趙瀅瀅,女,博士,深圳大學醫學部副教授、副研究員。
基本介紹
- 中文名:趙瀅瀅
- 學位/學歷:博士
- 職業:教師
- 專業方向:下丘腦生物節律
- 任職院校:深圳大學
個人經歷,研究方向,學術成果,
個人經歷
2012年獲美國康奈爾大學生物醫學博士,專業醫學生理學,2012至2014年美國康奈爾大學Weill研究所從事博士後工作。2014年7月加入深圳大學醫學部基礎醫學院生理學系,先後獲深圳市海外高層次人才(孔雀計畫C類),南山區領航人才,深圳市高層次人才。
研究方向
(1)下丘腦生物節律。
(2)睡眠障礙、阿爾茲海默症等多種衰老疾病中生物節律的變化及對疾病的影響
學術成果
主持並完成國家自然科學青年基金1項,廣東省自然科學基金1項,深圳市基礎研究等項目2項,多篇論文發表在有影響力的國際期刊。
科研項目
1. 深圳市自由探索項目:靶向period基因逆轉阿爾茲海默病生物節律紊亂的研究,2019/01-2022/12, 50萬,在研,主持
2. 廣東省自然科學基金 博士科研啟動基金2016A030310037:低頻旋恆磁場對卵母細胞發育成熟影響及其機制研究,2016/06-2019/06, 10萬,在研
3.國家自然科學基金青年基金31500940:核受體LXRβ對腎臟集合管上皮水通道蛋白AQP2的調節機制,2015/01-2018/12,24萬,結題
4. 深圳市海外高層次人才科研啟動 270萬,2017/01-2019/12,結題
發表文章
Wang Y, Zuo A, Huang X, Ying Y, Shu X, Chen X, Yang Y, Ma J, Lin G, Wang X, Mei L, Liu G, Zhao Y. Docetaxel-Loaded PAMAM-Based Poly (γ-benzyl-L-glutamate)-b- D -α - Tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles in Human Breast Cancer And Human Cervical Cancer therapy. J Microencapsul. 2019 Aug 12:1-33. (通訊作者)
Shu X, Zhang Y, Li M, Huang X, Yang Y, Zeng J, Zhao Y, Wang X, Zhang W, Ying Y. Topical ocular administration of the GLP-1 receptor agonist liraglutide arrests hyperphosphorylated tau-triggered diabetic retinal neurodegeneration via activation of GLP-1R/Akt/GSK3β signaling. Neuropharmacology. 2019 Jul 15;153:1-12.
Guan S, Zhao Y, Zhuo X, Song W, Geng X, Yang H, Wang J, Wu X, Yang J, Song X, Cheng L.Regional gender differences in an autosomal disease result in corresponding diversity differences. Sci Rep4.011. 2019 Apr 2;9(1):5472. (並列一作)
Zhu H, Zhang W, Zhao Y, Shu X, Wang W, Wang D, Yang Y, He Z, Wang X, Ying Y. GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions.Mol Neurodegener. 2018 Nov 22;13(1):62. (並列一作)
Yahalom V, Pillar N, Zhao Y, Modan S, Fang M, Yosephi L, Asher O, Shinar E, Celniker G, Resnik-Wolf H, Brantz Y, Hauschner H, Rosenberg N, Cheng L, Shomron N, Pras E. SMYD1 is the underlying gene for the AnWj-negative blood group phenotype. Eur J Haematol. 2018 Oct;101(4):496-501.
Shu X, Wang D, Zhao Y, Sun Y, Hu X, Huang X, Zeng J, Li C, Li Y, Zeng Y, Wang X, He Z, Ying Y. Extract from Moringa oleifera seeds suppresses the epithelial-mesenchymal transition-mediated metastasis of gastric cancer by targeting the metastatic suppressor NDRG1 Extract from Moringa oleifera seeds suppresses the epithelial-mesenchymal transition-mediated metastasis of gastric cancer by targeting the metastatic suppressor NDRG1. Journal of functional foods 50(2018)93-103 (並列一作)
Zhao Y, Guan S, Song W, Li Y, Ling L, Wang Y, Li X, Qin L, Yu H, Yang H, Wang J, Yang J, Liu J, Cheng L.Relative abundance of β-thalassemia-related mutations in southern China correlates with geographical coordinates. Ann Hematol. 2017 Nov;96(11):1961-1963. (並列一作)
Lin G, Chen T, Zou J, Wang Y, Wang X, Li J, Huang Q, Fu Z, Zhao Y, Lin MC, Xu G, Yong KT. Quantum Dots-siRNA Nanoplexes for Gene Silencing in Central Nervous System Tumor Cells. Front Pharmacol. 2017 Apr 4;8:182.
Zhao Y, Macgurn JA, Liu M, Emr S. The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress. Elife. 2013 Apr 16;2:e00459. (並列一作)
Henne WM, Buchkovich NJ, Zhao Y, Emr SD.The endosomal sorting complex ESCRT-II mediates the assembly and architecture of ESCRT-III helices. Cell. 2012 Oct 12;151(2):356-71.