《KCNQ/M電壓門控鉀通道在骨癌痛發生中的作用及其機制研究》是邢國剛為項目負責人，北京大學為依託單位的青年科學基金項目。
基本介紹
- 中文名：KCNQ/M電壓門控鉀通道在骨癌痛發生中的作用及其機制研究
- 項目類別 ：面上項目
- 依託單位 ：北京大學
- 項目負責人：邢國剛
科研成果,項目摘要,
科研成果
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | Down-regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia, whereas up-regulation of the channel by Sheng-Jing-San treatment improves the sperm motility of asthenozoospermia in rats | 期刊論文 | Bin Zhang|Jie Cai|Wei Sun|Guo-Gang Xing| |
2 | KCNQ/M (Kv7) 鉀通道參與骨癌痛大鼠中樞敏化的電生理學研究. | 期刊論文 | 蔡捷|崔彥軍|邢國剛| |
3 | 鞘內套用普瑞巴林對神經病理性疼痛大鼠的鎮痛作用及其電生理學機制研究. | 期刊論文 | 丁蕾|邢國剛|郭向陽|孟秀麗| |
4 | BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation | 期刊論文 | Song Li|Xiao-Dan Liu|You Wan|Guo-Gang Xing| |
5 | BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation. | 期刊論文 | Song Li|Xiao-Dan Liu|You Wan|Guo-Gang Xing (邢國剛)| |
6 | Functional upregulation of nav1.8 sodium channels on the membrane of dorsal root ganglia neurons contributes to the development of cancer-induced bone pain | 期刊論文 | Dong Fang|Jie Cai|You Wan|Guo-Gang Xing| |
7 | Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model | 期刊論文 | Jie Cai|You Wan|Ji-Sheng Han|Guo-Gang Xing| |
8 | Suppression of KCNQ/M (Kv7) potassium channels in the spinal cord contributes to the sensitization of dorsal horn WDR neurons and pain hypersensitivity in a rat model of bone cancer pain | 期刊論文 | Xiao-Dan Liu|Song Li|Juan Ren|Guo-Gang Xing| |
9 | 電壓門控型鈉離子通道Nav1.8 在骨癌大鼠DRG 神經元細胞膜上的表達上調. | 期刊論文 | 蔡 捷|萬 有|韓濟生|邢國剛| |
10 | Down-regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia, whereas up-regulation of the channel by Sheng-Jing-San treatment improves the sperm motility of asthenozoospermia in rats | 期刊論文 | Bin Zhang|Jie Cai|Wei Sun|Guo-Gang Xing| |
11 | Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats | 期刊論文 | You Wan|De-Hua Chui|Ji-Sheng Han|Guo-Gang Xing| |
12 | 慢性疼痛與抑鬱關係的研究進展 | 期刊論文 | 聞潔曦|邢國剛| |
13 | Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model | 期刊論文 | Jie Cai|You Wan|Ji-Sheng Han|Guo-Gang Xing| |
14 | Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats | 期刊論文 | Jie Cai|Xue-Jing Kang|You Wan|Guo-Gang Xing| |
15 | 脊神經結紮誘導大鼠脊髓背角SFKs-Y416p 和GluN2B 表達增加. | 期刊論文 | 蔡捷|萬有|崔顏軍|邢國剛| |
16 | The antiallodynic action of pregabalin may depend on the suppression of spinal neuronal hyperexcitability in rats with spared nerve injury | 期刊論文 | Jie Cai|Xiang-Yang Guo|Xiu-Li Meng|Guo-Gang Xing| |
17 | Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain | 期刊論文 | Jie Cai|You Wan|Ji-Sheng Han|Guo-Gang Xing| |
18 | 抑鬱症的生物學機制研究進展 | 期刊論文 | 郭雨欣|邢國剛| |
19 | Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway: roles in the development of bone cancer pain in a rat model | 期刊論文 | Song Li|Xiao-Dan Liu|Ji-Sheng Han|Guo-Gang Xing| |
項目摘要
外周敏化,即初級感覺神經元的過度興奮與骨癌痛的發生直接相關；KCNQ/M通道對神經元的興奮性起到剎車閘樣調節作用,可以抑制神經元興奮性的過度增強,提示該通道在骨癌痛的發生中可能具有重要作用。癌症微環境可以產生大量的NGF,參與癌症痛的形成；NGF可以通過酪氨酸磷酸化與PIP2水解來抑制M通道的功能、提高神經元的興奮性。我們前期的工作發現,骨癌大鼠DRG神經元上M通道的表達和功能明顯抑制,這種抑制可能與DRG神經元興奮性的增加和骨癌痛的發生有關。本課題擬從以下三個方面闡明KCNQ/M通道在骨癌痛中的作用及其機制：①建立大鼠骨癌痛模型；②是否由於KCNQ/M通道的抑制而引起DRG神經元的過度興奮,進而引起外周敏化和骨癌痛的發生？③是否由NGF通過酪氨酸磷酸化與PIP2水解來抑制KCNQ/M通道,從而引起DRG神經元過度興奮,導致外周敏化和骨癌痛的發生？旨在闡明癌症痛的發病機理,尋找治療新靶點。
