基本介紹
- 中文名：袁中玉
- 畢業院校：中山大學
- 學歷：博士研究生
- 臨床職稱：主任醫師
- 執業地點：中山大學腫瘤防治中心
- 職務：博士研究生導師
專長領域,學術任職,科研項目,發表論著,
專長領域
乳腺癌的綜合治療（內分泌治療、靶向治療、化學治療），尤其專注於三陰乳腺癌的治療和研究。
學術任職
廣東省胸部腫瘤協會乳腺癌專業委員會副主任委員
廣東省健康管理學會乳腺癌專業委員會副主任委員
廣東省中醫藥學會乳腺病專業委員會副主任委員
廣東省藥學會乳腺科用藥專家委員會副主任委員
廣東省胸部疾病學會乳腺病防治專業委員會副主任委員
廣東省抗癌協會靶向與個體化治療專業委員會常務委員
科研項目
(1) miR-657誘導乳腺癌早期轉移的分子機制
(2) 三陰乳腺癌遠處轉移的分子機制
(3) 可手術三陰乳腺癌標準輔助化療後卡培他濱節拍化療的前瞻性隨機對照臨床研究
(4) 曲妥珠單抗聯合化療或芳香化酶抑制劑一線治療Luminal B2型復發轉移性乳腺癌的多中心、隨機、對照臨床研究
(5) 神經節苷脂預防乳腺癌患者使用含紫杉類方案輔助化療所致神經毒性的多中心、前瞻性、隨機、安慰劑對照、雙盲臨床研究
(6) 比卡魯胺對比化療一線治療AR陽性晚期三陰乳腺癌患者的多中心、非劣效性、隨機對照臨床研究
(7) 鹽酸埃克替尼治療一線化療失敗的復發和/轉移性三陰型乳腺癌的單臂、開放II期臨床研究
(8) AHST支持下HDC治療轉移性三陰型乳腺癌的Ⅱ期臨床研究
(9) 拉帕替尼聯合化療治療曲妥珠單抗難治性轉移性乳腺癌的多中心、Ⅱ期臨床研究
發表論著
(1) Qin Tao, Yuan Zhong-Yu, Peng Rou-Jun, Bai Bing Zeng, Yin-Duo Shi, Yan-Xia Teng, Xiao-Yu Liu, Dong-Geng Wang, Shu-Sen(*). Clinicopathologic characteristics and prognostic factors for HER2-positive patients with metastatic breast cancer in southern China., Archives of Medical Science,2015,11(3):544-550.
(2) Yuan Zhong-Yu ,Luo Rong-Zhen, Peng Rou-Jun, Wang Shu-Sen, Xue Cong. High infiltration of tumor-associated macrophages in triple-negative breast cancer is associated with a higher risk of distant metastasis.,OncoTargets and herapy,2014,7: 1475-1480.
(3) Yuan Zhong-Yu, Dai Ting ,Wang Shu-Sen, Peng Rou-Jun, Li Xing-Hua, Qin, Tao, Song Li-Bing, Wang Xi, Overexpression of ETV4 protein in triple-negative breast cancer is associated with a higher risk of distant metastasis. OncoTargets and Therapy,2014,7:1733-1742.
(4) Luo Rong-Zhen, Yuan Zhong-Yu, Li Mei, Xi Shao-Yan, Fu Jia, He Jiehua(*), Accumulation of p62 is associated with poor prognosis in patients with triple-negative breast cancer.,OncoTargets and Therapy,2013,6:883-888.
(5) Qin Tao, Yuan Zhongyu, Peng Roujun, Bai Bing, Shi Yanxia, Teng Xiaoyu, Liu Donggeng, Wang Shusen(*), HER2-positive breast cancer patients receiving trastuzumab treatment obtain prognosis comparable with that of HER2-negative breast cancer patients.,OncoTargets and Therapy,2013,6:341-347.
(6) Dong Min,Wan, Xiang-bo, Yuan Zhong Yu, Wei Li Fan, Xin Juan Wang, Tian-tian Lv, Yan Chun Li, Xing Chen, Zhan-hong Chen, Jie Lin, Qu Wen, Jing-yun Ma, Xiao-kun, Liu Quentin(*), Wu Xiang Yuan(*), Low expression of Beclin 1 and elevated expression of HIF-1alpha refine distant metastasis risk and predict poor prognosis of ER-positive, HER2-negative breast cancer.,Medical Oncology,2013,30(1):355-355.
(7) Qin T. Yuan ZY, Peng RJ, Zeng YD, Shi YX, Teng XY, Liu DG, Bai B, Wang SS(*), Efficacy and tolerability of toremifene and tamoxifen therapy in premenopausal patients with operable breast cancer: A retrospective analysis,Current Oncology,2013,20(4):196-204.
(8) Xue Cong, Peng Roujun, Cao Ye, Wang Shusen, Shi Yanxia, An Xin, Xu Fei, Yuan Zhongyu(*), Ovarian Function, Not Age, Predicts the Benefit from Ovarian Suppression or Ablation for Premenopausal Women with Breast Cancer.,PLos One,2016,11(2):e0148849-e0148849.
(9) Qin Tao, Zeng Yin-duo, Qin Ge, Xu Fei, Lu Jia-bin, Fang Wen-feng, Xue Cong, Zhan Jian-hua, Zhang Xin-ke, Zheng Qiu-fan, Peng Rou-jun, Yuan Zhong-yu(*), Zhang Li(*), Wang Shu-sen(*), High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer.,Oncotarget,2015,6(32):33972-33981.
(10) Xue Cong, Peng RouJun, Wang ShuSen, Shi YanXia, An, Xin, Xu Fei, Yuan Zhong Yu(*), Operable breast cancer of the inner hemisphere is associated with poor survival.,Journal of Breast Cancer,2015,18(1):36-43.
(11) Li Xinghua, Liang Weijiang, Liu Junling, Lin Chuyong, Wu, Shu, Song Libing, Yuan Zhongyu(*), Transducin (ss)-like 1 X-linked receptor 1 promotes proliferation and tumorigenicity in human breast cancer via activation of beta-catenin signaling.,Breast Cancer Research,2014,16(5):465-465.
(12) Xu Jie, Wu Xing, Zhou Wei-hua, Liu An-wen, Wu Jian-bing, Deng Jin-yun, Yue Cai-feng, Yang Shao-bing, Wang Jing, Yuan Zhong-yu(*), Liu Quentin(*), Aurora-A identifies early recurrence and poor prognosis and promises a potential therapeutic target in triple negative breast cancer.,PLos One,2013,8(2):e56919-e56919.
(13) He Jie-Hua, Luo Rong-Zhen, Cai Mu-Yan, Li Mei, Lu Jia-Bing, Yuan Zhong-Yu(*), Decreased expression of light chain 3 (LC3) increased the risk of distant metastasis in triple-negative breast cancer.,Medical Oncology,2013,30(1):468-468.
(14) Fang Wang, Wenzhuo He, Huijuan Qiu, Xi Wang, Guifang Guo, Xuxian Chen, Yuming Rong, Feifei Zhou, Chenxi Yin, Zhongyu Yuan(*), Liangping Xia(*), Lymph Node Ratio and pN Staging Show Different Superiority As Prognostic Predictors Depending on the Number of Lymph Nodes Dissected in Chinese Patients With Luminal A Breast Cancer,Clinical Breast Cancer,2012,12(6):404-411.
(15) Xue Cong, Wang Xi, Peng Roujun, Shi Yanxia, Qin Tao, Liu Donggen, Teng Xiaoyu, Wang Shusen, Zhang Li(*), Yuan Zhongyu(*), Distribution, clinicopathologic features and survival of breast cancer subtypes in Southern China.,Cancer Science,2012,103(9):1679-1687.
(16) He Jiehua,Peng Roujun,Wang Shusen, Yuan Zhongyu(*), Peng Jiewen, Lin Guinan, Jiang Xiaomei, Qin Tao, Prognostic value of androgen receptor expression in operable triple-negative breast cancer: a retrospective analysis based on a tissue microarray.,Medical Oncology,2012,29(2):406-410.
(17) Wang Shusen, Shi Yanxia, Wang Xi, Liu Donggen, Yuan Zhongyu(*), Peng Roujun, Teng Xiaoyu, Qin Tao, Peng Jiewen, Lin Guinan,Jiang Xiaomei, Classical CMF regimen as adjuvant chemotherapy for triple-negative breast cancer may be more effective compared with anthracycline or taxane-based regimens.,Medical Oncology,2012,29(2):547-553.
(18) Liu Donggen, He Jiehua, Wang Shusen, Peng Roujun, Shi Yanxia, Teng Xiaoyu, Qin Tao, Yuan Zhongyu(*), EGFR expression correlates with decreased disease-free survival in triple-negative breast cancer: a retrospective analysis based on a tissue microarray.,Medical Oncology,2012,29(2):401-405.
(19) Wang Xi,Wang Shu-Sen,Peng Rou-Jun,Qin Tao,Shi Yan-Xia,Teng Xiao-Yu,Liu Dong-Gen, Chen Wei-Qing, Yuan Zhong-Yu(*), Interaction of coping styles and psychological stress on anxious and depressive symptoms in Chinese breast cancer patients.,Asian Pac J Cancer Prev,2012,13(4):1645-1649.
(20) Roujun Peng,Shusen Wang,Yanxia Shi,Donggen Liu,Xiaoyu Teng,Tao Qin,Yixin Zeng(*),Zhongyu Yuan(*),Patients 35 years old or younger with operable breast cancer are more at risk for relapse and survival: A retrospective matched case–control study,Breast,2011,20(6):568-573.
(21) Liu Dong-Gen, Wang Shu-Sen, Peng Rou-Jun, Qin Tao, Shi Yan-Xia, Teng Xiao-Yu, Wang Xi, Chen Wei-Qing, Yuan Zhong-Yu(*), Interaction of social support and psychological stress on anxiety and depressive symptoms in breast cancer patients.,Asian Pac J Cancer Prev,2011,12(10):2523-2529.
(22) Zhang Liang, Ding Ya, Liu Junling, Sun Jian, Yuan Zhongyu, Lei Fangyong, Wu Shu, Li Su, Zhang Dongsheng(*), MicroRNA-500 sustains nuclear factor-kappaB activation and induces gastric cancer cell proliferation and resistance to apoptosis.,Oncotarget,2015,6(4):2483-2495.
(23) Zou Zhengzhi, Zhang Qiongxia, Long Zijie, Chen, Yuan Zhongyu Jinna Tang, Zhiping Zhu Yuliang, Chen Shupeng, Xu Jie, Yan Min, Wang Jing, Liu Quentin(*), Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells.,Autophagy,2012,8(12):1798-1810.
(24) Shi Yan-Xia, Xia Qing, Peng Rou-Jun, Wang Shu-Sen, Yuan Zhong-Yu, An Xin, Cao Ye, Tan Yu-Ting, Jin Ying, Cai Xiu-Yu, Sun Yue-Li, Teng Xiao-Yu, Liu Dong-Geng(*), Jiang Wen-Qi(*), Comparison of clinicopathological characteristics and prognoses between bilateral and unilateral breast cancer.,Journal of Cancer Research and Clinical Oncology,2012,138(4):705-714.
(25) Shi Yan-Xia ,Tan Yu-Ting, Yuan Zhong-Yu, Wang Shu-Sen, Peng Rou-Jun, An Xin, Cao Ye, Jin Ying, Cai Xiu-Yu, Sun Yue-Li, Teng Xiao-Yu, Liu, Dong-Geng(*), Comparison of overall survival between the early use and delayed use of Trastuzumab therapy groups: a retrospective analysis of 128 patients with HER-2-positive advanced breast cancer.,Medical Oncology,2012,29(1):39-47.
