賈桂芳，博士，北京大學化學與分子工程學院特聘研究員，博士生導師，國家傑出青年科學基金獲得者，國家優秀青年科學基金獲得者。
基本介紹
- 中文名：賈桂芳
- 畢業院校：中國農業大學理學院
- 學位/學歷：博士
- 職業：教師
- 專業方向：與核酸相關的最前沿、熱點領域RNA表觀遺傳學
- 主要成就：2018年獲得國家優秀青年科學基金
2022年獲得國家傑出青年科學基金 - 任職院校：北京大學化學與分子工程學院
個人經歷,研究方向,學術成果,所獲榮譽,
個人經歷
1998-2002 中國農業大學理學院，理學學士
2003-2008 中國農業大學理學院，理學博士
2007-2012 美國芝加哥大學化學系，訪問學者、博士後
2012-2019 北京大學化學與分子工程學院，副研究員
2020-至今 北京大學化學與分子工程學院特聘研究員
2021-至今 北大-清華生命科學聯合中心，PI
研究方向
2.研究RNA去甲基修飾蛋白酶的對RNA的調控功能和致病機理；
3.研究N6-甲基腺嘌呤在植物中的功能與機理；
4.利用化學二硫鍵交聯技術對去甲基修飾蛋白酶與核酸複合物的結構解析和功能機理研究。
學術成果
1. Liu, J., Jia, G. *, Methylation modifications in eukaryotic messenger RNA, J Genet Genomics.
2. Liu, J.Z., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., Dai, Q., Chen, W., He, C. *, A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat. Chem. Biol..
3. Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., Ren, B., Pan, T., He, C.*, N6-methyladenosine-dependent regulation of messenger RNA stability. Nature.
4. Fu, Y.#, Jia, G.#, Pang, X., Wang, R. N., Wang, X., Li, C. J., Smemo, S., Dai, Q., Bailey, K. A., Nobrega, M. A., Han, K.-L., Cui, Q., He, C.*, FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA. Nat. Commun.(#co-first author)
5. Jia, G., Fu, Y., He, C.*, Reversible RNA adenosine methylation in biological regulation. Trends Genet.
6. Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, Charles J., Vågbø, Cathrine B., Shi, Y., Wang, W.-L., Song, S.-H., Lu, Z., Bosmans, Ralph P. G., Dai, Q., Hao, Y.-J., Yang, X., Zhao, W.-M., Tong, W.-M., Wang, X.-J., Bogdan, F., Furu, K., Fu, Y., Jia, G., Zhao, X., Liu, J., Krokan, Hans E., Klungland, A.*, Yang, Y.-G.*, He, C.*, ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. Mol. Cell.
7. Chen, B., Ye, F., Yu, L., Jia, G., Huang, X., Zhang, X., Peng, S., Chen, K., Wang, M., Gong, S., Zhang, R., Yin, J., Li, H., Yang, Y., Liu, H., Zhang, J., Zhang, H., Zhang, A., Jiang, H., Luo, C.*, Yang, C.G.*, “Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor”, J. Am. Chem. Soc.
8. Yi, C., Chen, B., Qi, B., Zhang, W., Jia, G., Zhang, L., Li, C. J., Dinner, A. R., Yang, C. G.*, He, C.* Duplex interrogation by a direct DNA repair protein in search of base damage. Nat. Struct. Mol. Biol.
9. Jia, G.#, Fu, Y.#, Zhao, X.#, Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y. G., He, C.*, N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol.(#co-first author)
10. Yi, C., Jia, G., Hou, G., Dai, Q., Zhang, W., Zheng, G., Jian, X., Yang, C.-G., Cui, Q., He, C.*, Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase. Nature.
11. Jia, G.#, Yang, C-G.#, Yang, S., Jian, X., Yi, C., Zhou, Z., He, C.*, Oxidative demethylation of 3-meT and 3-meU in single-stranded DNA and RNA by mouse and human FTO, FEBS Lett.
12. Jia G, Lv C, Zhu W, Qiu J, Wang X, Zhou Z.*, Applicability of cloud point extraction coupled with microwave assisted back-extraction to the determination of organophosphorous pesticides in human urine by gas chromatography with flame photometry detection, J. Hazard Mater., 2008.
13. Jia G, Li L, Qiu J, Wang X, Zhu W, Sun Y, Zhou Z.*, Determination of carbaryl and its metabolite 1-naphthol in water samples by fluorescence spectrophotometer after anionic surfactant micelle-mediated extraction with sodium dodecylsulfate, Spectrochim Acta Part A Mol. Biomol. Spectrosc., 2007.
14. Lv C, Jia G, Zhu W, Qiu J, Wang X, Zhou Z.*, Enantiomeric resolution of new triazole compounds by high perform liquid chromatography, J. Sep. Sci., 2007
15. Wang X, Jia G, Qiu J, Diao J, Zhu W, Lv C, Zhou Z.*, Stereoselective degradation of fungicide Benalaxyl in soils and Cucumber plants, Chirality, 2007.
16. Qiu J, Wang Q, Zhu W, Jia G, Wang X, Zhou Z.*, Stereoselective Determination of Benalaxyl in Plasma by ChiralHigh-Performance Liquid Chromatography with Diode Array Detector and Application to Pharmacokinetic Study in Rabbits, Chirality, 2007.
17. Zhu W, Qiu J, Dang Z, Lv C, Jia G, Li L, Zhou Z.*, Stereoselective Degradation Kinetics of Tebuconazole in Rabbits, Chirality, 2007
18. Zhu W, Dang Z, Qiu J, Lv C, Jia G, Li L, Zhou Z.*, Stereoselective Toxicokinetics and Tissue Distribution of Ethofumesate in Rabbits, Chirality, 2007.
19. Jia G, Bi C, Wang Q, Qiu J, Zhou W, Zhou Z.*, Determination of Etofenprox in environmental samples by HPLC after anionic surfactant micelle-mediated extraction (coacervation extraction), Anal. Bioanal. Chem., 2006.
20. Wang Q, Qiu J, Zhu W, Jia G, Li J, Bi C, Zhou Z*, Stereoselective Degradation Kinetics of Theta-cypermethrin in Rats, Environ. Sci. Technol., 2006
21. Qiu J, Wang Q, Wang P, Jia G, Li J, Zhou, Z*, Enantioselective degradation kinetics of Metalaxyl in Rabbits, Pestic. Biochem. Physiol., 2005
22. Wang Q, Qiu J, Wang P, Jia G, Wang P, Li J, Zhou Z.*, Stereoselective Kinetic Study of Hexaconazole Enantiomers in the Rabbit, Chirality, 2005
23. Jia G, Wang P， Qiu J， Sun Y， Xiao Y, Zhou Z*, Determination of DNA with imidacloprid by a Resonance Light Scattering Technique at Nanogram Levels and Its Application，Anal. Lett.
24. Jie N*, Jia G, Hou S, Xiong Y, Dong Y. Determination of deoxyribonucleic acids by a resonance light scattering technique and its application, Spectrochim Acta Part A Mol. Biomol. Spetrosc.
所獲榮譽
2024年4月，經第十九屆中國青年女科學家獎評審委員會評審，賈桂芳獲得第十九屆中國青年女科學家獎。
