葉金星(博士生導師)

葉金星，男，博士，教授，博士生導師，副院長。

基本介紹

• 中文名：葉金星
• 國籍：中國
• 畢業院校：中國科學院大連化學物理研究所
• 性別：男
• 學位：博士
• 職稱：教授

人物履歷

葉金星，1997年獲中南工業大學（現中南大學）工學學士學位；2000年獲廣西大學理學碩士學位，從事計算化學研究；2004年獲中國科學院大連化學物理研究所理學博士學位，從事有機合成化學研究。2004年至2006年先後在英國曼切斯特大學化學學院Darren J. Dixon教授實驗室(現在牛津大學)和日本名古屋大學諾貝爾獎獲得者野依良治教授研究室從事博士後研究。

已在Chem. Comm., Org. Lett., Adv. Synth & Catal, Org. Biomol. Chem.等雜誌發表二十餘篇論文和專利，文章共被他人引用440餘次，單篇最高被引用171次和114次。2007年受聘於華東理工大學藥學院，2008年入選上海市“浦江人才計畫”，負責國家自然科學基金、教育部和上海市教委科研項目和Eli Lilly國際合作項目，主要從事合成化學、藥物化學、過程化學的研究與開發。

研究方向

1．合成化學：新試劑、新催化劑、新反應的設計與發現，及其在有機合成中的套用。

華東理工大學教師葉金星

2. 藥物化學：活性天然產物的全合成與構效關係研究。

3．過程化學：手性藥物及中間體、天然藥物的合成新方法研究及其過程化學開發。

獲獎成果

1. 2004年 The Royal Society Postdoctoral Fellowship2. 2008年 上海市“浦江人才計畫”；3. 2011年 “天鼎-東嶽”研究生獎教金一等獎4. 2012年 Thieme Chemistry Journal Award

代表性論著

41. Huicai Huang, Wenbin Wu, Kailong Zhu, Juan Hu, Jinxing Ye, Highly Diastereo- and Enantioselective Cross-Cascade Reactions of Different Enones,Chem. Eur. J.,2013, 19, 3838-3841.

40. Kailong Zhu, Huicai Huang, Wenbin Wu, Yuan Wei, Jinxing Ye, Aminocatalyzed Asymmetric Diels–Alder Reaction of 2,4-Dienals and Rhodanine/Hydantoin Derivatives,Chem. Commun.,2013, 49, 2157-2159.

39. Wenbin Wu, Xin Li, Huicai Huang, Xiaoqian Yuan, Junzhu Lu, Kailong Zhu, Jinxing Ye, Asymmetric Intramolecular Oxa-Michael Reactions of Cyclohexadienones Catalyzed by a Primary Amine Salt,Angew. Chem. Int. Ed.,2013,52, 1743–1747.

38. Wenbin Wu, Huicai Huang, Xiaoqian Yuan, Kailong Zhu, Jinxing Ye, Asymmetric Construction of Spirocyclohexanonerhodanines Catalyzed by Simple Diamine Derived from Chiral tert-Leucine,Chem. Commun.,2012, 48, 9180–9182.

37. Feng Yu, Haoxiang Hu, Xiaodong Gu, Jinxing Ye, Asymmetric Michael Addition of Substituted Rhodanines to α,β-Unsaturated Ketones Catalyzed by Bulky Primary Amines,Org. Lett.,2012, 14, 2038–2041.

36. Huicai Huang, Kailong Zhu, Wenbin Wu, Zhichao Jin, Jinxing Ye, Highly Diastereoselective and Enantioselective Michael Addition of 5H-Oxazol-4-ones to α, β-Unsaturated Ketones Catalyzed by a New Bifunctional Organocatalyst with Broad Substrate Scope and Applicability,Chem. Commun.,2012, 48, 461-463.

35. Xiaoyan Luo, Zhiqiang Zhou, Xin Li, Xinmiao Liang, Jinxing Ye, Enantioselective Organocatalytic Phospha-Michael Reaction of α,β-Unsaturated Aldehydes,RSC Advances,2011, 1, 698–705.

34. Wenjun Li, Xin Li, Wenbin Wu, Xinmiao Liang, Jinxing Ye, Highly Diastereo- and Enantioselective One-Pot Michael-Aldol Reactions of α, β-Unsaturated Aldehydes with Imidazole Derivatives,Chem. Commun.,2011, 47, 8325–8327.

33. Juanjuan Yang, Huicai Huang, Zhichao Jin, Wenbin Wu, Jinxing Ye, Diastereoselective Synthesis of Bicyclo[2.2.2]octan-2-one Derivatives through An Unexpected Organocatalytic Tandem Michael-Michael Reaction,Synthesis,2011, 1984-1987.

32. Wenjun Li, Xin Li, Tingting Ye, Wenbin Wu, Xinmiao Liang, Jinxing Ye, Asymmetric Organocatalytic Michael/α-Alkylation Reaction of α, β-Unsaturated Aldehyde with Chloroacetophenone,Tetrahedron Lett.,2011, 52, 2715-2718.31. Xiaoyan Luo, Zhiqiang Zhou, Feng Yu, Xin Li, Xinmiao Liang, and Jinxing Ye, Asymmetric Vinylogous Michael Reaction of α, β-Unsaturated Aldehyde with Buteno-4-lactone,Chem., Lett.,2011, 40, 518-520.

30. Huicai Huang, Zhichao Jin, Kailong Zhu, Xinmiao Liang, Jinxing Ye, Highly Diastereo- and Enantioselective Synthesis of 5-Substituted 3-Pyrrolidin-2-Ones through A Direct Vinylogous Michael Addition under Multifunctional Catalysis,Angew. Chem. Int. Ed.,2011, 50, 3232-3235.

29. Wenjun Li, Wenbin Wu, Juanjuan Yang, Xinmiao Liang, Jinxing Ye, Asymmetric Direct Michael Addition of Acetophenone to α, β-Unsaturated Aldehyde,Synthesis,2011, 1085-1091.

28. Wenjun Li, Wenbin Wu, Feng Yu, Huicai Huang, Xinmiao Liang, Jinxing Ye, Catalytic Asymmetric Michael Addition with Curcumin Derivative,Org. Biomol. Chem.,2011, 9, 2505-2511.

27. Zhichao Jin, Xiao Wang, Huicai Huang, Xinmiao Liang, Jinxing Ye, Diastereo- and Enantioselective Synthesis of Oxazine and Oxazolidine Derivatives with Chiral Quaternary Carbon Center under Multifunctional Catalysis,Org. Lett.,2011, 13, 564-567.

26. Zhichao Jin, Huicai Huang, Wenjun Li, Xiaoyan Luo, Xinmiao Liang, Jinxing Ye, Enantioselective Organocatalytic Synthesis of Oxazolidine Derivatives through A One-pot Cascade Reaction,Adv. Synth. Catal.,2011, 353, 343-348.

25. Zhichao Jin, Feng Yu, Xiao Wang, Huicai Huang, Xiaoyan Luo, Xinmiao Liang, Jinxing Ye, A One-pot Asymmetric Organocatalytic Tandem Reaction for the Synthesis of Oxazine Derivatives,Org. Biomol. Chem.,2011, 9, 1809-1816.

24. Xiaoyan Luo, Zhichao Jin, Pengfei Li, Jiabin Gao, Weimin Yue, Xinmiao Liang, Jinxing Ye, Catalytic Asymmetric Michael Addition of α, β-Unsaturated Aldehydes with Ni(II) Complexes of the Schiff Base of Glycine,Org. Biomol. Chem.,2011, 9 (3), 793-801.

23. Xiaomin Sun, Feng Yu, Tingting Ye, Xinmiao Liang, Jinxing Ye, Catalytic Asymmetric Michael Reaction of α, β-Unsaturated Ketones with Sulfonyl Containing Nucleophiles: Chiral Synthesis of R-Muscone and S-Celery Ketone,Chem. Eur. J.,2011, 17, 430-434.

22. Juanjuan Yang, Wenjun Li, Zhichao Jin, Xinmiao Liang, Jinxing Ye, Enantioselective Michael Reaction of α-Alkyl-β-Keto Esters and Enones under Multifunctional Catalysis,Org. Lett.,2010, 12, 5218-5221.

21. Feng Yu, Zhichao Jin, Huicai Huang, Tingting Ye, Xinmiao Liang, Jinxing Ye, A Highly Efficient Asymmetric Michael Addition of α, α-Disubstituted Aldehydes to Maleimides Catalyzed by Primary Amine Thiourea Salt,Org. Biomol. Chem.,2010, 8, 4767-4774.

20. Yufeng Zhou, Xin Li, Wenjun Li, Chunlin Wu, Xinmiao Liang, Jinxing Ye, Asymmetric Organocatalytic Michael Addition of α, β-Unsaturated Ketone with 1,2,4-Triazole,Synlett,2010, (15) , 2357-2360.

19. Huicai Huang, Feng Yu, Zhichao Jin, Wenjun Li, Wenbin Wu, Xinmiao Liang, Jinxing Ye, Asymmetric Vinylogous Michael Reaction of α, β-Unsaturated Ketones with γ-Butenolide under Multifunctional Catalysis,Chem. Commun.,2010, 46, 5957-5959.

18. Feng Yu, Xiaomin Sun, Zhichao Jin, Shigang Wen, Xinmiao Liang, Jinxing Ye, Enantioselective Michael Addition of Ketones to Maleimides Catalyzed by Bifunctional Monosulfonyl DPEN Salt,Chem. Commun.,2010, 46, 4589-4591.

17. Shigang Wen, Pengfei Li, Haibo Wu, Feng Yu, Xinmiao Liang, Jinxing Ye, Enantioselective Organocatalytic Phospha-Michael Reaction of α, β-Unsaturated Ketones,Chem. Commun.,2010, 46, 4806-4808.

16. Chunlin Wu, Wenjun Li, Juanjuan Yang, Xinmiao Liang, Jinxing Ye, Asymmetric Organocatalytic Michael Addition of Anthrone to Enone,Org. Biomol. Chem.,2010, 8, 3244-3250.

15. Pengfei Li, Shigang Wen, Feng Yu, Qiaoxia Liu, Wenjun Li, Yongcan Wang, Xinmiao Liang, Jinxing Ye, Enantioselective Organocatalytic Michael Addition of Malonates to α, β-Unsaturated Ketones,Org. Lett.,2009, 3, 753-756.

14. Pengfei Li, Yongcan Wang, Xinmiao Liang, Jinxing Ye, Asymmetric Multifunctional Organocatalytic Michael Addition of Nitroalkanes to α, β-Unsaturated Ketones,Chem. Commun.,2008, 3302-3304.

13. Yongcan Wang, Pengfei Li, Xinmiao Liang, Jinxing Ye, Base - Base Bifunctional Catalysis: A Practical Strategy for Asymmetric Michael Addition of Malonates to α, β-Unsaturated Aldehydes,Adv. Synth. Catal.,2008, 350, 1383-1389.

12. Yongcan Wang, Pengfei Li, Xinmiao Liang, Tony Y. Zhang, Jinxing Ye, An Efficient Enantioselective Method for Asymmetric Michael Addition of Nitroalkanes to α, β-Unsaturated Aldehydes,Chem. Commun.,2008, 1232-1234.

11. Yongping Zhang, Zhimou Guo, Jinxing Ye, Qing Xu, Xinmiao Liang, Aiwen Lei, Preparation of novel β-cyclodextrin chiral stationary phase based on click chemistry,J. Chromatography A,2008, 1191, 188-192.

10. Yongcan Wang, Jinxing Ye, Xinmiao Liang, Convenient Preparation of Chiral α, β-Epoxyketones via Claisen-Schmidt Condensation-Epoxidation Sequence,Adv. Synth. Catal.,2007, 349, 1033-1036.

9. A. L. Tillman, Jinxing Ye, D. J. Dixon, Direct Enantio- and Diastereoselective Mannich Reactions of Malonate and beta-Keto Esters with N-Boc- and N-Cbz-Aldimines Catalysed by a Bifunctional Cinchonine Derivative,Chem. Commun.,2006, 1191-1193.

8. Jinxing Ye, Darren J. Dixon, Peter S. Hynes, Highly Enantioselective Michael Addition of Malonate Esters to Nitro Olefins Using a Cinchonine-derived Bifunctional Organic Catalyst,Chem. Commun.,2005, 4481-4483.

7. Feifang Zhang, Jinxing Ye, Qing Zhang, Jiping Chen, Xinmiao Liang, Enantioseparation of Ranolazine using Shiseido Chiral CD-Ph Column by RP-HPLC,Chin. J. Anal. Lab. (Chinese),2005, 24(7), 48-50.

6. Yongcan Wang, Jinxing Ye, Xinmiao Liang, Research on the Epoxidation of Enone under Micellar Condition,Chin. J. Org. Chem. (Chinese),2005, 25(8), 969-971.

5. Jinxing Ye, Feifang Zhang, Qing Zhang, Jiping Chen, Xinmiao Liang, Chiral Separation of β-Blocking Agents by RP-HPLC,J. Instru. Anal. (Chinese),2004, 23, 80-82.

4. Jinxing Ye, Yongcan Wang, Jiping Chen, Xinmiao Liang, Trichloroisocyanuric Acid: A Convenient Oxidation Reagent for Phase-Transfer Catalytic Epoxidation of Enones under Non-Aqueous Conditions,Adv. Synth. Catal.,2004, 346, 691-696.

3. Jinxing Ye, Yongcan Wang, Renhua Liu, Guofu Zhang, Qing Zhang, Jiping Chen, Xinmiao Liang, A Highly Enantioselective Phase-Transfer Catalyzed Epoxidation of Enones with a Mild Oxidant of trichloroisocyanuric Acid,Chem. Commun.,2003, 2714–2715.

2. Jiehan Hu, Jinxing Ye, Guobao Cheng, Xiangyun Long, Quantum chemistry Ab Initio Calculation of Vibration Spectrum of β-Elemene,Spectrosc. Spect. Anal. (Chinese),2001, 21, 163-168.

1. Jinxing Ye, Guobao Cheng, Jiehan Hu, Study on Computational Chemistry of Elemene and Its Derivatives: Ι. Theoretical Calculation of 13C NMR Chemical Shifts of β-Elemene,Chin. J. Mag. Reson. (Chinese),2000, 17, 115-120.