薛美蘭

薛美蘭

薛美蘭,女,博士,現任青島大學基礎醫學院副教授

基本介紹

  • 中文名:薛美蘭
  • 學位/學歷:博士
  • 職業:教師
  • 專業方向:天然海洋活性物質的功效評價、腫瘤預防與治療
  • 任職院校:青島大學基礎醫學院
  • 性別:女
個人經歷,研究方向,學術成果,榮譽獎項,

個人經歷

青島大學基礎醫學院生物化學與分子生物學系,博士

研究方向

天然海洋活性物質的功效評價、腫瘤預防與治療

學術成果

1.Xue M, Ji X, Liang H*, Liu Y,Wang B, Sun L, Li W, The effect of fucoidan on intestinal flora and intestinal barrier function in rats with breast cancer, Food Funct, 2018, 9(2): 1214-1223
2.Xue M, Liang H*, Tang Q, Xue C, He X, Zhang L, Zhang Z, Liang Z, Bian K, Zhang L, Li Z, The Protective and Immunomodulatory Effects of Fucoidan Against 7,12-Dimethyl benz[a]anthracene-Induced Experimental Mammary Carcinogenesis Through the PD1/PDL1 Signaling Pathway in Rats, Nutr Cancer, 2017, 69(8): 1234-1244
3.Xue M, Ji X, Xue C, Liang H*, Ge Y, He X, Zhang L, Bian K, Zhang L, Caspase-dependent and caspase-independent induction of apoptosis in breast cancer by fucoidan via the PI3K/AKT/GSK3β pathway in vivo and in vitro, Biomed Pharmacother, 2017, 94: 898-908
4.Xue M, Liu Y, Lyu R, Ge N, Liu M, Ma Y, Liang H*, Protective effect of aplysin on liver tissue and the gut microbiota in alcohol-fed rats, PLoS One, 2017, 12(6): e0178684
5.Xue M, Wang Q, Zhao J, Dong L, Ge Y, Hou L, Liu Y, Zheng Z,Docosahexaenoic acid inhibited the Wnt/β-catenin pathway and suppressed breast cancer cells in vitro and in vivo, J Nutr Biochem, 2014, 25(2):104-110
6. 張 婷,薛美蘭,劉 佳,劉 穎,梁爭艷,梁 惠*,褐藻糖膠對乳腺腫瘤大鼠腸道屏障損傷的保護作用,營養學報,2018,40(1) :59 ~ 63
7.Xue M, Ge Y*, Yu C, Zheng Z, He X, Zhao J,Apoptosis is induced by docosahexaenoic acid in breast cancer cells via death receptor and mitochondria-mediated pathways, Mol Med Rep, 2017,16(1):978-982
8.Zhang X,Zhuang T,Liang Z,Li L,Xue M,Liu J,Liang H*, Breast cancer suppression by aplysin is associated with inhibition of PI3K/AKT/FOXO3a pathway,Oncotarget, 2017, 8(38): 63923-63934
9.Xue M,Ge Y,Zhang J,Liu Y,Wang Q,Hou L,Zheng Z, Fucoidan inhibited 4T1 mouse breast cancer cell growth in vivo and in vitro via downregulation of Wnt/β-catenin signaling,Nutr Cancer,2013, 65(3): 460-468
10.Xue M,Ge Y*,Zhang J,Wang Q,Hou L,Liu Y,Sun L,Li Q, Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo,PLoS One,2012, 7(8): e43483
11.Xue M,Ge Y,Zhang J,Wang Q,Hou L, Gene transfer of Chlorella vulgaris n-3 fatty acid desaturase optimizes the fatty acid composition of human breast cancer cells,Braz J Med Biol Res,2012, 45(12): 1141-1149
四、主持的科研項目
1.青島市民生科技計畫項目,18-6-1-70-nsh,褐藻糖膠通過影響腸道微生態預防乳腺癌發生的作用機制,2018/09-2020/09,10萬元,在研、主持
2.國家自然科學基金委青年基金,81502298,Periostin-avβ3-FAK-PI3K通路在褐藻糖膠抗乳腺癌轉移中的作用機制研究,2016/01-2018/12,20.3萬元,已結題,主持
3.青島市博士後套用研究項目,2015165,基於TLR3/NF-κB信號通路探討褐藻糖膠抗乳腺癌轉移的作用及機制,2015/12-2017/07,5萬,已結題,主持
4.山東省自然科學基金面上項目,ZR2014JL056,褐藻糖膠誘導人乳腺癌細胞發生線粒體途徑凋亡的分子機制研究,2014/12-2017/12,18萬元,已結題,主持

榮譽獎項

海藻生物活性物質抑制腫瘤增殖和對酒精性肝損傷的保護作用研究,中國醫療保健國際交流促進會,華夏醫學科技獎,三等獎,2018
1. 2017年,青島大學教學十佳;
3. 2018年,青島大學十佳優秀共產黨員。
連續三年獲得青島大學青年卓越人才稱號

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