莊敏，畢業於田納西大學，上海科技大學助理教授。
基本介紹
- 中文名：莊敏
- 外文名：Zhuang M.
- 職業：助理教授
- 畢業院校：田納西大學
- 代表作品：Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase
個人簡介,研究內容,代表論文,
個人簡介
2003年本科畢業於南京大學基礎學科教學強化部；2009年在美國田納西大學健康醫學中心獲博士學位；2009年至2014年在加州大學舊金山分校進行博士後研究；2014年加入上海科技大學生命科學與技術學院任助理教授。
研究內容
研究方向專注於在腫瘤中下調或有變異突變的泛素連線酶。目標是綜合套用一系列的生化手段，研究蛋白質泛素修飾在腫瘤中的作用和識別新的靶向藥物靶點。
代表論文
Li G., Ci W., Karmakar S., Chen K., Dhar R., Fan Z., Guo Z., Zhang J., Ke Y., Wang L., Zhuang M., Hu S., Li X., Zhou L., Li X., Calabrese M.F., Watson E.R., Prasad S.M., Rinker-Schaeffer C., Eggener S.E., Stricker T., Tian Y., Schulman B.A., Liu J., White K.P.. SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer Cell 25, 1-14, 2014.
Zhuang M., Guan S., Wang H., Burlingame A.L., and Wells J.A.. Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. Mol Cell 49, 273-282, 2013.
Crawford E.D., Seaman J.E., Agard N., Hsu G.W., Julien O., Mahrus S., Nguyen H., Shimbo K., Yoshihara H.A., Zhuang M., Chalkley R.J., Wells J.A.. The DegraBase: a database of proteolysis in healthy and apoptotic human cells. Mol Cell Proteomics 12, 813-824, 2013.
Zhuang M., Calabrese M.F., Liu J., Waddell M.B., Nourse A., Hammel M., Miller D.J., Walden H., Duda D.M., Seyedin S.N., Hoggard T., Harper J.W., White K.P., Schulman B.A.. Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol Cell 36, 39-50, 2009.
Jin Y., Zhuang M. & Hendershot L.M.. ERdj3, a luminal ER DnaJ homologue, binds directly to unfolded proteins in the mammalian ER: identification of critical residues. Biochemistry 48, 41-49, 2009.
Huang D.T., Zhuang M., Ayrault O., Schulman B.A.. Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2. Nat Struct Mol Biol 15, 280-287, 2008.
Huang D.T., Hunt H.W., Zhuang M., Ohi M.D., Holton J.M., Schulman B.A.. Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity. Nature 445, 394-398, 2007.
Huang D.T., Paydar A., Zhuang M., Waddell M.B., Holton J.M., Schulman B.A.. Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. Mol Cell 17, 341-350, 2005.
