邢國剛，醫學博士，教授、博士生導師；北京大學神經科學研究所副所長；中國神經科學學會神經內穩態與內分泌分會常務委員，中國針灸學會針刺麻醉分會副主任委員；國家自然科學基金、北京市自然科學基金等評審專家
基本介紹
- 中文名：邢國剛
- 外文名：Guo-Gang Xing
- 學位/學歷：博士
- 任職單位：北京大學
- 職稱：教授
- 國籍：中國
- 民族：漢族
- 畢業院校：西安交通大學
人物簡介,人物經歷,社會任職,主要榮譽,研究方向,科研基金,研究論文,參編著作,
人物簡介
邢國剛，醫學博士，教授，博士生導師，北京大學神經科學研究所副所長。主要研究慢性痛，揭示疼痛慢性化及共病焦慮抑鬱的外周與中樞機制。主持和參加包括國家自然科學基金、北京市自然科學基金、國家重點基礎研究發展計畫(“973”計畫)課題、國家重大科研儀器研製項目、國家重點研發計畫項目、國家衛健委行業專項基金等多項國家級與省部級課題，在Advanced Materials, Molecular Psychiatry, The Journal of Neuroscience, Pain, Science Signaling等國內外學術期刊上發表研究論著100餘篇。參加編寫《神經科學》（第4版）、國家衛健委“十三五”規劃教材《生理學》及《康復生理學》（人民衛生出版社）等教材和專著10部。獲得北京市自然科學獎二等獎（2019年）、北京市科學技術獎二等獎（2012年）和中國針灸學會科學技術獎二等獎（2010年）等獎項。
人物經歷
2001年於西安交通大學獲得博士學位
2003年 北京大學神經科學研究所博士後出站
2004-2006年 美國Sanford Burnham Prebys (SBP) 醫學研究所和威斯康星大學神經科學系，訪問學者
2003年至今 北京大學神經科學研究所，任講師、副教授、教授
社會任職
中國神經科學學會神經內穩態與內分泌分會常務委員，中國針灸學會針刺麻醉分會副主任委員，中國神經科學學會感覺和運動分會、中華醫學會疼痛學分會、中華醫學會兒科學分會腦科學委員會、中國微循環學會神經變性病專業委員會等專業委員會委員。Brain Sciences、Journal of Pain Research、Frontiers in PainResearch、Annals of Biomedical Research、中國疼痛醫學雜誌等學術期刊編委。國家自然科學基金、北京市自然科學基金等評審專家。
主要榮譽
2019年北京市科學技術獎(自然科學獎)二等獎
2012年度北京市科學技術獎二等獎
2010年中國針灸學會科學技術獎二等獎
研究方向
(1) 疼痛與記憶、認知和情緒機制研究
採用分子生物學、細胞生物學、行為藥理學、基因組學、代謝組學和單細胞測序的方法，結合神經示蹤、活體鈣成像、電生理學、光遺傳學、化學遺傳學和表觀遺傳學技術，從分子、細胞水平，突觸水平，以及神經網路水平來研究離子通道與慢性痛的感覺、認知和負性情緒機制，包括疼痛記憶、認知障礙、焦慮、抑鬱及其共病的中樞神經網路機制。
(2) 幹細胞與神經發育障礙性疾病研究
採用細胞重編程技術，利用化學小分子誘導人尿源性和血源性誘導多能幹細胞（iPSCs），定向分化神經細胞、體外培養腦類器官，建立神經發育障礙性疾病的細胞模型及腦類器官模型；結合上述各種神經生物學技術和組學方法，研究神經發育障礙性疾病的發病機制；結合基因編輯技術進行疾病的干預措施研究。
(3) 男性生殖細胞發育及不孕不育機制研究
採用分子生物學、細胞生物學、形態學和行為藥理學的方法，結合電生理學、表觀遺傳學和細胞重編程技術，研究男性生殖細胞發育及不孕不育機制。
科研基金
國家自然科學基金、北京市自然科學基金、國家重點研發計畫項目、國家重點基礎研究發展計畫(科技部973計畫)項目、國家重大科研儀器研製項目、國家自然科學基金(儀器專項)、國防科技創新特區項目、國家衛生健康委員會行業專項基金項目、教育部留學回國人員科研啟動基金。
研究論文
Tongling Liufu, Haiyan Yu, Jiaxi Yu, Meng Yu, Yue Tian, Yichun Ou, JianwenDeng , Guo-GangXing*, ZhaoxiaWang*. Complex I deficiency in m.3243AG fibroblasts is alleviated byreducing NADH accumulation. Frontiersin Physiology. 2023Aug 15; 14:1164287.
Ke Xi, Si-Qing Cai, Hui-Fang Yan, Yue Tian, Jie Cai, Xiao-Mei Yang*,Jing‑Min Wang*, Guo-Gang Xing*. CSMD3 deficiency leads to motorimpairments and autism-like behaviors via dysfunction of cerebellar Purkinjecells in mice. The Journal of Neuroscience 2023 May 24;43(21):3949-3969.
Zhu-Lin Yuan, Xiao-Dan Liu, Zi-Xian Zhang,Song Li, Yue Tian, Ke Xi, Jie Cai, Xiao-Mei Yang, Min Liu, Guo-GangXing*. Activation ofGDNF-ERK-Runx1 signaling contributes to P2X3R gene transcription and bonecancer pain. iScience 2022 Aug 13;25(9): 104936.
Fan Xu, Xian-wei Zou, Li-qiong Yang, Shi-cong Mo, Quan-hao Guo, Jing Zhang, XiechuanWeng* and Guo-Gang Xing*. Facial muscle movements in patients with Parkinson’s diseaseundergoing phonation tests. Frontiers inNeurology 2022 Oct 31; 13:1018362.
Hong Yao, Minghui Liu, Leibo Wang, YumengZu, Chou Wu, Chenyu Li, Ruoxi Zhang, Haigen Lu, Feifei Li, Shuang Xi,Shuangquan Chen, Xuanyu Gu, Tianya Liu, Jie Cai,Shirong Wang, Maojun Yang, Guo-Gang Xing,Wei Xiong, Lan Hua, Yefeng Tang* and Gelin Wang*.Discovery of small-molecule activators of nicotinamidephosphoribosyltransferase (NAMPT) and their preclinical neuroprotectiveactivity. Cell Research 2022Jun;32(6):570-584.
Yajie Liu, Yu An, Guo-GangXing, Zirun Jin, KeXi, Yongwei Huo, Rui He, Hao Wang, Xiali Ouyang, YuepingHuang, Chang Huang, Li Han, Baixiao Zhao*. Effect of moxa smoke on spermparameters and oxidative stress in rats with asthenozoospermia. Anatomical Record (Hoboken) 2022Jun 6.
Wang Wang, Wei-Zhen Liu, Zi-Liang Wang, Dong-Xiao Duan, Xue-Yun Wang, Shi-Jin Liu, Zhi-Ju Wang, Guo-Gang Xing*, Ying Xing*. Spinalmicroglial activation promotes perioperative social defeat stress-inducedprolonged postoperative pain in a sex-dependent manner. Brain, Behavior, and Immunity 2022 Feb;100:88-104.
Min Hao, Zixian Zhang, Chao Liu, Yue Tian, Jiazhi Duan, Jianlong He,Zhaoyang Sun, He Xia, Shan Zhang, Shuhua Wang, Yuanhua Sang*, Guo-GangXing*, Hong Liu*. Hydroxyapatite NanorodsFunction as Safe and Effective Growth Factors Regulating Neural Differentiationand Neuron Development. Advanced Materials2021 Aug;33(33):e2100895.
Hong Jiang, Jiang-Ping Liu, Ke Xi, Ling-Yu Liu, Ling-Yu Kong, JieCai, Si-Qing Cai, Xi-Yuan Han, Jing-Gui Song, Xiao-Mei Yang, You Wan, Guo-GangXing*. Contribution of AMPA receptor-mediated LTDin LA/BLA-CeA pathway to comorbid aversive and depressive symptoms inneuropathic pain. The Journal of Neuroscience 2021 Aug25;41(34):7278-7299.
Jiang-Ping Liu, Hong-Bo Jing, Ke Xi,Zi-Xian Zhang, Zi-Run Jin, Si-QingCai, Yue Tian, Jie Cai and Guo-Gang Xing*. Contribution of TRESK two-pore domainpotassium channel to bone cancer-induced spontaneous pain and evoked cutaneouspain in rats. Molecular Pain 2021 Jun;17:17448069211023230.
Zi-Run Jin, DongFang, Bo-Heng Liu, Jie Cai, Wen-Hao Tang, Hui Jiang, Guo-Gang Xing*. Roles of CatSper channels in thepathogenesis of asthenozoospermia and the therapeutic effects of acupuncture-liketreatment on asthenozoospermia.Theranostics 2021 Jan 1;11(6):2822-2844.
Xiao-Yu Chen, Dan-Yu Song, Li Jiang, Dan-DanTan, Yi-Dan Liu, Jie-Yu Liu, Xing-Zhi Chang, Guo-Gang Xing, Tatsushi Toda, Hui Xiong*. Phenotype andgenotype study of chinese POMT2-related a-dystroglycanopathy. Frontiers inGenetics 2021 Aug 3;12:692479.
Shiyang Huang, Can Zheng, Guoguang Xie, Zhanming Song, Pingzhang Wang, Yun Bai, DixinChen, Yan Zhang, Ping Lv, Weiwei Liang, Shaoping She, Qingqing Li, ZhongtianLiu, Yun Wang, Guo-Gang Xing*, Ying Wang*. FAM19A5/TAFA5, a novel neurokine, plays acrucial role in depressive-like and spatial memory-related behaviors in mice.Molecular Psychiatry 2021Jun;26(6): 2363-2379.
Ran Huo, Song-Ping Han, Feng-Yu Liu, Xiao-Jing Shou, Ling-Yu Liu, Tian-Jia Song,Fu-Jun Zhai, Rong Zhang, Guo-Gang Xing*,Ji-Sheng Han*. Responses of Primary Afferent Fibers to Acupuncture-LikePeripheral Stimulation at Different Frequencies: Characterization bySingle-Unit Recording in Rats. NeuroscienceBulletin 2020 Aug;36(8):907-918.
Meng Xue, Ya-Lan Sun, Yang-Yang Xia, Zhi-Hua Huang, ChengHuang* and Guo-Gang Xing*.Electroacupuncture modulates spinal BDNF/TrkB signaling pathway and amelioratesthe sensitization of dorsal horn WDR neurons in spared nerve injury rats. International Journal of Molecular Sciences2020 Sep 7;21(18): E6524.
Ya-Jing Liang, Shi-Yang Feng, Ya-Ping Qi, Kai Li, Zi-Run Jin, Hong-Bo Jing, Ling-YuLiu, Jie Cai, Guo-Gang Xing*,Kai-Yuan Fu*. Contribution of microglial reaction to increased nociceptiveresponses in high-fat-diet (HFD)-induced obesity in male mice. Brain,Behavior, and Immunity 2019 Aug;80:777-792.
Yu Zhang, Shengwei Xu, Guihua Xiao, Yilin Song, Fei Gao, Mixia Wang, Hongyan Zhao,Guogang Xing, Xinxia Cai*. High frequency stimulation of subthalamicnucleus synchronously modulates primary motor cortex and caudate putamen basedon dopamine concentration and electrophysiology activities using microelectrodearrays in Parkinson's disease rats. SENSORSAND ACTUATORS B-CHEMICAL 2019 Dec 12; 301:127126.
Guihua Xiao, Yilin Song, Yu Zhang, Yu Xing, Hongyan Zhao, Jingyu Xie, Shengwei Xu, FeiGao, Mixia Wang, Guogang Xing, Xinxia Cai*. MicroelectrodeArrays Modified with Nanocomposites for Monitoring Dopamine and Spike Firingsunder Deep Brain Stimulation in Rat Models of Parkinson's Disease. ACS Sensors 2019 Aug 23;4(8):1992-2000.
Ling-Yu Liu, Rui-Ling Zhang, Lin Chen, Hong-Yan Zhao, JieCai, Jia-Kang Wang, Da-Qing Guo, Yan-Jun Cui*, Guo-Gang Xing*. Chronic stress increases pain sensitivity viaactivation of the rACC–BLA pathway in rats.Experimental Neurology 2019Mar;313:109-123.
Yue Yang, Song Li, Zi-Run Jin, Hong-Bo Jing, Hong-Yan Zhao, Bo-Heng Liu, Ya-JingLiang, Ling-Yu Liu, Jie Cai, You Wan, Guo-GangXing*. Decreased abundance of TRESK two-pore domain potassium channels insensory neurons underlies the pain associated with bone metastasis. Science Signaling 2018 Oct 16; 11(552):eaao5150.
Hong-Yan Zhao, Ling-Yu Liu, Jie Cai, Yan-Jun Cui*, Guo-Gang Xing*. ElectroacupunctureTreatment Alleviates the Remifentanil-induced Hyperalgesia by Regulating theActivities of Ventral Posterior Lateral Nucleus of the Thalamus Neurons inRats. Neural Plasticity 2018 Nov 11;2018:6109723.
Lin Chen, Song Li, Jie Cai, Tian-Jiao Wei, Ling-Yu Liu, Hong-Yan Zhao, Bo-Heng Liu,Hong-Bo Jing, Zi-Run Jin, Min Liu, You Wan, Guo-Gang Xing*. Activation of CRF/CRFR1 signaling in thebasolateral nucleus of the amygdala contributes to chronic forced swim-induceddepressive-like behaviors in rats. Behavioural Brain Research 2018 Feb 15; 338:134-142.
Xu Ding, Ya-Jing Liang, Li Su, Fei-Fei Liao, Dong Fang, Jun Tai, Guo-Gang Xing*. BDNF contributes to theneonatal incision-induced facilitation of spinal long-term potentiation and theexacerbation of incisional pain in adult rats. Neuropharmacology 2018 Jul 15; 137:114-132.
Ming-Jia Li, Ling-Yu Liu, Lin Chen, Jie Cai, You Wan, Guo-Gang Xing*. Chronic stress exacerbates neuropathic pain viathe integration of stress-affect related information and nociceptiveinformation in the central nucleus of the amygdala. Pain 2017 Apr;158(4):717-739.
Song Li, Jie Cai, Zhi-Bo Feng, Zi-Run Jin, Bo-Heng Liu, Hong-Yan Zhao, Hong-Bo Jing,Tian-Jiao Wei, Guan-Nan Yang, Ling-Yu Liu, Yan-Jun Cui*, Guo-Gang Xing*. BDNF contributes to spinal long-term potentiationand mechanical hypersensitivity via Fyn-mediated phosphorylation of NMDAreceptor GluN2B subunit at tyrosine 1472 in rats following spinal nerveligation. Neurochemical Research 2017Oct; 42(10): 2712-2729.
Fan Qu, Rong Li, Wei Sun, Ge Lin, Rong Zhang, Jing Yang, Li Tian, Guo-Gang Xing, Hui Jiang, Fei Gong,Xiao-Yan Liang, Yan Meng, Jia-Yin Liu, Li-Ying Zhou, Shu-Yu Wang, Yan Wu,Yi-Jing He, Jia-Yu Ye, Song-Ping Han, Ji-Sheng Han*. Use of electroacupunctureand transcutaneous electrical acupoint stimulation in reproductive medicine: agroup consensus. Journal of ZhejiangUniversity-SCIENCE B (Biomedicine & Biotechnology) 2017 Mar;18(3):186-193.
Li Li, Qinghai Liu, Long Fan, Wei Xiao, Lei Zhao, Yu Wang, Weiguang Ye, Fei Lan,Bin Jia, Hua Feng, Changman Zhou, Xiuqin Yue, Guo-Gang Xing*, Tianlong Wang*. Protective effects of oxymatrineagainst arsenic trioxide-induced liver injury. Oncotarget 2017 Feb 21;8(8):12792-12799.
Yi-Jing Li, Xing-Jie Ping, Chong Qi, Fang Shen, Lin-Lin Sun, Xiao-Wei Sun, Fei-Fei Ge, Guo-Gang Xing and Cai-Lian Cui*. Re-exposure to morphine-associated contextfacilitated long-term potentiation in the vSUB-NAc glutamatergic pathway viaGluN2B-containing receptor activation. AddictionBiology 2017 Mar; 22(2):435-445.
Jing Wang, Jing Wang, Guo-Gang Xing, Xiao-LiLi* and You Wan*. Enhanced Gamma Oscillatory Activity in Rats with ChronicInflammatory Pain. Frontiers inNeuroscience 2016 Nov 1; 10:489.
Dong Fang, Ling-Yu Kong, Jie Cai, Song Li, Xiao-Dan Liu, Ji-Sheng Han, Guo-Gang Xing*. Interleukin-6-mediatedfunctional upregulation of TRPV1 receptors in dorsal root ganglion neuronsthrough the activation of JAK/PI3K signaling pathway: roles in the developmentof bone cancer pain in a rat model. Pain 2015 Jun;156(6):1124-1144.
Xing Xiao, Xiao-Tao Zhao, Ling-Chi Xu, Lu-Peng Yue, Feng-Yu Liu,Jie Cai, Fei-Fei Liao, Jin-Ge Kong, Guo-GangXing, Ming Yi, You Wan*. Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons andalleviates CFA-induced inflammatory pain in rats. Pain 2015 Apr; 156(4):597-608.
Jie Cai, Dong Fang, Xiao-Dan Liu, Song Li, Juan Ren* and Guo-Gang Xing*. Suppression of KCNQ/M (Kv7) potassium channels inthe spinal cord contributes to the sensitization of dorsal horn WDR neurons andpain hypersensitivity in a rat model of bone cancer pain. Oncology Reports 2015 Mar; 33(3): 1540-1550.
Xu Ding, Jie Cai, Song Li, Xiao-Dan Liu, You Wan, Guo-Gang Xing*. BDNF contributes to the development of neuropathicpain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containingNMDA receptors activation in rats with spinal nerve ligation. Neurobiology of Disease 2015Jan; 73:428-451.
Xiao-Dan Liu, Jing-Jing Yang, Dong Fang, Jie Cai, You Wan*, Guo-Gang Xing*. Functional Upregulation of Nav1.8 Sodium Channelson the Membrane of Dorsal Root Ganglia Neurons Contributes to the Developmentof Cancer-Induced Bone Pain. PLoS One2014 Dec 11;9(12): e114623.
Hong Jiang, Dong Fang, Ling-Yu Kong, Zi-Run Jin, Jie Cai, Xue-Jing Kang, You Wan*and Guo-Gang Xing*. Sensitization ofneurons in the central nucleus of the amygdala via the decreased GABAergicinhibition contributes to the development of neuropathic pain-relatedanxiety-like behaviors in rats. MolecularBrain 2014 Oct 4; 7:72.
Lei Ding, Jie Cai, Xiang-Yang Guo, Xiu-LiMeng*, Guo-Gang Xing*. Theanti-allodynic action of pregabalin may depend on the suppression of spinalneuronal hyperexcitability via decreasing the dorsal horn N-methyl-D-aspartatereceptors in rats with spared nerve injury. PainResearch & Management 2014 Jul-Aug;19(4):205-211.
Yan Li,Jie Cai, Yin Han, Xin Xiao, Xiang-Lin Meng, Li Su, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Enhancedfunction of TRPV1 via up-regulation by insulin-like growth factor-1 in a ratmodel of bone cancer pain. Europeanjournal of pain 2014 Jul; 18(6):774-784.
Fei Yang, Jia Guo, Wei-Liang Sun, Feng-Yu Liu, Jie Cai, Guo-Gang Xing, You Wan*. Theinduction of long-term potentiation in spinal dorsal horn after peripheralnociceptive stimulation and contribution of spinal TRPV1 in rats. Neuroscience2014 Jun 6; 269:59-66.
Ling Hu, Xiang-Hong Jing, Cai-Lian Cui, Guo-GangXing, Bing Zhu*. NMDA receptors in the midbrain play a critical role indopamine-mediated hippocampal synaptic potentiation caused by morphine. Addiction Biology 2014 May;19(3):380-91.
X. Liu, B. Zhang, H. Yang, H. Wang, Y. Liu, A. Huang, T. Liu, X. Tian, Y. Tong, T. Zhou, T. Zhan, G. Xing, W. Xiao, X. Guo*, D. Fan*, X. Han, G. Liu*, Z. Zhou*, D. Chui*.Impaired synaptic vesicle recycling contributes to presynaptic dysfunction inlipoprotein lipase-deficient mice.Neuroscience2014 Nov 7; 280:275-281.
Min Liu, Huan Yang, Dong Fang, Jing-Jing Yang, Jie Cai, You Wan, De-Hua Chui,Ji-Sheng Han, Guo-Gang Xing*.Up-regulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglion contributes to thebone cancer pain. Pain2013 Sep;154(9):1551-1568.
Qin Zheng, Dong Fang, Ming Liu, Jie Cai, You Wan, Ji-Sheng Han, Guo-Gang Xing*.Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neuronscontributes to the development of bone cancer pain in a rat model. Pain 2013 Mar;154(3):434-448.
Ya-Nan Wang, Bo Wang, Min Liang, Cai-Yan Han, Bin Zhang, Jie Cai, Wei Sun*, Guo-Gang Xing*. Down-regulation ofCatSper1 channel in epididymal spermatozoa contributes to the pathogenesis ofasthenozoospermia, while up-regulation of the channel by Sheng-Jing-Santreatment improves the sperm motility of asthenozoospermia in rats. Fertility and Sterility 2013 Feb;99(2):579-587.
Qin Zheng, Dong Fang, Jie Cai, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Enhanced excitability of small dorsal root ganglionneurons in rats with bone cancer pain. MolecularPain 2012 Apr 3;8:24.
Feng-Yu Liu, Yan-Ni Sun, Fa-Tian Wang, Qian Li, Li Su, Zi-Fang Zhao, Xiang-Ling Meng,Hong Zhao, Xi Wu, Qian Sun, Guo-GangXing*, You Wan*. Activation of satellite glial cells in lumbar dorsal rootganglia contributes to neuropathic pain after spinal nerve ligation. Brain Research 2012 Jan 3;1427:65-77.
Yi-Lin Song, Nan-Sen Lin, Chun-Xiu Liu, Hong Jiang, Guo-Gang Xing, Xin-Xia Cai*. Anovel dual mode microelectrode array for neuroelectrical and neurochemicalrecording in vitro. Biosensors andBioelectronics 2012 Oct-Dec;38(1):416-20.
Ye-Nan Chi, Xu Zhang, Jie Cai, Feng-Yu Liu, Guo-GangXing, You Wan*. Formaldehyde increases intracellular calcium concentrationin primary cultured hippocampal neurons through NMDA receptors and T-typecalcium channels. Neuroscience Bulletin2012 Dec;28(6):715-22.
Ying Han, Yan Li, Xing Xiao, Jia Liu, Xiang-Ling Meng, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Formaldehydeup-regulates TRPV1 through MAPK and PI3K signaling pathways in a rat model ofbone cancer pain. Neuroscience Bulletin2012 Apr;28(2):165-72.
Ying-Ying Wang, Jiong Qin*, Ying Han, Jie Cai, Guo-GangXing*. Hyperthermia induces epileptiform discharges in cultured ratcortical neurons. Brain Research 2011Oct 12;1417:87-102.
Ming Yi, Haolin Zhang, Lixing Lao, Guo-GangXing, You Wan*. Anterior cingulate cortex is crucial for contra- but notipsi-lateral electro-acupuncture in the formalin-induced inflammatory painmodel of rats. Molecular Pain 2011 Aug22;7:61.
Jing Wang, Duan Li, Xiaoli Li, Feng-Yu Liu, Guo-GangXing, Jie Cai and You Wan*. Phase–amplitude coupling between theta andgamma oscillations during nociception in rat electroencephalography. Neuroscience Letters 2011 Jul20;499(2):84-87.
Feng-Yu Liu, Xiao-Xiu Qu, Jie Cai, Fa-Tian Wang, Guo-GangXing, You Wan*. Electrophysiological properties ofspinal wide dynamic range neurons in neuropathic pain rats following spinalnerve ligation. Neuroscience Bulletin2011 Feb;27(1):1-8.
Shan-Jing Geng, Fei-Fei Liao, Wen-Hao Dang, Xu Ding, Xiao-Dan Liu, Jie Cai, Ji-Sheng Han,You Wan, Guo-Gang Xing*.Contribution of the spinal cord BDNF to the development of neuropathic pain byactivation of the NR2B-containing NMDA receptors in rats with spinal nerveligation. Experimental Neurology2010 Apr;222(2):256-266.
Feng-Yu Liu, Xiao-Xiu Qu, Xu Ding, Jie Cai, Hong Jiang, You Wan, Ji-Sheng Han, Guo-Gang Xing*. Decrease in thedescending inhibitory 5-HT system in rats with spinal nerve ligation. Brain Research. 2010 May 12;1330:45-60.
Tianran Song, Yue Wang, Guian Chen* and GuogangXing*. Tyrosine hydroxylase-positive cells and dopaminergic neuronalfunction in human embryonic stem cells: An electrophysiological validation.Neural Regeneration Research 2010;5(3):185-190.
Xiao-Xiu Qu, Jie Cai, Ming-Jia Li, Ye-Nan Chi, Fei-Fei Liao, Feng-Yu Liu, You Wan,Ji-Sheng Han, Guo-Gang Xing*. Roleof the spinal cord NR2B-containing NMDA receptors in the development ofneuropathic pain. Experimental Neurology2009 Feb; 215(2):298-307.
Lu Yu, Fei Yang, Hao Luo, Feng-Yu Liu, Ji-Sheng Han, Guo-Gang Xing* and You Wan*. The role of TRPV1 in different subtypes of dorsal rootganglion neurons in rat chronic inflammatory nociception induced by completeFreund's adjuvant. Molecular Pain2008 Dec 4;4:61.
Yu-Qiu Jiang, Guo-Gang Xing, Sheng-LanWang, Hui-Yin Tu, Ye-Nan Chi, Jie Li, Feng-Yu Liu, Ji-Sheng Han, You Wan*.Axonal accumulation of hyperpolarization- activated cyclic nucleotide-gatedcation channels contributes to mechanical allodynia after peripheral nerveinjury in rat. Pain 2008 Jul 31; 137(3):495-506.
Yue Lu, Yan-Ni Sun, Xi Wu, Qian Sun, Feng-Yu Liu, Guo-Gang Xing, You Wan*. Role of alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionate(AMPA) receptor subunit GluR1 inspinal dorsal horn in inflammatory nociception and neuropathic nociception inrat. Brain Research 2008 Mar 20;1200:19-26.
Hao Luo, Isabella Shi Xu, Yi Chen, Fei Yang, Lu Yu,Guang-Xin Li, Feng-Yu Liu, Guo-Gang Xing,Yu-Shun Shi, Tan Li, Ji-Sheng Han and You Wan*. Behavioraland Electrophysiological Evidence for the Differential Functions of TRPV1 atEarly and Late Stages of Chronic Inflammatory Nociception in Rats. Neurochemical Research 2008Oct;33(10):2151-8.
Guo-Gang Xing*,Feng-Yu Liu, Xiao-Xiu Qu, Ji-Sheng Han, You Wan*. Long-term synaptic plasticityin the spinal dorsal horn and its modulation by electroacupuncture in rats withneuropathic pain. Experimental Neurology2007 Dec;208(2):323-332.
Feng-Yu Liu, Guo-Gang Xing,Xiao-Xiu Qu, Isabella S. Xu, Ji-Sheng Han, You Wan*. Roles of5-HT receptor subtypes in the inhibitory effects of 5-HT on C-fiber responsesof spinal wide dynamic range neurons in rats. The Journal of Pharmacology and Experimental Therapeutics 2007 Jun;321(3):1046-1053.
Guo-Gang Xing, Rengang Wang, Bo Yang, Dongxian Zhang*. Postnatal switching ofNMDA receptor subunits from NR2B to NR2Ain rat facial motor neurons. EuropeanJournal of Neuroscience 2006 Dec; 24(11):2987-2992.
Qian Sun,Guo-Gang Xing, Huiyin Tu, Ji-Sheng Han, YouWan*. Inhibition of hyperpolarization- activated current by ZD7288 suppressesectopic discharges of injured dorsal root ganglion neurons in a rat model ofneuropathic pain. Brain Research 2005Jan 25; 1032(1-2): 63-69.
Qian Sun, Huiyin Tu, Guo-GangXing, Ji-Sheng Han, You Wan*. Ectopic discharges from injured nerve fibersare highly correlated with tactile allodynia only in early, but not late, stagein rats with spinal nerve ligation. ExperimentalNeurology 2005 Jan;191(1):128-136.
參編著作
(1) 韓濟生主編《神經科學》（第4版），北京大學醫學出版社，2022年10月，ISBN 978-7-5659-2725-6，編寫章節：第6篇第7章：觸-壓覺、溫度覺與癢覺。
(2) 於龍川主編《神經生物學》（第2版），北京大學出版社，2022年9月，ISBN 978-7-301-33220-7，編寫章節：第一篇第二章：神經細胞的基本功能。
(3) 劉存志主編《現代針灸學導論》（第1版），中國中醫藥出版社，全國中醫藥行業高等教育“十三五”創新教材，2020年 1月，ISBN 978-7-5132-5939-2，編寫章節：第五章 現代針灸學機制。
(4) 王庭槐主編《生理學》（第9版），人民衛生出版社，國家衛生健康委員會“十三五”規劃教材，2018年 8月，ISBN 078-7-117-26659-8，編寫章節：第九章：感覺器官的功能。
(5) 羅自強、祁金順主編《生理學學習指導及習題集》（第3版），人民衛生出版社，國家衛生健康委員會“十三五”規劃教材，2018年 12月，ISBN 078-7-117-27739-6，編寫章節：第九章：感覺器官。
(6) 王瑞元主編《康復生理學》（第3版）人民衛生出版社，國家衛生健康委員會“十三五”規劃教材，2018年 3月，ISBN 078-7-117-26079-4，編寫章節：第十二章：神經系統的功能。
(7) 許壽生主編《康復生理學》學習指導及習題集（第2版），人民衛生出版社，2018年 3月，ISBN 078-7-117-27404-3，編寫章節：第十二章：神經系統的功能。
(8) 韓如泉、王保國、王國林主編《神經外科麻醉學》（第3版），人民衛生出版社，2018年 11月，ISBN 078-7-117-27209-4，編寫章節：第五十六章 疼痛治療的相關基礎。
(9) 王瑞元主編《生理學》（第2版）人民衛生出版社，2013年 3月，ISBN 078-7-117-17517-3/R.17518，編寫章節：第十二章：神經系統的功能。
(10) 許壽生主編《生理學》學習指導及習題集（第1版）人民衛生出版社，2013年 3月，ISBN 078-7-117-18139-6，編寫章節：第十二章：神經系統的功能。
(11) 於龍川主編《神經生物學》（第1版）北京大學出版社，2012年8月，ISBN 978-7-301-21113-7/Q.0126，編寫章節：第一篇第二章：神經細胞的基本功能。樊小力主編《人體機能學》（第1版）北京醫科大學出版社，2000年9月，ISBN 7-81071-075-3，編寫章節：第二章：細胞的分子結構和基本功能；第九章：感覺器官的功能。
