邱燁，男，博士，湖南大學生物學院助理教授、博士生導師。
基本介紹
- 中文名：邱燁
- 畢業院校：加拿大不列顛哥倫比亞大學
- 學位/學歷：碩士
- 專業方向：生物技術
- 任職院校：湖南大學
人物經歷,教育經歷,工作經歷,研究領域,科研項目,學術成果,
人物經歷
教育經歷
2010年獲得北京大學生物技術專業學士學位
2017年取得加拿大不列顛哥倫比亞大學病理系博士學位
工作經歷
2018年3月入職霉拳駝湖南大學生物學院。
研究領域
3. 篩選和改造對腫瘤細胞有感染特異性的病毒以研發病毒抗腫瘤藥物。
科研項目
國家自然科學基金青年項目“踏諒享舟高滲應激蛋白NFAT5的切割介導手足口病毒CV-A6感染的機制研究”
湖南省自然科學基金青年項目“高滲轉錄因子NFAT5在柯薩奇病毒感染及病毒性心肌炎中的作全嬸促用”
學術成果
發現細胞分子伴侶系統特別是熱休克蛋白Hsp70在柯薩奇病毒B3型感染有重要的正反饋促進作用。發現高滲反應蛋白NFAT5在柯薩奇病毒B3型感染被病毒蛋白酶切割，切割導致了NFAT5的失活，促進了病毒的複製並加劇了病毒性心肌炎的症狀，由此發現高滲溶液對病毒性心肌己判辨炎的治療作用。相關雄蜜籃良研究結果發表在PLoS Pathogens等國際學術期刊上。
代表性論文：
1. Ye Qiu, Xin Ye, Huifang Mary Zhang, Paul Hanson, Guangze Zhao, Lei Tong, Ronald Xie and Decheng Yang. Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral proteases promotes viral infectivity and virus-induced cell death. PloS Pathog. 2017; 13(12):e1006744
2. Ye Qiu, Xin Ye, Paul Hanson, Mary Zhang, Jeff Zong, Brian Cho and Decheng Yang. Hsp70-1: upregulation via selective phosphorylation of heat shock factor 1 during coxsackieviral infection and promotion of viral replication via the AU-rich element. Cell Mol Life Sci. 2016; 73(5): 1067-1084.
3. Fengping Wang#, Ye Qiu#, Huifang M. Zhang#, Paul J. Hanson, Xin Ye, Guangze Zhao, Ronald Xie, Lei Tong and Decheng Yang. Heat shock protein 70 promotes coxsackievirus b3 translation initiation and elongation via akt-mtorc1 pathway depending on activation of p70s6k and cdc2. Cellular microbiology, 2017; Epub ahead of print.
4. Gabriel Fung. Honglin Luo, Ye Qiu, Decheng Yang and Bruce McManus. Myocarditis. Circ Res, 2016; 118(3): 496-514.
5. Paul Hanson, Xin Ye, Ye Qiu, Huifang Mary Zhang, Maged Gomaa Hemida, Fengping Wang, T. Lim, Ada Gu,Brian Cho, H. Kim, Gabriel Fung, DavidGranvilleand Decheng Yang. Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes. Cell Death Differ. 2015.
6. Xin Ye, Huifang Mary Zhang, Ye Qiu, Paul J Hanson, Maged Gomaa Hemida, Wei Wei, Pamela A Hoodless, Fanny Chu and Decheng Yang. Coxsackievirus-Induced miR-21 Disrupts Cardiomyocyte Interactions via the Downregulation of Intercalated Disk Components. PLoS Pathog. 04/2014; 10(4):e1004070.
7. Tong, Lei#; Qiu, Ye#; Wang, Hui; Qu, Yunyue; Zhao, Yuanbo; Lin, Lexun; Wang, Yan; Xu, Weizhen; Zhao, Wenran; He, Hongyan; Zhao, Guangze; Zhang, Mary H.; Yang, Decheng; Ge, Yingyi*; Zhong, Zhaohua*. Expression profile and function analysis of long non-coding RNAs in the infection of coxsackievirus B3, VIROLOGICA SINICA, 2019.8.6, Epub ahead of print
8. Deng, Haoyu; Fung, Gabriel; Qiu, Ye; Wang, Chen; Zhang, Jingchun; Jin, Zheng-Gen; Luo, Honglin*. Cleavage of Grb2-Associated Binding Protein 2 by Viral Proteinase 2A during Coxsackievirus Infection , FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2017.3.16, 7
9. Zhang, Huifang M.; Qiu, Ye; Ye, Xin; Hemida, Maged G.; Hanson, Paul; Yang, Decheng*. P58(IPK) inhibits coxsackievirus-induced apoptosis via the PI3K/Akt pathway requiring activation of ATF6a and subsequent upregulation of mitofusin 2 , CELLULAR MICROBIOLOGY, 2014.3, 16(3): 411~424
10. Ye, Xin; Hemida, Maged Gomaa; Qiu, Ye; Hanson, Paul J.; Zhang, Huifang Mary; Yang, Decheng*. MiR-126 promotes coxsackievirus replication by mediating cross-talk of ERK1/2 and Wnt/beta-catenin signal pathways , CELLULAR AND MOLECULAR LIFE SCIENCES, 2013.12, 70(23): 4631~4644
11. Zhang, Huifang M.; Wang, Fengping ; Qiu, Ye; Ye, Xin; Hanson, Paul; Shen, Hongxing; Yang, Decheng*. Emodin inhibits coxsackievirus B3 replication via multiple signalling cascades leading to suppression of translation , BIOCHEMICAL JOURNAL, 2016.2.15, 473: 473~485
4. Gabriel Fung. Honglin Luo, Ye Qiu, Decheng Yang and Bruce McManus. Myocarditis. Circ Res, 2016; 118(3): 496-514.
5. Paul Hanson, Xin Ye, Ye Qiu, Huifang Mary Zhang, Maged Gomaa Hemida, Fengping Wang, T. Lim, Ada Gu,Brian Cho, H. Kim, Gabriel Fung, DavidGranvilleand Decheng Yang. Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes. Cell Death Differ. 2015.
6. Xin Ye, Huifang Mary Zhang, Ye Qiu, Paul J Hanson, Maged Gomaa Hemida, Wei Wei, Pamela A Hoodless, Fanny Chu and Decheng Yang. Coxsackievirus-Induced miR-21 Disrupts Cardiomyocyte Interactions via the Downregulation of Intercalated Disk Components. PLoS Pathog. 04/2014; 10(4):e1004070.
7. Tong, Lei#; Qiu, Ye#; Wang, Hui; Qu, Yunyue; Zhao, Yuanbo; Lin, Lexun; Wang, Yan; Xu, Weizhen; Zhao, Wenran; He, Hongyan; Zhao, Guangze; Zhang, Mary H.; Yang, Decheng; Ge, Yingyi*; Zhong, Zhaohua*. Expression profile and function analysis of long non-coding RNAs in the infection of coxsackievirus B3, VIROLOGICA SINICA, 2019.8.6, Epub ahead of print
8. Deng, Haoyu; Fung, Gabriel; Qiu, Ye; Wang, Chen; Zhang, Jingchun; Jin, Zheng-Gen; Luo, Honglin*. Cleavage of Grb2-Associated Binding Protein 2 by Viral Proteinase 2A during Coxsackievirus Infection , FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2017.3.16, 7
9. Zhang, Huifang M.; Qiu, Ye; Ye, Xin; Hemida, Maged G.; Hanson, Paul; Yang, Decheng*. P58(IPK) inhibits coxsackievirus-induced apoptosis via the PI3K/Akt pathway requiring activation of ATF6a and subsequent upregulation of mitofusin 2 , CELLULAR MICROBIOLOGY, 2014.3, 16(3): 411~424
10. Ye, Xin; Hemida, Maged Gomaa; Qiu, Ye; Hanson, Paul J.; Zhang, Huifang Mary; Yang, Decheng*. MiR-126 promotes coxsackievirus replication by mediating cross-talk of ERK1/2 and Wnt/beta-catenin signal pathways , CELLULAR AND MOLECULAR LIFE SCIENCES, 2013.12, 70(23): 4631~4644
11. Zhang, Huifang M.; Wang, Fengping ; Qiu, Ye; Ye, Xin; Hanson, Paul; Shen, Hongxing; Yang, Decheng*. Emodin inhibits coxsackievirus B3 replication via multiple signalling cascades leading to suppression of translation , BIOCHEMICAL JOURNAL, 2016.2.15, 473: 473~485
