費騰，男，東北大學生命科學與健康學院教授、博士生導師。
基本介紹
- 中文名：費騰
- 職業：教師
- 畢業院校：清華大學
- 學位/學歷：博士
- 專業方向：生命科學
- 任職院校：東北大學
人物經歷,學習經歷,工作經歷,研究方向,發表論文,
人物經歷
學習經歷
2001-2005東北大學生物工程專業，學士
2005-2010清華大學生命科學學院，博士
2011-2016哈佛大學醫學院/Dana-Farber癌症研究所，博士後
工作經歷
2016- 東北大學生命科學與健康學院，教授，博導
研究方向
本課題組主要運用多種高通量的功能基因組學結合精細的分子細胞學研究手段，探討腫瘤、代謝性疾病以及幹細胞領域相關的重大問題。鑑定參與上述過程的重要功能基因、基因元件以及非編碼RNA等，深入探討其分子機制，為疾病精準診療及再生醫學提供理論和實踐支持。
發表論文
(*co-first author; #corresponding author)
[1] Jeselsohn R, Bergholz JS, Pun M, Cornwell M, Liu W, Nardone A, Xiao T, Li W, Qiu X, Buchwalter G, Feiglin A, Abell-Hart K, Fei T, Rao P, Long H, Kwiatkowski N, Zhang T, Gray N, Melchers D, Houtman R, Liu XS, Cohen O, Wagle N, Winer EP, Zhao J, Brown M. Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations. Cancer Cell. 2018 Feb 12;33(2):173-186.e5.
[2] Willis S, Sun Y, Abramovitz M, Fei T, Young B, Lin X, Ni M, Achua J, Regan MM, Gray KP, Gray R, Wang V, Long B, Kammler R, Sparano JA, Williams C, Goldstein LJ, Salgado R, Loi S, Pruneri G, Viale G, Brown M, Leyland-Jones B. High Expression of FGD3, a Putative Regulator of Cell Morphology and Motility, Is Prognostic of Favorable Outcome in Multiple Cancers. JCO Precision Oncology. 2017 :1, 1-13. DOI:
[3] Fei T#. Targeting RNA binding protein in prostate cancer. Mol Cell Oncol. 2017 Jul 17;4(5):e1353855. doi: 10.1080/23723556.2017.1353855. eCollection 2017. PMID: 29057311
[4] Fei T*#, Chen Y*, Xiao T, Li W, Cato L, Zhang P, Cotter MB, Bowden M, Lis RT, Zhang SG, Wu Q, Feng FY, Loda M, He HH, Liu XS#, Brown M#. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5207-E5215. doi: 10.1073/pnas.1617467114. Epub 2017 Jun 13. PMID: 28611215
[5] Guo H, Ahmed M, Zhang F, Yao CQ, Li S, Liang Y, Hua J, Soares F, Sun Y, Langstein J, Li Y, Poon C, Bailey SD, Desai K, Fei T, Li Q, Sendorek DH, Fraser M, Prensner JR, Pugh TJ, Pomerantz M, Bristow RG, Lupien M, Feng FY, Boutros PC, Freedman ML, Walsh MJ, He HH. Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer. Nat Genet. 2016 Oct;48(10):1142-50. doi: 10.1038/ng.3637. PMID: 27526323
[6] Du Z, Sun T, Hacisuleyman E, Fei T, Wang X, Brown M, Rinn JL, Lee MG, Chen Y, Kantoff PW, Liu XS. Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer. Nat Commun. 2016 Mar 15;7:10982. doi: 10.1038/ncomms10982. PMID: 26975529
[7] Liu Y, Fei T, Zheng X, Brown M, Zhang P, Liu XS, Wang H. An Integrative Pharmacogenomic Approach Identifies Two-drug Combination Therapies for Personalized Cancer Medicine. Sci Rep. 2016 Feb 26; 6:22120. doi: 10.1038/ srep22120. PMID: 26916442
[8] Zhu G, Fei T, Li Z, Yan X, Chen YG. Activin Regulates Self-renewal and Differentiation of Trophoblast Stem Cells by Down-regulating the X Chromosome Gene Bcor. J Biol Chem. 2015 Sep 4;290(36):22019-29. PMID: 26221038
[9] Wang H, Zheng X, Fei T, Wang J, Li X, Liu Y, Zhang F. Towards pathway-centric cancer therapies via pharmacogenomic profiling analysis of ERK signaling pathway. Clin Transl Med. 2015 Dec;4(1):66. PMID: 26220863
[10] Hsieh CL, Fei T, Chen Y, Li T, Gao Y, Wang X, Sun T, Sweeney CJ, Lee GS, Chen S, Balk SP, Liu XS, Brown M, Kantoff PW. Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7319-24. PMID: 24778216
[11] He HH, Meyer CA, Hu SS, Chen MW, Zang C, Liu Y, Rao PK, Fei T, Xu H, Long H, Liu XS, Brown M. Refined DNase seq protocol and data analysis reveals intrinsic bias in transcription factor footprint identification. Nat Methods. 2014 Jan;11(1):73-8. PMID: 24317252
[12] Wang H, Meyer CA, Fei T, Wang G, Zhang F, Liu XS. A systematic approach identifies FOXA1 as a key factor in the loss of epithelial traits during the epithelial-to-mesenchymal transition in lung cancer. BMC Genomics. 2013 Oct 4;14(1):680. PMID: 24093963
[13] Du Z*, Fei T*, Verhaak RG, Su Z, Zhang Y, Brown M, Chen Y*, Liu XS. Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol. 2013 Jul;20(7):908-13. PMID: 23728290 (* as co-first author)
[14] Ni M, Chen Y, Fei T, Li D, Lim E, Liu XS, Brown M. Amplitude modulation of androgen signaling by c-MYC. Genes Dev. 2013 Apr 1;27(7):734-48. PMID: 23530127
[15] Zhang J*, Fei T*, Li Z*, Zhu G, Wang L, Chen YG. BMP induces cochlin expression to facilitate self-renewal and suppress neural differentiation of mouse embryonic stem cells. J Biol Chem. 2013 Mar 22;288(12):8053-60. PMID: 23344953 (* as co-first author)
[16] Li Z*, Fei T*, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG. BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell. 2012 Feb 3;10(2):171-82. PMID: 22305567 (* as co-first author)
[17] Sun Y*, Fei T*, Yang T*, Zhang F, Chen YG, Li H, Xu Z. The suppression of CRMP2 expression by BMP-SMAD gradient signaling controls multiple stages of neuronal development. J Biol Chem. 2010 Dec 10; 285(50):39039-50. PMID: 20926379 (* as co-first author)
[18] Fei T, Zhu S, Xia K, Zhang J, Li Z, Han JD, Chen YG. Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells. Cell Res. 2010 Dec; 20(12):1306-18. PMID: 21079647
[19] Fei T, Chen YG. Regulation of embryonic sem cell self-renewal and differentiation by TGF-β family signaling. Sci China Life Sci. 2010 Apr; 53(4):497-503. PMID: 20596917
[20]Fei T*, Xia K*, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Xiao H, Han J, Chen YG. Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Genome Res. 2010 Jan; 20(1):36 44. PMID: 19926752
[21] Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, Han Y, Feng XH, Meng A, Chen YG. Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol Cell Biol. 2007 Jun; 27(12):4488-99. PMID: 17438144
[22] Huang W, Chang HY, Fei T, Wu H, Chen YG. GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene. 2007 Apr 12; 26(17):2471-82. PMID: 17043650
[23] Ma J, Wang Q, Fei T, Han JD, Chen YG. MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood. 2007 Feb 1; 109(3):987-94. PMID: 17032917
