程家高

程家高，男，1978年生於山東，博士，華東理工大學藥學院教授、博士生導師。

基本介紹

• 中文名：程家高
• 畢業院校：中科院上海藥物研究所
• 學位/學歷：博士
• 職業：教師
• 專業方向：作用於菸鹼乙醯膽鹼受體
• 任職院校：華東理工大學

個人經歷

2000年7月畢業於山東曲阜師範大學化學系，獲理學學士學位；2005年7月畢業於中科院上海藥物研究所，獲有機化學藥物設計方向博士學位，導師：陳凱先院士、蔣華良院士；2007年9月華東理工大學藥學院博士後出站後留校工作，2009年晉升副教授，2016年晉升教授。

研究方向

（1）作用於菸鹼乙醯膽鹼受體、GABA受體等重要醫藥、農藥靶標的活性分子設計、合成及構效關係研究；（2）重磅殺蟲劑品種的作用機制、生態毒性及抗性機制研究。

學術成果

在JAFC; Chem. Biol. Drug. Des.; QSAR Comb. Sci.; J. Org. Chem.; Chem. Phys. Lett.; Bioorg. Med. Chem. Lett.; J. Phys. Org. Chem；JACS等國際重要學術期刊上發表外文SCI論文六十餘篇。作為課題負責人，共承擔國家自然科學基金3項、國家重點研發計畫子課題1項、教育部博士點基金等省部級科研基金3項、中央高校基本科研業務費3項；作為骨幹研究人員，承擔國家973、863、科技支撐課題等國家重點課題多項。

代表性科研項目

[1] 國家重點研發計畫項目課題，農藥對靶沉積的界面作用過程與傳輸機制，編號：2017YFD0200306，2017.07-2020.12；課題骨幹兼子課題負責人（霧滴對靶沉積的界面效應與關係模型，編號：2017YFD020030601）

[2] 國家自然科學基金，基於昆蟲和魚類GABA受體差異研究的低魚毒殺蟲劑合理設計，編號：21572059，2016.01-2019.12，負責人。

[3] 國家自然科學基金，分子聚集態及分子間相互作用對化合物生物活性的影響研究，編號：21172070，2012.01-2015.12，負責人。

[4] 國家自然科學基金，計算機輔助新菸鹼－菸鹼乙醯膽鹼受體的作用模式及新菸鹼類殺蟲劑的設計研究，編號：20802018，2009.01-2011.12，負責人。

[5] 中央高校基本科研業務費基金，綠色生態殺蟲劑的分子設計，編號：222201718004，2017.03-2017.12，負責人。

代表性研究論文

Chengchun Zhu#, Guanglong Li#, Keya Xiao, Xusheng Shao, Jiagao Cheng*, Zhong Li. Water bridges are essential to neonicotinoids: Insights from synthesis, bioassay and molecular modelling studies. Chin. Chem. Lett., 2019,

Bo Zhang#, Lei Zhang#, Lujue He#, Xiaodong Yang, Yali Shi, Shaowei Liao, Shan Yang, Jiagao Cheng*, Tianrui Ren*. Interactions of fipronil in fish and insects: experimental and molecular modeling studies. J. Agric. Food Chem. 2018

Wei Li#, Jiuhui Li#, Hongfeng Shen, Jiagao Cheng*, Zhong Li, Xiaoyong Xu*. Synthesis, nematicidal activity and docking study of novel chromone derivatives containing substituted pyrazole. Chin. Chem. Lett., 2018,

Xiaoqing Meng, Chengchun Zhu, Yue Feng, Weihua Li, Xusheng Shao, Zhiping Xu, Jiagao Cheng*, Zhong Li. “Computational Insights into the Different Resistance Mechanism of Imidacloprid versus Dinotefuran in Bemisia tabaci.” J. Agric. Food Chem. 2016,

Dan-Ping Jiang, Cheng-Chun Zhu, Xu-Sheng Shao, Jia-Gao Cheng*, Zhong Li. “Bioactive conformation analysis of anthranilic diamide insecticides: DFT-based potential energy surface scanning and 3D-QSAR investigations.” Chin. Chem. Lett., 2015,

Nan Zheng, Jiagao Cheng*, Wei Zhang, Weihua Li, Xusheng Shao, Zhiping Xu,Xiaoyong Xu, Zhong Li*. “Binding Difference of Fipronil with GABAARs in Fruitfly and Zebrafish: Insights from Homology Modeling, Docking and Molecular Dynamics Simulation Studies” J. Agric. Food. Chem. 2014,

Zheng Wang, Jinjin Ye, Rui Wu, Yang-Zi Liu, John S Fossey, Jiagao Cheng*, Wei-Ping Deng*. “Bi-aryl rotation in phenyl-dihydroimidazoquinoline catalysts for kinetic resolution of arylalkyl carbinols.” Catal. Sci. Technol. 2014,

Shuang Xia, Yue Feng, Jiagao Cheng*, Haibin Luo, Zhong Li*, Zhengming Li. “QAAR exploration on pesticides with high solubility: An investigation on sulfonylurea herbicide dimers formed through π-π stacking interactions.” Chin. Chem. Lett., 2014,

Shuang Xia, Jiagao Cheng*, Yue Feng, Xusheng Shao, Haibin Luo, Zhiping Xu, Xiaoyong Xu and Zhong Li*. “Computational Investigations about the Effects of Hetero-molecular Aggregation on Bioactivities: a Case of Neonicotinoids and Water.” Chin. J. Chem., 2014,

Ying Yang, Wei Zhang, Jiagao Cheng*, Yun Tang, Yanqing Peng, Zhong Li*. “Pharmacophore, 3D-QSAR and Bayesian Model Analysis for Ligands Binding at the Benzodiazepine Site of GABAA Receptors: the Key Roles of Amino Group and Hydrophobic Sites.”Chem. Biol. Drug. Des.2013,

Wei Zhang, Shuang Xia, Jinjin Ye, Yun Tang, Zhong Li*, Weiping Zhu, Jiagao Cheng*. “Structural Features of GABAA Receptor Antagonists: Pharmacophore Modeling and 3D-QSAR Studies.”Med. Chem. Res. 2013,

Hou-ling Dai, Li-xin Gao, Ying Yang, Jing-ya Li, Jiagao Cheng*, Jia Li*, Ren Wen, Yan-qing Peng, Jian-bin Zheng*. “Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.” Bioorgan. Med. Chem. Lett. 2012,

Wenwen Zhang, Yefeng Fan, Tao Yu, Zhiping Xu, Xiaoyong Xu*, Jiagao Cheng*, Zhong Li. “Synthesis, Insecticidal Assay and Molecular Docking Study of Novel Neonicotinoids N-Oxide Analogues. ” Chin. J. Chem., 2012,

Tingting Cao, Yipei Ma,Xiuhua Yan, Jiagao Cheng*, Youhua Luo, Liming He, Weiliang Zhu*. “Is Free Cyclooctatetraene Dianion an Aromatic System? A Quantum Chemistry Study”, Chin. J. Chem. 2009,

Lingyan He#,Jiagao Cheng#, Tao Wang, Caimei Li, Zhen Gong, Hong Liu, Bu-Bing Zeng, Hualiang Jiang, Weiliang Zhu. Cation-π complexes formed between cyclooctantetraene and alkaline earth metals: predicted and recorded NMR features, Chem. Phys. Lett. 2008,

Jiagao Cheng, WeiLiang Zhu, YanLi Wang, XiuHua Yan, Zhong Li, Yun Tang, HuaLiang Jiang*. The Open-Close Mechanism of M2 Channel Protein in Influenza A Virus: A Computational Study on the Hydrogen Bonds and Cation-pi interactions among His37 and Trp41, Sci. China Ser. B-Chem, 2008,

Jiagao Cheng, XiaoMin Luo, XiuHua Yan, Zhong Li, Yun Tang, HuaLiang Jiang. WeiLiang Zhu,Research Progress in Cation-pi interactions, Sci. China Ser. B-Chem, 2008,

Jiagao Cheng, Zhen Gong, Weiliang Zhu, Yun Tang, Weihua Li, Zhong Li, Hualiang Jiang. “Cation sitting in aromatic cages: ab initio computational studies on tetramethylammonium–(benzene)n (n=3–4) complexes”J. Phys. Org. Chem., 2007,

Jiagao Cheng, Weiliang Zhu, Yun Tang, Yufang Xu, Zhong Li, Kaixian Chen, Hualiang Jiang. “Effect of cation-π interaction on NMR: A theoretical investigation on complexes of Li+, Na+, Be2+, and Mg2+ with aromatics.” Chem. Phys. Lett. 2006,

Jiagao Cheng, Congmin Kang, Weiliang Zhu, Xiaomin Luo, Chum Mok Puah, Kaixian Chen, Jianhua Shen*, Hualiang Jiang*. “N-Methylformamide-Benzene Complex as a Prototypical Peptide N-H∙∙∙π Hydrogen-Bonded System: Density Functional Theory and MP2 Studies.” J. Org. Chem. 2003,