5(11):e13915.
  25. YuhuaZhou, Ping Lin, Qingtian Li, Lizhong Han, HuajunZheng, Yanxia Wei, Zelin Cui, Yuxing Ni, XiaokuiGuo*. Analysis of the microbiota of sputum samples from patients with lower respiratory tract infections. Acta Biochim Biophys Sin. 2010;42(10):754-761.
  26. Wu,Chenyun; Fen, Yan; Qian, Gaochao; Wu, Jianhua; Luo, Jun; Wang, Ying; Chen,Guangjie; Guo, Xiaokui*; Wang, Zhaojun*. α-galactosylceramide protects mice from lethal coxsackie virus B3 infection and subsequent myocarditis. Clin Exp Immunol. 2010, 162(1):178-187.
  27. Wei YX, Zhang ZY, Liu C, Zhu YZ, Zhu YQ, Zheng H, ZhaoGP, Wang S, Guo XK*.Complete genome sequence of Bifidobacterium longum JDM301. J Bacteriol. 2010; 192(15):4076-7.
  28. Qingtian Li,Yuhua Zhou ,Ke Dong ,Xiaokui Guo*. Potential therapeuticefficacy of a bactericidal–immunomodulatory fusion peptide againstmethicillin-resistant Staphylococcus aureus skin infection. 2010. Appl Microbiol Biotechnol . 2010, 86:305–309.
  29. Cai CS, Zhu YZ, Zhong Y, Xin XF, Jiang XG, Lou XL, He P,Qin JH, Zhao GP, Wang SY, Guo XK*.Development of O-antigen gene cluster-specific PCRs forrapid typing six epidemic serogroups of Leptospira in China. BMC Microbiol. 2010; 10:67.
  30. Liu C, Zhang ZY, Dong K, Guo XK. Adhesion and immunomodulatory effects of Bifidobacte riumlactis HN019 on intestinal epithelial cells INT-407. World J Gastroentero.2010; 16(18):2283-90.
  31. Ke Dong, Qingtian Li, Chang Liu, Yunyi Zhang, Guoping Zhao, and Xiaokui Guo. Cloning and characterization of three cheB genes in Leptospira interrogans. Acta Biochim Biophys Sin . 2010, 42 (3): 216-223.
  32. Yang J,Xu J, Chen X, Zhang Y, Jiang X, XiaokuiGuo, and Guoping Zhao. Decrease of Plasma Platelet-Activating Factor Acetylhydrolase Activity inLipopolysaccharide Induced Mongolian Gerbil Sepsis Model. PLoS ONE 2010, 5(2): e9190.
  33. Cao XJ, Dai J, Xu H, Nie S, Chang X, Hu BY, Sheng QH,Wang LS, Ning ZB, Li YX, Guo XK, Zhao GP, Zeng R. High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans. Cell Res. 2010; 20(2):197-210.
  34. Lin W, Yang HL, Yang Y, Hu BY, Tan LZ, Guo XK. Cloning, expression, and immunologicalevaluation of a novel protein belonging to OmpA family in Leptospira interrogans Recent Works on Microbes andInfections in China, World Scientific Publishing Co. Pte. Ltd. , 2009.P1-12
  35. Jiang,XG, Zhang XY, Zhong WJ, Nie YX, Yin WW, Li XW, Guo XK Surveillance of Leptospirosis and the MurineReservoirs in China 2005 Recent Works on Microbes and Infections in China,World Scientific Publishing Co. Pte. Ltd, 2009. P13-19.
  36. Yao Y,Xie Y, Perace D, Zhong Y, Lu J, Tao J,Guo XK, Kim KS.The type IIIsecretion system is involved in the invasion and intracellular survival ofEscherichia coli K1 in humanbrainmicrovascular endothelial cells.FEMS Microbiol Lett. 2009, 300(1):18-24.
  37. JianpingYuan, Ping Li, Jing Tao, Xiaodong Shi, Baoyu Hu, Huabiao Chen and XiaokuiGuo* H.pylori Escape Host Immunoreaction Through Inhibiting ILKExpressionByVacA.Cellular & Molecular Immunology, 2009, 6(3): 191-197.
  38. Zhang ZY, Liu C, Zhu YZ, Zhong Y, Zhu YQ, Zheng HJ, ZhaoGP, Wang SY, Guo XK. Complete genome sequence of Lactobacillus plantarum JDM1.J Bacteriol. 2009Aug;191(15):5020-5021.
  39. Zhang SM, Tian F, Jiang XQ, Li J, Xu C, Guo XK, Zhang FQ.Evidence for calcifying nanoparticles in gingivalcrevicular fluid and dental calculus in periodontitis. J Periodontol. 2009; 80(9):1462-70.
  40. TianF,Yu Y, Chen B, Li HR, Yao YF, Guo XK*. Bacterial, archaeal and eukaryotic diversity in Arctic sediment as revealed by16S rRNA and 18S rRNA gene clone libraries analysis. Polar Biology, 2009, 32(1):93-103.
  41. Zhao W, Chen CY, Zhang XY, Lai WQ, Hu BY, Zhao GP, QinJH, Guo XK*. Molecular characterization of the pL40 protein inLeptospirainterrogans. Can J Microbiol. 2009; 55(6):739-749.
  42. FengCY, Li QT, Zhang XY, Dong K, Hu BY,GuoXK. Immune strategies on single component LipL32 and multi-components recombinant LipL32-41-OmpL1 vaccines against Leptospira. Brazilian Journal of Medical and BiologicalResearch. 2009, 42(9):796-803
  43. Liu C, Zhang ZY, Dong K, Yuan JP, Guo XK*.Antibiotic resistance of probiotic strains of lactic acidbacteria isolated from marketed foods and drugs. Biomed Environ Sci. 2009; 22(5):401-412.
  44. Qin Lu,De-Hong Yu, Chao Fang, Fang Liu, Xun Ye, Yi Zhao, Jie Qin, Xiao-KuiGuo, Min Liang, Fang Hu and Hong-zhuan Chen. Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells. Cancer biology and therapy, 2009, 8(12): 1127-1134.
  45. Yang RF,Guo XK, Yang J, Jiang YQ, Pang B,Chen C, Yao YF, Qin JH, Li QT. Genomic research for important pathogenic bacteria in China. Science in China Series C: Life Sciences, 2009, 52(1):50-63.
  46. JunweiYang, Yixuan Zhang, Jing Xu, Yan Geng, Xiaoying Chen, Hongling Yang, ShengnanWang, Hengan Wang,Xucheng Jiang, XiaokuiGuo, Guoping Zhao. Serum activity of platelet-activating factoracetylhydrolase is a potential clinical marker for leptospirosis pulmonaryhemorrhage.PloS ONE. 2009 4(1): e4181.
  47. Zhu YZ, Li QT, Wang L, Zhong Y, Ding GH, Li G, JiaPL,Shi TL, Guo XK*. Gene expression profiling-based in silico approach toidentify potential vaccine candidates and drug targets against B. pertussis and B. parapertussis.OMICS. 2008 ;12(3):161-169.
  48. Qin JH, Zhang Q, Zhang ZM, Zhong Y, Yang Y, Hu BY, ZhaoGP, Guo XK*. Identification of a novel prophage-like gene cluster actively expressed in both virulent and avirulent strains of Leptospira interrogans serovar Lai. Infect Immun. 2008; 76(6):2411-2419.
  49. Zhang YX, Geng Y, Yang JW, Guo XK, Zhao GP. Cytotoxic activity and probable apoptotic effect of Sph2, asphigomyelinase hemolysin from Leptospira interrogans strain Lai. BMB Rep. 2008. 41(2):119-125.
  50. He P, Sheng YY, Shi YZ, Jiang XG, Qin JH, Zhang ZM, ZhaoGP, Guo XK*. Genetic diversity among major endemic strains of Leptospira interrogans in China. BMC Genomics. 2007. 8:204.[40]
  51. Ying Zou, Guo XK, Mathieu Picardeau, HaiXu, Guoping Zhao. A comprehensive survey on isoleucine biosynthesis pathways in seven epidemic Leptospira interrogans reference strains of China. FEMS Microbiology Letters, 2007, 269(1):90–96.
  52. Li QT,Zhu YZ, Chu JY,Wang YY, Xu YH, Hou QM, Zhang SM,Guo XK*. Protective immunity against Bordetellapertussis by a recombinant DNA vaccine and the effect of coinjection with agranulocyte- macrophage colony stimulating factor gene. Microbiol Immunol, 2006,50(12):929-936.
  53. Sun JC,Xu JL, Cao JP,Liu Q, Guo XK*, Shi TL. Predictionand systematic study of protein-protein interaction networks of Leptospira interrogans. Chinese Science Bulletin, 2006, 51(1):1-10.
  54. Yang HL, Zhu YZ, Qin JH, He P, Jiang XC, Zhao GP, Guo XK.In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans. BMC Genomics. 2006. 16;7:293.
  55. Li QT, Zhu YZ, Chu JY, Dong K, He P, Feng CY, Hu BY,Zhang SM, Guo XK. Granulocyte-macrophage colony-stimulating factor DNA prime-protein boost strategy to enhance efficacy of a recombinant pertussis DNA vaccine. Acta Pharmacol Sin. 2006 Nov;27(11):1487-1494.
  56. Qin JH, Sheng YY, Zhang ZM, Shi YZ, He P, Hu BY, Yang Y,Liu SG, Zhao GP, Guo XK. Genome-wide transcriptional analysis of temperature shiftinL. interrogansserovarlai strain 56601.BMC Microbiol. 2006 Jun9;6:51.
  57. Li ZH, Dong K, Yuan JP, Hu BY, Liu JX, Zhao GP, Guo XK. Characterization of the cheY genes from Leptospira interrogans and their effects on the behavior of Escherichia coli. Biochem Biophys Res Commun. 2006; 345(2):858-866.
  58. Guo XK, Zhao WQ, Kondo C, Shimojo N, Yamashita K, Aoki T, Hayakawa T. Tissue inhibitors of metalloproteinases-1 (TIMP-1) and-2(TIMP-2) are major serum factors that stimulate the TIMP-1 gene in human gingival fibroblasts. Biochim Biophys Acta. 2006; 1763(3):296-304.
  59. Li ZH, Dong K, Sun JC, Yuan JP, Hu BY, Liu JX, Zhao GP,Guo XK. Characterization of cheW genes of Leptospirainterrogansand their effects in Escherichia coli.Acta Biochim Biophys Sin. 2006; 38(2):79-88.
  60. Yang HL, Jiang XC, Zhang XY, Li WJ, Hu BY, Zhao GP, Guo XK. Thrombocytopenia in the experimental leptospirosis ofguinea pig is not related to disseminated intravascular coagulation.BMC Infect Dis. 2006 Feb 2;6:19.
  61. Zhang XY, Yu Y, He P, Zhang YX, Hu BY, Yang Y, NieYX,Jiang XG, Zhao GP, Guo XK. Expression and comparative analysis of genes encoding outer membrane proteins LipL21, LipL32 and OmpL1 in epidemic leptospires. Acta Biochim Biophys Sin. 2005; 37(10):649-656.
  62. Zhang YX, Geng Y, Bi B, He JY, Wu CF, Guo XK, Zhao GP. Identification and classification of all potential hemolysin encoding genes and their products from Leptospira interrogans serogroup Icterohae-morrhagiae serovar Lai. Acta Pharmacol Sin. 2005; 26(4): 453-461.
  63. Wang HT, Li ZH, Yuan JP, Zhao W, Shi XD, Tong SQ, Guo XK. Effect of Helicobacter pylori VacA on gene expression of gastric cancer cells. World J Gastroenterol. 2005; 11(1):109-13.
  64. Yuan JP, Li T, Chen HB, Li ZH, Yang GZ, Hu BY, Shi XD,Tong SQ, Li YX, Guo XK. Analysis of gene expression profile in gastric cancercells stimulated with Helicobacter pylori isogenic strains. J Med Microbiol. 2004; 53(Pt 10):965-974.
  65. . Li ZH, Nie BM, Chen H, Chen SY, He P, Lu Y,Guo XK, Liu JX. In vitro anti-coxsackie virusB(3) effect of ethyl acetateextract of Tian-hua-fen. World J Gastroenterol. 2004; 10(15):2263-6.
  66. Zhang YX, Guo XK, Wu C, Bi B, Ren SX, Wu CF, ZhaoGP. Characterization of a novel toxin-antitoxin module,VapBC, encoded by Leptospira interrogans chromosome. Cell Res. 2004; 14(3):208-216.
  67. Yuan JP, Li T, Li ZH, Yang GZ, Hu BY, Shi XD, Shi TL,Tong SQ, Guo XK.mRNA expression profiling reveals a role of Helicobacter pylori vacuolating toxin in escaping host defense. World J Gastroenterol. 2004; 10(10):1528-1532.
  68. He P,Zhang XY, Guo XK, Hu BY, Huang XT,Yang Y, Zhao GP. Identification and analysis of genes present in Leptospira interrogans serovar Lai but absent in L. biflexa serovar monvalerio. Acta Biochim Biophysica Sin, 2004, 36(12):832-839.
  69. XuH,Zhang Y, Guo XK, Ren S, StaempfliAA, Chiao J, Jiang W, Zhao G. Isoleucine biosynthesis in Leptospirainterrogans serotype lai strain 56601 proceeds via a threonine-independent pathway. J. Bacteriol, 2004, 186(16): 5400-5409.
  70. Yuan JP, Li T, Shi XD, Hu BY, Yang GZ, Tong SQ, Guo XK. Deletion of Helicobacter pylori vacuolating cytotoxingene by introduction of directed mutagenesis.World J Gastroenterol.2003; 9(10):2251-7.
  71. Yuan JP, Zhao W, Wang HT, Wu KY, Li T, Guo XK, Tong SQ. Coxsackie virus B3-induced apoptosis and caspase-3.Cell Res. 2003; 13(3):203- 209.
  72. Ren SX, Fu G, Jiang XG, Zeng R, Miao YG, Xu H, ZhangYX, Xiong H, Lu G, Lu LF, Jiang HQ, Jia J, Tu YF, Jiang JX, Gu WY, Zhang YQ,Cai Z, Sheng HH, Yin HF, Zhang Y, Zhu GF, Wan M, Huang HL, Qian Z, Wang SY, MaW, Yao ZJ, Shen Y, Qiang BQ, Xia QC, Guo XK, Danchin A, Saint GironsI,Somerville RL, Wen YM, Shi MH, Chen Z, Xu JG, Zhao GP.Unique physiological and pathogenicfeatures of Leptospira interrogans revealed by whole-genome sequencing. Nature. 2003; 422(6934):888-893.
  73. Zhao WQ, Li H, Yamashita-K, Guo XK, Hayakawa-T. Cell cycle- associated accumulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) in the nuclei of human gingival fibroblasts. Journalof Cell Science, 1998, 111:1147-1153.

相關詞條

熱門詞條

聯絡我們