葛瑞光

葛瑞光，男，博士，中山大學生命科學學院副教授、博士生導師。

基本介紹

• 中文名：葛瑞光
• 畢業院校：香港大學
• 學位/學歷：博士
• 專業方向：與疾病相關的金屬蛋白質組學和重要蛋白質的生物化學
• 任職院校：中山大學

研究方向

與疾病相關的金屬蛋白質組學和重要蛋白質的生物化學

人物經歷

1999年中國石油大學（華東）理學學士；

2002年南開大學理學碩士；

2006年香港大學哲學博士；

2006-2007香港大學高級研究助理；

2007-2008美國華盛頓大學聖路易斯分校霍華德修斯醫學研究所博士後；

2008年5月起中山大學生命科學學院“百人計畫”副教授，博士生導師。

講授課程

《生物化學II》

《研究型實驗系列—金屬蛋白質研究》

學術成就

1. 在Acc Chem Res, J Am Chem Soc, Proteomics, BBA-Mol Cell Res等雜誌發表論文30餘篇，其中通訊作者文章15篇，第一作者文章11篇；文章被引用超過1520次(2018.5)，其中被影響因子超過9分的論文引用超過120次，H-index 19；

2. 應邀參與了科學出版社一本中文專著以及Wiley和Royal Society of Chemistry雜誌社兩本外文專著的撰寫；應邀為Acc Chem Res, Curr Drug Metab, Metallomics以及Biometals等雜誌撰寫綜述；獲得Metallomics金屬組學中國特刊約稿;相關成果被Faculty of 1000，Health & Medicine Week以及Med. Hypotheses等專文評價；

3. 擔任國際期刊Immuno-Gastroenterology編委（2011-）；擔任JBIC、JPR、Omics、Metallomics、Chem Commun.等10餘種雜誌審稿人；荷蘭科學研究委員會基金項目外審專家；

4. 工作被寫入國外的教科書中：2014年牛津大學出版的由M. Weller等所編寫的《Inorganic Chemistry》（第六版）的第825頁對我們實驗室在含鉍金屬藥物的作用機制方面的工作做了引用，2011年Wiley-VCH出版的由E. Alessio編著的《Bioinorganic Medicinal Chemistry》的第10頁也引用我們實驗室關於鉍劑與病原體內蛋白質相互作用的工作；

5. 2011年獲評為首屆廣州珠江科技新星

論文專著

2004年

[1]Ge, R., Lin, H., Xu, X., Sun, X., Lin, H.,* Zhu, S., Ji, B., Li, F., and Wu, H. (2004) Catalysis of phosphoryl transfer from adenosine-5’-triphosphate (ATP) by trinuclear ‘chelate’ complexes.J. Inorg. Biochem.98, 917-924;

[2]Sun, X., Sun, H.,Ge, R., Richter, M., Woodworth, R. C., Mason, A. B., and He, Q.-Y.* (2004) The low pKa value of iron-binding ligand Tyr188 and its implication in iron release and anion binding of human transferrin. FEBS Lett. 573, 181-185;

2006年

[3]Ge, R., Watt, R. M., Sun, X., Tanner, J. A., He, Q.-Y., Huang, J.-D.,* and Sun, H.* (2006) Expression and characterization of a histidine-rich protein, Hpn: potential for Ni2+ storage inHelicobacter pylori.Biochem. J.393, 285-293;

[4]Ge, R., Zhang, Y., Sun, X., Watt, R. M., He, Q.-Y., Huang, J.-D.,* Wilcox, D. E., and Sun, H.* (2006) Thermodynamic and kinetic aspects of metal binding properties of the histidine-rich protein, Hpn.J. Am. Chem. Soc.128, 11330-11331;

2007年

[5]Ge, R., Sun, X., Gu, Q., Watt, R. M., Wong, B. C.-Y., Xia, H. H., Huang, J.-D., He, Q.-Y.,* and Sun, H.* (2007) A proteomic approach for the identification of bismuth-binding proteins inHelicobacter pylori.J. Biol. Inorg. Chem. 12, 831-842;

[6]Ge, R.and Sun, H.* (2007) Bioinorganic chemistry of bismuth and antimony: target sites for metallodrugs.Acc. Chem. Res.40, 267-274;

2008年

[7]Sun, X.,Ge, R., Chiu, J.-F., Sun, H., and He, Q.-Y.* (2008) Identification of proteins related to nickel homeostasis inHelicobacter pyloriby immobilized metal affinity chromatograph and two-dimensional gel electrophoresis. Metal-Based Drugs 2008: 289490;

[8]Cun, S., Li, H.,Ge, R., Lin, M. C. M., and Sun, H.* (2008) A histidine- and cysteine-rich metal binding domain at the C-terminus of GroES homologue fromHelicobacter pylori: implication for nickel homeostasis and bismuth susceptibility. J. Biol. Chem. 283, 15142-15151;

[9]Sun, X.,Ge, R., Chiu, J.-F., Zu, Y., Sun, H., and He, Q.-Y.* (2008) Lipoprotein MtsA of MtsABC inStreptococcus pyogenesprimarily binds ferrous ion with bicarbonate as a synergistic anion. FEBS Lett. 582, 1351-1354;

2009年

[10]Ge, R., and Sun, H.* (2009) Metallomics: an integrated biometal science. Sci. China Ser. B­-Chem. 52, 2055-2070;

[11]Ge, R., Sun, X., and He, Q.-Y.* (2009) Iron acquisition byStreptococcusspecies: an updated review. Front. Biol. China 4, 392-401;

[12]葛瑞光、陳卓、孫紅哲*（2009）金屬組學：研究生命體系中金屬離子的前沿交叉學科。中國科學B輯：化學，39，590-606;

[13]Xia, H., Qi, Y., Ng, S. S., Chen, X., Chen, S., Fang, M., Li, D., Zhao, Y.,Ge, R., Li, G., Chen, Y., He, M. L., Kung, H. F., Lai, L., and Lin M. C.* (2009) MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells. Biochem. Biophys. Res. Commun. 380, 205-210;

[14]Xia, H., Qi, Y., Ng, S. S., Chen, X., Chen, S.,Ge, R., Li, G., Chen, Y., He, M. L., Kung, H. F., Lai, L., and Lin M. C.* (2009) MircroRNA-146b inhibits glioma cell migration and invasion by targeting MMPs. Brain Res. 1269, 158-165;

[15]Sun, X., Baker, H. M.,Ge, R., Sun, H., He, Q.-Y.,* and Baker, E. N.* (2009) Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport inStreptococcus pyogenes. Biochemistry 48, 6184-6190;

[16]Sun, X.,Ge, R., Cai, Z., Sun, H., and He, Q.-Y.* (2009) Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2. J. Inorg. Biochem. 103, 1074-1081;

2010年

[17]Ge, R., Chu, I. K., and Sun, H.* (2010) Nuclear-based metallomics in metal-based drugs. In Advanced nuclear analytical techniques for metallomics and metalloproteomics. Eds. Chen C., Chai, Z., and Gao, Y., Royal Society of Chemistry, London, UK; pp 265~298;

[18]Sun, X., Ge, F., Xiao, C. L., Yin, X. F.,Ge, R., Zhang, L. H. and He, Q.-Y.* (2010) Phosphoproteomic analysis reveals the multiple roles of phosphorylation in pathogenic bacteriumStreptococcus pneumonia. J. Proteome Res. 9, 275-282;

[19]Sun, X.,Ge, R., Zhang, D., Sun, H. and He, Q.-Y.* (2010) Iron-containing lipoprotein SiaA in SiaABC, the primary heme transporter ofStreptococcus pyogenes. J. Biol. Inorg. Chem. 15, 1265-1273;

2011年

[20]Sun, X., Xiao, C. L.,Ge, R., Yin, X., Li, H., Li, N., Yang, X., Zhu, Y., He, X. and He, Q.-Y.* (2011) Putative copper- and zinc-binding motifs inStreptococcus pneumoniaeidentified by immobilized metal affinity chromatography and mass spectrometry. Proteomics, 11, 3288-3298;

[21]Tsang, C.-N.,Ge, R.and Sun, H.* (2011) Metallomics and metalloproteomics for arsenic, antimony and bismuth. In Biological chemistry of arsenic, antimony and bismuth. Eds. Sun, H., John Wiley & Sons; pp 353~376;

[22]Ge, R*., Sun, X., Xiao, C., Yin, X., Shan, W., Chen, Z., and He, Q.-Y.* (2011) Phosphoproteome analysis of the pathogenic bacteriumHelicobacter pylorireveals over-representation of tyrosine phosphorylation and multiply phosphorylated proteins. Proteomics 11, 1449-1461;

[23]Ge, R.*,Sun, X., Wang, D., Zhou, Q. and Sun, H. (2011) Histidine-rich protein Hpn fromHelicobacter pyloriforms amyloid-like fibrilsin vitroand inhibits the proliferation of gastric epithelial AGS cells. BBA-Mol. Cell Res. 1813, 1422-1427;

[24]Ge, R., Sun, X., and He, Q.-Y.* (2011) Overview of the metallometabolomic methodology for metal-based drug metabolism. Curr. Drug Metab. 12, 287-299;

[25]Ge, R.*, and Sun, X. (2011) Iron trafficking system inHelicobacter pylori. Biometals 25, 247-258;

[26]Ge, R.*and Sun, X. (2011) The in vivo functions of a histidine-rich protein Hpn inHelicobacter pylori: linking gastric and Alzheimer’s disease together? Med. Hypothesis 77, 788-890;

[27]Ge, R.*and Shan, W. (2011) Bacterial phosphoproteomic analysis reveals the correlation between protein phosphorylation and bacterial pathogenicity. Genomics Proteomics Bioinformatics 9, 119-127;

2012年

[28]Ge, R.*, Chen, Z., and Zhou, Q. (2012) The actions of bismuth in the treatment ofHelicobacter pyloriinfections: an update. Metallomics 4, 239-243;

[29]Ge, R.*(2012) Proton pump inhibitors are double-edged sword in the treatment ofHelicobacter pyloriinfections? Annals Gastroenterol. 25, 87-88;

[30]Chen, Z., Zhou, Q. andGe, R.*(2012) Inhibition of fumarase by bismuth(III): implications for the tricarboxylic acid cycle as a potential target of bismuth drugs inHelicobacter pylori. Biometals 25, 95-102;

[31]葛瑞光（2012）第五章蛋白質體外研究—結構與功能，《功能蛋白研究》，科學出版社;

2013年

[32]Wang, D., Luo, B., Shan, W., Hao, M., Sun, X. andGe, R.*(2013) The effects of EF-Ts and bismuth on EF-Tu inHelicobacter pylori: implications for an elegant timing for the introduction of EF-Ts in the elongation and EF-Tu as a potential drug target. Metallomics 5(7), 888-895;

[33]Ge, R.*, Wang, D., Hao, M. and Sun, X. (2013) Nickel tranfficking system responsible for urease maturation inHelicobacter pylori. World J. Gastroentro. 19(45), 8211-8218;

2014年

[34]Zhou, Q., Qi, S., Sun, X. andGe, R.*(2014) The interactions of a histidine-rich protein Hpn with the membrane mimics: implications for pathological roles of Hpn inHelicobacter pylori. Helicobacter 19(2), 129-135;

[35]Ge, R.*, Wang, D., Hao, M. and Sun, X. (2014) Nickel tranfficking system responsible for urease maturation inHelicobacter pylori. In World Clinical Gastroenterology. Eds. Ma, L., Chua, M.-S. and So, S., Baishideng Publishing Group Inc.; pp 2132~2139;

[36]Ge, R.*, and Sun, X.* (2014) Iron acquisition and regulation systems inStreptococcusspecies. Metallomics 6(5), 996-1003;

2015年

[37]Huang, D., Qiu, S.,Ge, R., He, L., Li, M., Li, Y. and Peng, Y.* (2015) miR-340 suppresses glioblastoma multiforme. Oncotarget 6(11) 9257-9270;

2016年

[38]Shan, W., Kung, H.F. andGe, R.*(2016) Comparison of iron-binding ability between Thr70-NapA and Ser70-NapA ofHelicobacter pylori. Helicobacter 21(3) 192-200;

[39]Liu SH, Tang YT*, Qiu RL, Ying RR,Ge, R.and Ji XH (2016) Responses of carbonic anhydrase to cadmium in the zinc/cadmium hyperaccumulatorPicris divaricate Vant. Pedosphere 26(5) 709-716;

2017年

[40]Wu J, Jia Q, Wu S, Zeng H, Sun Y, Wang C,Ge R.*, Xie W.* (2017)The crystal structure of the Pyrococcus abyssi mono-functional methyltransferase PaTrm5b. BBRC 493(1) 240-245;

2018年

[41]Liu YT, Pan Y, Lai F, Yin XF,Ge R*, He QY*, Sun X.* (2018) Comprehensive analysis of the lysine acetylome and its potential regulatory roles in the virulence of Streptococcus pneumoniae. J. Proteomics 176 46-55;