基本介紹
- 中文名：葛澤梅
- 職業：教師
- 專業方向：雜環類化合物的設計、合成、合成方法及生物活性研究
- 任職院校：北京大學藥學院
個人經歷,研究方向,學術成果,
個人經歷
多年來一直從事有機化學、藥物化學、化學生物學的科研與教求寒洪學工作。已主持完成國家自然科學基金2項，作為主要參加者完成國家自然科學基金3項以及“973”子課題等。目前主持或承擔國家“希擔十一五”“北京大學綜合性創新藥物研究開發技術大平台”的候選藥物研究品種及新藥臨床前研究課題。在國內外學術刊物上發表論文40餘篇，申請專利6項。
研究方向
1.基於作用機制的戒燥兆擔雜環類化合物的設計、合成、合成方法及生物活性研究少趨戶
2.氨基二硫代甲酸酯類化合物的再詢嬸設計、合成擔櫻滲及抗腫瘤活性研究
3.新煮芝主祝型酪氨酸激酶抑制劑的設計、合成及活性研究
4. 硫醇替代試劑的套用擴展與研究
學術成果
1. Ri-Dong Li, Xin Zhang, Qiao-Yan Li,Ze-Mei Ge,Run-Tao Li,Novel EGFR inhibitors prepared by combination of dithiocarbamic acidesters and 4-anilinoquinazolines.Bioorg. Med. Chem. Lett. 2011, 21, 3637–3640.
2. Wang, Junfeng; Qi, Chao;Ge, Zemei*;Cheng, Tieming; Li, Runtao*.Efficient direct asymmetric vinylogous Michael addition reactions of ？g-butenolides to chalcones catalyzed by vicinal primary-diamine saltsChem. Commun.,2010, 46, 2124–2126 .
3. Wang, Junfeng; Li, Qin; Qi, Chao; Liu, Yi;Ge, Zemei*;Li, Runtao*.Primary 1,2-diamine catalysis III: an unexpected domino reaction for the synthesis of multisubstituted cyclohexa-1,3-dienamines.Organic & Biomolecular Chemistry,(2010),8(19),4240-4242.
4. Wang, Junfeng; Wang, Xin;Ge, Zemei*;Cheng, Tieming; Li, Runtao*.Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism.Chem. Commun.,2010, 46, 1751–1753 .
5.MENG LEI, SHUAI XIA, JUNFENG WANG,ZEMEI GE,*TIEMING CHENG, AND RUNTAO LI*，An Ef？cient Dipeptide-Catalyzed Direct Asymmetric Aldol Reaction of Equimolar Reactants in Solid Media，CHIRALITY,22:580–586(2010).
6. Fang-bin Han,Ze-mei Ge,*Tie-ming Cheng,Run-tao Li* ,Novel One-Pot, Four-Component Synthesis of 3-Alkyldithiocarbonyl-oxazolidines from Aminoethanols, Ketones, Carbon Disulfide, and Halides,Synlett.,2009,4, 648-650.
7. Zhong-qing Wang,Ze-mei Ge,*Tie-ming Cheng, Run-tao Li*, Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water,Synlett.,2009,7, 2020-2022.
8. Jun-feng Wang,Meng Lei,Qin Li,Ze-mei Ge,*Xin Wang, Run-tao Li*,A novel and ef？cient direct aldol condensation from ketones and aromatic aldehydes catalyzed by proline–TEA through a new pathway,Tetrahedron.65(2009),4826-4833
9. ZHU, Jirang(朱繼讓), LI, Ridong(李日東),GE, Zemei*(葛澤梅),CHENG, Tieming(程鐵明), LI, Runtao*(李潤濤),Synthesis of β-Hydroxy Sulfides via Thiolysis of Epoxides Using S-Alkylisothiouronium Salts as Thiol Equivalents in Basic Aqueous Medium,Chinese Journal of Chemistry,2009, 27, 791-796.
10. WANG, Zhongqing(王仲清),GE, Zemei*(葛澤梅),CHENG, Tieming(程鐵明), LI, Runtao*(李潤濤), An Efficient Four-Component, One-Pot Synthesis ofPoly-Substituted Pyrimidines in Water,Chinese Journal of Chemistry,2009, 27, 834-838.
11. XuYan,Ze-Mei Ge*,Tie-Ming Cheng and Run-Tao Li*, One-pot synthesis of 1,3,4-oxadiazole-5-thioethers in water,Journal of Chinese Pharmaceutical Sciences17(2008 )277-280.
12. Song-wen Lin,Qi Sun,Run-tao Li,Tie-ming Cheng,Ze-mei Ge,Potassium Phosphate Promoted Aza-Markovnikov Addition of N-Heterocycles to Vinyl Esters.Synthesis,2007, 13, 1933-1938.
13. YanZhao,Ze-Mei Ge,Tie-Ming Cheng,Run-Tao Li,Thia-Michael Addition Using Cheap and OdorlessS-Alkylisothiouronium Salts as Thiol Equivalents in Water.Synlett.,2007, 10, 1529-1532.
14. Qi Sun,Run-Tao Li,Wei Guo,Jing-Rong Cui,Tie-Ming ChengandZe-Mei Ge,*Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP),Bioorganic & Medicinal Chemistry Letters,2006, 16, 3727-3730.
15.GE, Ze-Mei, LI, Qin, ZHENG, Shao-Jun, CHENG, Tie-Ming, CUI, Yu-Xin, LI, Run-Tao*, Facile One-pot Synthesis of Ethyl 3-Alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates,Chinese Journal of Chemistry,2006,24, 381-385.
16.Ze-mei Ge,Jia-ling Cui, Yan-ling Wang, Tie-ming Cheng,Run-tao Li*. A mild and efficient synthesis of 4, 5-disubstituted 3-amino-4-hydroxythiazolidine-2-thiones and S, N- disubstituted 1, 3, 4- thiadiazole-2-thiones.Synthesis,2004,8,1257-1261.
6. Fang-bin Han,Ze-mei Ge,*Tie-ming Cheng,Run-tao Li* ,Novel One-Pot, Four-Component Synthesis of 3-Alkyldithiocarbonyl-oxazolidines from Aminoethanols, Ketones, Carbon Disulfide, and Halides,Synlett.,2009,4, 648-650.
7. Zhong-qing Wang,Ze-mei Ge,*Tie-ming Cheng, Run-tao Li*, Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water,Synlett.,2009,7, 2020-2022.
8. Jun-feng Wang,Meng Lei,Qin Li,Ze-mei Ge,*Xin Wang, Run-tao Li*,A novel and ef？cient direct aldol condensation from ketones and aromatic aldehydes catalyzed by proline–TEA through a new pathway,Tetrahedron.65(2009),4826-4833
9. ZHU, Jirang(朱繼讓), LI, Ridong(李日東),GE, Zemei*(葛澤梅),CHENG, Tieming(程鐵明), LI, Runtao*(李潤濤),Synthesis of β-Hydroxy Sulfides via Thiolysis of Epoxides Using S-Alkylisothiouronium Salts as Thiol Equivalents in Basic Aqueous Medium,Chinese Journal of Chemistry,2009, 27, 791-796.
10. WANG, Zhongqing(王仲清),GE, Zemei*(葛澤梅),CHENG, Tieming(程鐵明), LI, Runtao*(李潤濤), An Efficient Four-Component, One-Pot Synthesis ofPoly-Substituted Pyrimidines in Water,Chinese Journal of Chemistry,2009, 27, 834-838.
11. XuYan,Ze-Mei Ge*,Tie-Ming Cheng and Run-Tao Li*, One-pot synthesis of 1,3,4-oxadiazole-5-thioethers in water,Journal of Chinese Pharmaceutical Sciences17(2008 )277-280.
12. Song-wen Lin,Qi Sun,Run-tao Li,Tie-ming Cheng,Ze-mei Ge,Potassium Phosphate Promoted Aza-Markovnikov Addition of N-Heterocycles to Vinyl Esters.Synthesis,2007, 13, 1933-1938.
13. YanZhao,Ze-Mei Ge,Tie-Ming Cheng,Run-Tao Li,Thia-Michael Addition Using Cheap and OdorlessS-Alkylisothiouronium Salts as Thiol Equivalents in Water.Synlett.,2007, 10, 1529-1532.
14. Qi Sun,Run-Tao Li,Wei Guo,Jing-Rong Cui,Tie-Ming ChengandZe-Mei Ge,*Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP),Bioorganic & Medicinal Chemistry Letters,2006, 16, 3727-3730.
15.GE, Ze-Mei, LI, Qin, ZHENG, Shao-Jun, CHENG, Tie-Ming, CUI, Yu-Xin, LI, Run-Tao*, Facile One-pot Synthesis of Ethyl 3-Alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates,Chinese Journal of Chemistry,2006,24, 381-385.
16.Ze-mei Ge,Jia-ling Cui, Yan-ling Wang, Tie-ming Cheng,Run-tao Li*. A mild and efficient synthesis of 4, 5-disubstituted 3-amino-4-hydroxythiazolidine-2-thiones and S, N- disubstituted 1, 3, 4- thiadiazole-2-thiones.Synthesis,2004,8,1257-1261.
