基本介紹
- 中文名：解亭
- 外文名：XIE TING
- 畢業院校：羅格斯大學
- 職業：教師
教育經歷,工作經歷,研究方向,個人作品,2020-今,2015-2019,2010-2014,2005-2009,1994-2004,主要貢獻,
教育經歷
1996年 羅格斯大學 分子生物學與生物化學博士
1990年 中國農業大學 碩士
1987年 中國農業大學 學士
工作經歷
2021年 香港科技大學 生命科學部 講席教授 主任
2000-2020 美國Stowers醫學研究所 研究員
1996-1999 約翰霍普金斯大學 博士後
研究方向
幹細胞自我更新與分化
視網膜退行性疾病以及潛在療法
個人作品
2020-今
Tu R, Duan B, Song X, Chen S, Scott A, Hall K, Blanck J, DeGraffenreid D, Li H, Perera A, Haug J, Xie T. Multiple niche compartments orchestrate stepwise germline stem cell progeny differentiation. Current Biology. 2021; 31(4): 827-839.
Pang J, Le L, Zhou Y, Tu R, Hou Q, Tsuchiya D, Thomas N, Wang Y, Yu Z, Alexander R, Thexton M, Lewis B, Corbin T, Durnin M, Li H, Ashery-Padan R, Yan D, Xie T. Notch signaling controls ciliary body morphogenesis and secretion by directly regulating Nectin expression. Cell Reports. 2021; 34(2): 108603.
Tu R, Duan B, Song X, Xie T. Glypican Dlp-mediated Hedgehog and Wnt signaling interdependence is crucial in the niche for germline stem cell progeny differentiation. Science Advances. 2020; aaz0480.
Zuo F, Tu R, Duan B, Yang Z, Ping Z, Song X, Chen S, Price A, Li H, Scott A, Perera A, Li S, Xie T. Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs. Proc Natl Acad Sci U S A. 2020; 117(7): 3603-3609.
2015-2019
Mao Y, Tu R, Huang Y, Mao D, Yang Z, Lau PK, Ni J, Guo Y, Xie T. The exocyst functions in niche cells to promote germline stem cell progeny differentiation by directly controlling EGFR membrane trafficking. Development. 2019;146(13): dev174615.
Ma X, Zhu X, Han Y, Story B, Do T, Song X, Wang S, Zhang Y, Blanchette M, Gogol M, Malanowski K, Peak A, Anoja P, Xie T. Aubergine controls germline stem cell self-renewal and progeny differentiation via distinct mechanisms. Developmental Cell 2017; 41(2):157-169.
Ma X, Han Y, Song X, Do T, Yang Z, Ni J, Xie T. DNA damage-induced CHK2 activation compromises germline stem cell self-renewal and lineage differentiation. Development. 2016; 143(23):4312-4323.
Lu T, Wang S, Gao Y, Mao Y, Yang Z, Liu L, Song X, Ni J, Xie T. COP9-Hedgehog axis regulates the function of the germline stem cell progeny differentiation niche in the Drosophila Ovary. Development. 2015; 142(24):4242-52.
Fu Z, Geng C, Wang H, Yang Z, Weng C, Li H, Deng L, Liu L, Liu N, Ni J, Xie T. Twin promotes the maintenance and differentiation of germline stem cell lineage through modulating multiple pathways. Cell Reports. 2015; 13(7):1366-79.
Wang S, Gao Y, Song X, Ma X, Zhu X, Mao Y, Yang Z, Ni J, Li H, Malanowski KE, Anoja P, Park J, Haug J and Xie T. Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche. eLife. 2015; 4:e08174.
Ouyang J, Yu W, Liu J, Zhang N, Florens L, Chen J, Liu H, Washburn M, Pei D, Xie T. Cyclin-dependent kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent state. J Biol Chem. 2015; 290(37):22782-94.
2010-2014
Pan L, Wang S, Lu T, Weng C, Song X, Park JK, Sun J, Yang ZH, Yu J, Tang H, McKearin DM, Chamovitz DA, Ni J, Xie T. Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. 2014; 514(7521):233-6.
Chen S, Li H, Gaudenz K, Paulson A, Guo F, Trimble R, Peak A, Seidel C, Deng C, Furuta Y, Xie T. Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis. Cell Res. 2013; 23(2):254-73.
Zhou Y, Tanzie C, Yan Z, Chen S, Duncan M, Gaudenz K, Li H, Seidel C, Lewis B, Moran A, Libby RT, Kiernan AE, Xie T. Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye. Proc Natl Acad Sci U S A. 2013; 110: 8966-71.
Li T, Lewallen M, Chen S, Yu W, Zhang N, Xie T. Multipotent stem cells isolated from the adult mouse retina are capable of producing functional photoreceptor cells. Cell Res. 2013; 23(6):788-802.
Kirilly D, Wang S, Xie T. Self-maintained escort cells form a germline stem cell differentiation niche. Development. 2011; 138:5087-5097.
Wang X, Pan L, Wang S, Zhou J, McDowell W, Park J, Haug J, Staehling K, Tang H, Xie T. Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation. PLoS Genet. 2011; 7:e1002426.
Chen S, Kaneko S, Ma X, Chen X, Ip YT, Xu L, Xie T. Lissencephaly-1 controls germline stem cell self-renewal through modulating bone morphogenetic protein signaling and niche adhesion. Proc Natl Acad Sci U S A. 2010; 107:19939-19944.
2005-2009
Shen R, Weng C, Yu J, Xie T. eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary. Proc Natl Acad Sci U S A. 2009; 106:11623-11628.
Shen R, Xie T. Stem cell self-renewal versus differentiation: tumor suppressor Mei-P26 and miRNAs control the balance. Cell Res. 2008; 18:713-715.
Jin Z, Kirilly D, Weng C, Kawase E, Smith S, Schwartz J, Xie T. Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary. Cell Stem Cell. 2008; 2:39-49.
Song X, Call GB, Kirilly D, Xie T. Notch signaling controls germline stem cell niche formation in the Drosophila ovary. Development. 2007; 134:1071-1080.
Pan L, Chen S, Weng C, Call G, Zhu D, Tang H, Zhang N, Xie T. Stem cell aging is controlled both intrinsically and extrinsically in the Drosophila ovary. Cell Stem Cell. 2007; 1:458-469.
Jin Z, Xie T. Dcr-1 maintains Drosophila ovarian stem cells. Curr Biol. 2007; 17:539-544.
Xi R, Xie T. Stem cell self-renewal controlled by chromatin remodeling factors. Science. 2005; 310:1487-1489.
Xi R, Doan C, Liu D, Xie T. Pelota controls self-renewal of germline stem cells by repressing a Bam-independent differentiation pathway. Development. 2005; 132:5365-5374.
Kirilly D, Spana EP, Perrimon N, Padgett RW, Xie T. BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev Cell. 2005; 9:651-662.
1994-2004
Song X, Wong MD, Kawase E, Xi R, Ding BC, McCarthy JJ, Xie T. Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary. Development. 2004; 131:1353-1364.
Kawase E, Wong MD, Ding BC, Xie T. Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testis. Development. 2004; 131:1365-1375.
Zhu CH, Xie T. Clonal expansion of ovarian germline stem cells during niche formation in Drosophila. Development. 2003; 130:2579-2588.
Song X, Xie T. Wingless signaling regulates the maintenance of ovarian somatic stem cells in Drosophila. Development. 2003; 130:3259-3268.
Song X, Zhu CH, Doan C, Xie T. Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science. 2002; 296:1855-1857.
Song X, Xie T. DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary. Proc Natl Acad Sci USA. 2002; 99:14813-14818.
Xie T, Spradling AC. A niche maintaining germ line stem cells in the Drosophila Ovary. Science. 2000; 290:328-330.
Xie T, Spradling AC. decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell. 1998; 94:251-260.
Xie T, Finelli AL, Padgett RW. The Drosophila saxophone gene: a serine-threonine kinase receptor of TGF-b superfamily. Science. 1994; 263:1756-1759.
主要貢獻
解亭博士主要研究方向為幹細胞生物學和組織再生。他是研究幹細胞生態位及其控制自我更新的機制的領導者和先驅之一。解亭博士是最早通過實驗證明存在幹細胞生態位的人之一。他的實驗室還提出並證明了控制幹細胞譜系規範的分化生態位的存在；以及闡明了這兩個生態位如何協同工作來控制幹細胞發育，從而控制組織再生。最近，他將研究興趣擴大到視網膜退行性疾病和開發新的治療策略。迄今為止，他已在知名期刊上發表了 70 多篇文章，包括括Nature, Science 和 Cell。他於 2003 年獲得哈德遜獎，並一直擔任青光眼基金會科學顧問委員會和Cell Research , Development等八種科學期刊的編委。
