蔣衛(武漢大學醫學研究院教授)

蔣衛(武漢大學醫學研究院教授)

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蔣衛，武漢大學醫學研究院教授，專 業：細胞生物學、發育生物學，研究方向：幹細胞生物學和表觀遺傳調控

基本介紹

  • 中文名：蔣衛
  • 國籍：中國
  • 民族：漢族
  • 畢業院校：北京大學
  • 學位/學歷：博士
  • 專業方向：細胞生物學、發育生物學
  • 職稱：教授
人物經歷,教育經歷,工作經歷,研究方向,獲獎記錄,發表論文概況 ,代表性論文,

人物經歷

教育經歷

2001-2005 北京大學生命科學學院生物科學專業，學士
2005-2010 北京大學生命科學學院細胞生物學專業，博士

工作經歷

2011-2012 美國霍華德休斯醫學研究所及北卡羅萊納大學教堂山分校，博士後
2012-2015 美國霍華德休斯醫學研究所及哈佛醫學院、波士頓兒童醫院，博士後
2015- 武漢大學醫學研究院教授、中南醫院特聘研究員

研究方向

幹細胞分化
表觀遺傳學調控
長非編碼RNA
疾病模型
糖尿病

獲獎記錄

HMS Epigenetics Initiative Travel Grant (2015);
Juvenile Diabetes Research Foundation (JDRF) Postdoctoral Fellowship (2012-2015);
Beta Cell Biology Consortium (BCBC) Investigator Retreat, Scholarship (2012, 2013);

發表論文概況

已在國際刊物發表論文 40 多篇，被 SCI 引用 2000 余次，第一作者論文單篇最高被引用 300 余次。

代表性論文

（ 20 out of 40+ ）（ co-first authors；*co-responding authors）
  1. Song Ding, Xianchun Lan, Yajing Meng, Chenchao Yan, Mao Li, Xiang Li*, Jian Chen*, Wei Jiang*. (2021). CHD8 safeguards early neuroectoderm differentiation in human ESCs and protects from apoptosis during neurogenesis. Cell Death & Disease. (in press)
  2. Yajing Meng, Tianzhe Zhang, Ran Zheng, Song Ding, Jie Yang, Yingan Jiang*, Wei Jiang*. (2021). Depletion of demethylase KDM6 enhances early neuroectoderm commitment of human PSCs. Frontiers in Cell and Developmental Biology 9:702462. DOI: 10.3389/fcell.2021.702462.
  3. Ran Zheng, Ting Geng, Dan-Ya Wu, Tianzhe Zhang, Hainan He, Hai-Ning Du, Donghui Zhang*, Yi-Liang Miao*, Wei Jiang*. (2021). Derivation of feeder-free human extended pluripotent stem cells. Stem Cell Reports 16(7):1686-1696. DOI: 10.1016/j.stemcr.2021.06.001.
  4. Pei Lu, Mao Li, Donghui Zhang*, Wei Jiang*. (2021). Lnc-ing pluripotency maintenance and early differentiation in human pluripotent stem cells. FASEB Journal 35(4): e21438. DOI: 10.1096/fj.202002278R.
  5. Ran Liu, Kaiyu Qian, Yu Xiao*, Wei Jiang*. (2021). Generation of two induced pluripotent stem cell lines from blood cells of a prostate cancer patient carrying germline mutation in CHEK2. Stem Cell Research. 53:102299. DOI: 10.1016/j.scr.2021.102299.
  6. Jie Yang, Pei Lu, Mao Li, Chenchao Yan, Tianzhe Zhang, Wei Jiang*. (2020). GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation. Stem Cell Reports 15(3):694-705. DOI: 10.1016/j.stemcr.2020.07.014.
  7. Jie Yang, Wei Jiang*. (2020). The Roles of SMAD2/3 in Human Embryonic Stem Cells. Frontiers in Cell and Developmental Biology 8:653. DOI: 10.3389/fcell.2020.00653.
  8. Yangyang Yu, Wei Jiang*. (2020). Pluripotent Stem Cell Differentiation as an Emerging Model to Study Human Prostate Development. Stem Cell Research & Therapy 11(1):285. DOI: 10.1186/s13287-020-01801-9.
  9. Mengtian Tan, Lai Jiang, Yinglei Li, Wei Jiang*. (2019). Dual inhibition of BMP and WNT signals promotes pancreatic differentiation from human pluripotent stem cells. Stem Cells International 2019: 5026793. DOI: 10.1155/2019/5026793.
  10. Ting Geng, Donghui Zhang, Wei Jiang*. (2019). Concise Review: Epigenetic Regulation of Transition among Different Pluripotent States. Stem Cells 37(11):1372-1380. DOI: 10.1002/stem.3064.
  11. Yinglei Li, Wei Jiang*. (2019). The path and surface marker of SC-β cells. Science Bulletin 64(16), 1122-1124. DOI: 10.1016/j.scib.2019.06.018.
  12. Xiaojuan Su, Mengtian Tan, Bo Duan, Jie Cai*, Wei Jiang*, Lina Zhang*. (2019). Hierarchical microspheres with macropores fabricated from chitin as 3D cell culture. Journal of Materials Chemistry B 7(34), 5190-5198. DOI: 10.1039/c9tb01046g.
  13. Zhang D*, Jiang W*. (2015). From one-cell to tissue: reprogramming, cell differentiation and tissue engineering. Bioscience 65 (5): 468-475. DOI: 10.1093/biosci/biv016.
  14. Jiang W*, Liu Y, Liu R, Zhang K, Zhang Y*. (2015). LncRNA DEANR1 facilitates human endoderm differentiation by activating FOXA2 expression. Cell Reports 11(1), 137–148. DOI: 10.1016/j.celrep.2015.03.008.
  15. Jiang W*, Zhang D, Bursac N, Zhang Y*. (2013). WNT3 is a biomarker capable of predicting definitive endoderm differentiation potential of hESCs. Stem Cell Reports 1 (1), 46-52. DOI: 10.1016/j.stemcr.2013.03.003.
  16. Jiang W, Wang J, Zhang Y*. (2013). Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway. Cell Research 23(1), 122-130. DOI: 10.1038/cr.2012.119.
  17. Jiang W, Sui X, Zhang D, Liu M, Ding M, Shi Y*, Deng H*. (2011). CD24: A novel surface marker for PDX1-positive pancreatic progenitors derived from human embryonic stem cells. Stem Cells 29(4):609-617. DOI: 10.1002/stem.608.
  18. Zhang D, Jiang W, Liu M, Sui X, Yin X, Chen S, Shi Y, Deng H*. (2009). Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Research 19(4):429-438. DOI: 10.1038/cr.2009.28. 封面文章；被同期專文評述關注；獲賽諾菲 - 安萬特 Cell Research 2009 年度最佳研究論文獎
  19. Jiang W, Bai Z, Zhang D, Shi Y, Yong J, Chen S, Ding M, Deng H*. (2008). Differentiation of mouse nuclear transfer embryonic stem cells into functional pancreatic beta cells. Diabetologia 51:1671-1679. DOI: 10.1007/s00125-008-1065-1.
  20. Jiang W, Shi Y, Zhao D, Chen S, Yong J, Zhang J, Qing T, Sun X, Zhang P, Ding M, Li D*, Deng H*. (2007). In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Research 17:333-344. DOI: 10.1038/cr.2007.28.

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