郝爽，博士，教授，博士生導師，東北大學人才項目青年特聘教授。
基本介紹
- 中文名：郝爽
- 學位/學歷：博士
- 職稱：教授
教育和工作經歷,研究方向,代表性論文,
教育和工作經歷
2002-2006 河北工業大學，生物工程專業，學士
2006-2012 大連理工大學，環境科學與生命學院，生物化工專業，神經藥理學博士
2012-2019 美國貝勒醫學院/德州兒童醫院Jan and Dan Duncan神經科學研究所，神經病學，博士後
2019- 東北大學生命科學與健康學院，教授，博士生導師
研究方向
主要研究方向集中在神經科學領域中的腦重大疾病的機理和治療。將神經病學、神經生物學等基礎研究與臨床治療相結合，採用多學科交叉融合的方法揭示神經發育障礙和神經退行性疾病等神經系統疾病的發病機制，探討可行性臨床治療方法，為實現腦疾病的精準醫療提供理論和實踐支持。
代表性論文
(1) Shuang Hao, Bin Tang, Zhenyu Wu, Kerstin Ure, Yaling Sun, Huifang Tao, Yan Gao, Akash J. Patel, Daniel J. Curry, Rodney C. Samaco, HudaY. Zoghbi&Jianrong Tang. 2015. Forniceal deep brain stimulation rescues hippocampal memory in Rett syndrome mice. Nature. 526: 430-434.
(2) WuChen, Zhao-Lin Cai, Eugene S Chao, Hongmei Chen, Colleen M Longley, Shuang Hao,Hsiao-Tuan Chao, Joo Hyun Kim, Jessica E Messier, Huda Y Zoghbi, Jianrong Tang, John W Swann, Mingshan Xue. 2020. Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy. eLIFE. DOI: 10.7554/eLife.48705.
(3) Vincenzo A. Gennarino, Elizabeth E. Palmer, Laura M. McDonell, Li Wang, Carolyn J. Adamski, Christian P. Schaaf, Jill A. Rosenfeld, Jessica A. Panzer, Ute Moog, Shuang Hao, Ann Bye, Edwin P. Kirk, Pawel Stankiewicz, Amy M. Breman, Arran McBride, Tejaswi Kandula, Holly A. Dubbs, Rebecca Macintosh, Michael Cardamone, Ying Zhu, Kevin Ying, Kerith-Rae Dias, Megan T. Cho, Lindsay B. Henderson, Berivan Baskin, Paula Morris, Jiang Tao, Mark J. Cowley, Marcel E. Dinger, Tony Roscioli, OanaCaluseriu, Oksana Suchowersky, Rani K. Sachdev, Olivier Lichtarge, Jianrong Tang, Kym M. Boycott, J. Lloyd Holder, Jr., and Huda Y. Zoghbi. 2018. A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures. Cell. 172: 924-936.
(4) Amy E Pohodich, Hari Yalamanchili, Ayush T Raman, Ying-Wooi Wan, Michael Gundry, Shuang Hao, Haijing Jin, Jianrong Tang, Zhandong Liu, Huda Y Zoghbi. 2018, Forniceal deep brain stimulation induces gene expression and splicing changes that promote neurogenesis and plasticity. eLIFE.DOI: 10.7554/eLife.34031.
(5) James P. Orengo, Meike E. van der Heijden, Shuang Hao, Jianrong Tang, Harry T. Orr, and Huda Y. Zoghbi. 2018. Motor neuron degeneration correlates with respiratory dysfunction in SCA1. Dis Model Mech. DOI: 10.1242/dmm.032623.
(6) Cristian A. Lasagna-Reeves, Maria de Haro, Shuang Hao, Jeehye Park, Maxime W.C. Rousseaux, Ismael Al-Ramahi, PaymaanJafar-Nejad, Luis Vilanova-Velez, Lauren See, Antonia De Maio, Larissa Nitschke, Zhenyu Wu, Juan C. Troncoso, Thomas F. Westbrook, Jianrong Tang, Juan Botas and Huda Y. Zoghbi. 2016. Reduction of Nuak1 Decreases Tau And Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. 92: 407-418.
(7) Hui Lu, Ryan T. Ash, Lingjie He, Sara E. Kee, Wei Wang, Dinghui Yu, Shuang Hao, Xiangling Meng, Kerstin Ure, Yaling Sun, Daoyun Ji, Jiangrong Tang, Benjamin R. Arenkiel, Stelios M. Smirnakis, and Huda Y. Zoghbi. 2016. Loss and gain of MeCP2 lead to similar hippocampal circuit abnormalities that are rescued by deep brain stimulation in a Rett syndrome mouse model. Neuron. 91: 739-747.
(8) YehezkelSztainberg, Hong-mei Chen, John W. Swann, Shuang Hao, Bin Tang, Zhenyu Wu, Jianrong Tang, Ying-Wooi Wan, Zhandong Liu, Frank Rigo& Huda Y. Zoghbi. 2015. Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides. Nature. 528: 123-126.
(9) Kihoon Han, J. Lloyd Holder, Jr, Christian P. Schaaf, Hui Lu, Hongmei Chen, Hyojin Kang, Jianrong Tang, ZhenyuWu, Shuang Hao, SauWai Cheung, Peng Yu, Hao Sun, Amy M. Breman, Ankita Patel,Hui-Chen Lu & Huda Y. Zoghbi. 2013. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 503: 72-77.
(10) Shuang Hao, Yong-Ming Bao, Li- Jia An, Wei Cheng, Rong-Guo Zhao, Jing Bi, He- Shuang Wang, Chang- Sen Sun, Ji-Wen Liu, Bo Jiang. 2011. Effects of Resibufogenin and Cinobufagin on voltage-gated potassium channels in primary cultures of rat hippocampal neurons. Toxicol in Vitro. 25: 1644-1653.
(11) Shuang Hao, Yong-Ming Bao, Rong-Guo Zhao, He-Shuang Wang, Jing Bi, Li- jia An, Bo Jiang. 2011. Effects of Resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons. Neurosci Lett.501: 112-116.
(12) Aihong Zhang, Shuang Hao, Jing Bi, Yongming Bao, Xiuli Zhang, Lijia An, Bo Jiang. 2009. Effects of catalpol on mitochondrial function and working memory in mice after lipopolysaccharide-induced acute systemic inflammation. Exp ToxicolPathol. 61: 461-469.
(13) Jing Bi, Bo Jiang, Shuang Hao, Aihong Zhang, Yuesheng Dong, Tao Jiang, Lijia An. 2009. Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons. Neurochem Int. 54: 264–270
(14) Jing Bi, Xiaobo Wang, Lei Chen, Shuang Hao, Lijia An, Bo Jiang, Lei Guo. 2008. Catalpol protects mesencephalic neurons against MPTP induced neurotoxicity via attenuation of mitochondrial dysfunction and MAO-B activity. Toxicol in Vitro. 22: 1883-1889.
(15) Xiuli Zhang, Bo Jiang, Zhibo Li, Shuang Hao, Lijia An. 2007. Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. PharmacolBiochemBehav. 88: 64-72.
