肖蘇龍

肖蘇龍

肖蘇龍，男，博士，北京大學研究員，博士生導師。

基本介紹

  • 中文名：肖蘇龍
  • 學位/學歷：博士
  • 職業：教師
  • 專業方向：調控病毒-細胞識別的新型抗病毒藥物
  • 任職院校：北京大學
個人經歷,研究方向,學術成果,榮譽獎勵,

個人經歷

教育經歷
1994.09 – 1998.07北京醫科大學，藥物化學專業，本科
2000.09 – 2004.07北京大學，藥物化學專業，碩士，導師：楊銘教授
2006.09 – 2011.01 北京大學，藥物化學專業，博士，導師：楊銘教授
2007.09 – 2008.09北京大學-彼埃爾-瑪麗居里大學，中法聯合培養博士（留學基金委），導師：楊銘教授（中），張勇民院士（法）
工作經歷
1998. 08– 1999.07 北京醫科大學，天然藥物及仿生藥物國家重點實驗室，實習研究員
1999. 08– 2014.07 北京大學醫學部，天然藥物及仿生藥物國家重點實驗室，助理研究員
2014. 08– 2017.12 北京大學醫學部，天然藥物及仿生藥物國家重點實驗室，副研究員，碩士研究生導師
2018. 01– 2021.07 北京大學醫學部，藥物化學系，副研究員，博士研究生導師
2021.08 – 至今 北京大學醫學部，藥物化學系，研究員

研究方向

調控病毒-細胞識別的新型抗病毒藥物的研究；
非天然胺基酸定點修飾蛋白質的生物治療研究；
環糊精的結構修飾及多價化在藥物研發中的套用

學術成果

科研基金
  1. 國家自然科學基金面上項目：神經氨酸酶-轉鐵蛋白受體1結合介導流感病毒內吞的分子機制及干預研究（No.22377006, 2024-2027）
  2. 國家自然科學基金國際合作與交流項目：靶向病毒膜蛋白抗新冠及流感病毒進入的新型二萜及三萜衍生物的合成、活性及機制研究（No. 82161148006, 2021-2023）
  3. 國家自然科學基金面上項目（主持）：基於五環三萜-HR2螺旋結構域選擇性結合廣譜抑制病毒-細胞膜融合的機制研究（No. 21877007，2019-2022）
  4. 植物化學與西部資源持續利用國家重點實驗室 （開放課題）（主持）：綴合環糊精的三萜新衍生物的合成及其調控流感病毒進入細胞的分子機制研究 （2019.01-2021.01）
  5. 國家自然科學基金重點項目（參與）：海洋微生物來源新型抗流感病毒先導分子的發現與作用機制研究（No. 81630089，2017-2021）
  6. 國家自然科學基金面上項目（主持）：新型五環三萜-環糊精多價物的合成、抗流感進入構效關係及分子機制研究（No. 81573269，2016-2019）
  7. 國家自然科學基金面上項目（主持）：以“病毒進入細胞”為靶的五環三萜抗病毒藥物研究（No. 81373271，2014-2017）
  8. 國家自然科學基金國際合作與交流項目（參與）：基於三萜類化合物調控流感病毒與宿主細胞識別的新型抗病毒藥物研究 （No. 81361168002, 2014-2017）
  9. 國家自然科學基金青年基金（參與）：調控流感病毒與宿主細胞識別的傳統中藥活性成分及其分子機制研究（No. 81202975,2013-2015）
  10. 科技部“973”重大研究計畫（參與）：基於基因密碼子擴展的蛋白質標記新方法（No. 2010CB912300，2010-2014）
代表性論文
  1. Wang H, Xu R, Liang S, Ran F, Zhang L, Zhang Y, Zhou D, Xiao S.* Selective and facile deacetylation of pentacyclic triterpenoid under methanolic ammonia condition and unambiguous NMR analysis. Chin. Chem. Lett. 2020, 31(2), 333-336
  2. Wang Y,# Li S,# Tian Z, Sun J, Liang S, Zhang B, Bai L, Zhang Y, Zhou X, Xiao S, Zhang Q, Zhang L, Zhang C,*Zhou D.*Generation of a caged lentiviral vector through an unnatural amino acid for photo-switchable transduction.Nucleic Acids Res.2019,47(19), e114.
  3. Liang S, Li M, Yu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.* Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents. Eur. J. Med. Chem.2019, 166, 328-338.
  4. Li H,# Li M,# Xu R,# Wang S, Zhang Y, Zhang L, Zhou D,* Xiao S.* Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates. Eur. J. Med. Chem. 2019, 163, 560-568.
  5. Jiao P, Wang S, Liang S, Li M, Gao Q, Ji D, Chen Y, Li H, Ran F, Zhang Y, Zhang L, Zhou D,*Xiao S.*Facile preparation and characterization of novel oleanane-type triterpene functionalized β-cyclodextrin conjugates.Chin. Chem. Lett.2019, 30(3), 690-693.
  6. Si L, Meng K, Tian Z, Zhang Z, Soloveva V, Li H, Fu G, Xia Q, Xiao S, Zhang L, Cunningham J. M, Zhou D.* Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevalentin viral envelopes. Sci. Adv.2018, 11(4), eaau8408.
  7. Li M, Li H, Liang S, Tian Z, Zhou D, Xiao S.* Recent progresses of novel anti-influenza entry inhibitors. Sci. Sin. Chim.2018, 48(11), 589-599.
  8. Zhu X, Xiao S, Zhou D, Sollogoub M, Zhang Y*. Design, synthesis and biological evaluation of water-soluble per-O-methylated cyclodextrin-C60conjugates as anti-influenza virus agents. Eur. J. Med. Chem.2018, 146, 194-205
  9. Xiao S,* Tian Z, Wang Y, Si L, Zhang L, Zhou D.*Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives.Med. Res. Rev.2018,38(3), 951-976.
  10. Shi Y,# Si L,# Han X,# Fan Z, Wang S, Tian Z, Li M, Sun J, Jin H, Zhang Y,Zhou D, Xiao S.*Synthesis of novel pentacyclic triterpene-Neu5Ac2en derivatives and investigation of their in vitro anti-influenza entry activity.MedChemComm.2017, 8, 1531-1541
  11. Meng L, Wang Q, Tang T, Xiao S, Zhang L, Zhou D, Yu F.* Design, synthesis and biological evaluation of pentacyclic triterpene dimers as HCV entry inhibitors. Chin. J. Chem. 2017, 35(8), 1322-1328.
  12. Wang W, Zhao Z, Zhang Z, Zhang C, Xiao S, Ye X, Zhang L, Xia Q, Zhou D.* Redirecting killer T cells through incorporation of azido sugars for tethering ligands. Chembiochem. 2017, 18(21), 2082-2086.
  13. Han X,# Si L,# Shi Y, Fan Z, Wang S, Tian Z, Li M, Sun J, Jiao P, Ran F, Zhang Y,Zhou D, Xiao S.*Synthesis and in vitro anti-influenza virus evaluation of novel sialic acid (C-5 and C-9)-pentacyclic triterpene derivatives.Molecules2017, 22(7), 1018.
  14. Tian Z,# Si L,# Meng K, Zhou X, Zhang Y, Zhou D,Xiao S.* Inhibition of influenza virus infection by multivalent pentacyclic triterpene-functionalized per-O-methylated cyclodextrin conjugates. Eur. J. Med. Chem. 2017, 134, 133-139.
  15. Tian Z, Meng K, Shi Y, Zhang N, Liu X, Jin H, Zhang Y, Zhang L, Zhou D, Xiao S.*Facile preparation of a symmetric hexavalent oleanolic acid/per-O-methylated α-cyclodextrin conjugate with two conformations in solution and unambiguous NMR analysis. Tetrahedron 2017, 73 (17), 2512-2517. （"Front Cover Article"）
  16. Wu S, Yang L, Sun W, Si L, Xiao S, Wang Q, Dechoux L, Thorimbert S, Sollogoub M, Zhou D, Zhang Y. Design, synthesis and biological evaluation of gentiopicroside derivatives as potential antiviral inhibitors. Eur. J. Med. Chem.;2017, 130, 308-319.
  17. Si L,# Xu H,# Zhou X, Zhang Z, Tian Z, Zhang B, Niu Z, Yao T, Wang Y, Li S, Zhang C, Fu G, Xiao S, Xia Q, Zhang L, Zhou D*. Generation of influenza A viruses as live but replication-incompetent virus vaccines. Science2016, 354(6316), 1170-1173.
  18. Wu Y, Zhu H, Zhang B, Liu F, Chen J, Wang Y, Wang Y, Zhang Z, Wu L, Si L, Xu H, Yao T, Xiao S, Xia Q, Zhang L, Yang Z, Zhou D.* Synthesis of site-specific radiolabeled antibodies for radioimmunotherapy via genetic code expansion. Bioconjug. Chem.2016, 27(10), 2460-2468.
  19. Xiao S,* Wang Q, Si L, Zhou X, Zhang Y, Zhang L, Zhou D.* Synthesis and biological evaluation of novel pentacyclic triterpene α-cyclodextrin conjugates as HCV entry inhibitors. Eur. J. Med. Chem.2016, 124, 1-9.
  20. Han X, Shi Y, Si L, Fan Z, Wang H, Xu R, Jiao P, Meng K, Tian Z, Zhou X, Jin H, Wu X, Chen H, Zhang Y, Zhang L, Xiao S,* Zhou D.* Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors. MedChemComm.2016, 7, 1932-1945. ("HOT" Article)
  21. Xu H, Wang Y, Lu J, Zhang B, Zhang Z, Si L, Wu L, Yao T, Zhang C, Xiao S, Zhang L, Xia Q,* Zhou D.* Re-exploration of the codon context effect on amber codon-guided incorporation of non-canonical amino acids in E. coli by the blue-white screening assay. Chembiochem. 2016, 17, 1-12.
  22. Yu F,* Wang Q, Wang H, Si L, Liu J, Han X, Xiao S, Zhang L, Zhou D.* Synthesis and biological evaluation of echinocystic acid derivatives as HCV entry inhibitors. Chin. Chem. Lett.2016, 27, 711-713.
  23. Han Wang,# Renyang Xu,# Yongying Shi, Longlong Si, Pingxuan Jiao, Zibo Fan, Xu Han, Xingyu Wu, Xiaoshu Zhou, Fei Yu, Yongmin Zhang, Lihe Zhang, Demin Zhou*, Sulong Xiao*. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors.Eur. J. Med. Chem.2016, 110, 376-388.
  24. 俞飛,* 鄭永祥, 彭逸雲, 周德敏, 肖蘇龍*. 齊墩果酸A環及C環內酯衍生物的設計合成. 有機化學. 2016, 36, 512-519.
  25. Sulong Xiao,* Longlong Si, Zhenyu Tian, Pingxuan Jiao, Zibo Fan, Kun Meng, Xiaoshu Zhou, Han Wang, Renyang Xu, Xu Han, Ge Fu,Yongmin Zhang, Lihe Zhang, Demin Zhou*. Pentacyclic triterpenes grafted on CD cores to interfere with influenza virus entry: A dramatic multivalent effect. Biomaterials. 2016, 78, 74-85.
  26. 肖蘇龍,*王晗, 王琪, 韓旭, 徐仁洋, 孟坤, 田振宇, 張禮和, 周德敏.* 基於五環三萜先導結構的抗病毒抑制劑研究進展. 中國科學（化學）. 2015, 45(9), 865-883.
  27. Han Wang,# Fei Yu,# Yiyun Peng, Qi Wang, Xu Han, Renyang Xu, Xiaoshu Zhou, Chuanxing Wan, Zibo Fan, Pingxuan Jiao, Yongmin Zhang, Lihe Zhang, Demin Zhou, Sulong Xiao.* Synthesis and biological evaluation of ring A and/or C expansion and opening echinocystic acid derivatives for anti-HCV entry inhibitors. European Journal of Medicinal Chemistry. 2015, 102, 594-599
  28. Zheng Yongxiang, Yu Fei, Wu Yiming, Si Longlong, Xu Huan, Zhang Chuanling, Xia Qing,Xiao Sulong,Wang Qi, He Qiuchen, Chen Peng, Wang Jiangyun, Zhang Lihe, Taira Kazunari, Zhou Demin.* Broaden the versatility of lentiviral vector as a tool in nucleic acid research via genetic code expansion. Nucleic Acids Res., 2015, 43(11),:e73
  29. Maorong Yu, Longlong Si, Yufei Wang, Yiming Wu, Fei Yu, Pingxuan Jiao, Yongying Shi, Han Wang, Sulong Xiao, Ge Fu, Ke Tian, Yitao Wang, Zhihong Guo, Xinshan Ye, Lihe Zhang and Demin Zhou.* Discovery of pentacyclic triterpenoids as potential entry inhibitors of influenza viruses. J. Med. Chem. 2014, 57(23): 10058-10071
  30. Sulong Xiao, Qi Wang, Longlong Si, Yongying Shi, Han Wang, Fei Yu, Yongmin Zhang, Yingbo Li, Yongxiang Zheng, Chuanling Zhang, Chunguang Wang, Lihe Zhang, Demin Zhou.* Synthesis and anti-HCV entry activity studies of new β-cyclodextrin-pentacyclic triterpene conjugates. ChemMedChem., 2014, 9(5): 1060-1070.
  31. Fei Yu, Yiyun Peng, Qi Wang, Yongying Shi, Longlong Si, Han Wang, Yongxiang Zheng, Emily Lee, Sulong Xiao,* Maorong Yu, Yingbo Li, Chuanling Zhang, Hengli Tang, Chunguang Wang, Lihe Zhang, and Demin Zhou,* Development of bivalent oleanane-type triterpenes as potent HCV entry inhibitors. Eur. J. Med. Chem., 2014, 77: 258-268.
  32. Sulong Xiao, Ming Yang, Fei Yu, Lihe Zhang, Demin Zhou, Pierre Sinaÿ, Yongmin Zhang. Synthesis of four mono-functionalized α-cyclodextrin derivatives for confirming DIBAL-H-promoted bis-de-O-methylation mechanism. Tetrahedron. 2013, 69(20): 4053-4060.
  33. Wang Han,# Wang Qi#, Xiao Sulong#, Sun Dian, Ye Min, Zhang Lihe, Zhou Demin. Elucidation of the pharmacophore of echinocystic acid as a new lead for blocking HCV entry. Eur. J. Med. Chem., 2013, 64: 160-168.
  34. Fe Yu, Qi Wang, Zhen Zhang, Yiyun Peng, Yongying Shi, Yongxiang Zheng, Sulong Xiao*, Han Wang, Yongyan Qiu, Xiaoxi Huang, Chuanke Zhao, Chuanling Zhang, Dian Sun, Lihe Zhang and Demin Zhou*. Development of oleanane-type triterpene as a new class of HCV entry inhibitors. J. Med. Chem., 2013, 56, 4300-4319.
  35. Su-long Xiao, Qi Wang, Fei Yu, Yi-yun Peng, Ming Yang, Matthieu Sollogoub, Pierre Sinaÿ, Yong-min Zhang, Li-he Zhang, De-min Zhou. Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors. Bioorganic & Medicinal Chemistry. 2012, 20 (18), 5616-5622
  36. Su Long Xiao, De Min Zhou, Ming Yang, Fei Yu, Li He Zhang, Pierre Sinaÿ, Yong Min Zhang. Synthesis of two mono-deoxy β-cyclodextrin derivatives as useful tools for confirming DIBAL-H promoted bis-de-O-methylation mechanism. Chinese Chemical Letter. 2012, 23(12): 1315-1318.
  37. Sulong Xiao, Demin Zhou, Ming Yang *, Pierre Sinaÿ, Matthieu Sollogoub, Yongmin Zhang *.Facile preparation of two tetrols from permethylated α-cyclodextrin and unambiguous NMR analysis. Tetrahedron Letters. 2011, 52(41): 5273-5276
  38. Sulong Xiao, Ming Yang, Pierre Sinaÿ, Matthieu Sollogoub*, Yongmin Zhang*. Diisobutylaluminum hydride (DIBAL-H) promoted secondary rim regioselective demethylations of permethylated β-cyclodextrin: a mechanistic proposal. Eur. J. Org. Chem.. 2010, 2010(8): 1510-1516
  39. Zhang, Z.; Wang, H.; Du, L. Y.; Chen, K. B.; Xiao, S. L.; Yu, F.; Zhang, L. H.; Zhou, D. M. Discovery and development of antiviral drugs. Journal of Chinese Pharmaceutical Sciences. 2010, 19(6): 409-422
  40. Zhi-Dong Xu, Min Wang, Su-Long Xiao, Ming Yang. Novel peptide derivatives of Bleomycin A5: synthesis, antitumor activity and interaction with DNA. Bioorg. Med. Chem. Lett. 2005,15(18)：3996-3999
  41. 王 敏, 肖蘇龍, 徐志棟, 屠鵬飛, 於曉琳, 楊 銘. 具有抗HIV-1 Tat-TAR RNA結合活性的海藻糖新衍生物的設計和合成. 中國新藥雜誌. 2004, 13(10): 907-911
  42. Wang Min, Xu Zhidong, Tu Pengfei, Yu Xiaolin, Xiao Sulong, Yang Ming. α,α-Trehalose derivatives bearing guanidino groups as inhibitors to HIV-1 Tat–TAR RNA interaction in human cells. Bioorganic and Medicinal Chemistry Letters. 2004, 14(10): 2585-2588
  43. Zhi-Dong Xu, Min Wang, Su-Long Xiao, Yan-Juan Zhang, Ming Yang. Novel Bleomycin analogues: synthesis, antitumor activity, and interaction with DNA.Helvetica Chimica Acta. 2004, 87(11): 2834-2841
  44. Zhi-Dong Xu, Min Wang, Su-Long Xiao, Chun-Li Liu and Ming Yang. Synthesis, biological evaluation and DNA binding properties of novel Bleomycin analogues. Bioorganic & Medicinal Chemistry Letters. 2003, 13(15): 2595–2599
  45. Zhi-Dong Xu, He Liu, Su-Long Xiao, Ming Yang, Xian-He Bu. Synthesis, crystal structure, antitumor activity and DNA-binding study on the Mn(II) complex of 2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline. Journal of Inorganic Biochemistry. 2002, 90(3-4): 79-84
  46. Xu Zhidong, Liu He, Wang Min, Xiao Sulong, Yang Ming, Bu Xianhe. Cobalt (II) complex of 6,7-dicycanodipyridoquinoxaline with antitumor activities: synthesis, crystal structure and binding with DNA. Journal of Chinese Pharmaceutical Sciences. 2002, 11(4): 125-131
  47. Zhi-Dong Xu, He Liu, Min Wang, Su-Long Xiao, Ming Yang, Xian-He Bu. Manganese (II) complex of 6,7-dicycanodipyridoquinoxaline with antitumor activities: synthesis, crystal structure and binding with DNA. Journal of Inorganic Biochemistry. 2002, 92(3-4): 149–155
  48. 肖蘇龍, 楊　銘.人免疫缺陷病毒-1整合酶及其抑制劑的研究進展。國外醫學（藥學分冊）. 2002, 29(3): 157-161
  49. Su-long Xiao, Wei Lin, Chao Wang, Ming Yang. Synthesis and biological evaluation of DNA targeting flexible side-chain substituted β-carboline derivatives. Bioorganic & Medicinal Chemistry Letters. 2001, 11(4): 437-441
  50. 楊銘, 肖蘇龍, 周田彥, 張家美, 王保懷, 李芝芬, 孟興蓮, 王夔. 新的手性鉑絡合物與DNA兩種不同結合方式中的分子識別. 北京醫科大學學報. 2000, 32(3): 198-202
參編著作
  1. 藥物研究中的分子識別（第2版）（楊銘主編，北京大學醫學出版社，2015.8）
  2. 抗腫瘤抗病毒藥物與核酸相互作用的分子機制（楊銘主編，P99-138，北京大學醫學出版社，2009.4）
  3. 結構生物學概論（楊銘主編，P68-89，北京醫科大學出版社, 2002.7.）
授權或申請專利
  1. 一種新的三萜-環糊精共價化合物及其製備方法和用途。周德敏、肖蘇龍、司龍龍、俞飛、史勇英、王晗、張禮和（申請號：ZL 2013 1 0684679.6）
  2. 三萜衍生物及其抗流感用途。（申請號：201210402726.9）（發明人：周德敏、於茂榮、肖蘇龍、俞飛、彭逸雲、邱允儼、張禮和）（2012）
  3. 刺囊酸衍生物及其生物轉化方法和用途。（申請號：ZL 2012 1 0015068.8）（發明人：周德敏，王晗， 葉敏，肖蘇龍，孫迪安，張禮和）（2012）
  4. 定點突變和定點修飾的病毒膜蛋白、其製備方法及其套用 （ZL 2012 1 0214038.X，周德敏，鄭永祥，趙傳科，張傳領，俞飛，肖蘇龍，張禮和）
  5. 定點突變和定點修飾的生長激素、其製備方法及其套用 （ZL 2012 1 0214451.6，周德敏，張傳領，肖蘇龍，張雨帆，俞飛，趙傳科，陳景賢，張禮和）
  6. 具有抗HIV和抗癌活性的3-取代的β-咔啉新化合物，製備方法及其組合物和用途。（ZL 011 44531.9，楊銘，林偉，於曉琳，肖蘇龍）
  7. 具有抗病毒活性的氨基糖苷類化合物及其製備方法。（ZL 02 1 53987.1，楊銘，王敏，徐志棟，肖蘇龍）

榮譽獎勵

  1. 2016年度北京大學醫學部SCI論文引用獎（2017.03）
  2. 2015年中國藥學大會暨第十五屆中國藥師周優秀論文二等獎 (2015.11)
  3. 北京大學醫學部大學生創新實驗一等獎（指導教師）（2014.12）
  4. 第三屆中法藥學交流會暨產業化推進會優秀牆報獎 三等獎 （2014.08）
  5. 北京大學黃廷芳/信和青年傑出學者獎（2013.12）
  6. 北京大學醫學部優秀共產黨員（2012.06）
  7. 第十屆全國青年藥學科技工作者科研成果交流會優秀論文一等獎（2010.07）
  8. Best Poster Award in 2 ASICEF Workshop on Interdisciplinary Research Topics. (2008.06)
  9. 教育部高等學校科學技術獎(自然科學獎)二等獎(基於病毒基因轉錄調控機制探索抗HIV新靶標及其新型抑制劑的研究)(第五)(2007.01)
  10. 北京市科技進步二等獎（項目名稱：以核酸分子識別為基礎新型HIV抑制劑的研究）（第六）（2005.02）
  11. 教育部提名國家科學技術獎（自然科學獎）二等獎（項目名稱：抗腫瘤抗病毒藥物研究中的分子識別）（第五）（2004.02）
  12. 第六屆全國青年藥學科技工作者學術交流會優秀論文一等獎（第三）（2002.09）
  13. 北京大學醫學部優秀教師（2002.09）

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