胡新立，北京大學分子醫學所副研究員。
基本介紹
- 中文名：胡新立
- 學位/學歷：博士
- 職業：教師
- 專業方向：分子醫學
- 任職院校：北京大學分子醫學研究所
個人經歷,學術成果,
個人經歷
1991年進入北京大學生物系細胞專業讀研究生，1996年獲得博士學位。
學術成果
2014
Wang H, Xu X, Fassett J, Kwak D, Liu X, Hu X, Falls TJ, Bell JC, Li H, Bitterman P, et al. Double-stranded RNA-dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heart failure. Circulation [Internet]. 2014;(13):1397-1406. 訪問連結 SCI被引用次數：19.
Lu Z, Xu X, Fassett J, Kwak D, Liu X, Hu X, Wang H, Guo H, Xu D, Yan S, et al. Loss of the eukaryotic initiation factor 2α kinase general control nonderepressible 2 protects mice from pressure overload-induced congestive heart failure without affecting ventricular hypertrophy. Hypertension [Internet]. 2014;(1):128-135. 訪問連結 SCI被引用次數：16.
Xu X, Lu Z, Fassett J, Zhang P, Hu X, Liu X, Kwak D, Li J, Zhu G, Tao Y, et al. Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2. Hypertension [Internet]. 2014;(4):723-728. 訪問連結 SCI被引用次數：34.
2013
Zhang P, Xu X, Hu X, Wang H, Fassett J, Huo Y, Chen Y, Bache RJ. DDAH1 deficiency attenuates endothelial cell cycle progression and angiogenesis. PLoS ONE [Internet]. 2013;(11). 訪問連結 SCI被引用次數：10.
Fassett JT, Hu X, Xu X, Lu Z, Zhang P, Chen Y, Bache RJ. AMPK attenuates microtubule proliferation in cardiac hypertrophy. American Journal of Physiology - Heart and Circulatory Physiology [Internet]. 2013;(5):H749-H758. 訪問連結 SCI被引用次數：25.
Fassett JT, Xu X, Kwak D, Wang H, Liu X, Hu X, Bache RJ, Chen Y. Microtubule Actin Cross-Linking Factor 1 Regulates Cardiomyocyte Microtubule Distribution and Adaptation to Hemodynamic Overload. PLoS ONE [Internet]. 2013;(9). 訪問連結 SCI被引用次數：28.
2012
Chen Y, Guo H, Xu D, Xu X, Wang H, Hu X, Lu Z, Kwak D, Xu Y, Gunther R, et al. Left ventricular failure produces profound lung remodeling and pulmonary hypertension in mice: Heart failure causes severe lung disease. Hypertension [Internet]. 2012;(6):1170-1178. 訪問連結 SCI被引用次數：61.
2011
Fassett JT, Hu X, Xu X, Lu Z, Zhang P, Chen Y, Bache RJ. Adenosine kinase regulation of cardiomyocyte hypertrophy. American Journal of Physiology - Heart and Circulatory Physiology [Internet]. 2011;(5):H1722-H1732. 訪問連結 SCI被引用次數：13.
Hu X, Xu X, Lu Z, Zhang P, Fassett J, Zhang Y, Xin Y, Hall JL, Viollet B, Bache RJ, et al. AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development. Hypertension [Internet]. 2011;(4):696-703. 訪問連結 SCI被引用次數：39.
Zhang P, Hu X, Xu X, Chen Y, Bache RJ. Dimethylarginine dimethylaminohydrolase 1 modulates endothelial cell growth through nitric oxide and Akt. Arteriosclerosis, Thrombosis, and Vascular Biology [Internet]. 2011;(4):890-897. 訪問連結 SCI被引用次數：22.
Hu X, Atzler D, Xu X, Zhang P, Guo H, Lu Z, Fassett J, Schwedhelm E, Böger RH, Bache RJ, et al. Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arteriosclerosis, Thrombosis, and Vascular Biology [Internet]. 2011;(7):1540-1546. 訪問連結 SCI被引用次數：62.
Xu D, Guo H, Xu X, Lu Z, Fassett J, Hu X, Xu Y, Tang Q, Hu D, Somani A, et al. Exacerbated pulmonary arterial hypertension and right ventricular hypertrophy in animals with loss of function of extracellular superoxide dismutase. Hypertension [Internet]. 2011;(2):303-309. 訪問連結 SCI被引用次數：35.
2010
Lu Z, Xu X, Hu X, Lee S, Traverse JH, Zhu G, Fassett J, Tao Y, Zhang P, Remedios CD, et al. Oxidative stress regulates left ventricular PDE5 expression in the failing heart. Circulation [Internet]. 2010;(13):1474-1483. 訪問連結 SCI被引用次數：95.
Lu Z, Xu X, Hu X, Fassett J, Zhu G, Tao Y, Li J, Huang Y, Zhang P, Zhao B, et al. PGC-1α regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload. Antioxidants and Redox Signaling [Internet]. 2010;(7):1011-1022. 訪問連結 SCI被引用次數：117.
2009
Fassett JT, Xu X, Hu X, Zhu G, French J, Chen Y, Bache RJ. Adenosine regulation of microtubule dynamics in cardiac hypertrophy. American Journal of Physiology - Heart and Circulatory Physiology [Internet]. 2009;(2):H523-H532. 訪問連結 SCI被引用次數：11.
Hu X, Xu X, Zhu G, Atzler D, Kimoto M, Chen J, Schwedhelm E, Lüneburg N, Böger RH, Zhang P, et al. Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1- deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine. Circulation [Internet]. 2009;(22):2222-2229. 訪問連結 SCI被引用次數：55.
2008
Lu Z, Fassett J, Xu X, Hu X, Zhu G, French J, Zhang P, Schnermann J, Bache RJ, Chen Y. Adenosine A3 receptor deficiency exerts unanticipated protective effects on the pressure-overloaded left ventricle. Circulation [Internet]. 2008;(17):1713-1721. 訪問連結 SCI被引用次數：30.
Zhang P, Hu X, Xu X, Fassett J, Zhu G, Viollet B, Xu W, Wiczer B, Bernlohr DA, Bache RJ, et al. AMP activated protein kinase-α2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice. Hypertension [Internet]. 2008;(5):918-924. 訪問連結 SCI被引用次數：118.
Hu X, Xu X, Huang Y, Fassett J, Flagg TP, Zhang Y, Nichols CG, Bache RJ, Chen Y. Disruption of sarcolemmal atp-sensitive potassium channel activity impairs the cardiac response to systolic overload. Circulation Research [Internet]. 2008;(9):1009-1017. 訪問連結
Xu X, Fassett J, Hu X, Zhu G, Lu Z, Li Y, Schnermann J, Bache RJ, Chen Y. Ecto-5′ -nucleotidase deficiency exacerbates pressure-overload- induced left ventricular hypertrophy and dysfunction. Hypertension [Internet]. 2008;(6):1557-1564. 訪問連結 SCI被引用次數：29.
Lu Z, Xu X, Hu X, Zhu G, Zhang P, Deel EVD, French JP, Fassett JT, Oury TD, Bache RJ, et al. Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction. Hypertension [Internet]. 2008;(1):19-25. 訪問連結 SCI被引用次數：63.
van Deel ED, Lu Z, Xu X, Zhu G, Hu X, Oury TD, Bache RJ, Duncker DJ, Chen Y. Extracellular superoxide dismutase protects the heart against oxidative stress and hypertrophy after myocardial infarction. Free Radical Biology and Medicine [Internet]. 2008;(7):1305-1313. 訪問連結 SCI被引用次數：61.
Xu X, Hu X, Lu Z, Zhang P, Zhao L, Wessale JL, Bache RJ, Chen Y. Xanthine Oxidase Inhibition With Febuxostat Attenuates Systolic Overload-Induced Left Ventricular Hypertrophy and Dysfunction in Mice. Journal of Cardiac Failure [Internet]. 2008;(9):746-753. 訪問連結 SCI被引用次數：45.
2007
Zhang P, Xu X, Hu X, Deel EVD, Zhu G, Chen Y. Inducible nitric oxide synthase deficiency protects the heart from systolic overload-induced ventricular hypertrophy and congestive heart failure. Circulation Research [Internet]. 2007;(7):1089-1098. 訪問連結 SCI被引用次數：105.
Park SW, Hu X, Gupta P, Lin Y-P, Ha SG, Wei L-N. SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. Nature Structural and Molecular Biology [Internet]. 2007;(1):68-75. 訪問連結 SCI被引用次數：38.
2005
Park SW, Huq MMD, Hu X, Wei L-N. Tyrosine nitration on p65: A novel mechanism to rapidly inactive nuclear factor-κB. Molecular and Cellular Proteomics [Internet]. 2005;(3):300-309. 訪問連結
2004
Chen Y, Hu X, Wei L-N. Molecular interaction of retinoic acid receptors with coregulators PCAF and RIP140. Molecular and Cellular Endocrinology [Internet]. 2004;(1-2):43-50. 訪問連結
Wei L-N, Hu X. Receptor interacting protein 140 as a thyroid hormone-dependent, negative co-regulator for the induction of cellular retinoic acid binding protein I gene. Molecular and Cellular Endocrinology [Internet]. 2004;(1-2):39-48. 訪問連結 SCI被引用次數：15.
Hu X, Chen Y, Farooqui M, Thomas MC, Chiang C-M, Wei L-N. Suppressive Effect of Receptor-interacting Protein 140 on Coregulator Binding to Retinoic Acid Receptor Complexes, Histone-modifying Enzyme Activity, and Gene Activation. Journal of Biological Chemistry [Internet]. 2004;(1):319-325. 訪問連結 SCI被引用次數：26.
2003
Bi J, Hu X, Loh HH, Wei L-N. Mouse κ-opioid receptor mRNA differential transport in neurons. Molecular Pharmacology [Internet]. 2003;(3):594-599. 訪問連結 SCI被引用次數：26.
2002
Hu X, Bi J, Loh HH, Wei L-N. Regulation of mouse κ opioid receptor gene expression by different 3′-untranslated regions and the effect of retinoic acid. Molecular Pharmacology [Internet]. 2002;(4):881-887. 訪問連結 SCI被引用次數：24.
2001
Wei L-N, Farooqui M, Hu X. Ligand-dependent Formation of Retinoid Receptors, Receptor-interacting Protein 140 (RIP140), and Histone Deacetylase Complex is Mediated by a Novel Receptor-interacting Motif of RIP140. Journal of Biological Chemistry [Internet]. 2001;(19):16107-16112. 訪問連結 SCI被引用次數：44.
Bi J, Hu X, Loh HH, Wei L-N. Regulation of mouse κ opioid receptor gene expression by retinoids. Journal of Neuroscience [Internet]. 2001;(5):1590-1599. 訪問連結 SCI被引用次數：30.
Bi J, Hu X, Zhou FC, Wei L-N. Upregulation of cellular retinoic acid-binding protein I expression by ethanol. Development Growth and Differentiation [Internet]. 2001;(5):553-561. 訪問連結
Hu X, Bi J, Loh HH, Wei L-N. An Intronic Ikaros-binding Element Mediates Retinoic Acid Suppression of the Kappa Opioid Receptor Gene, Accompanied by Histone Deacetylation on the Promoters. Journal of Biological Chemistry [Internet]. 2001;(7):4597-4603. 訪問連結 SCI被引用次數：29.
2000
Xin-Li H, Xun-Lei Z. Analysis of a suppressor element of mouse Nodal gene in its 5′ flanking sequences. Acta Genetica Sinica. 2000;(2):107-.
Hu XL, Zhou XL. Analysis of a suppressor element of mouse Nodal gene in its 5' flanking sequences. Acta Genetica Sinica [Internet]. 2000;(2):101-107. 訪問連結
Hu X-L, Zhou X-L, Wu H-L. Analysis of an inhancer element of mouse Nodal gene in its 5′ flanking sequence. Acta Genetica Sinica [Internet]. 2000;(3):208-209. 訪問連結
Wei L-N, Hu X, Chinpaisal C. Constitutive activation of retinoic acid receptor β2 promoter by orphan nuclear receptor TR2. Journal of Biological Chemistry [Internet]. 2000;(16):11907-11914. 訪問連結 SCI被引用次數：19.
Wei L-N, Hu X, Bi J, Loh H. Post-transcriptional regulation of mouse κ-opioid receptor expression. Molecular Pharmacology [Internet]. 2000;(2):401-408. 訪問連結 SCI被引用次數：36.
Wei L-N, Hu X, Chandra D, Seto E, Farooqui M. Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing. Journal of Biological Chemistry [Internet]. 2000;(52):40782-40787. 訪問連結 SCI被引用次數：123.
1999
Zhou X-L, Hu X-L, Wu H-L. Delineation of the Cis-regulatory Sequences of the nodal Gene. Acta Genetica Sinica [Internet]. 1999;(2):148-149. 訪問連結
Hu X, Cao S, Loh HH, Wei L-N. Promoter activity of mouse κ opioid receptor gene in transgenic mouse. Molecular Brain Research [Internet]. 1999;(1):35-43. 訪問連結
Wei L-N, Chang L, Hu X. Studies of the type I cellular retinoic acid-binding protein mutants and their biological activities. Molecular and Cellular Biochemistry [Internet]. 1999;(1-2):69-76. 訪問連結 SCI被引用次數：10.
1997
Chinpaisal C, Chang L, Hu X, Lee C-H, Wen W-N, Wei L-N. The orphan nuclear receptor TR2 suppresses a DR4 hormone response element of the mouse CRABP-I gene promoter. Biochemistry [Internet]. 1997;(46):14088-14095. 訪問連結 SCI被引用次數：20.
