《腦對痛覺信息的動態加工過程》是羅非為項目負責人，北京大學為依託單位的面上項目。
基本介紹
- 中文名：腦對痛覺信息的動態加工過程
- 項目類別 ：面上項目
- 依託單位 ：北京大學
- 項目負責人：羅非
科研成果 ,項目摘要,
科研成果
結題項目詳情
序號 | 標題 | 類型 | 作者 |
|---|---|---|---|
1 | A Novel Cognitive Model of Reading: Neuropsychology Research on Internal Processing of the brain | 會議論文 | Luo, Fei|Zheng, Xu-Li|Shan, Chun-Lei|Yin, Wen-Gang| |
2 | Single unit activity in basal ganglia mesolimbic system in spontaneous epileptic rats, a new approach to seizure prediction | 會議論文 | Li, Zhuo-Ming|Krim, H|Woodward, Donald J|Luo, Fei|Chang, Jing-Yu|Shi, Li-Hong| |
3 | Encoding pain intensity with thalamic and cortical neurons in awake and anesthetized rats | 會議論文 | Woodward, Donald J|Chang, Jing-Yu|Wang, Jin-Yan|Luo, Fei|Zhang, Yang| |
4 | The effects of depression on nociceptive behaviors in rats | 會議論文 | Luo, Fei|Shi, Miao|Wang, Jin-Yan| |
5 | Acupuncture for the treatment of drug addiction | 期刊論文 | Cui, Cai-Lian|Luo, Fei|Wu, Liu-Zhen| |
6 | 抑鬱情緒與疼痛感受的相互關係 | 會議論文 | 羅非|史妙|王錦琰| |
7 | mPer2 controls circadian rhythm of pain sensitivity and enkephalin expression | 會議論文 | Vijayakumar, S|Brewer, KL|Mcmillen, BA|Ding, Jian-Ming|Chintalgattu, V|Nolan, T|Smith, M|Luo, Fei| |
8 | Democratic organization of the thalamocotical neural ensembles in nociceptive signal processing | 會議論文 | Wang, Jin-Yan|Luo, Fei| |
9 | Ensemble neuronal pain coding: thalamocortical pathways and beyond | 會議論文 | Luo, Fei| |
10 | Effect of low frequency stimulation of pedunculopontine nucleus on Parkinsonian motor deficits and neural activity in 6-OHDA lesioned rats | 會議論文 | Chang, Jing-Yu|Woodward, Donald J|Luo, Fei|Li, Zhuo-Ming| |
11 | Effects of STN DBS on sensorimotor process in unilateral dopamine lesioned rats | 會議論文 | Shi, Li-Hong|Woodward, Donald J|Li, Zhuo-Ming|Chang, Jing-Yu|Luo, Fei| |
12 | 疼痛現象中的心理成分及其基礎與臨床研究 | 會議論文 | 羅非| |
13 | Discrimination of noxious from non-noxious electrical stimuli by thalamic and cortical neural ensembles in rats | 會議論文 | Luo, Fei|Woodward, Donald J|Wang, Jin-Yan|Chang, Jing-Yu| |
14 | 疼痛現象中的心理成分及其基礎與臨床研究 | 會議論文 | 羅非| |
15 | 丘腦皮層神經元群放電與疼痛感知覺的形成 | 會議論文 | 羅非| |
16 | 桂皮醛、桂皮酸對IL-1β誘導大鼠腦微血管內皮細胞PGE2釋放及P-38 MAPK的影響 | 會議論文 | 姜廷良|郭建友|羅非| |
17 | 丘腦 - 皮層感覺通路的反饋調節對疼痛的影響 | 會議論文 | 王寧|羅非|王錦琰| |
18 | Repeated 100 Hz TENS for the treatment of chronic inflammatory hyperalgesia and suppression of spinal release of substance P in monoarthritic rats | 期刊論文 | Tian, Jin-Bin|Liu, Hong-Xiang|Han, Ji-Sheng|Wang, Jin-Shu|Luo, Fei|Deng, Zu-Guo|Xiong, Liang|Jiang, Yu-Hui|Liu, Cheng| |
19 | Corticofugal outputs facilitate acute, but inhibit chronic pain in rats | 會議論文 | Wang, Jing-Yan|Luo, Fei|Wang, Ning| |
20 | Dissection of placebo analgesia in mice: opioid and non-opioid systems | 會議論文 | Wang, Jin-Yan|Luo, Fei|Guo, Jian-You| |
21 | Basal ganglia neural responses during behaviorally effective deep brain stimulation of the subthalamic nucleus in rats performing a treadmill locomotion test | 期刊論文 | Luo, F|Shi, LH|Woodward, DJ|Chang, JY| |
22 | Dynamic changes in brain activations and functional connectivity during affectively different tactile stimuli | 期刊論文 | Wang, Jin-Yan|Liu, Jian-Yu|Luo, Fei|Hua, Qing-Ping|Zeng, Xiang-Zhu|Guo, Jian-You| |
23 | Dynamic neuronal responses in cortical and thalamic areas during different phases of formalin test in rats | 期刊論文 | Woodward, Donald J.|Han, Ji-Sheng|Wang, Jin-Yan|Huang, Jin|Luo, Fel|Chang, Jing-Yu|Baccala, Luiz A.| |
24 | Anticipation of pain enhances the nociceptive transmission and functional connectivity within pain network in rats | 期刊論文 | Wang, Jin-Yan|Chang, Jing-Yu|Woodward, Donald J.|Baccala, Luiz A.|Luo, Fei|Zhang, Han-Ti| |
25 | Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson’s disease | 期刊論文 | Zhang, Wang-Ming|Luo, Fei|Shi, Li-Hong|Chang, Jing-Yu|Woodward, Donald J| |
26 | 大鼠時間感知的行為學研究 | 期刊論文 | 王寧|張景渝|羅非|王錦琰| |
27 | 衝動與藥物依賴 | 期刊論文 | 崔彩蓮|羅非|左艷芳| |
28 | Democratic organization of the thalamocortical neural ensembles in nociceptive signal processing | 期刊論文 | Luo, Fei|Wang, Jin-Yan| |
29 | 海馬位置細胞對空間信息的處理 | 期刊論文 | 左艷芳|崔彩蓮|羅非| |
30 | Temporal sequence of ictal discharges propagation in the corticolimbic basal ganglia system during amygdala kindled seizures in freely moving rats | 期刊論文 | Shi, Li-Hong|Woodward, Donald J.|McIntyre, Dan C.|Chang, Jing-Yu|Luo, Fei| |
31 | Temporal strategy for discriminating noxious from non-noxious electrical stimuli by cortical and thalamic neural ensembles in rats | 期刊論文 | Wang, Jin-Yan|Chang, Jing-Yu|Luo, Fei|Woodward, Donald J.| |
32 | 第二觸覺系統:編碼觸覺情緒成分的C纖維 | 期刊論文 | 華慶平|羅非| |
33 | Neural responses in multiple basal ganglia regions following unilateral dopamine depletion in behaving rats performing a treadmill locomotion task | 期刊論文 | Chang, JY|Shi, LH|Woodward, DJ|Luo, F| |
34 | Studies of the neural mechanisms of deep brain stimulation in rodent models of Parkinson's disease | 期刊論文 | Woodward, Donald J.|Luo, Fei|Zhang, Wang-Ming|Shi, Li-Hong|Chang, Jing-Yu| |
35 | Deep brain stimulation of the substantia nigra pars reticulata exerts long lasting suppression of amygdala-kindled seizures | 期刊論文 | Chang, JY|Shi, LH|Luo, F|Woodward, D| |
36 | A comparison between spontaneous electroencephalographic activities induced by morphine and morphine-related environment in rats | 期刊論文 | Han, Ji-Sheng|Chen, Ji-Huan|Qiao, Zhi-Mei|Zuo, Yan-Fang|Luo, Fei|Cui, Cai-Lian|Wang, Jin-Yan| |
37 | 預期作用對大鼠皮層-丘腦神經元傷害性反應的調節 | 期刊論文 | 羅非|王錦琰|張含荑| |
38 | 針刺治療藥物成癮的研究進展 | 期刊論文 | 崔彩蓮|吳鎏楨|韓濟生|羅非| |
39 | 傷害性軀體感覺的中樞網路動態編碼過程 | 期刊論文 | 王錦琰|羅非| |
40 | 中樞刺激鎮痛方法及其機制研究評述 | 期刊論文 | 王錦琰|周佳樹|羅非| |
41 | Corticofugal outputs facilitate acute, but inhibit chronic pain in rats | 期刊論文 | Fei Luo|Jin-Yan Wang|Ning Wang| |
42 | Modulation of central nociceptive coding by acupoint stimulation | 期刊論文 | Wang, Jin-Yan|Luo, Fei| |
43 | 丘腦-皮層感覺通路上的反饋調節 | 期刊論文 | 王錦琰|王寧|羅非| |
44 | 參與疼痛感覺辨別的丘腦皮層結構 | 期刊論文 | 王錦琰|張楊|羅非| |
45 | Corticofugal influences on thalamic neurons during nociceptive transmission in awake rats | 期刊論文 | Woodward, Donald J.|Wang, Jin-Yan|Luo, Fei|Chang, Jing-Yu|Baccala, Luiz A.|Han, Ji-Sheng| |
46 | 機械傷害刺激激活丘腦-皮層神經網路的多通道記錄研究 | 期刊論文 | 羅非|王錦琰| |
47 | The Neuroscience Research Institute at Peking University: A place for the solution of pain and drug abuse | 期刊論文 | Yu, Albert C. H.|Wang, Ke-Wei|Han, Ji-Sheng|Chui, De-Hua|Wu, Liu-Zhen|Cui, Cai-Lian|Xing, Guo-Gang|Wang, Yun|Wan, You|Luo, Fei|Wang, Xiao-Min| |
48 | 疼痛心理學的發展及其臨床和社會意義 | 期刊論文 | 羅非|王錦琰| |
49 | Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems | 期刊論文 | Jian-You Guo|Fei Luo|Jin-Yan Wang| |
50 | Dynamic processing of nociception in cortical network in conscious rats: A laser-evoked field potential study | 期刊論文 | Han, Ji-Sheng|Luo, Fei|Wang, Jin-Yan|Qiao, Zhi-Mei| |
項目摘要
痛覺是人體重要的保護性功能，慢性痛又是困擾人類的重大疾病之一。腦對痛覺信息加工的動態過程至今不明。本項目以傷害性雷射刺激作為人和動物的正常痛覺模型，以足底注射福馬林作為動物持續性病理痛模型，配合條件性和非條件性實驗設計，利用清醒自由活動大鼠神經元群單位放電多通道同步記錄技術，同步記錄丘腦內、外側核群、初級和次級軀體感覺皮層、前扣帶皮層、內側前額葉、後頂葉皮層及杏仁複合體在疼痛刺激期間的神經元群放電活動，分析中樞在正常及病理狀態下處理疼痛的感覺、情緒和認知信息時，上述腦區內部及其相互間的信息動態流動情況。並在正常人及慢性痛患者記錄雷射痛覺誘發電位，運用動態源分析技術，分析正常及病理疼痛發生時人腦不同區域活動及其相互間的動態信息流動過程，以期揭示編碼疼痛的感覺、情緒和認知信息的中樞過程和機制，以及此機制在病理情況下的異常改變，為治療慢性頑固性疼痛提供理論依據。具有重大的理論和實際意義。
