研究方向
1.神經病理性疼痛的機制及治療
2.神經藥理學
主持科研項目
(1)國家自然科學基金面上基金,靶向AMPK治療紫杉醇誘導的外周神經病變的線粒體機制研究 (項目編號:81971065)55萬
(2)國家自然科學基金青年基金,基於Toll樣受體7激動劑的海洛因疫苗構建及其抗海洛因作用研究(項目編號:81401106)23萬
(3)深圳市基礎研究面上項目,靶向AMPK防治化療誘導的外周神經病變的線粒體機制研究 (項目編號:JCYJ20190808154603578)40萬
(4)深圳市基礎研究項目,華蟾素對化療藥物誘導的神經病理性疼痛的保護作用及機制研究
項目編號:JCYJ20160520175235342,30萬
(5)深圳大學-企業橫向課題,中成藥華蟾素鎮痛作用及其機制研究,40萬
(6)深圳大學青年教師科研啟動項目,人才培養項目,高水平大學一般項目,總計 24萬
代表性論文
Jing Guo, Xiyuan Ba, Megumi Matsuda, Changyu Jiang, Wuping Sun, Lizu Xiao, Donglin Xiong2, Xiang Liao, Y Hao*. Oxytocin elicits itch scratching behavior via spinal GRP/GRPR system. Frontiers in Neuroscience, 2020. 14:581977.
Jiali Wang, Changyu Jiang, Xiyuan Ba, Shimin Yang, Zelin Huang, Guangyi Jin, Yue Hao*. Selective activation of metabotropic glutamate receptor 7 blocks paclitaxel-induced acute neuropathic pain and suppresses spinal glial reactivity in rats. Psychopharmacology, 2020, 238(1), 107-119.
Ba XY, Wang JL, Zhou SY, Luo XX, Peng Y, Yang SM, Hao Y*, G Jin. Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses TRPV1 up-regulation and spinal astrocyte activation in rats. Biomedicine & pharmacotherapy. 108 (2018): 76–84.
Yang S, Yu Z, Sun W, Jiang C, Ba X, Zhou Q, Xiong D, Xiao L, Deng Q, Hao Y*. The antiviral alkaloid berberine ameliorates neuropathic pain in rats with peripheral nerve injury. Acta Neurol Belg. 2020; 120(3):557-564.
Hao Y, Luo XX, Ba XY, Wang JL, Zhou SY, Yang SM, Fang CJ, Jiang CY, Sun WP. Huachansu suppresses TRPV1 up-regulation and spinal astrocyte activation to prevent oxaliplatin-induced peripheral neuropathic pain in rats. Gene, 2018.9, 680: 43-50
Hao Y*, Martin-Fardon R, Weiss F. Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: factor in the transition to dependence. Biol Psychiatry. 2010;68:240-8.
Sun W, Zhou Q, Ba X, Feng X, Hu X, Cheng X, Liu T, Guo J, Xiao L, Jiang J, Xiong D, Hao Y*, Chen Z, Jiang C. Oxytocin relieves neuropathic Pain through GABA release and presynaptic TRPV1 inhibition in spinal cord. Front Mol Neurosci. 2018,17;11:248.
Sun WP, Kou DQ, Yu ZJ, Yang SM, Jiang CY, Xiong DL, Xiao LZ, Deng QW, Xie HT, Hao Y*. A Transcriptomic Analysis of Neuropathic Pain in Rat Dorsal Root Ganglia Following Peripheral Nerve Injury. NeuroMolecular Medicine, 2019:1-14.