譚華榮 ，博士， 研究員，中科院“百人計畫”首批入選者、國家傑出青年基金獲得者，1991年畢業於英國東英大學和英國John Innes研究所，獲理學博士學位。現任中國微生物學會副理事長，中國遺傳學會常務理事、微生物遺傳專業委員會主任，北京遺傳學會副理事長。《微生物學報》主編、《遺傳學報》副主編、《科學通報》特邀編輯。在國內率先開展了微生物發育與分化的分子生物學研究，在國際上首次發現了與鏈黴菌分化有關的發育控制啟動子，並闡明了其作用的分子機制。完成了圈卷產色鏈黴菌尼可黴素生物合成基因簇的克隆、異源表達、DNA全序列分析及基因作用的分子機理研究, 初步揭示了核苷肽類抗生素—尼可黴素的生物合成途徑。在基因表達，轉錄調控方面取得了突出成績，有良好的工作基礎。已在國內外刊物發表研究論文100餘篇，其中SCI收錄刊物論文50餘篇。
基本介紹
- 中文名：譚華榮
- 國籍：中國
- 職業：博士 研究員
- 畢業院校：英國東英大學
研究方向,承擔課題,重要成果,
研究方向
微生物發育分化和微生物次生代謝的分子調控，以鏈黴菌為模式系統，研究發育分化中基因的時空表達及其作用的分子機制，為揭示生命現象的基本規律及與抗生素生物合成的關係提供理論依據。研究微生物次生代謝的生物合成途徑、途徑改造及其基因的特異調控和全局調控，為定向改良生產菌的生產能力和獲得新的代謝產物提供理論指導。
承擔課題
國家自然科學基金面上項目“鏈黴菌形態分化基因—sabR的調控機制”及“傑多黴素生物合成調控基因—jadR1作用的分子機制”、國家973項目中的課題“農用抗生素的生物合成與調控”，國家863項目“尼可黴素途徑特異性調控及其最佳化”等多項科研任務。
重要成果
近年來的代表性論文
1).Linqi Wang, Xiuyun Tian, Juan Wang, Haihua Yang, Keqiang Fan, Gangming Xu, Keqian Yang* andHuarong Tan*. Autoregulation of antibiotic biosynthesis by binding of the end product to an atypical response regulator.Proc Natl Acad Sci USA., 2009, 106 (21): 8617-8622.
2).Gang Liu, Yuqing Tian, Haihua Yang,Huarong Tan*. A pathway-specific transcriptional regulatory gene for nikkomycin biosynthesis in S. ansochromogenes that also influences colony development.Mol Microbiol.,2005, 55 (6): 1855-1866.
3).Haihua Yang, Linqi Wang, Zhoujie Xie, Yuqing Tian, Gang Liu,Huarong Tan*. The tyrosine degradation gene hppD is transcriptionally activated by HpdA and repressed by HpdR in Streptomyces coelicolor, while hpdA is negativelyautoregulated and repressed by HpdR.Mol Microbiol., 2007, 65(4): 1064-1077.
4).Yuanyuan Pan, Gang Liu, Haihua Yang, Yuqing Tian andHuarongTan*. The pleiotropic regulator AdpA-L directly controls the pathway-specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes.Mol Microbiol., 2009, 72(3): 710-723.
5).Rui Li, Gang Liu, Zhoujie Xie, Xihong He, Wenqing Chen, Zixin Deng andHuarong Tan*. PolY, a transcriptional regulator with ATPase activity, directly activates transcription of polR in polyoxin biosynthesis in Streptomyces cacaoi.Mol Microbiol., 2010, 75(2): 349-364.
6).Gangming Xu, Juan Wang, Linqi Wang, Xiuyun Tian, Haihua Yang, Keqiang Fan, Keqian Yang*, andHuarong Tan*. Pseudo gamma-butyrolactone receptors respond to antibiotic signals to coordinate antibiotics biosynthesis.J Biol Chem., 2010, 285(35): 27440-27448.
7).Guoqing Niu, Gang Liu, Yuqing Tian andHuarong Tan*. SanJ, an ATP-dependent picolinate-CoA ligase, catalyzes the conversion of picolinate to picolinate-CoA during nikkomycin biosynthesis in S. ansochromogenes.Metab Eng., 2006, 8(3): 183-195.
8).Yirong Li, Hongbo Ling, Wenli Li,Huarong Tan*. Improvement of nikkomycin production by enhanced copy of sanU and sanV in Streptomyces ansochromogenes and characterization of a novel glutamate mutase encoded by sanU and sanV.Metab Eng., 2005, 7(3): 165-173.
9).Shuli Zhang, Bo Liu, Haihua Yang*, Yuqing Tian, Gang Liu, Lei Li andHuarong Tan*. Characterization of EndoTT, a novel sequence-specific single-stranded DNA endonuclease from Thermoanaerobacter tengcongensis.Nucleic Acids Res, 2010, 38(11): 3709-3720.
10).Qiyu Bao, Yuqing Tian, Wei Li, Zuyuan Xu, Zhenyu Xuan, Songnian Hu, Wei Dong, Jian Yang, Yanjiong Chen, Yanfen Xue, Yi Xu, Xiaoqin Lai, Li Huang, Xiuzhu Dong, Yanhe Ma, Lunjiang Ling,Huarong Tan*, Runsheng Chen*, Jian Wang, Jun Yu, Huanming Yang*. A complete sequence of the Thermoanaerobacter tengcongensis genome.Genome Res., 2002, 12(5):689-700.
2).Gang Liu, Yuqing Tian, Haihua Yang,Huarong Tan*. A pathway-specific transcriptional regulatory gene for nikkomycin biosynthesis in S. ansochromogenes that also influences colony development.Mol Microbiol.,2005, 55 (6): 1855-1866.
3).Haihua Yang, Linqi Wang, Zhoujie Xie, Yuqing Tian, Gang Liu,Huarong Tan*. The tyrosine degradation gene hppD is transcriptionally activated by HpdA and repressed by HpdR in Streptomyces coelicolor, while hpdA is negativelyautoregulated and repressed by HpdR.Mol Microbiol., 2007, 65(4): 1064-1077.
4).Yuanyuan Pan, Gang Liu, Haihua Yang, Yuqing Tian andHuarongTan*. The pleiotropic regulator AdpA-L directly controls the pathway-specific activator of nikkomycin biosynthesis in Streptomyces ansochromogenes.Mol Microbiol., 2009, 72(3): 710-723.
5).Rui Li, Gang Liu, Zhoujie Xie, Xihong He, Wenqing Chen, Zixin Deng andHuarong Tan*. PolY, a transcriptional regulator with ATPase activity, directly activates transcription of polR in polyoxin biosynthesis in Streptomyces cacaoi.Mol Microbiol., 2010, 75(2): 349-364.
6).Gangming Xu, Juan Wang, Linqi Wang, Xiuyun Tian, Haihua Yang, Keqiang Fan, Keqian Yang*, andHuarong Tan*. Pseudo gamma-butyrolactone receptors respond to antibiotic signals to coordinate antibiotics biosynthesis.J Biol Chem., 2010, 285(35): 27440-27448.
7).Guoqing Niu, Gang Liu, Yuqing Tian andHuarong Tan*. SanJ, an ATP-dependent picolinate-CoA ligase, catalyzes the conversion of picolinate to picolinate-CoA during nikkomycin biosynthesis in S. ansochromogenes.Metab Eng., 2006, 8(3): 183-195.
8).Yirong Li, Hongbo Ling, Wenli Li,Huarong Tan*. Improvement of nikkomycin production by enhanced copy of sanU and sanV in Streptomyces ansochromogenes and characterization of a novel glutamate mutase encoded by sanU and sanV.Metab Eng., 2005, 7(3): 165-173.
9).Shuli Zhang, Bo Liu, Haihua Yang*, Yuqing Tian, Gang Liu, Lei Li andHuarong Tan*. Characterization of EndoTT, a novel sequence-specific single-stranded DNA endonuclease from Thermoanaerobacter tengcongensis.Nucleic Acids Res, 2010, 38(11): 3709-3720.
10).Qiyu Bao, Yuqing Tian, Wei Li, Zuyuan Xu, Zhenyu Xuan, Songnian Hu, Wei Dong, Jian Yang, Yanjiong Chen, Yanfen Xue, Yi Xu, Xiaoqin Lai, Li Huang, Xiuzhu Dong, Yanhe Ma, Lunjiang Ling,Huarong Tan*, Runsheng Chen*, Jian Wang, Jun Yu, Huanming Yang*. A complete sequence of the Thermoanaerobacter tengcongensis genome.Genome Res., 2002, 12(5):689-700.
