趙勤儉，博士，曾任廈門大學公共衛生學院副院長。
現任重慶醫科大學藥學院特聘教授、博士生導師。
基本介紹
人物履歷,教育經歷,工作經歷,職務任免,學術成就,研究領域,主持課題,所獲榮譽,代表論文,
人物履歷
教育經歷
1981.9–1986.7 北京醫科大學,藥物化學,學士
1986.9–1989.7 北京醫科大學,藥物化學,碩士
1989.9–1994.5 美國天主教大學,生物有機化學,博士
工作經歷
1993.11-1997.06 約翰•霍普金斯大學醫學院，藥理與分子科學系及生物化學系，博士後
1997.07-2011.06 美國默克公司研發部，研究員、高級研究員、傑出高級研究員/科學主任
2011.06-2015.10 廈門大學公共衛生學院，特聘教授
2015.10-2021.12 廈門大學公共衛生學院，特聘教授、公共衛生學院副院長
2021.03-今 重慶醫科大學藥學院，特聘教授
職務任免
2022年1月14日，廈門大學黨委常委會研究決定：不再聘任趙勤儉為廈門大學公共衛生學院副院長。
學術成就
自1997年起在世界著名藥企默克公司從事生物藥物相關的研製工作。在疫苗、治療性蛋白的研發和生產中建立了多種關鍵的研究工具和質控手段。作為主要成員參與了世界第一個癌症疫苗的研製全過程，負責其中部分關鍵工藝的研發及產品的質量控制。2010年入選中組部國家級人才，次年回國全職擔任廈門大學公共衛生學院教授、博導，主要從事生物大分子藥物質量分析與新型佐劑方面的研究，其最佳化後的鋁佐劑現已成功助力國家疫苗中心自主研發的戊肝疫苗及HPV16/18雙價苗（已獲批上市）等國產疫苗中。由其主導研發的鋅鋁複合佐劑、新型雙膦酸佐劑已申請5項專利，並已將其套用到重組新冠疫苗及流感疫苗研發當中。學術方面，在Science Translational Medicine、PNAS、Trends in Biotechnology等國際知名期刊共發表130餘篇SCI論文，其中第一作者、共第一作者或通訊作者80餘篇；作為通訊作者共發表國內（核心）期刊中文文章21篇，申請或授權專利共8項（其中中國專利6項，美國專利2項），並擔任多個知名疫苗專業期刊雜誌編委。
研究領域
新型免疫調節劑
利用活性代謝物調控機體免疫，以達到預防及治療疾病的目的
微納米顆粒免疫刺激劑的開發及其安全性、有效性評估
免疫調節劑在抗腫瘤及預防感染方面的機制研究
生物大分子藥物及疫苗製劑的質量分析
重組類病毒顆粒（virus-like particles, VLPs）
表位鑑定（Epitope identification）
體外相對效力分析（in vitrorelative potency, IVRP）
新型疫苗佐劑研究
佐劑製備、理化性質鑑定
佐劑安全性、有效性評估
疫苗佐劑免疫調節機制
主持課題
1.國家自然科學基金面上項目，32070925，基於礦化雙膦酸微納米顆粒的新型佐劑免疫作用機制研究，2021/01-2024/12，58萬，在研，主持
2.國家自然科學基金重點項目，31730029，多聚化抗原誘導高效體液免疫應答的機制研究，2018/01-2022/12，250萬，在研，參與（核心骨幹成員）
3.國家自然科學基金面上項目，31670939，植物源多糖及寡糖引發平衡的Th1/Th2類免疫反應機制研究，2017/01-2020/12，60萬，已結題，主持
4.國家自然科學基金面上項目，81471934，人乳頭瘤病毒樣顆粒不同中和表位的特性與結構基礎研究，2015/01-2018/12，72萬，已結題，主持
5.國家自然科學基金面上項目，81273327，人乳頭瘤病毒樣顆粒表位的鑑定和中和機制研究，2013/01-2013/12，16萬，已結題，主持
6.“十二五”863重大項目，2012AA02A408，疫苗研發關鍵技術及產品研發，2012/01-2015/12，1600萬元，已結題，主持
所獲榮譽
1.榮獲“工業生物技術獎”，授予單位：美國化學學會生物化學技術部，2006年9月
2.求是傑出科技成就集體獎，香港求是科技基金會，2015年9月（夏寧邵，李少偉，張軍，吳婷，黃守傑，李益民，葛勝祥，顧穎，鄭子崢，袁權，潘暉榕，吳文翰，趙勤儉，史維國，羅文新，陳毅歆，程通，俞海）
3.全國抗擊新冠肺炎疫情先進集體獎（廈門大學國家傳染病診斷試劑與疫苗工程技術研究中心），授予單位：中共中央、國務院、中央軍委，2020年9月
代表論文
Yangtao Wu, Xiaofen Huang, Lunzhi Yuan, Shaojuan Wang, Yali Zhang, Hualong Xiong, Rirong Chen, Jian Ma, Ruoyao Qi, Meifeng Nie, Jingjing Xu, Zhigang Zhang, Liqiang Chen, Min Wei, Ming Zhou, Minping Cai, Yang Shi, Liang Zhang, Huan Yu, Junping Hong, Zikang Wang, Yunda Hong, Mingxi Yue, Zonglin Li, Dabing Chen, Qingbing Zheng, Shaowei Li, Yixin Chen, Tong Cheng, Jun Zhang*, Tianying Zhang*, Huachen Zhu*,Qinjian Zhao*, Quan Yuan*, Yi Guan*, Ningshao Xia*. A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters. Science Translational Medicine. 2021, 13(606):eabg1143. DOI: 10.1126/scitranslmed.abg1143.
Xin Wang, Xiaochen Yin, Boya Zhang, Chenfeng Liu, Yahua Lin, Xiaofen Huang, Yufang Li, Chenguang Shen, Weibin Zheng, Guofeng Fu, Junyu Chen, Yanling Wen, Wei Zhang, Bo-Sheng Pan, Mujin Fang, Zizheng Zheng, Zheng Zhang, Quan Yuan, Guo Fu, Jun Zhang, Yixin Chen, Ningshao Xia,Qinjian Zhao*. A prophylactic effect of aluminum-based adjuvants against respiratory viruses via priming local innate immunity. Emerging Microbes & Infections. 2022. DOI: 10.1080/22221751.2022.2050951.
Xinyuan Zhang, Zhigang Zhang, Ningshao Xia,Qinjian Zhao*. Carbohydrate-containing nanoparticles as vaccine adjuvants. Expert Review of Vaccines. 2021, 20(7):797-810.
Xiaofen Huang, Yike Li, Meifeng Nie, Mingxi Yue, Yufang Li, Zhijie Lin, Huirong Pan, Mujin Fang, Ting Wu, Shaowei Li, Jun Zhang, Ningshao Xia*, Qinjian Zhao∗. Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal. Journal of Pharmaceutical Analysis. 2021, 11(5):617-627.
Xiao Zhang, Bingchun Zhao, Mingmei Ding, Shuo Song, Yinfeng Kang, Yang Yu, Miao Xu, Tong Xiang, Ling Gao, Qisheng Feng,Qinjian Zhao*, Mu-Sheng Zeng*, Claude Krummenacher, Yi-Xin Zeng*. A novel vaccine candidate based on chimeric virus-like particle displaying multiple conserved epitope peptides induced neutralizing antibodies against EBV infection. Theranostics. 2020, 10(13): 5704-5718.
Lijie Ren, Zhigang Zhang, Xinyuan Zhang, Zhibo Kong, Shaowei Li，Qinjian Zhao*. In situ analysis of biomolecular interactions on nano/microparticles in formulations. Journal of Pharmaceutical and Biomedical Analysis. 2021, 201:114130.
Bin He, Zhigang Zhang, Xinyuan Zhang, Ziming Tang, Chang Liu, Zizheng Zheng, Shaowei Li, Jun Zhang, Ningshao Xia,Qinjian Zhao*. Functional epitopes on hepatitis E virions and recombinant capsids are highly comformation-dependent. Human Vaccines & Immunotherapeutics. 2020, 16(7):1554-1564.
Yike Li, Xiaofen Huang, Zhigang Zhang, Shaowei Li, Jun Zhang, Ningshao Xia,Qinjian Zhao*. Prophylactic hepatitis E vaccines: antigenic analysis and serological evaluation. Viruses. 2020, 12(1):109.
Xiaochen Yin, Xin Wang, Zhigang Zhang, Yufang Li, Zhijie Lin, Huirong Pan, Ying Gu, Shaowei Li, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Demonstration of real-time and accelerated stability of hepatitis E vaccine with a combination of different physicochemical and immunochemical methods. Journal of Pharmaceutical and Biomedical Analysis. 2020, 177:112880.
Zhigang Zhang, Tianying Zhang, Lu Cao, Xin Wang, Jiali Cao, Xiaofen Huang, Yashuang Cai, Zhijie Lin, Huirong Pan, Quan Yuan, Mujin Fang, Shaowei Li, Jun Zhang, Ningshao Xia,Qinjian Zhao*. Simultaneous in situ visualization and quantitation of dual antigens adsorbed on adjuvants using high content analysis. Nanomedicine. 2019, 14(19):2535-2548.
Siyi Chen, Xiaofen Huang, Yike Li, Xin Wang, Huirong Pan, Zhijie Lin, Qingbing Zheng, Shaowei Li, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Altered antigenicity and immunogenicity of human papillomavirus virus-like particles in the presence of thimerosal. European Journal of Pharmaceutics and Biopharmaceutics. 2019, 141:221-231.
Kaihang Wang, Lizhi Zhou, Xiao Zhang, Cuiling Song, Tingting Chen, Jiajia Li, Minghua Zheng, Yingbin Wang, Qingbing Zheng, Zizheng Zheng, Hai Yu, Ting Wu, Ying Gu, Jun Zhang,Qinjian Zhao*, Shaowei Li*, Ningshao Xia. Hepatitis E vaccine candidate harboring a non-particulate immunogen of E2 fused with CRM197 fragment A. Antiviral Research. 2019, 164:154-161.
Xin Wang, Min Li, Zhijie Lin, Huirong Pan, Zimin Tang, Zizheng Zheng, Shaowei Li, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Multifaceted characterization of recombinant protein-based vaccines: An immunochemical toolbox for epitope-specific analyses of the hepatitis E vaccine. Vaccine. 2018, 36(50):7650-7658.
Cai Zhang, Xiaofen Huang, Siyi Chen, Yike Li, Yufang Li, Xin Wang, Jixian Tang, Lin Xia, Zhijie Lin, Wenxin Luo, Tingdong Li, Shaowei Li, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Epitope clustering analysis for vaccine-induced human antibodies in relationship to a panel of murine monoclonal antibodies against HPV16 viral capsid. Vaccine. 2018, 36(45):6761-6771.
Zhigang Zhang, Jun Zhang, Ningshao Xia,Qinjian Zhao*. Expanded strain coverage for a highly successful public health tool: Prophylactic 9-valent human papillomavirus vaccine. Human Vaccines & Immunotherapeutics. 2017, 13(10):2280-2291.
Xin Wang, Zhiqiang An, Wenxin Luo, Ningshao Xia,Qinjian Zhao*. Molecular and functional analysis of monoclonal antibodies in support of biologics development. Protein & Cell. 2017. 9(1):74–85.
Yahua Lin, Xin Wang, Xiaofen Huang, Jun Zhang, Ningshao Xia,Qinjian Zhao*. Calcium phosphate nanoparticles as a new generation vaccine adjuvant. Expert Review of Vaccines. 2017, 16(9):895-906.
Xiaofen Huang, Xin Wang, Jun Zhang, Ningshao Xia, Qinjian Zhao*. Escherichia coli-derived virus-like particles in vaccine development. npj Vaccines. 2017, 2:3. DOI: 10.1038/s41541-017-0006-8..
Zhang X, Wei M, Sun G, Wang X, Li M, Lin Z, Li Z, Li Y, Fang M, Zhang J, Li S, Xia N*,Zhao Q*. Vaccine. Real-time stability of a hepatitis E vaccine (Hecolin®) demonstrated with potency assays and multifaceted physicochemical methods. Vaccine, 2016, 34(48):5871-5877.
Lu Cao, Xin Wang, Mujin Fang, Ningshao Xia,Qinjian Zhao*. Detection of subtle differences in analogous viral capsid proteins by allowing unrestricted specific interaction in solution competition ELISA. Journal of Virological Methods, 2016, 236: 1-4.
Min Li, Xin Wang, Lu Cao, Zhijie Lin, Minxi Wei, Mujin Fang, Shaowei Li, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Quantitative and epitope-specific antigenicity analysis of the human papillomavirus 6 capsid protein in aqueous solution or when adsorbed on particulate adjuvants. Vaccine, 2016, 34(37): 4422-4428.
Qingshan Lin, Kunyu Yang, Fangping He, Jie Jiang, Tingting Li, Zhenqin Chen, Rui Li, Yixin Chen, Shaowei Li*,Qinjian Zhao*, Ningshao Xia. Production of Influenza Virus HA1 Harboring Native-Like Epitopes by Pichia pastoris. Applied Biochemistry and Biotechnology, 2016, 179(7): 1275–1289.
Lin Xia#, Yangfei Xian#, Daning Wang, Yuanzhi Chen, Xiaofen Huang, Xingjian Bi, Hai Yu, Zheng Fu, Xinlin Liu, Shaowei Li, Zhiqiang An, Wenxin Luo*,Qinjian Zhao*, Ningshao Xia. A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5. Scientific Report, 2016, 6: 19042.
Xiao Zhang, Shaowei Li, Yorgo Modis, Zhihai Li, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Functional assessment and structural basis of antibody binding to human papillomavirus capsid. Review in Medical Virology, 2016, 26:115-128.
Xin Wang, Min Li, Shaowei Li, Ting Wu, Jun Zhang, Ningshao Xia*,Qinjian Zhao*. Prophylaxis against Hepatitis E: at risk populations and human vaccines. Expert review of vaccines, 2016, 15(7): 815-827.
