趙允(中國科學院分子細胞科學卓越創新中心副主任，徐匯區人大常委會副主任)

趙允(中國科學院分子細胞科學卓越創新中心副主任，徐匯區人大常委會副主任)

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趙允，男，漢族，1971年1月生，遼寧蓋州人。理學博士，正高級研究員。1992年8月參加工作，2010年4月加入九三學社。

現任上海市徐匯區人大常委會副主任，九三學社上海市徐匯區委員會主任委員，中科院分子細胞科學卓越創新中心副主任、研究組組長，博士生導師。

基本介紹

  • 中文名：趙允
  • 國籍：中國
  • 民族：漢族
  • 出生日期：1971年1月
  • 畢業院校：山東大學(學士)、北京大學(博士)
  • 籍貫：遼寧蓋州
  • 政治面貌：九三學社社員
  • 職稱：正高級研究員
人物經歷,教育背景,工作經歷,學術任職,社會兼職,研究方向,所獲榮譽,科研活動,科研項目,參與會議,代表論著,

人物經歷

教育背景

1992年山東大學微生物系微生物學專業畢業，獲理學學士學位
2001年北京大學生命科學院分子細胞生物學專業畢業，獲理學博士學位

工作經歷

2001-2004年在美國哈佛大學醫學院從事博士後研究工作
2004-2008年在美國德州大學西南醫學中心從事博士後研究工作
2008年6月起任中科院上海生科院生物化學與細胞生物學研究所(現中國科學院分子細胞科學卓越創新中心)研究員，研究組長

學術任職

2016.01.01-2021.12.31,第三屆發育生物學專業委員會委員
2015.01.01-2020.12.31,中國細胞生物學學會第十一屆理事會理事

社會兼職

2021.05.21-，九三學社上海市徐匯區委員會主任委員
2022.01.07-，上海市徐匯區人大常委會副主任
2022.12，九三學社第十五屆中央委員會委員。
中國人民政治協商會議上海市第十四屆委員會委員。

研究方向

細胞內信號傳導通路的異常與疾病發生的分子基礎

所獲榮譽

（1） 細胞凋亡與NF-kappaB激活的信號傳導研究, 一等獎, 部委級, 2006
（2） 全國優秀博士學位論文, 一等獎, 部委級, 2003
（3） 非細胞體系核重建（裝配）的系統研究, 一等獎, 部委級, 2001

科研活動

科研項目

（ 1 ） Hh 信號通路中Ci SUMO 化修飾的作用機制及功能研究, 負責人, 國家任務, 2014-01--2017-12
（ 2 ） 發育中PRC1調控H h信號通路Ci/Gli轉錄的分子機制及功能研究, 負責人, 國家任務, 2017-01--2021-12
（ 3 ） 著絲粒蛋白質機器調控細胞命運抉擇的效應機制, 參與, 國家任務, 2017-07--2022-06

參與會議

（1）Mechanism of the graded Hh signal transduction 廈門舉辦的第三屆“模式生物與人類健康”發育遺傳學全國學術研討會。 2014-07-18
（2）Mechanism of the graded Hh signal transduction。 台北舉辦的2014 國際癌症新知研討會/第十一屆前瞻生物醫學科學新知研討會暨第十三屆海峽兩岸生物醫學研討會 2014-06-28
（3）Decoding Ci: from partial degradation to inhibition 第47 屆亞太地區發育生物學年會 2014-05-30
（4）Ter94 is involved the selective degradation of Ci 新加坡參加會議 2013-10-08

代表論著

  1. Yiao Jiang, Jiayin Peng, Jiawen Song, Juan He, Man Jiang, Jia Wang, Liya Ma, Yuang Wang, Moubin Lin, Hailong Wu, Zhao Zhang, Dong Gao, Yun Zhao*. Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2. Nature Metabolism. 2021; Nov;3(11):1569-1584. doi: 10.1038/s42255-021-00488-3.
  2. Yitian Luo, Guoyue Wan, Xuan Zhou, Qiuwen Wang, Yunbin Zhang, Juan Bao, Yao Cong, Yun Zhao*, Dianfan Li*. Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release. Frontiers in Molecular Biosciences. 2021; Sep 7; 8:701826. doi: 10.3389/fmolb.2021.701826. eCollection 2021.
  3. Luwei He*, Huaguang Li, Chenyu Pan, Yutong Hua, Jiayin Peng, Zhaocai Zhou, Yun Zhao*, Moubin Lin*. Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling. Cancer Communications. 2021; 41(8):726-746.
  4. Hui Zhang, Moubin Lin, Chao Dong, Yang Tang, Liwei An, Junyi Ju, Fuping Wen, Fan Chen, Meng Wang, Wenjia Wang, Min Chen, Yun Zhao, Jixi Li, Steven X Hou, Xinhua Lin, Lulu Hu, Wenbo Bu, Dianqing Wu, Lin Li, Shi Jiao, Zhaocai Zhou. An MST4-pβ-Catenin Thr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis. Advance Science. 2021; e2004850. doi: 10.1002/advs.202004850.
  5. Yitian Luo, Guoyue Wan, Xiang Zhang, Xuan Zhou, Qiuwen Wang, Jialin Fan, Hongmin Cai, Liya Ma, Hailong Wu, Qianhui Qu*, Yao Cong*, Yun Zhao*, Dianfan Li*. Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae. Structure. 2021; 29(11):1286-1294.
  6. Heng Feng , Wenhui Xing, Yujiao Han, Jun Sun, Mingxiang Kong , Bo Gao, Yang Yang, Zi Yin, Xiao Chen , Yun Zhao , Qing Bi, Weiguo Zou. Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification. The Journal of Clinical Investigation. 2020; 130(12):6354-6365.
  7. Shuo Zhang, Juan Zhao, Xiangdong Lv , Jialin Fan, Yi Lu, Tao Zeng , Hailong Wu, Luonan Chen* , Yun Zhao*. Analysis on gene modular network reveals morphogen-directed development robustness in Drosophila. Cell Discovery. 2020; 6:43. doi: 10.1038/s41421-020-0173-z
  8. Yang Tang, Gemin Fang, Fenghua Guo, Hui Zhang, Xiaoxu Chen, Liwei An, Min Chen, Li Zhou, Wenjia Wang, Tiantian Ye, Lei Zhou, Pingping Nie, Haijun Yu, Moubin Lin, Yun Zhao, Xinhua Lin, Zengqiang Yuan, Shi Jiao, Zhaocai Zhou. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell. 2020; 38(1):115-128.e9. doi: 10.1016/j.ccell.2020.05.019
  9. Ke Zhang, Fang Yu, Jian Zhu, Sue Han, Jiehui Chen, Xuanyuan Wu, Yingying Chen, Tingyu Shen, Jiaoyang Liao, Wenke Guo, Xianfa Yang, Ran Wang, Yun Qian, Jiaxin Yang, Leping Cheng, Yun Zhao, Chi-Chung Hui, Jinsong Li, Guangdun Peng, Shuijin He, Naihe Jing, Ke Tang. Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neuro developmental Disorders with an NR2F1 Point Mutation. Cell Reports. 2020; 21;31(3):107521. doi: 10.1016/j.celrep.2020.03.085
  10. Liwei An, Pingping Nie, Min Chen, Yang Tang, Hui Zhang, Jingmin Guan, Zhifa Cao, Chun Hou, Wenjia Wang, Yun Zhao, Huixiong Xu, Shi Jiao, Zhaocai Zhou. MST4 Kinase Suppresses Gastric Tumorigenesis by Limiting YAP Activation via a Non-Canonical Pathway. Journal of Experimental Medicine. 2020; 217(6):e20191817.
  11. Xue Feng, Tiantian Lu, Jinhui Li, Ruizeng Yang, Liqiao Hu, Yi Ye, Feifei Mao, Lingli He, Jinjin Xu, Zuoyun Wang, Yingbin Liu, Yonglong Zhang, Hongbin Ji, Yun Zhao, Shuqun Cheng, Wei Tian and Lei Zhang. The tumor suppressor Interferon Regulatory Factor 2 Binding Protein 2 regulates Hippo pathway in liver cancer by a feedback loop in mice. Hepatology. 2020; 71(6):1988-2004
  12. Ruoying Yu, Huihui Wu, Hazrat Ismail , Shihao Du , Jun Cao, Jianyu Wang, Tarsha Ward, Fengrui Yang, Ping Gui, Mahboob Ali, Lingluo Chu, Fei Mo, Qi Wang, Youjun Chu, Yun Zhao, Mingliang Ye, Guowei Fang, Peng R Chen, Zhen Dou, Xinjiao Gao, Wenwen Wang, Xing Liu, Xuebiao Yao. Methylation of PLK1 by SET7/9 Ensures Accurate Kinetochore-Microtubule Dynamics. Journal of Molecular Cell Biology. 2020; 12(6):462-476.
  13. Jialin Fan, Yajie Gao, Yi Lu, Wenqing Wu, Shuo Yuan, Hailong Wu, Dahua Chen and Yun Zhao*. PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila. Cell Discovery. 2019; 5:44.
  14. Lingli He, Liang Yuan, Yang Sun, Pingyang Wang, Hailin Zhang, Xue Feng, Zuoyun Wang, Wenxiang Zhang, Chuanyu Yang, Yi Arial Zeng, Yun Zhao, Ceshi Chen and Lei Zhang. Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression. Cancer Research. 2019; 79(17):4399-4411
  15. Xue Feng, Zuoyun Wang, Fei Wang, Tiantian Lu, Jinjin Xu, Xueyan Ma, Jinhui Li, Lingli He, Wenxiang Zhang, Sheng Li, Wenjun Yang, Shu Zhang, Gaoxiang Ge, Yun Zhao, Ping Hu, Lei Zhang. Dual function of VGLL4 in muscle regeneration. EMBO J. 2019; 38:e101051
  16. Wei Yu, Xueyan Ma, Jinjin Xu, Andreas Wilhelm Heumüller, Zhaoliang Fei, Xue Feng, Xiaodong Wang, Kuo Liu, Jinhui Li, Guizhong Cui, Guangdun Peng, Hongbin Ji, Jinsong Li, Naihe Jing, Hai Song, Zhiqiang Lin, Yun Zhao, Zuoyun Wang, Bin Zhou, and Lei Zhang. VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genet. 2019; 15(2):e1007977.
  17. Yang Tang, Min Chen, Li Zhou, Jian Ma, Yehua Li, Hui Zhang, Zhubing Shi, Qi Xu, Xiaoman Zhang, Ziyang Gao, Yun Zhao, Yunfeng Cheng, Shi Jiao and Zhaocai Zhou. Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling. Cell Discovery. 2019; 5:3.
  18. Xiangdong Lv, Hao Chen, Shuo Zhang, Zhao Zhang, Chenyu Pan, Yuanxin Xia, Jialin Fan, Wenqing Wu, Yi Lu, Lei Zhang, Hailong Wu and Yun Zhao*. Distinct Functions of Polycomb Group Proteins in Regulating Ci Transcription in Developing Drosophila. Journal of Molecular Cell Biology. 2018, 10(5):475-478.
  19. Xiangdong Lv, Hao Chen, Shuo Zhang, Zhao Zhang, Chenyu Pan, Yuanxin Xia, Jialin Fan, Wenqing Wu, Yi Lu, Lei Zhang, Hailong Wu and Yun Zhao*. Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci). Journal of Molecular Cell Biology. 2018, 10(5):437-447.
  20. Wenxiang Zhang, Jinjin Xu, Jinhui Li, Tong Guo, Dan Jiang, Xue Feng, Xueyan Ma, Lingli He, Wenqing Wu, Mengxin Yin, Ling Ge, Zuoyun Wang, Margaret S. Ho, Yun Zhao, Zhaoliang Fei and Lei Zhang. The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex. Journal of Biological Chemistry. 2018, 293(44):17119-17134.
  21. Xueyan Ma, Peixue Li, Peihao Chen, Jinhui Li, Hongling Huang, Chao Wang, Wenjing Li, Jianping Ding, Yun Zhao, Fa-Xing Yu, Xiangbing Qi and Lei Zhang. Staurosporine targets the Hippo pathway to inhibit cell growth. Journal of Molecular Cell Biology. 2018, 10(3):267-269.
  22. Chenyu Pan, Yue Xiong, Xiangdong Lv, Yuanxin Xia, Shuo Zhang, Jialin Fan, Hao Chen, Feng Liu, Hailong Wu, Zhaocai Zhou, Lei Zhang and Yun Zhao*. UbcD1 regulates the Hedgehog signaling by directly controlling Ci ubiquitination and processing. EMBO Reports. 2017, 18(11):1922-1934.
  23. Yuhong Han, Yue Xiong, Xuanming Shi, Jiang Wu, Yun Zhao* and Jin Jiang*. Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system. PLoS Biology. 2017, 15(8):e2002063.
  24. Shuo Zhang, Chenyu Pan, Xiangdong Lv, Wei Wu, Hao Chen, Wenqing Wu, Hailong Wu, Lei Zhang, and Yun Zhao. Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis. Scientific Reports. 2017, 7: 5101.
  25. Xu Xiao, Jing-jie Tang, Chao Peng, Yan Wang, Lin Fu, Zhi-ping Qiu, Yue Xiong, Lian-fang Yang, Hai-wei Cui, Xiao-long He, Lei Yin, Wei Qi, Catherine C.L. Wong, Yun Zhao, Bo-liang Li, Wen-wei Qiu and Bao-liang Song. Cholesterol modification of Smoothened is required for Hedgehog signaling. Molecular Cell. 2017, 66(1):154-162.
  26. Jiajun Xu, Xue Hao, Meng-Xin Yin, Yi Lu, Yunyun Jin, Jinjin Xu, Ling Ge, Wenqing Wu, Margaret Ho, Yingzi Yang, Yun Zhao and Lei Zhang. Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity. Development. 2017, 144: 1510-1517.
  27. Yi Hao, Qinbo Zhou, Jing Ma, Yun Zhao, and Shusheng Wang. miR-146a is upregulated during retinal pigment epithelium (RPE)/choroid aging in mice and represses IL-6 and VEGF-A expression in RPE cells. J Clin Exp Ophthalmol. 2016, 7(3): 562.
  28. Lin Fu, Hailong Wu, Steven Y Cheng, Daming Gao, Lei Zhang and Yun Zhao. Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway. eLIFE. 2016, 5:e15690.
  29. Xiangdong Lv, Zhijun Han, Hao Chen, Bo Yang, Xiaofeng Yang, Yuanxin Xia, Chenyu Pan, Lin Fu, Shuo Zhang, Hui Han, Min Wu, Zhaocai Zhou, Lei Zhang, Lin Li, Gang Weiand Yun Zhao. A positive role for polycomb in transcriptional regulation via H4K20me1. Cell Research. 2016, 26:529-542.
  30. Xiangdong Lv, Chenyu Pan, Zhao Zhang, Yuanxin Xia, Hao Chen, Shuo Zhang, Tong Guo, Hui Han, Haiyun Song, Lei Zhang and Yun Zhao. SUMO regulates somatic cyst stem cells maintenance and directly targets Hedgehog pathway in adult Drosophila testis. Development. 2016, 143(10):1655-1662.

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