基本介紹
- 中文名：袁燕秋
- 畢業院校：美國哈佛大學
- 學位/學歷：博士
- 職業：教師
- 職務：中山大學博士生導師
- 職稱：中山大學副教授
人物經歷,教育經歷,工作經歷,科研項目,發表論文,
人物經歷
教育經歷
2008年，理學博士，化學與化學生物學系，美國哈佛大學，論文導師: Suzanne Walker
2003年，理學學士，套用化學系，中國科學技術大學
工作經歷
2017年9月 起 中山大學副教授
2015年1月 - 2017年8月 丹麥哥本哈根大學助理教授
2011年8月 - 2014年12月 美國諾華生物醫學研究所（NIBR）二級研究員（Investigator II）
2008年8月 - 2011年7月 美國諾華生物醫學研究所（NIBR）一級研究員（Investigator I）
科研項目
中山大學“百人計畫二期”啟動項目。
發表論文
1.Chen X, Giraldes J, Sprague ER, Shakya S, Chen Z, Wang Y, Joud C, Mathieu S, Chen CH, Straub C, Duca J, Hurov K,Yuan Y, Shao W, Touré BB. "Addition" and "Subtraction": Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors.J. Med. Chem.,2017, 60, 2155-2161.
2.Touré BB, Giraldes J, Smith T, Sprague ER, Wang Y, Mathieu S, Chen Z, Mishina Y, Feng Y, Yan-Neale Y, Shakya S, Chen D, Meyer M, Puleo D, Brazell JT, Straub C, Sage D, Wright K,Yuan Y, Chen X, Duca J, Kim S, Tian L, Martin E, Hurov K, Shao W. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.J. Med. Chem.,2016, 59, 4711-23.
3.Six DA,Yuan Y, Leeds JA, Meredith TC.Deletion of the β-Acetoacetyl Synthase FabY in Pseudomonas aeruginosa Induces Hypoacylation of Lipopolysaccharide and Increases Antimicrobial Susceptibility.Antimicrob. Agents Chemother.,2014,58, 153-161.
4.Yuan Y, Sachdeva M, Leeds JA, Meredith TC. Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the FabY class of β-ketoacyl acyl carrier protein synthases.J. Bacteriol.,2012,194, 5171-5184.
5.Yuan Y, Leeds JA, Meredith TC. Pseudomonas aeruginosa directly shunts β-oxidation degradation intermediates into de novo fatty acid biosynthesis.J. Bacteriol.,2012,194, 5185-5196.
6.Fuse S, Tsukamoto H,Yuan Y, Wang TS, Zhang Y, Bolla M, Walker S, Sliz P, Kahne D. Functional and structural analysis of a key region of the cell wall inhibitor moenomycin.ACS Chemical Biology,2010,5, 701-11.
7.Yuan Y, Fuse S, Sliz P, Kahne D, Walker S. Structural and functional analysis of the H-bonding network that anchors moenomycin in the peptidoglycan glycosyltransferase active site: implications for antibiotic design.ACS Chemical Biology,2008,3, 429-436.
8.Barrett D, Wang TS,Yuan Y, Zhang Y, Kahne D, Walker S. Analysis of glycan polymers produced by peptidoglycan glycosyltransferases.J. Biol. Chem.,2007,208, 31964-31971.
9.Yuan Y, Barrett D, Zhang Y, Kahne D, Sliz P, Walker S. Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis.Proc. Natl. Acad. Sci. U. S. A.,2007,104, 5348-5453.
10.Ginsberg C, Zhang YH,Yuan Y, Walker S. In vitro reconstitution of two essential steps in wall teichoic acid biosynthesis.ACS Chem. Biol.,2006,1, 25-28.
11.Zhang YH, Ginsberg C,Yuan Y, Walker S. Substrate selectivity and kinetic mechanism ofBacillus subtilisTagA.Biochemistry,2006,45, 10895-10904.
12.Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S. In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides.J. Am. Chem. Soc.,2005,127, 14128-14129.
13.Chen L,Yuan Y, Helm JS, Hu Y, Rew Y, Shin D, Boger DL, Walker S. Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics.J. Am. Chem. Soc.,2004,126, 7462-7463.
