葉社房

葉社房

葉社房，男，廈門大學材料學院教授。

基本介紹

  • 中文名：葉社房
  • 職業：科研人員
  • 專業方向：納米材料功能化修飾對生物效應的影響及機制
  • 任職院校：廈門大學材料學院
研究方向,學術成果,

研究方向

研究興趣集中在納米材料功能化修飾對生物效應的影響及機制

學術成果

項目
（1）多肽納米核酸及藥物傳遞的系列研究，研究為利用多肽修飾設計具有溶酶體逃逸機制的納米藥物傳遞系統提供了重要科學依據。
（2）二硫化鉬、碳納米管、富勒烯及石墨烯改性及生物效應的研究，研究為功能化納米材料的生物醫學套用提供重要理論支撐。工作得到多項國家自然科學基金和留學回國基金及福建省自然科學基金的資助；
同時還參與了多項國家自然科學基金面上項目和重點項目的研究。
論文
  1. Sunkui Ke, Youlin Lai, Tong Zhou, Lihuang Li, Yange Wang, Lei Ren, and Shefang Ye. Molybdenum Disulfide Nanoparticles Resist Oxidative Stress-Mediated Impairment of Autophagic Flux and Mitigate Endothelial Cell Senescence and Angiogenic Dysfunctions. ACS Biomater. Sci. Eng., 2018
  2. Shan W, Zhang D, Wu Y, Lv X, Hu B, Zhou X, Ye S, Bi S, Ren L, Zhang X.Modularized peptides modified HBc virus-like particles for encapsulation and tumor-targeted delivery of doxorubicin. Nanomedicine. 2018
  3. Li Y, Song L, Lin J, Ma J, Pan Z, Zhang Y, Su G, Ye S, Luo FH, Zhu X, Hou Z. Programmed Nanococktail Based on pH-Responsive Function Switch for Self-Synergistic Tumor-Targeting Therapy. ACS Appl Mater Interfaces. 2017
  4. Li Y, Lin J, Ma J, Song L, Lin H, Tang B, Chen D, Su G, Ye S, Zhu X, Luo F, Hou Z. Methotrexate-Camptothecin Prodrug Nanoassemblies as a Versatile Nanoplatform for Biomodal Imaging-Guided Self-Active Targeted and Synergistic Chemotherapy. ACS Appl Mater Interfaces. 2017
  5. Cheng Y, Zhang S, Kang N, Huang J, Lv X, Wen K, Ye S, Chen Z, Zhou X, Ren L. Polydopamine-Coated Manganese Carbonate Nanoparticles for Amplified Magnetic Resonance Imaging-Guided Photothermal Therapy. ACS Appl Mater Interfaces. 2017
  6. Li Y, Liu G, Ma J, Lin J, Lin H, Su G, Chen D, Ye S, Chen X, Zhu X, Hou Z. Chemotherapeutic drug-photothermal agent co-self-assembling nanoparticles for near-infrared fluorescence and photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy. J Control Release. 2017
  7. Ke S, Zhou T, Yang P, Wang Y, Zhang P, Chen K, Ren L, Ye S. Gold nanoparticles enhance TRAIL sensitivity through Drp1-mediated apoptotic and autophagic mitochondrial fission in NSCLC cells. Int J Nanomedicine. 2017
  8. Kang N, Liu Y, Zhou Y, Wang D, Chen C, Ye S, Nie L, Ren L. Phase and Size Control of Core-Shell Upconversion Nanocrystals Light up Deep Dual Luminescence Imaging and CT In Vivo. Adv Healthc Mater. 2016
  9. Shefang Ye, Peiyan Yang, Keman Cheng, Tong Zhou, Yange Wang, Zhenqing Hou, Yuanqin Jiang, and Lei Ren. Drp1-Dependent Mitochondrial Fission Mediates Toxicity of Positively Charged Graphene in Microglia. ACS Biomaterials Science & Engineering, 2016
  10. Shefang Ye, Tong Zhou, Dongmei Pan, Yiquan Lai, Peiyan Yang, Mingliang Chen, Yange Wang, Zhenqing Hou, Lei Ren, Yuanqin Jiang. Fullerene C60 derivatives attenuated microglia-mediated prion peptide neurotoxicity. 2016. Journal of Biomedical Nanotechnology. 2016
  11. Shefang Ye, Tong Zhou, Keman Cheng, Mingliang Chen, Yange Wang, Yuanqin Jiang, Peiyan Yang. Carboxylic Acid Fullerene （C60） Derivatives Attenuated Neuroinflammatory Responses by Modulating Mitochondrial Dynamics. Nanoscale Res Lett. 2015
  12. Cuilin Lin, Yifang Wang, Youqun Lai, Wei Yang, Fei Jiao, Honggang Zhang, Shefang Ye, Qiqing Zhang. Incorporation of carboxylation multiwalled carbon nanotubes into biodegradable poly （lactic-co-glycolic acid） for bone tissue engineering, Colloids and Surfaces B: Biointerfaces, 2011
  13. Shefang Ye, Miaomiao Tian, Tianxiao Wang, Lei Ren, Dong Wang, Lihua Shen, Ting Shang. Synergistic Effects of Cell Penetrating Peptide Tat and Fusogenic Peptide HA2 Enhance Cellular Internalization and Gene Transduction of Organosilica Nanoparticles. Nanomedicine, 2012
  14. Xiangrui Yang, Shichao Wu, Yange Wang, Yang Li, Di Chang, Yin Luo, Shefang Ye, Zhenqing Hou. Evaluation of self-assembled HCPT-loaded PEG-b-PLA nanoparticles by comparing with HCPT-loaded PLA nanoparticles Nanoscale Research Letters, 2014
  15. Shefang Ye, Min Chen, Yuanqin Jiang, Mingliang Chen, Tong Zhou, Yange Wang, Zhenqing Hou, Lei Ren. Polyhydroxylated fullerene attenuates oxidative stress-induced apoptosis via a fortifying Nrf2-regulated cellular antioxidant defence system. Int J Nanomedicine. 2014
  16. Yuanqin Jiang, Honggang Zhang, Yange Wang, Min Chen, Shefang Ye, Zhenqing Hou, Lei Ren. Modulation of apoptotic pathways of macrophages by surface-functionalized multi-walled carbon nanotubes. PLoS One, 2013
  17. Shefang Ye, Honggang Zhang, Yifang Wang, Fei Jiao, Cuilin Lin, Qiqing Zhang. Carboxylated single-walled carbon nanotubes induce an inflammatory response in human primary monocytes through oxidative stress and NF-B activation. Journal of Nanoparticle Research, 2011
  18. Shefang Ye, Yifang Wang, Honggang Zhang, Cuilin Lin, Yihui Wu, Qiqing Zhang. Role of NADPH oxidase in multi-wall carbon nanotubes-induced oxidative stress and cytotoxicity in human macrophages. Journal of Nanoscience and Nanotechnology 2011
  19. Cuilin Lin, Yifang Wang, Youqun Lai, Wei Yang, Fei Jiao, Honggang Zhang, Shefang Ye and Qiqing Zhang. Incorporation of carboxylation multiwalled carbon nanotubes into biodegradable poly （lactic-co-glycolic acid） for bone tissue engineering. Colloids and Surfaces B: Biointerfaces, 2011
  20. Shefang Ye, Wen Wen, Yifang Wang, Cuilin Lin, Yihui Wu, Qiqing Zhang. Multi-walled carbon nanotubes induces nuclear factor-B activation in A549 Cells. Chemical Journal of Chinese Universities, 2010
  21. Fei Cui, Jinyan Lin, Yang Li, Yanxiu Li, Hongjie Wu, Fei Yu, Mengmeng Jia, Xiangrui Yang, Shichao Wu, Liya Xie, Shefang Ye, Fanghong Luo, and Zhenqing Hou. Bacillus-Shape Design of Polymer Based Drug Delivery Systems with Janus-Faced Function for Synergistic Targeted Drug Delivery and More Effective Cancer Therapy. Molecular Pharmaceutics 2015
  22. Yang Li, Jinyan Lin, Xiangrui Yang, Yanxiu Li, Shichao Wu, Yu Huang, Shefang Ye, Liya Xie, Lizong Dai, and Zhenqing Hou. Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug–Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release. ACS Applied Materials & Interfaces 2015
  23. Zhenqing Hou, Yang Li, Yuancan Huang, Chunxiao Zhou, Jinyan Lin, Yixiao Wang, Fei Cui, Shuifan Zhou, Mengmeng Jia, Shefang Ye, and Qiqing Zhang.Phytosomes Loaded with Mitomycin C–Soybean Phosphatidylcholine Complex Developed for Drug Delivery. Molecular Pharmaceutics 2013
  24. Xiangrui Yang, Shichao Wu, Yang Li, Yu Huang, Jinyan Lin, Di Chang, Shefang Ye, Liya Xie, Yuan Jiang and Zhenqing Hou. Integration of an anti-tumor drug into nanocrystalline assemblies for sustained drug release. Chem. Sci., 2015
  25. Jinyan Lin, Yang Li, Hongjie Wu, Xiangrui Yang, Yanxiu Li, Shefang Ye, Zhenqing Hou and Changjian Lin. Tumor-targeted co-delivery of mitomycin C and 10-hydroxycamptothecin via micellar nanocarriers for enhanced anticancer efficacy. RSC Adv., 2015
  26. Ning Kang, Yu Liu, Yaming Zhou, Dong Wang, Chuan Chen, Shefang Ye, Liming Nie and Lei Ren. Phase and Size Control of Core–Shell Upconversion Nanocrystals Light up Deep Dual Luminescence Imaging and CT In Vivo. Advanced Healthcare Materials 2016
  27. Zhenqing Hou, Le Li, Chuanming Zhan, Peijuan Zhu, Di Chang, Qiwei Jiang, Shefang Ye, Xiangrui Yang, Yang Li, Liya Xie, Qiqing Zhang. Preparation and in vitro evaluation of an ultrasound-triggered drug delivery system: 10-Hydroxycamptothecin loaded PLA microbubbles, Ultrasonics, 2012
  28. Dongtao Ge, Xiangdong Tian, Rucai Qi, Sanqing Huang, Jing Mu, Shimin Hong, Shefang Ye, Xiuming Zhang, Donghui Li, Wei Shi, A polypyrrole-based microchip for controlled drug release, Electrochimica Acta. 2009

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