基本介紹
- 中文名：莫日根
- 外文名：Morigen
- 國籍：中國
- 畢業院校：挪威奧斯陸大學
- 職稱：教授
研究領域,學術論文,
研究領域
DNA複製是個嚴格控制的細胞過程，與細胞周期的其它環節密切協調。複製起始的準確時空調控是一個正常細胞周期開始的必要條件。準確DNA複製使子細胞得到完整的遺傳物質，以此將遺傳信息從親代完整的傳給子代。本實驗室主要以大腸桿菌為模式生物研究DNA複製調控分子機理，複製與基因表達、代謝和細胞周期其它環節之間的聯繫和協調。
2. 癌細胞DNA複製與基因組穩定性。
DNA複製差錯或異常（過多或過少）複製會降低基因組穩定性，並由此可能引發細胞癌變或發育缺陷。根據2006年的統計，人細胞有165種蛋白質參與DNA複製，38種疾病與DNA複製差錯有關。最近美國科學家發現干擾DNA複製起始負調控蛋白質Geminin的表達會選擇性地抑制癌細胞生長。這對開發和發展抗癌藥物意義重大。本實驗室將逐步開展癌細胞DNA複製與基因組穩定性等方面的研究工作。
DNA複製差錯或異常（過多或過少）複製會降低基因組穩定性，並由此可能引發細胞癌變或發育缺陷。根據2006年的統計，人細胞有165種蛋白質參與DNA複製，38種疾病與DNA複製差錯有關。最近美國科學家發現干擾DNA複製起始負調控蛋白質Geminin的表達會選擇性地抑制癌細胞生長。這對開發和發展抗癌藥物意義重大。本實驗室將逐步開展癌細胞DNA複製與基因組穩定性等方面的研究工作。
Research interests:
1. The Escherichia coli DNA replication and cell cycle.
2. DNA replication in cancer cells.
學術論文
1. Liu F, Qimuge, Hao J, Yan H, Bach T, Fan L, Morigen* AspC-mediated aspartate metabolism coordinates the Escherichia coli cell cycle,PLoS ONE, 9(3):e92229, 2014.
2. Morigen, Flatten I, K Skarstad The Escherichia coli datA site promotes proper regulation of cell division, SGM-Microbiol, DOI:10.1099/mic.0.074898-0, 2014.
3. Fan L,Morigen* Rho and Ras GTPases in semaphorin-mediated neuronal development, Advances in Bioscience and Biotechnology,4:136-142, 2013.
4. Johnsen L, Flåtten I, Morigen, Dalhus B, Bjørås M, Waldminghaus T, K Skarstad The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation of Replication, Mol Microbiol , 79(2):433-446, 2011.
5. Weatherspoon-Griffin N, Zhao G, Kong W, Kong Y, Morigen, Andrews-Polymenis H, McClelland M, Y Shi The CpxR/CpxA two-component system up-regulates two Tat-dependent peptidoglycan amidases to confer bacterial resistance to antimicrobial peptide, J Biol Chem, 286(7):5529-39, 2011.
6.Morigen, Odsbu I, K Skarstad Growth rate dependent numbers of SeqA structures organize the multiple replication forks in rapidly growing Escherichia coli, Genes Cells, 14:643-657, 2009.
7. Wang J, Morigen BayesPI--a new model to study protein-DNA interaction: a case study of condition-specific protein binding parameters for yeast transcription factors, BMC Bioinformatics, 10:345, 2009.
8. Odsbu I., Morigen, K Skarstad A reduction in ribonucleotide reductase activity slowsdown the chromo some replication fork but does not change its localization, PLoS ONE, 4(10):e7617, 2009.
9. Flåtten I, Morigen, K Skarstad DnaA protein interacts with RNA polymerase and protects it from the effect of rifampicin,Mol Microbiol, 71(4):1018-1030, 2009.
10. Bach T, Morigen, K Skarstad The initiator protein DnaA contributes to keeping new origins inactivated by promoting the presence of hemimethylated DNA, J Mol Biol, 384(5):1076-85, 2008.
11. Morigen, Molina F, K Skarstad Deletion of the datA site does not affect once-per-cell-cycle timing but induces rifampin-resistant replication,J Bacteriol, 187(12):3913-20, 2005.
12. Morigen, Løbner-Olesen A, K Skarstad Titration of the Escherichia coli DnaA protein to excess datA sites causes destabilizationof replication forks, delayed replication initiation and delayed cell division, Mol Microbiol, 50:349-362, 2003.
13. Morigen, Boye E, Skarstad K, A Løbner-Olesen Regulation of chromosomal replication by DnaA protein availability in Escherichiacoli: effects of the datA region, Biochim Biophys Acta, 1521: 73-80, 2001.
14. Weigel C, Messer W, Preiss S, Welzeck M, Morigen, E Boye The sequence requirements for a functional Escherichia coli replication origin are different for the chromosome and a minichromosome, Mol Microbiol, 40(2): 498-507, 2001.
