胡松年,字茂老,生於北宋哲宗元佑二年(公元1087年),卒於南宋高宗紹興十六年(公元1146年),海州懷仁 (今江蘇省贛榆區)人,(《建炎以來系年要錄》卷三五)。
基本介紹
- 本名:胡松年
- 字號:字茂老
- 所處時代:宋朝
- 出生地:海州懷仁
- 出生時間:北宋哲宗元佑二年
- 去世時間:南宋高宗紹興十六年
歷史人物,人物生平,社會評價,個人作品,科學人物,
歷史人物
人物生平
幼孤貧,母粥機織,供他讀書。松年讀書過目不忘,尤其精通《易經》。政和二年(公元1112年)任濰州教授,八年,經徽宗面試,改校書郎兼資善堂贊讀。為殿試參詳官,以沈晦第一,徽宗十分高興,說:“朕久聞晦名,今乃得之”。松年遷中書舍人,不久,除給事中、兼侍講。高宗年間,先後自左朝奉大夫拜吏部尚書,遷端明殿學士,除簽書樞密院事,權參知政事(副宰相)。又進禮部尚書、參知政事。胡松年積極抗金,並在軍隊建設、選用人才、對金鬥爭策略等重大問題上,都直言敢諫,提出了許多好的建議。後來,以疾提舉洞霄宮,卜居陽羨言村(今宜興宜城東約4里處)。他築堂以自娛,匾日“橫山”,由孫覿題書“橫山堂”。並題詩云:“波間指點見青紅,雪脊山曾棱倚半空。幻出生綃三四幅,遊人渾在畫圖中。蒼雲千里蔭平寬,露葉風枝繞舍寒。莫遣先生賦歸去,且令小吏報平安。”松年雖閒居鄉間,但仍不忘朝廷之事,對“和耀科斂、防秋利害”屢有進言,帝皆嘉納。
他憂國憂民,為官清正。在出任平江(今蘇州)知府時,人還未到任所,貪官污吏、土豪劣紳便聞風斂跡。他到任以後,在大街上張榜公布興利除害等17件大事,讓廣大百姓獻計獻策,監督執行,深受人民擁護愛戴。他曾多次上書朝廷,建議堅決抗金,大造戰船,建立水軍,加強長江防線,得到朝廷的賞識。朝廷要派人出使金國,不少人感到疑慮和害怕,胡松年挺身而出,接受朝廷出使金國的任命。在金國朝廷上,不顧個人安危,不辱使命,出色地維護了國家和民族的尊嚴。因主戰有功,被提升為吏部尚書權參知政事。朝廷每次給予他的賞賜,都以“軍興費廣”為由拒受。有人勸他積蓄點錢財,留給子孫,他都以“兒孫自有兒孫福”、“給子孫留財產,會助長子孫懶惰”的道理,婉言謝絕。他的高風亮節、優良品質,備受時人的尊敬和後代的讚譽。秦檜當政時.胡松年從不“曲意阿附”。宋紹興五年,胡松年因遭攻訐而引疾辭職,改任宣州知州。紹興十六年(1146年)胡松年病逝,享年60歲,墓葬宜城梅林,後遷葬故里。
社會評價
松年平生不喜蓄財,不立異沽名,喜賓客,薪俸收入常不夠支用。有人以為子孫計,勸其節用,松年曰:“賢而多財則損其志,況俸稟,主上所以養老臣也。”又當時秦檜為相,士大夫出於自身安危考慮,多曲意阿附於他,只有松年鄙視秦檜,至死不與秦檜通一封書信。這些,都深得世人的高度讚譽。
個人作品
《宋史》 卷三七九有傳。今錄詩三首。
《石州詞》
月上疏簾,風射小窗,孤館岑寂。一杯強洗愁懷,萬里堪嗟行客。亂山無數,晚秋雲物蒼然,何如輕抹淮山碧。喜氣拂征衣,作眉間黃色。
役役。馬頭塵暗斜陽,隴首路回飛翼。夢裡姑蘇城外,錢塘江北。故人應念我,負吹帽佳時、同把金英摘。歸路且加鞭,看梅花訊息。
《石州詞》
歌闋陽關,腸斷短亭,惟有離別。畫船送我薰風,瘦馬迎人飛雪。平生幽夢,豈知塞北江南,而今真嘆河山闊。屈指數分攜,早許多時節。
愁絕。雁行點點雲垂,木葉霏霏霜滑。正是荒城落日,空山殘月。一尊誰念我,苦樵悴天涯、陡覺生華髮。賴有紫樞人,共揚鞭丹闕。
科學人物
姓名:胡松年
性別:男
出生年月:1969年1月21日
出生地:天津市
簡歷
學習經歷:
1991年9月-1996年7月中國農業大學 生物化學專業 獲理學博士學位
1987年9月-1991年7月天津商學院 食品工程專業 獲理學學士學位
科研工作經歷:
2003年2月-至今 中國科學院北京基因組研究所 研究員 博士生導師
2002年2月-2008年9月 浙江大學沃森基因組科學研究院教授 碩士生導師
1999年8月-2003年2月 中國科學院遺傳與發育研究所人類基因組中心總工程師
1998年8月–1999年7月 美國西雅圖華盛頓大學基因組中心訪問學者
1996年9月–1998年7月 中國醫學科學院基礎醫學研究所助理研究員
學術任職:
2011年至今 Nature Reviews Genetics (Chinese Edition) 編委
2010年至今 Frontiers in Plant Genetics and Genomics 編委
2008年至今 BMC Research Notes 編委
2007年至今 遺傳 編委
獲獎情況:
2008年 中國科學院朱李月華優秀教師獎
2007年 利用EST信息資源大規模克隆家蠶功能基因 浙江省科學技術一等獎
2006年 中國科學院優秀教師獎
2003年 中國雜交水稻基因組計畫 中國科學院傑出科技成就集體獎
2002年 中國雜交水稻基因組計畫 香港求是科技基金求是傑出科技成就集體獎
主持和承擔的科研項目:
項目資助 類別 | 項目名稱(批准號) | 起止年份 | 資助金額(萬元) | 本人在項目中的作用 | 進展 |
國家自然 科學基金 | 1%人類基因組計畫“完成圖”的繪製(30199010) | 2000.6-2001.6 | 500 | 項目成員 (第3位) | 已完成 |
中科院 知識創新 | 1%人類基因組和中國重要戰略資源生物基因組計畫(KSCX1-01) | 2000.6-2001.12 | 2500 | 項目成員 (第5位) | 已完成 |
北京市科委 | 大規模基因組測序技術平台的建立與最佳化 | 2000.10-2001.10 | 100 | 項目負責人 | 已完成 |
科技部 863計畫 | 超級雜交水稻(秈稻) 基因組測序(2001AA225041) | 2001.1-2002.12 | 1500 | 項目成員 (第2位) | 已完成 |
科技部 863計畫 | 水稻基因組精細圖的繪製(2002AA229021) | 2002.1-2003.12 | 1500 | 項目成員 (第9位) | 已完成 |
科技部 | 家豬基因組計畫(2002AA229061) | 2002.1-2004.12 | 80 | 項目成員 (第2位) | 已完成 |
國家自然 科學基金 | 人類基因組的研究策略和套用(30221004) | 2003.1-2005.12 | 720 | 項目成員 (第6位) | 已完成 |
中科院 知識創新 | 家蠶基因組框架圖和家雞基因組多態性圖譜的繪製(KSCX1-SW-25) | 2003.7-2005.6 | 3500 | 項目成員 (第9位) | 已完成 |
國家自然 科學基金 | 常染色體顯性先天性靜止性夜盲症致病基因的篩查與致病機理研究(30470962) | 2005.1-2007.12 | 18 | 項目負責人 | 已完成 |
科技部 973計畫 | 轉錄組縱深信息挖掘(“以細胞為單元的人類基因轉錄組與蛋白質組的關聯性研究”項目下屬課題)(2006CB910403) | 2006.11-2010.8 | 329 | 課題負責人 | 已完成 |
國家自然 科學基金 | 水稻中細胞器到細胞核以及細胞器間的DNA序列遷移及其在基因組進化,細胞器起源和進化中的研究(30600111) | 2007.2-2009.12 | 22 | 項目成員 (第2位) | 已完成 |
中科院 知識創新 | 非編碼RNA的鑑定、功能研究以及算法軟體的開發(KSCX2-EW-R-01-04) | 2011.1-2013.12 | 140 | 子課題 負責人 | 進行中 |
主要學術成績
1、 人類基因組計畫及後續研究
2、水稻基因組計畫及後續研究
3、以第二代測序為基礎的哺乳動物轉錄組學研究
4、小鼠基因組表觀修飾與基因表達的研究
擬開展研究方向
1.第二代測序數據產出和數據管理平台構建
2.非編碼RNA的注釋
3.小鼠基因表達和表觀調控的網路研究
近五年內發表的5篇代表性論著
1. Cui, P., L. Zhang, Q. Lin, F. Ding, C. Xin, X. Fang, S. Hu, and J. Yu, A novel mechanism of epigenetic regulation: nucleosome-space occupancy. Biochemical and Biophysical Research Communications, 2010. 391(1): p. 884-889. (並列通訊作者)
2. Cui, P., Q. Lin, C. Xin, L. Han, L. An, Y. Wang, Z. Hu, F. Ding, L. Zhang, S. Hu, H. Hang, and J. Yu, Hydroxyurea-induced global transcriptional suppression in mouse ES cells. Carcinogenesis, 2010. 31(9): p. 1661-1668. (並列通訊作者)
3. Cui, P., Q. Lin, F. Ding, C. Xin, W. Gong, L. Zhang, J. Geng, B. Zhang, X. Yu, J. Yang, S. Hu, and J. Yu, A comparison between ribo-minus RNA-sequencing and polyA-selected RNA-sequencing. Genomics, 2010. 96(5): p. 259-265. (並列通訊作者)
4. Mu, Y., F. Ding, P. Cui, J. Ao, S. Hu, and X. Chen, Transcriptome and expression profiling analysis revealed changes of multiple signaling pathways involved in immunity in the large yellow croaker during Aeromonas hydrophila infection. BMC Genomics, 2010. 11(1): p. 506. (並列通訊作者)
5. Zhou Q, Yu XM, Lin HB, Wang L, Yun QZ, Hu SN, Wang DM: Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese. The Pharmacogenomics Journal 2009. (並列通訊作者)
近五年內發表的全部論著
6. Zhu, J., F. He, D. Wang, K. Liu, D. Huang, J. Xiao, J. Wu, S. Hu, and J. Yu, A novel role for minimal introns: routing mRNAs to the cytosol. PLoS One, 2010. 5(4): p. e10144.
7. Zhang, Y., F. Zhang, H. Lin, L. Shi, P. Wang, Q. Gong, X. Li, M. Wang, S. Hu, J. Chu, and D.-M. Wang, Nucleotide polymorphism of the TNF gene cluster in six Chinese populations. Journal of Human Genetics, 2010. 55(6): p. 350-357.
8. Zhang, W., D. Yu, Z. Sun, R. Wu, X. Chen, W. Chen, H. Meng, S. Hu, and H. Zhang, Complete genome sequence of Lactobacillus casei Zhang, a new probiotic strain isolated from traditional home-made koumiss in Inner Mongolia of China. Journal of Bacteriology, 2010. 192(19): p. 5268-5269.
9. Zhang, W., D. Yu, Z. Sun, W. Chen, S. Hu, H. Meng, and H. Zhang, The comparative analysis of a prophage remnant Lcazh1 in relation to other Lactobacillus prophages, particularly Lp3. International Journal of Dairy Technology, 2010. 63(3): p. 413-417.
10. Zhang, G., M. Su, D. Wang, S. Hu, M. Liu, J. Li, H. Lin, F. Zhang, D. Tian, H. Yang, Z. Liu, S. Lian, Q. Guo, X. Li, and Y. Gao, Genetic heterogeneity of oesophageal cancer in high-incidence areas of southern and northern china. PLoS One, 2010. 5(3): p. e9668.
11. Zhang, G., W. Chu, S. Hu, T. Meng, L. Pan, R. Zhou, Z. Liu, and J. Zhang, Identification and analysis of muscle-related protein isoforms expressed in the white muscle of the mandarin fish (Siniperca chuatsi). Marine Biotechnology (New York, N.Y.), 2010.(並列通訊作者)
12. Zhang, C., D. Zhou, S. Zheng, L. Liu, S. Tao, L. Yang, S. Hu, and Q. Feng, A chymotrypsin-like serine protease cDNA involved in food protein digestion in the common cutworm, Spodoptera litura: Cloning, characterization, developmental and induced expression patterns, and localization. Journal of insect physiology, 2010. 56(7): p. 788-799.
13. Ye, J., L.-H. Su, C.-L. Chen, S. Hu, J. Wang, J. Yu, and C.-H. Chiu, Analysis of pSC138, the multidrug resistance plasmid of Salmonella enterica serotype Choleraesuis SC-B67. Plasmid, 2010.
14. Yang, Y., W. Gong, W. Wang, X. Yu, S. Hu, and J. Yu, The alterations of energy metabolism-related protein patterns in brown adipose tissue of rats during cold-induced thermogenesis. Progress in Biochemistry and Biophysics, 2010. 37(10): p. 1108-1119.
15. Wu, Q., J. Song, Y. Sun, F. Suo, C. Li, H. Luo, Y. Liu, Y. Li, X. Zhang, H. Yao, X. Li, S. Hu, and C. Sun, Transcript profiles of Panax quinquefolius from flower, leaf and root bring new insights into genes related to ginsenosides biosynthesis and transcriptional regulation. Physiologia Plantarum, 2010. 138(2): p. 134-149.
16. Wang, L., L. Jiang, S. Hu, and Y. Wang, Characterization of evolutionarily conserved microRNAs in amphioxus. Genomics, Proteomics & Bioinformatics, 2010. 8(1): p. 10-21. (並列通訊作者)
17. Qu, H., H. Wu, T. Zhang, Z. Zhang, S. Hu, and J. Yu, Nucleotide compositional asymmetry between the leading and lagging strands of eubacterial genomes. Research in Microbiology, 2010. 161(10): p. 838-846.
18. Niu, J., H. Hu, S. Hu, G. Wang, G. Peng, and S. Sun, Analysis of expressed sequence tags from the Ulva prolifera (Chlorophyta) Chinese Journal of Oceanology and Limnology, 2010. 28(1): p. 26-36. (並列通訊作者)
19. Mu, Y., F. Ding, P. Cui, J. Ao, S. Hu, and X. Chen, Transcriptome and expression profiling analysis revealed changes of multiple signaling pathways involved in immunity in the large yellow croaker during Aeromonas hydrophila infection. BMC Genomics, 2010. 11(1): p. 506. (並列通訊作者)
20. Liu, W., D. Huang, K. Liu,S. Hu, J. Yu, G. Gao, and S. Song, Discovery, identification and comparative analysis of non-specific lipid transfer protein (nsLtp) family in Solanacese. Genomics, Proteomics & Bioinformatics, 2010. 8(4): p. 229-237.
21. Liu, F., D. Wang, J. Fu, G. Sun, Y. Shen, L. Dong, B. Zhang, S. Hu, and J. Li, Identification of immune-relevant genes by expressed sequence tag analysis of head kidney from grass carp (Ctenopharyngodon idella). Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2010. 5(2): p. 116-123. (並列通訊作者)
22. Lin, H., H. Fan, F. Zhang, X. Huang, K. Lin, L. Shi, S. Hu, J. Chu, and D.-M. Wang, Genetic relationships of ethnic minorities in Southwest China revealed by microsatellite markers. PLoS One, 2010. 5(3): p. e9895.
23. Li, K., J. Geng, J. Qu, Y. Zhang, and S. Hu, Effectiveness of 10 polymorphic microsatellite markers for parentage and pedigree analysis in plateau pika (Ochotona curzoniae). BMC Genetics, 2010. 11(1): p. 101. (並列通訊作者)
24. He, X., S. Tao, J. Jin, S. Hu, and J. Yu, The most redundant sequences in human CpG island library are derived from mitochondrial genome. Genomics Proteomics Bioinformatics, 2010. 8(2): p. 81-91. (並列通訊作者)
25. Hao, L., X. Ge, H. Wan, S. Hu, M.J. Lercher, Y. Jun, and W.-H. Chen, Human functional genetic studies are biased against the medically most relevant primate-specific genes. BMC Evolutionary Biology, 2010. 10: p. 316.
26. Guo, H., W. Wang, N. Yang, B. Guo, S. Zhang, R. Yang, Y. Yuan, J. Yu, S. Hu, Q. Sun, and J. Yun, DNA barcoding provides distinction between Radix Astragali and its adulterants. Science China Life Sciences 2010. 53(8): p. 992-9.
27. Geng, J., K. Li, Y. Zhang, and S. Hu, A modified enrichment method to construct microsatellite library from Plateau Pika genome (Ochotona curzoniae). Genomics, Proteomics & Bioinformatics, 2010. 8(1): p. 72-76. (並列通訊作者)
28. Feng, B., L. Dong, D. Niu, S. Meng, B. Zhang, D. Liu, S. Hu, and J. Li, Identification of immune genes of the agamaki clam (Sinonovacula constricta) by squencing and bioinformatic analysis of ESTs. Marine Biotechnology (New York, N.Y.), 2010. 12(3): p. 282-291. (並列通訊作者)
29. Deng, X., L. Gu, C. Liu, T. Lu, F. Lu, Z. Lu, P. Cui, Y. Pei, B. Wang, S. Hu, and X. Cao, Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America, 2010. 107(44): p. 19114-9.
30. Cui, P., L. Zhang, Q. Lin, F. Ding, C. Xin, X. Fang, S. Hu, and J. Yu, A novel mechanism of epigenetic regulation: nucleosome-space occupancy. Biochemical and Biophysical Research Communications, 2010. 391(1): p. 884-889. (並列通訊作者)
31. Cui, P., Q. Lin, C. Xin, L. Han, L. An, Y. Wang, Z. Hu, F. Ding, L. Zhang, S. Hu, H. Hang, and J. Yu, Hydroxyurea-induced global transcriptional suppression in mouse ES cells. Carcinogenesis, 2010. 31(9): p. 1661-1668. (並列通訊作者)
32. Cui, P., Q. Lin, F. Ding, C. Xin, W. Gong, L. Zhang, J. Geng, B. Zhang, X. Yu, J. Yang, S. Hu, and J. Yu, A comparison between ribo-minus RNA-sequencing and polyA-selected RNA-sequencing. Genomics, 2010. 96(5): p. 259-265. (並列通訊作者)
33. Chen, X., X. Yu, Y. Cai, H. Zheng, D. Yu, G. Liu, Q. Zhou, S. Hu, and F. Hu, Next-generation small RNA sequencing for microRNAs profiling in the honey bee Apis mellifera. Insect Molecular Biology, 2010. 19(6): p. 799-805. (並列通訊作者)
34. Chen, K., L. Wang, M. Yang, J. Liu, C. Xin, S. Hu, and J. Yu, Sequence signatures of nucleosome positioning in Caenorhabditis elegans. Genomics Proteomics Bioinformatics, 2010. 8(2): p. 92-102.
35. Cai, Y., X. Yu, Q. Zhou, C. Yu, H. Hu, J. Liu, J. Yang, H. Lin, B. Zhang, P. Cui, S. Hu, and J. Yu, Novel microRNAs in silkworm (Bombyx mori). Functional and Integrative Genomics, 2010. 10(3): p. 405-415. (並列通訊作者)
36. Zhu J, Sun Y, Zhao F-Q, Yu J, Craig R, Hu S: Analysis of tarantula skeletal muscle protein sequences and identification of transcriptional isoforms. BMC Genomics 2009, 10:117.
37. Zhou Q, Yu XM, Lin HB, Wang L, Yun QZ, Hu SN, Wang DM: Genetic polymorphism, linkage disequilibrium, haplotype structure and novel allele analysis of CYP2C19 and CYP2D6 in Han Chinese. The Pharmacogenomics Journal 2009. (並列通訊作者)
38. Zhao D, Song S, Wang Q, Zhang X, Hu S, Chen L: Discovery of immune-related genes in Chinese mitten crab (Eriocheir sinensis) by expressed sequence tag analysis of haemocytes. Aquaculture 2009, 287(3-4):297-303.
39. Zhang WY, Yu DL, Sun ZH, Alrideng C, Hu SN, Meng H, Zhang HP: Preliminary analysis of glutathione S-transferase homolog from Lactobacillus casei Zhang. Annals of Microbiology 2009, 59(4):727-731.
40. Zhang G, Zhang L, Zhang M, Pan L, Wang F, Huang J, Li G, Yu J, Songnian H: Screening and assessing 11 Mycobacterium tuberculosis proteins as potential serodiagnostical markers for discriminating TB patients from BCG vaccinees. Genomics Proteomics & Bioinformatics 2009, 7(3):107-115.
41. Zhang F, Zhang B, Xiang H, Hu S: Comparative analysis of clustered regularly interspaced short palindromic repeats (CRISPRs) loci in the genomes of halophilic archaea. Acta Microbiologica Sinica 2009, 49(11):1445-1453.
42. Zhan X, Ke C-H, Hu H-Y, Hu S-N, Wang D-X, Chen F: Isolation and characterization of eleven microsatellite loci in small abalone, Haliotis diversicolor Reeve. Conservation Genetics 2009, 10(4):1185-1187. (並列通訊作者)
43. Yu X, Zhou Q, Cai Y, Luo Q, Lin H, Hu S, Yu J: A discovery of novel microRNAs in the silkworm (Bombyx mori) genome. Genomics 2009, 94(6):438-444. (並列通訊作者)
44. Xu X, Song S, Wang Q, Qin F, Liu K, Zhang X, Hu S, Zhao Y: Analysis and comparison of a set of expressed sequence tags of the parthenogenetic water flea Daphnia carinata. Molecular Genetics and Genomics 2009, 282(2):197-203.
45. Wu P, Qi D, Chen L, Zhang H, Zhang X, Qin J, Hu S: Gene discovery from an ovary cDNA library of oriental river prawn Macrobrachium nipponense by ESTs annotation. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 2009, 4(2):111-120. (並列通訊作者)
46. Wang L, Hao L, Li X, Hu S, Ge S, Yu J: SNP deserts of Asian cultivated rice: genomic regions under domestication. Journal of Evolutionary Biology 2009, 22(4):751-761.
47. Wang D, Zhang S, He F, Zhu J, Hu S, Yu J: How do variable substitution rates influence Ka and Ks calculations? . Genomics, Proteomics & Bioinformatics 2009, 7(3):116-127.
48. Song S, Huang Y, Wang X, Wei G, Qu H, Wang W, Ge X, Hu S, Liu G, Liang Y et al: HRGD: a database for mining potential heterosis-related genes in plants. Plant Molecular Biology 2009, 69(3):255-260.
49. Liu WQ, Feng Y, Wang Y, Zou QH, Chen F, Guo JT, Peng YH, Jin Y, Li YG, Hu SN et al: Salmonella paratyphi C: genetic divergence from Salmonella choleraesuis and pathogenic convergence with Salmonella typhi. PLoS One 2009, 4(2):e4510.
50. Lin WC, Li SC, Shin JW, Hu SN, Yu XM, Huang TY, Chen SC, Chen HC, Chen SJ, Huang PJ et al: Identification of microRNA in the protist Trichomonas vaginalis. Genomics 2009, 93(5):487-493.
51. Li X, Tan L, Zhu Z, Huang H, Liu Y, Hu S, Sun C: Patterns of nucleotide diversity in wild and cultivated rice Plant Systematics and Evolution 2009, 281(1-4):97-106.
52. Li X, Tan L, Wang L, Hu S, Sun C: Isolation and characterization of conserved non-coding sequences among rice (Oryza sativa L.) paralogous regions. Molecular Genetics and Genomics 2009, 281(1):11-18.
53. Li K-x, Geng J-n, Yang J, Zhang Y-m, Hu S-n: Isolation and characterization of 13 microsatellite loci in the plateau pika (Ochotona curzoniae). Conservation Genetics 2009, 10:785-787. (並列通訊作者)
54. Kou Z, Hu S, Li T: Genome evolution of novel influenza A (H1N1) viruses in humans. Chinese Science Bulletin 2009, 54:2159-2163.
55. Jiang H, Yin Y, Zhang X, Hu S, Wang Q: Chasing relationships between nutrition and reproduction: A comparative transcriptome analysis of hepatopancreas and testis from Eriocheir sinensis Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 2009, 4(3):227-234.
56. Jiang H, Cai YM, Chen LQ, Zhang XW, Hu SN, Wang Q: Functional annotation and analysis of expressed sequence tags from the hepatopancreas of mitten crab (Eriocheir sinensis). Marine Biotechnology (New York, NY) 2009, 11(3):317-326.
57. Ji R, Cui P, Ding F, Geng J, Gao H, Zhang H, Yu J, Hu S, Meng H: Monophyletic origin of domestic bactrian camel (Camelus bactrianus) and its evolutionary relationship with the extant wild camel (Camelus bactrianus ferus). Animal Genetics 2009, 40(4):377-382. (並列通訊作者)
58. Feng B, Dong L, Niu D, Meng S, Zhang B, Liu D, Hu S, Li J: Identification of immune genes of the agamaki clam (Sinonovacula constricta) by sequencing and bioinformatic analysis of ESTs. Marine Biotechnology (New York, NY) 2009. (並列通訊作者)
59. Ding F, Tang P, Hsu MH, Cui P, Hu S, Yu J, Chiu CH: Genome evolution driven by host adaptations results in a more virulent and antimicrobial-resistant Streptococcus pneumoniae serotype 14. BMC Genomics 2009, 10:158.
60. Cui P, Liu H, Lin Q, Ding F, Zhuo G, Hu S, Liu D, Yang W, Zhan K, Zhang A et al: A complete mitochondrial genome of wheat (Triticum aestivum cv. Chinese Yumai), and fast evolving mitochondrial genes in higher plants. Journal of Genetics 2009, 88(3):299-307.
61. Cong P, Luo Y, Bao W, Hu S: Genomic organization and promoter analysis of the Trichomonas vaginalis core histone gene families. Parasitology International 2009.
62. Chen Y, Zhu W, Sui S, Zhang X, Hu S: Sequence and evolutionary analysis of VP1 gene of ovine rotavirus NT. Acta Microbiologica Sinica 2009, 49(8):1055-1062.
63. Chen Y, Zhu W, Sui S, Yin Y, Hu S, Zhang X: Whole genome sequencing of lamb rotavirus and comparative analysis with other mammalian rotaviruses. Virus Genes 2009, 38(2):302-310. (並列通訊作者)
64. Chen WH, Ge X, Wang W, Yu J, Hu S: A gene catalogue for post-diapause development of an anhydrobiotic arthropod Artemia franciscana. BMC Genomics 2009, 10:52.
65. Chen H, Huang L, Hua X, Ying L, Hu Y, Wang C, Chen W, Yu X, Xu Z, Tian B, Hu S,Hua Y: Pleiotropic effects of RecQ in Deinococcus radiodurans. Genomics 2009, 94(5):333-340. (並列通訊作者)
66. Chai H, Yu DL, Zhang B, Fu Y, Hu SN: Analysis of expressed sequence tags in porcine uterus tissue. Biochemical Genetics 2009, 47(1-2):117-125. (並列通訊作者)
67. Cai Y, Yu X, Hu S, Yu J: A brief review on the mechanisms of miRNA regulation. Genomics, Proteomics & Bioinformatics 2009, 7(4):147-154. (並列通訊作者)
68. Bai Z, Yin Y, Hu S, Wang G, Zhang X, Li J: Identification of genes involved in immune response, microsatellite, and SNP markers from expressed sequence tags generated from hemocytes of freshwater pearl mussel (Hyriopsis cumingii). Marine Biotechnology (New York, NY) 2009, 11(4):520-530.
69. Zhu J, He F, Hu S, Yu J: On the nature of human housekeeping genes. Trends in Genetics 2008, 24(10):481-484.
70. Zhang Y, Chang B, Hu S, Wang D, Fang Q, Huang X, Zeng Q, Qi M: Single nucleotide polymorphisms and haplotype of four genes encoding cardiac ion channels in Chinese and their association with arrhythmia. Annals of Noninvasive Electrocardiology 2008, 13(2):180-190.
71. Zhang W, Yu D, Sun Z, Chen X, Bao Q, Meng H, Hu S, Zhang H: Complete nucleotide sequence of plasmid plca36 isolated from Lactobacillus casei Zhang. Plasmid 2008, 60(2):131-135.
72. Yu X, Zhou Q, Li SC, Luo Q, Cai Y, Lin WC, Chen H, Yang Y, Hu S, Yu J: The silkworm (Bombyx mori) microRNAs and their expressions in multiple developmental stages. PLoS One 2008, 3(8):e2997.
73. Ye Z, Hu S, Yu J: Adaptive clustering algorithm for community detection in complex networks. Physical Review E, Statistical, Nonlinear, and Soft Matter Physics 2008, 78(4 Pt 2):046115.
74. Wang W, Meng B, Ge X, Song S, Yang Y, Yu X, Wang L, Hu S, Liu S, Yu J: Proteomic profiling of rice embryos from a hybrid rice cultivar and its parental lines. Proteomics 2008, 8(22):4808-4821.
75. Wang W, Luo Q, Guo H, Bossier P, Van Stappen G, Sorgeloos P, Xin N, Sun Q, Hu S, J. Y: Phylogenetic analysis of brine shrimp (Artemia) in China using DNA barcoding. Genomics Proteomics Bioinformatics 2008, 6(3-4):155-162.
76. Wang F, Wang J, Jian H, Zhang B, Li S, Zeng X, Gao L, Bartlett DH, Yu J, Hu S et al: Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3. PLoS One 2008, 3(4):e1937. (並列通訊作者)
77. Luo Y, Xu X, Ding Z, Liu Z, Zhang B, Yan Z, Sun J, Hu S, Hu X: Complete genome of Phenylobacterium zucineum--a novel facultative intracellular bacterium isolated from human erythroleukemia cell line K562. BMC Genomics 2008, 9:386. (並列通訊作者)
78. Luo Q, Zhou Q, Yu X, Lin H, Hu S, Yu J: Genome-wide mapping of conserved microRNAs and identification of their host transcripts in Tribolium castaneum. Journal of Genetics & Genomics 2008, 35(6):349-355.
79. Li X, Tian F, Huang H, Tan L, Zhu Z, Hu S, Sun C: Construction of the physical map of the gpa7 locus reveals that a large segment was deleted during rice domestication. Plant Cell Reports 2008, 27(6):1087-1092.
80. Li X, Tan L, Huang H, Zhu Z, Li C, Hu S, Sun C: Construction of a bacterial artificial chromosome (BAC) library of common wild rice (Oryza rufipogon Griff.) for map-based cloning of genes selected during the domestication of rice. Biotechnology Letters 2008, 30(3):555-561.
81. Li J, Wang Y, Hu S, Zhou R, Yu X, Wang B, Guan L, Yang L, Zhang F, Faraone SV: The monoamine oxidase B gene exhibits significant association to ADHD. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics 2008, 147(3):370-374. (並列通訊作者)
82. Jiang Y, Zhou Z, Qian Y, Wei Z, Yu Y, Hu S, Li L: Plasmid-mediated quinolone resistance determinants qnr and aac(6')-Ib-cr in extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in China. The Journal of Antimicrobial Chemotherapy 2008, 61(5):1003-1006.
83. Huang J, Zhang L-x, Hu S-n, Yu J: Optimizing expression of LZ-8 protein and primary assaying of its immunomodulatory activity. Journal of Zhejiang University (Agric & Life Sci) 2008, 34(1):7-12.
84. Huang J, Jiang X, Zhang X, Chen W, Tian B, Shu Z, Hu S: Expressed sequence tag analysis of marine fungus Schizochytrium producing docosahexaenoic acid. Journal of Biotechnology 2008, 138(1-2):9-16.
85. Ge X, Chen W, Song S, Wang W, Hu S, Yu J: Transcriptomic profiling of mature embryo from an elite super-hybrid rice LYP9 and its parental lines. BMC Plant Biology 2008, 8:114. (並列通訊作者)
86. Gao WR, Wang XS, Liu QY, Peng H, Chen C, Li JG, Zhang JS, Hu SN, Ma H: Comparative analysis of ESTs in response to drought stress in chickpea (C. arietinum L.). Biochemical and Biophysical Research Communications 2008, 376(3):578-583. (並列通訊作者)
87. Feng Y, Chen CJ, Su LH, Hu S, Yu J, Chiu CH: Evolution and pathogenesis of Staphylococcus aureus: lessons learned from genotyping and comparative genomics. FEMS Microbiology Reviews 2008, 32(1):23-37.
88. Chu C, Feng Y, Chien AC, Hu S, Chu CH, Chiu CH: Evolution of genes on the Salmonella virulence plasmid phylogeny revealed from sequencing of the virulence plasmids of S. enterica serotype Dublin and comparative analysis. Genomics 2008, 92(5):339-343.
89. Chen S-L, Sun Y-Q, Song J-Y, Li Y, Li C-J, Hu S-N, Li X-W, Yao H, Zhang X-W: Analysis of expressed sequence tags (EST) from Panax quinquefolium root. Acta Pharmaceutica Sinica 2008, 43(6):2-8.
90. Chen K, Meng Q, Ma L, Liu Q, Tang P, Chiu C, Hu S, Yu J: A novel DNA sequence periodicity decodes nucleosome positioning. Nucleic Acids Research 2008, 36(19):6228-6236.
91. Chen H, Xu G, Zhao Y, Tian B, Lu H, Yu X, Xu Z, Ying N, Hu S, Hua Y: A novel OxyR sensor and regulator of hydrogen peroxide stress with one cysteine residue in Deinococcus radiodurans. PLoS One 2008, 3(2):e1602. (並列通訊作者)
92. Zhou X, Wang W, Lu F, Hu S, Jiang L, Yan D, Zhang X, Yu X, Yu J, Qu J: A comparative gene expression profile of the whole eye from human, mouse, and guinea pig. Molecular Vision 2007, 13:2214-2221.
93. Zhang Z, Deng Y, Tan J, Hu S, Yu J, Xue Q: A genome-wide microsatellite polymorphism database for the indica and japonica rice. DNA Research 2007, 14(1):37-45.
94. Yan J, Tang H, Liu Y, Ma W, Zhang Q, Gao J, Jiao Z, Shang L, Jing Y, Hu S et al: Allele frequencies of mitochondrial D-loop (CA)n repeat polymorphism in six Chinese ethnic groups. Legal Medicine (Tokyo) 2007, 9(6):330-331.
95. Tian X, Zheng J, Hu S, Yu J: The discriminatory transfer routes of tRNA genes among organellar and nuclear genomes in flowering plants: a genome-wide investigation of indica rice. Journal of Molecular Evolution 2007, 64(3):299-307.
96. Song S, Qu H, Chen C, Hu S, Yu J: Differential gene expression in an elite hybrid rice cultivar (Oryza sativa, L) and its parental lines based on SAGE data. BMC Plant Biology 2007, 7:49.
97. Liu QY, Wang XX, Zhang JZ, Chen WH, He XW, Lin Y, Wang JF, Zhu Y, Hu SN, Wang XN: Mapping cynomolgus monkey MHC class I district on chromosome 6p13 using pooled cDNAs. Biotechnic & Histochemistry 2007, 82(4):267-272.
98. Gorodkin J, Cirera S, Hedegaard J, Gilchrist MJ, Panitz F, Jorgensen C, Scheibye-Knudsen K, Arvin T, Lumholdt S, Sawera M, Hu S et al: Porcine transcriptome analysis based on 97 non-normalized cDNA libraries and assembly of 1,021,891 expressed sequence tags. Genome Biology 2007, 8(4):R45.
99. Fan X, Fang Y, Hu S, Wang G: Generation and analysis of 5318 expressed sequence tags (ESTs) from filamentous sporophyte of Porphyra haitanensis Ueda (Rhodophyta). Journal of Phycology 2007, 43(6):1287 -1294. (並列通訊作者)
100.Cui P, Ji R, Ding F, Qi D, Gao H, Meng H, Yu J, Hu S, Zhang H: A complete mitochondrial genome sequence of the wild two-humped camel (Camelus bactrianus ferus): an evolutionary history of camelidae. BMC Genomics 2007, 8:241. (並列通訊作者)
101.Chen WH, Lv G, Lv C, Zeng C, Hu S: Systematic analysis of alternative first exons in plant genomes. BMC Plant Biology 2007, 7:55.
102.Chen H, Xu Z, Tian B, Chen W, Hu S, Hua Y: Transcriptional profile in response to ionizing radiation at low dose in Deinococcus radiodurans. Progress in Natural Science 2007, 17(5):529-536. (並列通訊作者)
103.Zhao H, Li Q, Li J, Zeng C, Hu S, Yu J: The study of neighboring nucleotide composition and transition/transversion bias. Science in China: Series C Life Sciences 2006, 49(4):395-402.
104.Zhang B, Liu Q, Yin W, Zhang X, Huang Y, Luo Y, Qiu P, Su X, Yu J, Hu S et al: Transcriptome analysis of Deinagkistrodon acutus venomous gland focusing on cellular structure and functional aspects using expressed sequence tags. BMC Genomics 2006, 7:152.
105. Yu H, Wang J, Ye J, Tang P, Chu C, Hu S, Chiu CH: Complete nucleotide sequence of pSCV50, the virulence plasmid of Salmonella enterica serovar Choleraesuis SC-B67. Plasmid 2006, 55(2):145-151.
106.Yang G, Deng Y-J, Yan C-X, Wu D-Y, Hu S-N, Zhu B-F, Li S-B, Zhang X-Q, Liu Y: Frequencies distribution of human leukocyte antigen-B27 subtypes in healthy Chinese. Acta Academiae Medicinae Sinicae 2006, 28(2):240-243.
107.Yang G, Deng YJ, Hu S, Wu DY, Li SB, Zhu J, Zhu BF, Liu Y: HLA-A, -B, and-DRB1 polymorphism defined by sequence-based typing of the Han population in Northern China. Tissue Antigens 2006, 67(2):146-152.
108.Yan J, Liu Y, Tang H, Zhang Q, Huo Z, Hu S, Jun Y: Mutations at 17 STR loci in Chinese population. Forensic Science International 2006, 162(1-3):53-54.
109.Tian X, Zheng J, Hu S, Yu J: The rice mitochondrial genomes and their variations. Plant Physiology 2006, 140(2):401-410.
1 1 0. S u Z, Dong X, Zhang B, Zeng Y, Fu Y, Yu J, Hu S: Gene expression profiling in porcine mammary gland during lactation and identification of breed- and developmental-stage-specific genes. Science in China: Series C Life Sciences 2006, 49(1):26-36. (並列通訊作者)
111.Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Hu S et al: The DNA sequence, annotation and analysis of human chromosome 3. Nature 2006, 440(7088):1194-1198.
112.Liu Q, Zhang X, Yin W, Li C, Huang Y, Qiu P, Su X, Hu S, Yan G: A catalog for transcripts in the venom gland of the Agkistrodon acutus: identification of the toxins potentially involved in coagulopathy. Biochemical and Biophysical Research Communications 2006, 341(2):522-531.
113.Liu Q, Hu S, Yin W, Su X, Zhang X, Li C, Qiu P, Yan G: Construction of a cDNA library from Agkistrodon acutus venom gland and identification of Agkihagin, a novel transcript for metalloproteinase. Chinese Journal of Pharmacology and Toxicology 2006, 20(2):81-90.
114.Deng Y, Yang G, Wu D, Hu S, Li S, Zhu J, Zhu B, Liu Y: HLA-A, B, DRB1 gene polymorphism of Beijing population was studied by high-resolution polymerase chain reaction sequence-based typing. Chinese Journal of Medical Genetics 2006, 23(1):103-106.
Chen WH, Wang XX, Lin W, He XW, Wu ZQ, Lin Y, Hu SN, Wang XN: Analysis of 10,000 ESTs from lymphocytes of the cynomolgus monkey to improve our understanding of its immune system. BMC Genomics 2006, 7:-. (並列通訊作者)
北京基因組研究所“傳承者讀書會”——《基因組那點事與我的成長》
6月6日下午,基因組所一層報告廳內座無虛席,新一期“傳承者”讀書會在大家的期待中精彩開講。本期主講人胡松年研究員,以《基因組那點事與我的成長》為題,以通俗易懂的方式向大家介紹了什麼是基因組學、基因組學的研究對象與技術發展,並講述了自己在基因組科學領域中的探索和成長曆程。
胡松年研究員投身基因組學研究已逾十五年,作為人類基因組計畫1%部分和水稻基因組計畫等在中國基因組學領域具有里程碑意義的重要事件的主要參與者和見證者,他在本學科領域內有很高的造詣和許多不為人知的深刻感悟。讀書會上,他以幽默風趣的語言,為大家普及了基因組學的基礎知識,讓我們對世界基因組學突飛猛進的發展有了巨觀的了解,對最新的儀器設備和技術方法有了進一步認識,報告中更令人印象深刻的是我國科研工作者排除萬難、勇於探索的精神。
此次讀書會,胡松年研究員的講解讓大家從另一個角度感受到了科學家的青春之路及與科學結下的不解之緣。講至曾經在艱苦環境下科研人員不畏艱難克服壓力並且苦中作樂的經歷,在場聽眾也隨之一起數度哽咽,無不動容。
人類基因組草圖公布十周年紀念會
在人類基因組草圖繪製完成10年後的2010年6月26日,由中國科協科學技術普及部、中國遺傳學會、中國科學院北京基因組研究所、中國科學院遺傳與發育生物學研究所共同主辦的“人類基因組草圖公布十周年紀念會”在北京國家會議中心隆重舉行。中國科協科學技術普及部部長楊文志,中國科學院生命科學與生物技術局副局長蘇榮輝,中國老年基因會秘書長常金城,中國科學院北京基因組研究所黨委書記楊衛平,中國科學院北京基因組研究所副所長於軍等領導,以及來自基因研究領域專家、學者等300餘人出席了紀念會。
“我覺得國際人類基因組計畫1%項目做下來很大的感覺對國家的榮譽。到4月,我們一共做了500198個(序列),當時做完之後沒有歡呼雀躍的感覺,就是想終於做完了,沒有給國家丟臉。那時的工作條件非常艱苦,陳老師(中國科學院原遺傳研究所所長陳受宜)在我們工作的小樓內放了一張紙,上面寫著‘窮棒子精神永放光芒!’。感覺精神的激勵要遠遠大於肉體上的承受能力。做科研是一定要有一些精神,這是我做完1%項目最大的感觸。”雖然國際人類基因組計畫1%基因組測序項目完成已10年,但中國科學院北京基因組研究所研究員胡松年回想當年時仍抑制不住激動之情,在發言中數度哽咽。