童德文

男，漢族1967年11月1日出生，博士（後），教授，博士研究生導師，民盟盟員。1991年7月畢業於西北農業大學獸醫專業，獲農學學士學位。1991年9月考取西北農業大學獸醫內科學專業家畜中毒性疾病研究方向碩士研究生，2002年遴選為碩士生導師。2005年被評為西北農林科技大學青年學術骨幹，同年在紐西蘭Lincoln University研修。2006年12月晉升教授，同年被評為“西北農林科技大學優 秀教師”。2007年6月遴選為博士生導師，併入選2007年教育部“新世紀優秀 人才支持計畫”。

現任西北農林科技大學動物醫學院副院長。

基本介紹

• 中文名：童德文
• 外文名：Dong Dewen
• 國籍：中國
• 民族：漢族
• 出生日期：1967年11月1日
• 職業：大學教授
• 畢業院校：西北農業大學
• 主要成就：獸醫學科導論
• 代表作品：《動物醫學進展》

基本信息

童德文，男，漢族，博士，三級教授，博士生導師，教育部新世紀優秀 人才，教育部高等院校動物醫學類專業教學指導委員會委員，陝西省三秦人才，陝西省重點科技創新團隊“動物重大疫病新型疫苗研發創新團隊”帶頭人，陝西省教學團隊“基礎獸醫學教學團隊”帶頭人，陝西省精品資源共享課程“ 動物病理解剖學”負責人，西北農林科技大學基礎獸醫學學科帶頭人，《動物醫學進展》雜誌副主編。

1994年7月畢業獲農學碩士學位並留在該校獸醫系基礎獸醫學教研室，主要從事動物病理學和動物毒理學的教研工作。1996年9月，考取西北農林科技大學臨床獸醫學專業博士研究生，2001年1月畢業獲農學博士學位，同年12月晉升副教授

現任西北農林科技大學動物醫學院副院長。

研究方向

動物病理、細胞生理及病理。

主要研究領域

1.動物重大疫病病原與宿主細胞互作機制研究；

2.動物重大疫病新型疫苗研發。

社會兼職

中國畜牧獸醫學會會員；中國畜牧獸醫學會動物病理學分會理事；中國畜牧獸醫學會動物毒物學分會常務理事、副秘書長；《動物醫學進展》雜誌編委，國家自然科學基金評審專家。

主講課程

主要承擔本科生的《獸醫病理解剖學》、《獸醫學科導論》，碩士研究生的《高級動物病理學》、《基礎獸醫學進展》、《研究生班討論》和博士研究生的《細胞與分子病理學》等課程的教學工作。

課題項目

（科學研究，2005—2007）

近3年主持的科研課題：

1、國家自然科學基金（30371067）；

2、霍英東教育基金（91033）；

3、國際科學基金（NO2906-1）；

4、中國博士後基金（2003034417）；

5、西北農林科技大學科研專項；

6、2005年度西北農林科技大學“青年學術骨幹支持計畫”；

7、2007年度教育部“新世紀優秀 人才支持計畫”。

8，高等院校博士點基金

9， 陝西省科技統籌創新工程計畫項目

10， 中央重大農業技術推廣資金項目

獲獎情況

近3年來，作為技術負責人和主要參加人驗收和鑑定登記的科研成果4項，獲得優秀論文10篇。作為發明人共申請發明專利4項，其中作為第1發明人授權專利1項，第2發明人授權專利1項。

出國留學經歷

2005年在紐西蘭Lincoln University研修

代表性論文

1.Tongtong Wang, Qian Du, Xingchen Wu, Yingying Niu, Lijuan Guan, Zhenyu Wang, Xiaomin Zhao, Shan-Lu Liu, Dewen Tong*, Yong Huang*, Porcine MKRN1 modulates the replication and pathogenesis of PCV2 by inducing capsid protein ubiquitination and degradation. Journal of Virology, 2018. 92(11): e00100-18.

2.Liang Zhang, Zhenyu Wang, Jie Zhang, Xiaomao Luo, Qian Du, Lingling Chang, Xiaomin Zhao, Yong Huang,Dewen Tong*,Porcine parvovirus infection impairs progesterone production in luteal cells through MAPKs, p53 and mitochondria-mediated apoptosis. Biology of Reproduction, 2018. doi: 10.1093/biolre/ioy014.

3.Xiaomin Zhao, Xiaoyuan Bai, Lijuan Guan, Juejun Li, Xiangjun Song, Xuelian Ma, Jianxiong Guo, Zhichao Zhang, Qian Du, Yong Huang*,Dewen Tong*,MicroRNA-4331 promotes transmissible gastroenteritis virus (TGEV)-induced mitochondrial damage via targeting RB1, upregulating interleukin-1 receptor accessory protein (IL1RAP), and activating p38 MAPK pathway in vitro. Molecular & Cellular Proteomics, 2018. 17(2): p. 190-204.

4.Beibei Cui, Wenli Liu, Xiaoya Wang, Yu Chen, Qian Du, Xiaomin Zhao, Hai Zhang, Shan-Lu Liu,Dewen Tong*,Yong Huang*, Brucella Omp25 upregulates miR-155, miR-21-5p, and miR-23b to inhibit interleukin-12 production via modulation of programmed death-1 signaling in human monocyte/macrophages. Frontiers in Immunology, 2017. 8(6): p. 1-15.

5.Xiaomao Luo, Xiujuan Zhang, Xingchen Wu, Xuefeng Yang, Cong Han, Zhenyu Wang, Xiaomin Zhao, Shan-Lu Liu,Dewen Tong*,Brucella down-regulates TNF-α to promote intracellular survival via Omp25 regulation of different microRNAs in porcine and murine macrophages. Frontiers in Immunology, 2018. 8(1): p. 1-17.

6.Zheng Lu, Lingling Chang, Qian Du, Yong Huang, Xiujuan Zhang, Xingchen Wu, Jie Zhang, Ruizhen Li, Zelin Zhang, Wenlong Zhang, Xiaomin Zhao,Dewen Tong*,Arctigenin induces an activation response in porcine alveolar macrophage through TLR6-NOX2-MAPKs signaling pathway. Frontiers in Pharmacology, 2018. doi: 10.3389/fphar.2018.00475.

7.Wenlong Zhang, Zelin Zhang, Jinxuan Chen,Dewen Tong*,Ghrelin is expressed in the pregnant mammary glands of dairy goats and promotes the cell proliferation of mammary epithelial cells. General and Comparative Endocrinology, 2018. 260(12): p. 115-124.

8.Wenlong Zhang, Zhenyu Wang, Liang Zhang, Zelin Zhang, Jinxuan Chen, Weicong Chen,Dewen Tong*,Melatonin stimulates the secretion of progesterone along with the expression of cholesterol side-chain cleavage enzyme (P450scc) and steroidogenic acute regulatory protein (StAR) in corpus luteum of pregnant sows. Theriogenology, 2018. 108(2): p. 297-305.

9.Liang Zhang, Yong Huang, Zhenyu Wang, Xiaomao Luo, Hongling Zhang, Qian Du, Lingling Chang, Xiaomin Zhao,Dewen Tong*,Establishment and characterization of a telomerase immortalized porcine luteal cells. Theriogenology, 2017. 94(11): p. 105-113.

10.Delong Li, Qian Du, Bin Wu, Juejun Li, Lingling Chang, Xiaomin Zhao, Yong Huang,Dewen Tong*,Immunogenicity of adenovirus vaccines expressing the PCV2 capsid protein in pigs. Vaccine, 2017. 35(36): p. 4722-4729.

11.Delong Li, Dan Xu, Zengguo Wang, Qian Du, Lingling Chang, Xiaomin Zhao, Yong Huang,Dewen Tong*,Immunogenicity evaluation of modified adenovirus vaccines expressing porcine circovirus type 2 capsid protein in pigs.Viral Immunol,2017. 30(2): p. 111-119.

12.Dan Xu, Qian Du, Cong Han, Zengguo Wang, Xiujuan Zhang, Tongtong Wang, Xiaomin Zhao, Yong Huang,Dewen Tong*,p53 signaling modulation of cell cycle arrest and viral replication in porcine circovirus type 2 infection cells. Veterinary Research, 2016. 47(1): p. 120-131.

13.HonglingZhang, Yong Huang, Lili Wang, Tingting Yu, Zengguo Wang, Lingling Chang, Xiaomin Zhao, Xiaomao Luo, Liang Zhang,Dewen Tong*,Immortalization of porcine placental trophoblast cells through reconstitution of telomerase activity. Theriogenology, 2016. 85(8): p. 1446-1456.

14.Delong Li, Yong Huang, Qian Du, Zhenyu Wang, Lingling Chang, Xiaomin Zhao,Dewen Tong*,CD40 Ligand and GMCSF coexpression enhance the immune responses and protective efficacy of PCV2 adenovirus vaccine. Viral Immunology, 2016. 29(3): p. 148-158.

15.Xiaomin Zhao, Hailing Xiang, Xiaoyuan Bai, Naijiao Fei, Yong Huang, Xiangjun Song, Hongling Zhang, Liang Zhang,Dewen Tong*,Porcine parvovirus infection activates mitochondria-mediated apoptotic signaling pathway by inducing ROS accumulation. Virology Journal, 2016. 13(1): p. 26-35.

16.Xiaomin Zhao, Xiangjun Song, Xiaoyuan Bai, Naijiao Fei, Yong Huang, Zhimin Zhao, Qian Du, Hongling Zhang, Liang Zhang,Dewen Tong*,miR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1). PeerJ, 2016. 4: p. 1635-1652.

17.Yunpeng Fan, Xia Ma, Jing Zhang, Lin Ma, Yuanyuan Gao, Weimin Zhang, Xiaoping Song*, Weifeng Hou, Chao Guo,Dewen Tong*,Ophiopogon polysaccharide liposome can enhance the non-specific and specific immune response in chickens. Carbohydrate Polymers, 2015. 119: p. 219-227.

18.Yunpeng Fan, Meimei Ren, Weifeng Hou, Chao Guo,Dewen Tong*,Lin Ma, Weimin Zhang, Mengmeng He, Xiaoping Song*, The activation of epimedium polysaccharide-propolis flavone liposome on Kupffer cells. Carbohydrate Polymers, 2015. 133: p. 613-623.

19.Xiangjun Song, Xiaomin Zhao, Yong Huang, Hailing Xiang, Wenlong Zhang,Dewen Tong*,Transmissible gastroenteritis virus (TGEV) infection alters the expression of cellular microRNA species that affect transcription of TGEV Gene 7. International Journal of Biological Sciences, 2015. 11(8): p. 913-922.

20.Xingang Xu, Honglei Zhang, Qi Zhang, Jie Dong, Yong Huang,Dewen Tong*,Porcine epidemic diarrhea virus M protein blocks cell cycle progression at S-phase and its subcellular localization in the porcine intestinal epithelial cells. Acta Virologica, 2015. 59(3): p. 265-275.

21.Hongling Zhang, Yong Huang, Qian Du, Xiaomao Luo, Liang Zhang, Xiaomin Zhao,Dewen Tong*,Porcine parvovirus infection induces apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated pathway. Biochemical and Biophysical Research Communications, 2015. 456(2): p. 649-655.

22.Li Ding, Yong Huang, Qian Du, Feng Dong, Xiaomin Zhao, Wenlong Zhang, Xingang Xu,Dewen Tong*,TGEV nucleocapsid protein induces cell cycle arrest and apoptosis through activation of p53 signaling. Biochemical and Biophysical Research Communications, 2014. 445(2): p. 497-503.

23.Yunpeng Fan, Xiaoping Song, Yuanyuan Gao, Ying Chen, Lin Ma, Weimin Zhang, Weifeng Hou, Chao Guo,Dewen Tong*,Preparation and optimization of ophiopogon polysaccharide liposome and its activity on Kupffer cells. International Journal of Pharmaceutics, 2014. 477(1-2): p. 421-430.

24.Yong Huang, Feng Dong, Qian Du, Hongling Zhang, Xiaomao Luo, Xiangjun Song, Xiaomin Zhao, Wenlong Zhang,Dewen Tong*,Swainsonine induces apoptosis through mitochondrial pathway and caspase activation in goat trophoblasts. International Journal of Biological Sciences, 2014. 10(7): p. 789-797.

25.Wei Li, Yong Huang, Xiaomin Zhao, Wenlong Zhang, Feng Dong, Qian Du,Dewen Tong*,Swainsonine induces caprine luteal cells apoptosis via mitochondrial-mediated caspase-dependent pathway. Journal of Biochemical and Molecular Toxicology, 2014. 28(10): p. 456-464.

26.Jun Zhang, Dan Xu, Jia Nie, Jingsong Cao, Yonggong Zhai,Dewen Tong*,Yuguang Shi*, Monoacylglycerol acyltransferase-2 is a tetrameric enzyme that selectively heterodimerizes with diacylglycerol acyltransferase-1. Journal of Biological Chemistry, 2014. 289(15): p. 10909-10918.

27.LiDing, Yong Huang, Meiling Dai, Xiaomin Zhao, Qian Du, Feng Dong, Lili Wang, Ruichao Huo, Wenlong Zhang, Xingang Xu,Dewen Tong*,Transmissible gastroenteritis virus infection induces cell cycle arrest at S and G2/M phases via p53-dependent pathway. Virus Research, 2013. 178(2): p. 241-251.

28.Li Ding, Xiaomin Zhao, Yong Huang, Qian Du, Feng Dong, Hongling Zhang, Xiangjun Song, Wenlong Zhang,Dewen Tong*,Regulation of ROS in transmissible gastroenteritis virus-activated apoptotic signaling. Biochemical and Biophysical Research Communications, 2013. 442(1-2): p. 33-37.

29.Feng Dong, Yong Huang, Wei Li, Xiaomin Zhao, Wenlong Zhang, Qian Du, Hongling Zhang, Xiangjun Song,Dewen Tong*,The isolation and characterization of a telomerase immortalized goat trophoblast cell line. Placenta, 2013. 34(12): p. 1243-1250.

30.Yong Huang, Li Ding, Zhaocai Li, Meiling Dai, Xiaomin Zhao, Wei Li, Qian Du, Xingang Xu,Dewen Tong*,Transmissible gastroenteritis virus infection induces cell apoptosis via activation of p53 signaling. Journal of General Virology, 2013. 94: p. 1807-1817.

31.Yong Huang, Wei Li, Xiaomin Zhao, Li Ding, Gaoshui Yu, Feng Dong, Qian Du, Xingang Xu,Dewen Tong*,Swainsonine differentially affects steroidogenesis and viability in caprine luteal cells in vitro. Theriogenology, 2013. 80(1): p. 41-49.

32.Yong Huang, Meng Shao, Xingang Xu, Xiujuan Zhang, Qian Du, Xiaomin Zhao, Wenlong Zhang, Yahui Lyu,Dewen Tong*,Evidence for different patterns of natural inter-genotype recombination between two PCV2 parental strains in the field. Virus Research, 2013. 175(1): p. 78-86.

33.Xingang Xu, Honglei Zhang, Qi Zhang, Jie Dong, Yabing Liang, Yong Huang, Hungjen Liu*,Dewen Tong*,Porcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression. Virology Journal, 2013. 10: p. 26-33.

34.Xingang Xu, Honglei Zhang, Qi Zhang, Yong Huang, Jie Dong, Yabing Liang, Hungjen Liu*,Dewen Tong*,Porcine epidemic diarrhea virus N protein prolongs S-phase cell cycle, induces endoplasmic reticulum stress, and up-regulates interleukin-8 expression. Veterinary Microbiology, 2013. 164(3-4): p. 212-221.

35.Wenlong Zhang, Gaoshui Yu, Yong Huang, Dan Xu, Jingjing Ren, Liang Jiang, Changlong Wu,Dewen Tong*,Expression of ghrelin and GHSR-1a in mammary glands of dairy goat during the lactation and the effects of gherlin on regulation of mammary function in vitro . Molecular and Cellular Endocrinology, 2013. 370(1-2): p. 20-31.

36.Li Ding, Xingang Xu, Yong Huang, Zhaocai Li, Kuan Zhang, Guangda Chen, Gaoshui Yu, Zhisheng Wang, Wei Li,Dewen Tong*,Transmissible gastroenteritis virus infection induces apoptosis through FasL- and mitochondria-mediated pathways. Veterinary Microbiology, 2012. 158(1-2): p. 12-22.

37.Wei Li, Xingang Xu, Yong Huang, Zhaocai Li, Gaoshui Yu, Zhisheng Wang, Li Ding,Dewen Tong*,Establishment and evaluation of a stable steroidogeniccaprine luteal cell line. Theriogenology, 2012. 78(2): p. 263-272.

38.Zhaocai Li, Yong Huang, Feng Dong, Wei Li, Li Ding, Gaoshui Yu, Dan Xu, Yuanyuan Yang, Xingang Xu,Dewen Tong*,Swainsonine promotes apoptosis in human oesophageal squamous cell carcinoma cells in vitro and in vivo through activation of mitochondrial pathway. Journal of Biosciences, 2012. 37(6): p. 1005-1016.

39.Xingang Xu, Guangda Chen, Yong Huang, Li Ding, Zhaocai Li, Chingdong Chang, Chiyoung Wang,Dewen Tong*,Hungjen Liu*, Development of multiplex PCR for simultaneous detection of six swine DNA and RNA viruses. Journal of Virological Methods, 2012. 183(1): p. 69-74.

40.Xingang Xu, Zhisheng Wang, Qi Zhang, Zhaocai Li, Li Ding, Wei Li, Hungyi Wu, Chingdong Chang, Longhuw Lee,Dewen Tong*,HungjenLiu*, Baculovirus as a PRRSV and PCV2 bivalent vaccine vector: baculovirusvirions displaying simultaneously GP5 glycoprotein of PRRSV and capsid protein of PCV2. Journal of Virological Methods, 2012. 179(2): p. 359-366.

41.Xingang Xu,KuanZhang,YongHuang,LiDing,GuangdaChen,HongleiZhang,Dewen Tong*,Bovine herpes virus type I induces apoptosis through Fas-dependent and mitochondria-controlled manner in Madin-Darby bovine kidney cells. Virology Journal, 2012. 9: p. 202-215.

42.Xingang Xu, Hongni Zhao, Qi Zhang, Li Ding, Zhaocai Li, Wei Li, Hungyi Wu, Kuopin Chuang,Dewen Tong*,Hungjen Liu*, Oral vaccination with attenuated salmonella entericaserovar typhimurium expressing Cap protein of PCV2 and its immunogenicity in mouse and swine models. Veterinary Microbiology, 2012. 157(3-4): p. 294-303.

43.Zhaocai Li, Xingang Xu, Yong Huang, Li Ding, Zhisheng Wang, Gaoshui Yu, Dan Xu, Wei Li,Dewen Tong*,Swainsonine activates mitochondria-mediated apoptotic pathway in human lung cancer A549 cells and retards the growth of lung cancer xenografts. International Journal of Biological Sciences, 2012. 8(3): p. 394-405.

44.Zhisheng Wang, Xingang Xu, Hungjen Liu, Zhaocai Li, Li Ding, Gaoshui Yu,Dewen Tong*,Immunogenicity of the envelope GP3 protein of porcine reproductive and respiratory syndrome virus displayed on baculovirus. Acta Virologica, 2011. 55(2): p. 139-146.

45.Zhisheng Wang, Xinggang Xu, Hungjen Liu, Zhaocai Li, Li Ding, Gaoshui Yu, Dan Xu,Dewen Tong*,Immunogenicity of envelope GP5 protein displayed on baculovirus and protective efficacy against virulent porcine reproductive and respiratory syndrome virus challenge in piglets. African Journal of Microbiology Research, 2011. 5(18): p. 2682-2691.

46.Xingang Xu,Dewen Tong, Zhisheng Wang, Qi Zhang, Zhaocai Li, Kuan Zhang, Wei Li, Hungjen Liu*, Baculovirus virions displaying infectious bursal disease virus VP2 protein protect chickens against infectious bursal disease virus infection. Avian Diseases, 2011. 55(2): p. 223-229.

47.Xingang Xu, Zhisheng Wang, Qi Zhang, Zhaocai Li, Hongni Zhao, Wei Li,Dewen Tong*,Hungjen Liu*, Baculovirus surface display of E envelope glycoprotein of Japanese encephalitis virus and its immunogenicity of the displayed proteins in mouse and swine models. Vaccine, 2011. 29(4): p. 636-643.

48.Jinyi Wang*, Li Ren, Li Li, Wenming Liu, Jing Zhou, Wenhao Yu, Dewen Tong, Shulin Chen, Microfluidics: a new cosset for neurobiology. Lab on a Chip, 2009. 9(5): p. 644-652.

49.Xingang Xu,Dewen Tong, Mingtang Chiou, Yaoching Hsieh, Wenling Shih, Chingdong Chang, Minghuei Liao, Yanming Zhang, Hungjen Liu*, Baculovirus surface display of NS3 nonstructural protein of classical swine fever virus. Journal of Virological Methods, 2009. 159(2): p. 259-264.

50.Xingang Xu, Mingtang Chiou, Yanming Zhang,Dewen Tong, Jianhe Hu, Miaotao Zhang, Hungjen Liu*,Baculovirus surface display of E-rns envelope glycoprotein of classical swine fever virus. Journal of Virological Methods, 2008. 153(2): p. 149-155.

51.Dewen Tong*,Jinyi Wang*, Peihong Mu, Qiang Dong, Baoyu Zhao, Wenming Liu, Jun Zhao, Li Li, Tao Zhou, Analysis of several serum enzymes and blood urea nitrogen of swainsonine-HSA immunized goats. Animal Feed Science and Technology, 2008. 142(1-2): p. 74-88.