胡煒(中國科學院水生生物研究所研究員)

2016年6月12日，農業部向社會公示了第五屆農業轉基因生物安全委員會委員名單，胡煒為國家農業轉基因生物安全委員成員。

基本介紹

博士生導師,學科組,代表論著,

博士生導師

簡歷：
1968年11月出生，博士，中國科學院水生生物研究所研究員，博士生導師，中國水產學會水產生物技術專業委員會委員，《農業生物技術學報》和《遺傳》編委。1991年畢業於南開大學生物系，獲理學學士學位；2002年獲中科院研究生院博士學位。主要從事魚類生殖發育調控、魚類基因工程育種、克隆胚胎再程式化機制等研究。主持國家自然科學基金重點項目、863項目、973課題及湖北省傑出青年人才基金等多項研究。以第一作者和通訊作者身份在Biology of Reproduction，PLoS One，General and Comparative Endocrinology，Marine biotechnology，Aquaculture以及《中國科學》等國內外刊物上發表論文30餘篇，以第一發明人身份獲美國發明專利1項，獲中國發明專利2項

學科組

魚類基因工程學科組
學科組長：胡煒
學科組成員：朱作言研究員、院士；胡煒研究員；陳尚萍高級實驗師
魚類基因工程學科組的研究工作發端於上世紀70年代末的魚類細胞核移植試驗：朱作言先生在著名實驗胚胎學家童第周先生的領導下，通過合作研究完成鯉鯽間的細胞核移植，首次實現脊椎動物的種間克隆。上世紀80年代，朱作言先生領導開創魚類基因轉移研究新領域，研製世界首批快速生長的轉基因魚。以上成果作為近代中國科技領域的兩大重要科研成就被載入《世界科學年史》（A. Hellemans & B. Bunch, 美國Simon & Schuster出版社）。
胡煒

代表論著

1.Chen Ji.Cui Xiaojuan, Jia Shaoting, Luo Daji, Cao Mengxi, Zhang Yunsheng, Hu Hongling, Huang Kaiyao, Zhu Zuoyan &Hu Wei.Disruption ofdmc1produces abnormal sperm in medaka (Oryzias latipes).ScientificReports,2016,6, 30912; doi: 10.1038/srep30912.
2.Mikwar M, Navarro-Martin L, Volkoff H,Hu Weiand Trudeau V.L. Stimulatory effect of the secretogranin-ll derived peptide secretoneurin on food intake and locomotion in female goldfish(Carassius auratus), Peptides, 2016 Apr;78:42-50.
3.Peng Wei, Cao Mengxi, Chen Ji, Li Yongming, Wang Yaping, Zhu Zuoyan,Hu Wei. GnIH plays a negative role in regulating GtH expression in the common carp,Cyprinus carpioL. General and Comparative Endocrinology, 2016, 235 :18–28.
4.Shu Yuqin, Lou Qiyong, Dai Ziru, Dai Xiangyan, He Jiangyan,Hu Wei& Yin Zhan, The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models.ScientificReports,2016, 6:18597, DOI: 10.1038/srep18597.
5.Zhou Y,Wang M,Jiang M,Peng L,Wan C,Liu J,Liu W,Zhao R,Zhao X,Hu W,Liu S,Xiao Y.Autotetraploid cell line induced by SP600125 from crucian carp and its developmental potentiality.ScientificReports, 2016, 6:21814. doi: 10.1038/srep21814.
6.Zhu T. B, Zhang L. H,Zhang T. L, WangY. P,Hu W, Ringø E. and Zhu Z. Y.Effects of sustained predation by fast-growing transgenic common carp (Cyprinus carpioLinnaeus, 1758) on gastropods in artificial environments.J. Appl. Ichthyol.2016; DOI:10.1111/jai.13130
7.胡煒，朱作言。美國轉基因大西洋鮭產業化對我國的啟示。中國工程科學，2016，18（3）：105-109。
8.Zhang Yunsheng,Chen Ji,Cui Xiaojuan,Luo Daji, XiaHui,Dai Jun,Zhu Zuoyan,Hu Wei. A controllable on-off strategy for the reproductive containment of fish. Scientific Reports, 2015,5,7614; DOI:10.1038/srep07614.
9.Song Yanlong, DuanXiaohai, Chen Ji, Zhu Zuoyan,Hu Wei. The distribution of Kiss1- and Kiss2-positive neurones and their connections with GnRH3 neurones in the zebrafish brain. Journal of Neuroendocrinology, 2015, 27(3): 198–211.
10.Tang Haipei, Liu Yun, Luo Daji, Ogawa Satoshi, Yin Yike, Li Shuisheng, Zhang Yong,Hu Wei, Parhar Ishwar S, Lin Haoran, Liu Xiaochun, Cheng Christopher H.K.. The kiss/kissr systems are dispensable for zebrafish reproduction: evidence from gene knockout studies，Endocrinology, 2015, 156:589-599.
11.Chu Lianhe, Li Jianzhen, Liu Yun,Hu Wei, Cheng Christopher H.K..Targeted gene disruption in zebrafish reveals noncanonical functions of Lh signaling in reproduction. Molecular Endocrinology,2014, 28(11):1785-95.
12.Cao Mengxi, Chen Ji, Peng Wei, Wang Yaping, Liao Lanjie, Li Yongming, Trudeau Vance L., Zhu Zuoyan,Hu Wei.Effects of growth hormone over-expression on reproduction in the common carpCyprinus carpioL.General and Comparative Endocrinology, 2014, 195:47-57.
13.Garcia-ReyeroNatàlia, Tingaud-SequeiraAngèle, Cao Mengxi, Zhu Zuoyan, Perkins Edward,Hu Wei. Endocrinology: Advances through omics and related technologies, General and Comparative Endocrinology, 2014, 203:262-273.(Invited review)
14.Liu Y, Luo D, Lei Y, Zhao H,Hu W, Cheng HK, A highly effective TALEN-mediated approach for targeted gene disruption inXenopus tropicalisand zebrafish,Methods, 2014, 69: 58–66.
15.Qiu Chao, Cheng Bin, Zhang Yunsheng, Huang Rong, Liao Lanjie, Luo Daji,Hu Wei, Wang Yaping. Efficient Knockout of Transplanted Green Fluorescent Protein Gene in Medaka using TALENs. Marine Biotechnology. 2014, DOI 10.1007/s10126-014-9584-x
16.Zhong C, Song Y, Wang Y, Zhang T, Duan M, Li Y, Liao L, Zhu Z,Hu W.Increased food intake in growth hormone-transgenic common carp (Cyprinus carpioL.) may be mediated by upregulating Agouti-related protein (AgRP). General and Comparative Endocrinology，2013，192, 81-88.
17.Chen Ji,HU Wei& ZHU ZuoYan. Progress in studies of fish reproductive development regulation. Chinese Science Bulletin, 2013,58:7-16.陳戟，胡煒，朱作言，魚類生殖發育調控研究進展。科學通報，2013,58:103-114.
18.LianHao,Hu Wei, Huang Rong, Du Fukuan, Liao Lanjie, Zhu Zuoyan, Wang Yaping. Transgenic Common Carp Do Not Have the Ability to Expand Populations. PLoS ONE, 2013, 8(6): e65506.
19. Liu Yun, Luo Daji, Zhao Hui, Zhu Zuoyan,Hu Wei,Cheng Christopher H. K..Inheritable and Precise Large Genomic Deletions of Non-Coding RNA Genes in Zebrafish Using TALENs.PLoS ONE, 2013,8(10): e76387.
20.Zhong Chengrong, Song Yanlong, Wang Yaping, Li Yongming, Liao Lanjie, XieShouqi, Zhu Zuoyan,Hu Wei. Growth hormone transgene effects on growth performance are inconsistent among offspring derived from different homozygous transgenic common carp (Cyprinus carpioL.). Aquaculture, 2012, 356–357: 404–411.
21.Cao Mengxi, DuanJundan, Cheng Nana, ZhongXueping, Wang Zequn,Hu Wei, Zhao Haobin. Sexually dimorphic and ontogenetic expression of dmrt1, cyp19a1a and cyp19a1b inGobiocypris rarus. Comparative Biochemistry and Physiology, Part A, 2012, 162: 303–309.
22. Cao Mengxi, Yang Yuhui, Xu Hongyan, DuanJundan, Cheng Nana, Wang Jialin,Hu Wei, Zhao Haobin. Germ cell specific expression of Vasa in rare minnow,Gobiocypris rarus,Comparative Biochemistry and Physiology, Part A, 2012, 162:163–170.
23. Guan Bo, Ma Hong, Wang Yaping, Hu Yuanlei, Lin Zhongping, Zhu Zuoyan,Hu Wei. Vitreoscilla Hemoglobin (VHb) Overexpression Increases Hypoxia Tolerance in Zebrafish (Danio rerio). Marine Biotechnology, 2011, 13（2）: 336-344. (cover paper)
24. Li Deliang, FU Cuizhang, Wang Yaping, Zhu Zuoyan,Hu Wei. The hematological response to exhaustive exercise in ‘all-fish’ growth hormone transgenic common carp (Cyprinus carpioL.). Aquaculture, 2011,311:263-268.
25. Luo Daji,Hu Wei, Chen Shangping, Zhu Zuoyan. Critical Developmental Stages For The Efficiency Of Somatic Cell Nuclear Transfer In Zebrafish.International Journal of Biological Sciences, 2011,7: 476-486.
26. Xu Jing, Huang Wei, ZhongChengrong, Luo Daji, Li Shuangfei, Zhu Zuoyan andHu Wei, Defining Global Gene Expression Changes of the Hypothalamic-Pituitary-Gonadal Axis in Female sGnRH-Antisense Transgenic Common Carp (Cyprinus carpio). PLoS One, 2011, 6(6): e21057.
27. Xu Zhuwei, Li Qi, Wang Yun, Song Chaojun, Zhang Tao, Chen Lihua, JiJianguo, Yang Angang, Zhu Zuoyan,Hu Wei, Jin Boquan. Production, characterization, and applications of mouse monoclonal antibodies against gonadotropin, somatolactin, and prolactin from common carp (Cyprinus carpio). General and Comparative Endocrinology, 2010, 167:373-378.
28. Tang Bin,Hu Wei, Hao Jun and Zhu Zuoyan. Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio). General and Comparative Endocrinology, 2010,167:408-416.
29. Dai J, Cui X, Zhu Z,Hu W. Non-Homologous End Joining Plays a Key Role in Transgene Concatemer Formation in Transgenic Zebrafish Embryos. International Journal of Biological Sciences, 2010; 6:756-768.
30. Duan M., Zhang T.,Hu W., Guan B., Wang Y., Li Z. & Zhu Z.. Increased mortality of “all-fish” growth hormone transgenic common carp (Cyprinus carpioL.) under a short-term risk of predation. Journal of Applied Ichthyology, 2010,26:908–912.
31. Guan Bo,HU Wei, ZHANG Tanglin, DUAN Ming, LI Deliang, WANG Yaping, ZHU Zuoyan. Acute and chronic un-ionized ammonia toxicity to ‘all-fish’ growth hormone transgenic common carp (Cyprinus carpioL.). Chinese Science Bulletin, 2010, 55: 4032-4036.
32.Hu Weiand Zhu Zuoyan. Integration mechanisms of transgenes and population fitness of GH transgenic fish. Science in China Ser C-Life Sci, 2010, 53:401-408.
33. Luo Yu-Shan,Hu Wei, Liu Xiao-Chun, Lin Hao-Ran, Zhu Zuo-Yan. Molecular cloning and mRNA expression pattern of Sox9 during sex reversal in orange-spotted grouper (Epinephelus coioides). Aquaculture, 2010,306:322-328.
34.Luo D,Hu W, Chen S, Xiao Y, Sun Y, Zhu Z. Identification of Differentially Expressed Genes Between Cloned and Zygote-Developing Zebrafish (Danio rerio) Embryos at the Dome Stage Using Suppression Subtractive Hybridization. Biology of Reproduction, 2009，80：674-684.
35. Guan B,Hu W, Zhang T, Wang Y, Zhu Z. Metabolism traits of 'all-fish' growth hormone transgenic common carp (Cyprinus carpioL.). Aquaculture 2008; 284: 217-223.
36.Hu Wei, Li Shuangfei, Tang Bin, Wang Yaping, Lin Haoran，Liu Xiaochun, Zou Jun & Zhu Zuoyan. Antisense for gonadotropin-releasing hormone reduces gonadotropin synthesis and gonadal development in transgenic common carp (Cyprinus carpio). Aquaculture, 2007, 271: 498–506.
37.Hu Wei, Wang Yaping& Zhu Zuoyan. Progress in the evaluation of transgenic fish for possible ecological risk and its containment strategies. Science in China Ser C-Life Sci. 2007, 50:573-579.胡煒，汪亞平，朱作言。轉基因魚生態風險評價及其對策研究進展。中國科學C輯：（生命科學），2007,37:377-381。
38. Wang Yun,Hu Wei, Liu Weiyi, Wang Yaping, Zhu Zuoyan. Identification and characterization of a novel alternative splicing transcript of gonadotropin alpha subunit in the common carp (Cyprinus Carpio). Journal of Fish Biology, 2007, 71: 1082–1094.
39.Hu Wei, Wang Yaping and Zhu Zuoyan. Perspective of fish gonad manipulation for biotechnical applications. Chinese Science Bulletin 2006,51(18):1-7.胡煒，汪亞平，朱作言。魚類性腺發育調控的生物技術前景分析。科學通報，2005,50:2689-2694.
40.Hu W, Wang Y, Chen S and Zhu Z. Nuclear transplantation in different strains of zebrafish, Chinese Science Bulletin,2002, 47(15):1277-1280.
發明專利目錄：
1. Hu Wei, Zhang Yunsheng, Dai Jun and Zhu Zuoyan. Controllable on-off method for fish reproduction. United States Patent and Trademark Office,2015年獲美國發明專利，專利號：US 9,187,764 B2
2. Hu Wei,Zhu Z, Ma H, Guan B, Lin Z, and Hu R.Recombinant gene which enhances the ability of fish to tolerate low dissolved oxygen stress and the use thereof.United States Patent and Trademark Office, 2013年獲美國發明專利，專利號：US8, 546, 644B2.
3. Hu Wei, Zhu Zuoyan, Wang Yaping and Li Shuangfei. Method for preparing a sterile transgenic carp. United States Patent and Trademark Office,2007年獲美國發明專利，專利號：US7,230,156B2.
4. 胡煒，馮科，陳戟，朱作言。一種黃鱔基因編輯的方法。中國發明專利，2016年8月10日受理，申請號：201610651812.1
5. 胡煒，湯斌，汪亞平，朱作言，一種雌性鯉魚性逆轉為雄性鯉魚的培育方法，2012年獲中國發明專利，專利號：ZL201110186519.X
6. 胡煒，張運生，戴軍，朱作言，一種控制魚類生殖的方法。2013年獲中國發明專利，專利號：ZL201310049161.5
7. 胡煒，朱作言，汪亞平，黎雙飛。不育轉基因魚的製備方法，2007年獲中國發明專利授權，專利號：ZL031254551。
8. 胡煒，朱作言，黎雙飛，汪亞平。一種殼聚糖甲基睪酮緩釋藥條的製備方法，2007年獲中國發明專利授權，專利號：ZL200510018148.9。
9. 吳玉萍，朱作言，胡煒，徐安龍。魚類基因原位修飾育種的方法，2006年獲中國發明專利授權，專利號：ZL200410015247.7
10.朱作言，鐘家玉。一種魚類電脈衝精子轉基因方法，中國發明專利，2004，專利號：ZL01114202.2

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